Keynote Conference - Interevent

July 25th- 28th, 2012 

Rio de Janeiro, Brazil 

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Scientific Content 

Welcome to ICCB 2012 

SBBC Council and Committees 

ICCB 10th Annual Meeting Supporters 

Meeting at a Glance 

Pre-Meeting Educational Activities 

Wednesday Program 

Thursday Program 

Friday Program 

Saturday Program 

Travel Awards 

Contents 

www.sbbc.org.br 

General Information 

Meeting Registration 

Meeting Policies 

Meeting resources 

Transportation and Hotel Map 

General Travel Information 

Important phone numbers 

RioCentro Convention Center Attendee Resources 

RioCentro Convention Center Floor Plans 

Exhibitors 

Exhibitor Listings 

Exhibit Hall Floor Plan 

Poster Information 

Poster sessions and assignment 

Presentation instructions 

Poster title list 

Authors 

Author Index 

2

Welcome! 

Welcome to the heart of biomedical sciences! As important as the function of cells 

for life, cell biology is at the center stage of science nowadays, either through the 

promises in therapy strategies and biotechnology or through the development of new 

tools and concepts, not to forget its importance and influence on science education. 

The program is dense, explores the many aspects of this fascinating area, and 

counts on the contribution from internationally recognized experts. We would like to 

express our sincere gratitude to invited speakers, guests, participants, exhibitors and the 

staff working to the different committees. This is also a great opportunity to thank the 

Brazilian Society for Cell Biology (SBBC) and the International Federation of Cell Biology 

(IFCB) for the partnership, and the different government agencies and institutions that 

contributed for both organizational and financial aspects, especially FIOCRUZ. 

The ICCB2012 is a happy and timely coincidence between the International 

Congress on Cell Biology and the Congress of the Brazilian Society for Cell Biology, which 

was detected and worked out in 2004. By that time, SBBC hosted the Ibero-American 

Congress of Cell Biology (CIABIC) in Campinas, and it became clear that integration of 

Latin America should be strongly encouraged for the following years. In practical terms, 

ICCB2012 will gather more than 2000 participants, which is twice as large as SBBC biennial 

meetings. 

ICCB2012 is one of the sixty nine international events taking place in Rio in 2012, 

and the city will host the World Soccer Cup in 2014 and Olympic Games in 2016. All this 

only reinforces the vibrating environment that we will be in for the next four days. 

We hope that by putting this meeting together we will be able to contribute to the 

discussion and definition of Cell Biology for the next years and moreover, we intend to 

create a forum to highlight the importance of science development in a nation whose 

origin roots up the hills in the Wonderful City and increases the pathways and 

connections for its integration regionally. Have a great ICCB and enjoy your stay in Rio! 

Hernandes F Carvalho and Patricia Gama 

Co-Chairs ICCB 2012 

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10 th ICCB and 16 th SBBC Meetings 

Co-Organizers 

The Brazilian Society for Cell Biology (SBBC) 

EXECUTIVE COMMITTEE 

President Wilson Savino - Fiocruz, Rio de Janeiro 

Vice-President Vilma R Martins – Hospital A C Camargo, São Paulo 

Directors Marimélia Porcionatto - UNIFESP, São Paulo 

Patrícia Gama - USP, São Paulo 

Flavia A C Gomes - UFRJ, Rio de Janeiro 

Secretary Irene Yan - USP, São Paulo 

Treasurer Marinilce F Santos - USP, São Paulo 

The International Federation for Cell Biology (IFCB) 

President Denys Wheatley - Aberdeen, Scotland, UK 

Vice-President Cheng-Wen Wu - NHRI, Taiwan 

Secretary General Hernandes F Carvalho - UNICAMP, Brazil 

Executive organization 

Av. das Américas 3500 – Bl. Hong Kong 3000 - Sl. 405 

Le Monde Office - Barra da Tijuca - RJ - 22640-102 

Tel.: 55 21 3326-3320 Fax: 55 21 2437-1483 

www.interevent.com.br 

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Co-Chairs 

Organizing Committee 

Hernandes F Carvalho (State University of Campinas) 

International Federation for Cell Biology IFCB 

Patrícia Gama (University of São Paulo) 

Brazilian Society for Cell Biology SBBC 

Brazilian Committee 

Estela Bevilacqua (University of São Paulo) 

Flávia Gomes (Federal University of Rio de Janeiro) 

Irene Yan (University of São Paulo) 

Marinilce F Santos (University of São Paulo) 

Marimélia Porcionatto (Federal University of São Paulo) 

Milton Moraes (FIOCRUZ) 

Thereza Christina Barja-Fidalgo (University of Rio de Janeiro) 

International Contacts 

Europe: Anne Eichmann (College de France, France; Yale University, USA) 

US: Bechara Kachar (NIDCD, NIH, USA) 

Latin America: Gabriel Rabinovitch (Buenos Aires University, Argentina) 

Asia: Ken Wen Wu (NHRI, Taiwan) 

Australia: James Armitage (Monash University, Australia) 

Scientific Committee 

Bechara Kachar Hernandes F Carvalho Nadja Souza-Pinto 

Betina Malnic Hugo Armelin Paolo Meda 

Carla Collares Irene Yan Patrícia Bozza 

Carlos Ramos Ivarne Tersariol Patrícia Gama 

Célia Regina Garcia Jorg Kobarg Renata Pasqualini 

Celuta Sales Alviano José Garcia Abreu Ricardo Guellerman 

Cláudia Mermelstein José Mauro Granjeiro Roger Chammas 

Claudio Simon José Xavier Neto Ruy Jaeger 

Constance Oliver Klaus Hartfelder Sang Won Han 

Edna Kimura Luiz Renato França Sérgio Schenckman 

Emer Suavinho Ferro Manoel Costa Silvana Allodi 

Enilza Espreafico Mari Sogayar Vilma R Martins 

Estela Bevilacqua Maria Célia Jamur Vivaldo Moura Neto 

Fábio Papes Maria Isabel Cano Wadih Arap 

Fernando Costa e Silva Filho Marimélia Porcionatto Wanderley de Souza 

Flávia CA Gomes Marinilce F Santos Wilma Kempinas 

Glaucia Santelli Marlene Benchimol Wilson Savino 

Gustavo Amarante Mendes Mirian Jasulionis 

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The organizers gratefully acknowledge the 

Financial Support 

Institutional Support 

FCW 

Fundação 

Conrado 

Wessel 

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The organizers gratefully acknowledge Exhibitors and Sponsors 

Fairport Biolince 

INFABIC- INCT 

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Program at a Glance 

July 25th (Wednesday) 

Room # 201 202 204 205 

Courses 

206 207 208 209 212 

Cell Migration Image J Cell culture as Transcriptional Plant Cell Neurobiology Advanced Muscle cell Cellular and 

Marcelo Lamers A public domain alternative model regulation & Biology signaling and Microscopy differentiation molecular 

for image for animal transcriptome Adriana S plasticity in glial Manoel Costa Claudia tools for 

processing and experimentation analyses Hemerly 

cells 

Mermelstein & invertebrate 

09h00- 10h30 

analysis 

Ruy Jaeger 

Silvya S Maria- 

Engler & 

Klaus Hartfelder 

Flávia Gomes 

Cécile Gauthier- 

Rouviere 

models 

Silvana 

Silvia Berlanga 

(SBBC & French 

Society for Cell 

Biology) 

Allodi 

10h30- 10h45 Cooffe Break 

10h45- 12h15 

Cell Migration Image J analysis Cell culture as 

alternative model 

for animal 

experimentation 

Transcriptional 

regulation & 

transcriptome 

analyses 

Plant Cell 

Biology 

12h00 Exhibits open 

12h15 Lunch 

Neurobiology 

signaling in glial 

cells 

Advanced 

Microscopy 

Muscle cell 

differentiation 

Cellular and 

molecular 

tools for 

invertebrate 

models 

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12h30 Special Interest Activities 

Room # 201 202 204 205 206 207 208 209 

Round Table: 

12h45-14h45 

12h45-14h45 12h45-17h00 

Publishing in Cell 

SBBC Workshop: 

IFCB Workshop: Workshop: 

Biology 

Can universities 

Scientific Writing Creative Cell 

12h30- 14h00 Roger Chammas 

help schools? 

Denys Wheatley Biology in 

Marimélia 

schools 

Porcionatto 

Luiz Anastacio 

Alves 

14h00-15h00 

L #1 

Claudio Joazeiro 

Neurodegeneration 

L #2 

Daria M-Rosen 

Metabolic stress 

L #3 

Mark Ellisman 

Frontiers in 

Microscopy 

Imaging 

L #4 

Y Shav-Tal 

Single gene 

tracking 

12h45-14h45 

Can universities 

help schools? 

15h00 Coffee Break 

15h30-17h00 

Symp #1 

Prions 

Jerson Lima e Silva 

Symp #2 

Programs, 

Genes, and 

Homeostasis 

José Xavier Neto 

Symp #3 

Gene Therapy 

Sang Won Han 

Symp #4 

Cell Biology and 

Reproduction 

Luiz Renato 

França 

17h30 Exhibits close 

Opening Ceremony (Main Hall) 

17h30 

Keynote Conference 

Elaine Fuchs 

L #5 

Célia R Garcia 

Host Parasite 

Interaction: 

Malaria 

Symp #5 

Host Parasite 

Interaction 

Wanderley de 

Souza 

12h45-14h45 

IFCB Workshop: 

Scientific Writing 

12h45-17h00 

Workshop: 

Creative Cell 

Biology in 

schools 

12h45-17h00 

Workshop: 

Creative Cell 

Biology in 

schools 

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July 26th (Thursday) 

Room # 201 202 204 205 207 208 

08h45 - 10h15 

Symp #6 

Membrane biology 

José Garcia Abreu 

Symp #7 

Signaling in 

Development 

Ricardo G P Ramos 

Symp #8 

Epithelial 

Proliferation & 

Differentiation 

Mari Sogayar 

Symp #9 

Immune Cell 

Biology 

Wilson Savino 


10h15 Break 

10h45- 11h45 

Keynote Conference (Main Hall) 

Douglas Green 

11h45-13h45 

Pavillion 5 (1 st and 2 nd floors) / 1st Poster Session 

Poster Presentation 11h45-12h45 even nrs 

Poster presentation 12h45-13h45 odd nrs 

Room # 201 202 

12h15-13h45 

Special Symp 

Selected abstracts 

(Professionals) 

Special Symp 


(Graduate students) 

Symp #10 

Cell Biology and 

Education 

Bruce Alberts & 

Cynthia Jensen 

(American Society 

for Cell Biology & 

IFCB) 

Room # 204 

IFCB General Assembly 

Symp #11 

Glia Club 

Vivaldo Moura 

Neto & Bernardo 

Castellano 

13h00-14h00 Exhibitors - technical conferences 

Room # 205 207 208 

GE Healthcare Nikon Life Technologies 

14h00-15h00 


Bruce Alberts 

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Room # 201 202 204 205 207 208 

15h15-16h15 

L #6 

Juan Bonifacino 

Polarized Sorting in 

neurons 

L #7 

Anne Eichman 

Guidance of 

vascular patterning 

L #8 

Hans Clevers 

Intestinal stem cell 

16h15-16h45 Coffee Break 

16h45-18h15 

Symp #12 

Protein Folding and 

Assembly 

Carlos Ramos 

Symp #13 

Vascular Cell 

Biology 

Robson Monteiro 

Symp #14 

Cell Cycle control 

mechanisms 

Hugo Armelin & 

Patrícia Gama 


18h30-19h30 

L #9 

Mauro Pavão 

Targeting proteinglycan 

interactions 

Symp #15 

Migration and 

Regeneration 

Fernando Costa e 

Silva Filho 


Ruslan Medzhitov 

July 27th (Friday) 

L #10 

Alejandro Schinder 

Neurobiology 

Symp #16 

Inflammation 

Patricia Bozza 

Symp #17 

Glia 

Flávia Gomes 

Room # 201 202 204 205 207 208 

08h45 - 10h15 

Symp #18 

Cancer therapy 

Jorg Kobarg 

Symp #19 

Regulators of 

neural transmission 

Vilma Martins & 

Roy Larson 

Symp #20 

Tissue Regeneration 

Juan Larrain 

Symp #21 

Metabolic 

Programming 

James Armitage 


10h15 Break 

10h45- 11h45 


Daniel St Johnston 

11h45-13h45 

Pavillion 5 (1 st and 2 nd floors) / 2nd Poster session 

Poster Presentation 11h45-12h45 even nrs 

Poster presentation 12h45-13h45 odd nrs 

Symp # 22 

Mitochondria 

Nadja Souza-Pinto 

& Enilza Espreafico 

Room # 204 

SBBC General Assembly 

Symp #23 

Cytotoxicity 

Sandra Azevedo & 

Tamara Lah Turnsec 

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Room # 201 202 

12h15-13h45 

Special Symp 


(Undergraduate 

students) 

Special Symp 


(Graduate students) 

13h00-14h00 Exhibitors - technical conferences 

Room # 205 207 208 

Carl Zeiss BD Roche 

Room # 201 202 204 205 207 208 

14h15-15h15 

L #11 

Miriam Jasiulionis 

Epigenetics and 

malignant 

transformation 

L #12 

Stefan Linder 

Podosomes, 

microtubules and 

motor proteins 

L #13 

Marcelo Morales 

Bone-marrow stem 

cell therapy 

15h15-15h45 Coffee Break 

15h45-17h15 

Symp #24 

Cancer 

Renata Pasqualini 

Symp #25 

Cell motility 

James Sellers 

Symp # 26 

RNA regulation 

Jean Pierre Perrault 

(Canadian Cell 

Biology Society) & 

Carla C Oliveira 

Symp #27 

Maternal interface 

Estela Bevilacqua 

17h30-18h30 


Jennifer Lippincott-Schwartz 


Symp #28 

Cells as biosensors 

Glaucia Santelli & 

Paulo Saldiva 

Special Symp 

Oral Presentations 

(Extra Session) 

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July 28th (Saturday) 


Room # 201 202 204 205 

L# 14 

L# 15 

L# 16 

L #17 

Rick Horwitz Stephen Doxsey Andrzej Bartke Sérgio Ferreira 

9h00-10h00 Mechanosensing Mitotic Growth hormone Neurodegenerative 

through myosin II centrosomes in 

asymmetric events 

and Aging 

disorders 

10h00 Coffee Break 

Symp # 29 

Symp #30 

Symp #31 

Symp #32 

MMPs and TIMPs Telomeres Cancer Stemness Unconventional 

10h30-12h00 

Ruy Jaeger Maria Isabel Cano Ken Wu 

(Taiwan Society for 

Cell and Molecular 

Biology) 

organelles 

Marlene Benchimol 


12h00 Lunch 

Room # 201 202 204 

L #18 

L# 19 

L #20 

13h00 

Peter Friedl 

Cell migration 

Xavier Belles 

MicroRNAs and 

metamorphosis 

Rafael Linden 

Prions 

14h15- 15h15 Closing conference (Main Hall) 

Richard Hynes 

15h15-15h45 Closing remarks (Main Hall) 

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ATTENDEE AND EXHIBITOR REGISTRATION 

Wednesday, July 25 th 7h30-17h30 

Thursday, July 26 th 8h00-18h00 

Friday July 27 th 8h00-17h00 

Saturday July 28 th 8h00-16h00 

GENERAL INFORMATION 

SBBC MEETING MANAGEMENT/BUSINESS OFFICE 

Registration counter and Exhibition Hall 14h00- 17h00 

MEDIA DESK & VIP ROOM- 2 nd floor Room 210 8h00- 17h00 

BADGES/REPLACEMENT POLICY 

Meeting badges must be worn at all times while in RioCentro Convention Center. Children 

over the age of 12 must wear a badge. There is a R$ 30,00 charge for lost or misplaced 

badges. Photo identification will be required for replacement. To avoid these charges, 

please remember to bring your meeting badge and materials with you. 

CAMERAS 

Cameras and other recording devices are prohibited in Poster Sessions. 

DRINKING AND SMOKING POLICIES 

The SBBC and IFCB encourage responsible drinking for those drinking alcohol. Coffee and 

water will be offered at Coffee breaks. Alcoholic beverages are allowed only in specific 

areas. According to Rio de Janeiro State Law 5.517 it is prohibited to smoke in any area at 

any public area, including the Convention Center. 

Food Court 

A Food Court will be available during meeting hours and will be organized with different 

restaurants. 

EXHIBIT HALL HOURS 

Wednesday 12h00- 17h30 

Thursday and Friday 10h00-18h00 

Saturday 9h00- 13h00 

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GROUND TRANSPORTATION 

In Rio de Janeiro, public transportation includes buses, subway and trains. Ticket costs 

around R$ 3,00. An integrated special ticket (bilhete único) can be used both in buses and 

subway. A special bus service runs from the Airports (Galeão and Santos Dumont) to 

specific sites in the city. For more information: www.rioonibus.com 

https://www.cartaoriocard.com.br/scrcpr/ For bus routes check: 

http://www.vadeonibus.com.br/vadeonibus/index.php 

Taxis are yellow in Rio de Janeiro, and there are two other companies working as red and 

blue. 

There will be a bus service to and from Riocentro, see the map below. 

LOST AND FOUND AND MESSAGE CENTER 

Please contact Registration Desk for lost and found. Messages for invited speakers and/or 

attendees should be left at ICCB registration desk. 

POSTER SESSIONS 

Poster Sessions will be held at 1 st and 2 nd floors (Room 203) and will be organized according 

to the different areas (informed below). 

Poster Session I: Thursday, July 26 th 

Poster Session II: Friday, July 27 th 

Author presentation for both sessions: 

11h45- 12h45 even numbers 

12h45-13h45- odd numbers 

Poster numbers will identify the boards. Tapes and hangers should be brought to the area 

by presenters. The Organizing Committee will not provide these items and will not collect 

and keep Posters that are left on the Boards. 

SAFETY AND SECURITY 

Rio de Janeiro is a large city and care should be taken as in any other huge city. We are 

committed to make the necessary efforts to ensure a safe, productive and nice event for 

everyone. Please remember to take off your badge when exiting the Convention Center. 

Please be aware of your surroundings at all times. For emergencies while in RioCentro, 

contact a uniformed security officer. For emergencies while in your hotel, please follow the 

specific instructions. 

WEATHER 

July monthly highs average 25 o C, lows average 15 o C. It is usually a dry season in Rio de 

Janeiro. 

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Transportation and hotels 

Two differents Routes will be serving the Congress. 

Transportation System 

Routes Blue Route: from Barra da Tijuca Beach Red Route: From Avenida das 

Américas 

Stops Praia Linda, Windsor Barra, Sheraton Barra 

and Casa del Mar 

Barra First and Bourbon Residence 

Guests staying at the hotels: Paradiso All Suites, Transamérica Barra and Royalty Barra must take 

the Blue Route transportation. 

Departures to Rio Centro (Blue Route and Red Route) 

July 25th Beetween 07:15 | 07:30 Between 12:00 | 12:15 Between 16:30 | 16:45 

July 26th Between 07:30 | 07:45 Between 09:00 | 09:15 



Return from Rio Centro (Blue Route and Red Route) 

July 25th and July 26 th 19:45 

July 27th 18:45 

July 28th 15:45 (*) 

(*) On this day, there will be transportation departuring from Rio Centro to the Internacional 

Airport (Galeão) and Santos Dumont Airport, in this order. 

A free bus will be running from Barra Shopping (BS) to Riocentro (RC) and back at hourly 

schedule (starting at 12h30 at BS on July 25 th and 8h00 (BS) on the 

following days). For more information contact the registration desk. 

16

More on travelling information 

BARRA DA TIJUCA 

Barra da Tijuca is Rio´s most modern living complex and community; sophisticated, vibrant and 

offering innumerable attractions such as fine bars and restaurants serving world class cuisine, airconditioned 

shopping malls featuring world famous fashions and designers labels, theme parks, 

ecological reserves and sports of all types. Only 15 km from Ipanema Beach and 18 km from 

Copacabana this part of the city is on continued expansion and is becoming Rio’s business and 

economic center extended by miles of an outrageous virgin beach. While in Rio don’t miss the 

opportunity to discover the city. 

PASSPORT & VISAS 

Passports are required for all foreigners. Brazil’s visa requirements are based upon reciprocity. If 

your home country requires a visa for Brazilian travelers, you will need one for your visit. Additional 

information can be obtained from the nearest Brazilian Embassy or Consulate. Your passport 

expiration date should be at least six months from the date of your arrival. For more information, 

please visit http://www.passportsandvisas.com/visas/brazil-visa-faq.asp 

HEALTH 

There are no compulsory health requirements for entry into Brazil. We suggest that you contact 

your local Consulate for current advice. Please note that if you are entering Brazil via Colombia, 

Equador or Peru, you will be required to provide a current yellow fever vaccination certificate for 

immigration purposes. 

MEDICAL AND INSURANCE SERVICES 

Rio de Janeiro and Brazil have a number of internationally respected hospitals, clinics and doctors, 

but treatment is costly, so visitors are strongly advised to take out medical trip insurance. 

The Congress Organization is not liable for any health problems, personal accidents, lost baggage or 

cancellation of travel arrangements, flights, etc. We recommend that participants provide their 

own insurance policies. 

FOOD & DRINKS 

The most common dishes feature various meats, rice and the ubiquitous Brazilian black beans 

(feijão), while restaurants many times offer all-you-can-eat barbecues and buffets. 

Many kinds of alcoholic drinks are available, including excellent lager style beers such as Antarctica, 

Brahma, Cerpa and Skol. The most popular local beverage is Cachaça, most commonly served as 

'Caipirinha' with slices of lime or lemon. There are no restrictions on licensing hours. Soft drinks 

include Guarana (a carbonated cola-like drink, made from the Amazon fruit, guarana) and many 

varieties of fruit juices (sucos). Brazilian coffee tends to be served less strong than Italian coffee, so 

if stronger coffee is desired, request express coffee (café expresso). If you would like to avoid sugar 

in juices or coffee, you should specifically request that it not be added. 

FOREIGN EXCHANGE 

The Brazilian monetary unit is the Real (R$). Exchange rates are published daily in the newspaper. 

Cash and traveler checks, especially US Dollars (USD), can be exchanged at most banks, exchange 

houses and major hotels. 

• Bank notes (paper money) are in denominations of R$ 100, R$ 50, R$ 10, R$ 5, R$ 1. 

• Coins are 1.00 real, 50 centavos (cents), 25 centavos, 10 centavos and 5 centavos. 

• Banking Hours - 10:00-16:00 Monday to Friday. 

17

TIPPING 

In most restaurants and bars, a 10% service fee is added to the bill. More sophisticated places may 

add 15%. If service is not included, it will be stated at the bottom of the bill: “Serviço não incluído.” 

Airport and hotel porters: the R$ is equivalent to the USD of $1.00 per suitcase. Hotels: Hotels 

generally include any service charge on the bill. Restaurants: Tips are discretionary, but often found 

on the final bills as a "suggestion." In Brazil, a typical tip remains 10%. Taxis: Tips are not expected 

by taxi drivers although most passengers will round the fare up if satisfied with the service 

SOME LAST ADVICES TO ENJOY RIO 

Below, are a few general recommendations to help you enjoy a safe and relaxing trip to Rio de 

Janeiro: 

Never leave your luggage unattended or with a stranger and please be aware that some may 

attempt to create a distraction to divert your attention from your belongings. 

The sun in Brazil can be more direct and stronger - extra precautions are necessary 

Be aware of dangerous undertows; stay near other bathers and observe the warning flags. Do not 

go to the beach at night. Avoid wearing expensive jewellery or watches, carry limited amounts of 

cash and keep your passport and other important travel documents at your hotel. When not in use, 

it is advised that you carry your camera in your pocket and as a precaution, be sure to carry your 

bag in front of you. 

IMPORTANT PHONE NUMBERS 

Brazil code: 55 

Rio de Janeiro code 21 

Police 190 

Emergency and Fireman 193 

Internacional Airport 0800999099 

Domestic Airport (Santos Dumont) 0800244646 

Riocentro 3035 9100 

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Meeting will be held at RioCentro Convention Center 

Av Salvador Allende 6555, Barra da Tijuca, Rio de Janeiro, RJ, 22780-160 Brazil 

At Riocentro ICCB is at Pavillion 5 

You are here 

Pavillion 5 

Google maps 

19

Exhibitors 

Ambriex 

AOTEC 

BD Biosciences 

Biogen 

Biolince 

Biometrix 

Carl Zeiss 

Fairport 

FUNPEC- 

Peprotec 

GE Healthcare 

INFABIC- INCT 

Inopat 

John Wiley 

Life 

Technologies 

Lonza 

Merck Millipore 

Nikon 

Nobilis Tur 

Nova Analítica 

Olympus 

Perkin Elmer 

Promega 

Roche 

SBBC 

SBS Livraria 

Sigma 

Spectrun 

Pavillion 5 1 st floor 

Pavillion 5 2 nd Floor 

20

Pre-meeting activities 

SBBC Educational program 

Workshop “Experiencing Biology” 

June 23 rd , 2012 

Escola Estadual Leda Guimarães Natal (Parelheiros, São Paulo, SP) 

Coordination: Profa Dra Marimélia Porcionatto (UNIFESP) 

Advanced Optical Microscopy Course 

July 16th- 20 th 

Universidade Federal do Rio de Janeiro, UFRJ 

Coordination: Prof Dr Manoel Luis Costa 

� Courses 

9h00- 12h15 (Coffee Break 10h30- 10h45) 

Wednesday, July 25 

Room 201 Cell Migration 

Marcelo Lamers, Peter Friedl, Alan Horwitz 

Room 202 Image J: A public domain for image processing and analysis 

Ruy Jaeger 

Room 204 Cell culture as alternative model for animal experimentation 

Silvya Stuchi Maria-Engler, Silvia Berlanga 

Room 205 Transcriptional regulation & transcriptome analyses 

Klaus Hartfelder 

Room 206 Plant Cell Biology 

Adriana Silva Hemerly, Marcelo Dornelas 

Room 207 Neurobiology signaling and plasticity in glial cells 

Flávia Gomes, Arturo Ortega, Ricardo A Melo Reis, Adan Aguirre, Marcelo Santiago 

Room 208 Advanced Microscopy 

Manoel Costa, Clarissa Henry, John Murray, João Menezes 

Room 209 Muscle cell differentiation 

Cláudia Mermelstein, Cécile Gauthier-Rouviere (SBBC & SFBC) 

Room 212 Cellular and molecular tools for invertebrate models 

Silvana Allodi, Cintia M Barros, Dib Ammar, Rodrigo Fonseca, Juliana Américo 

12h00 – Exhibits open 

21

� Round Table and Workshops 

12h30- 14h00 

Room 201 Special Interest Subgroup 

Round Table: Publishing in Cell Biology 

Chair Roger Chammas 

Bruce Alberts, Fiona Watt 

12h45- 14h45 

Room 206 SBBC Workshop: Can universities help schools? 

Marimélia Porcionatto 

Room 208 IFCB Workshop: Scientific Writing 

Denys Wheatley 

12h45- 17h00 

Room 209 Workshop: Creative Cell Biology in schools 

Luiz Anastácio Alves, Flávia Lima, Daniela Uziel Rozental 

� Lectures 

14h00- 15h00 

Room 201 L# 1 


The Scripps Research Institute, La Jolla, USA 

The ribosome-associated E3 ubiquitin ligase, Listerin (Ltn1), is 

implicated in neurodegeneration and mediates a novel pathway of 

protein quality control 

Chair: Marilene H Lopes 

Room 202 L# 2 

Daria Mochly-Rosen 

Stanford University, USA 

Excessive mitochondrial fission mediated by �PKC and by Drp1 

activation; new targets for neuroprotection 

Chair: Déborah Schechman 

Room 204 L# 3 

Mark Ellisman 

University of California San Diego, USA 

New approaches for correlated LM and 3D EM applied to 

MULTISCALE CHALLENGES: Bridging Gaps in Knowledge and 

Understanding 

Chair: Marcia Attias 

22

Room 205 L# 4 

Yaron Shav-Tal 

Bar-Ilan University, Ramat Gan, Israel 

Dynamics of gene expression in real-time measured on single 

genes in single living cells 

Chair: Jean Pierre-Perreault 

Room 207 L#5 

Célia Regina Garcia 

Universidade de São Paulo, Brasil 

PfCBF transcription factor, a new player for signal 

transduction in melatonin-pathways in malaria parasites 

Chair: Sérgio Schenkman 

15h00- Coffee Break 

� Symposia and Special Interest Subgroups 

15h30- 17h00 

Room 201 Symp #1 Special Subgroup 

Prion protein in physiology and pathology 

Chair: Jerson Silva 

Vilma Martins 

Hospital A.C. Camargo, São Paulo, Brasil 

Neurodegeneration and cancer: a crosstalk between prion protein and its ligand 

STI1 

David Harris 

Boston University School of Medicine, Boston, USA 

Neurotoxic Activities of PrP C in Prion and Alzheimer’s Diseases 

Jerson Silva 

Federal University of Rio de Janeiro, Rio de Janeiro, Brazil 


Programs, Genes and Homeostasis 

Chair: José Xavier Neto 

Michael Schubert 

Université de Lyon, France 

Retinoic acid signaling in development and evolution 

Kleber Franchini 

LNLS, Campinas, Brazil 


LNLS, Campinas, Brasil 

Ancient programs of gene expression in development and homeostasis 

23


Gene Therapy 

Chair: Martin Bonamino 

Luigi Naldini 

Director, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Italy 

A Hematopoietic Stem Cell (HSC) Specific microRNA Gives Novel Insights into the 

Regulation of HSC Homeostasis and Allows Safer HSC-based Gene Therapy 

Martin Bonamino 

Instituto Nacional de Cancer, Rio de Janeiro, Brazil 

Conditional models for Chimeric Antigen Receptor (CAR) based activation of T 

lymphocytes 


Cell Biology & Reproduction 

Chair: Luiz Renato França 

Richard Sharpe 

University of Edinburgh, UK 

Fetal testis differentiation and function, its regulation and its disorders 

Maria Christina Werneck Avellar 

Universidade Federal de São Paulo, Brazil 

Antimicrobial Proteins Secreted by the Epididymis 

Luiz Renato França 

UFMG, Belo Horizonte, Brazil 

Spermatogonial stem cell niche in vertebrates 


Host Parasite Interaction 

Chair: Wanderley de Souza 

Wanderley de Souza 

Universidade Federal do Rio de Janeiro (UFRJ), Brazil 

Introductory notes 

Sérgio Schenkman 

Universidade Federal de São Paulo (UNIFESP), Brazil 

Dephosphorylation of eIF5A is Required for Translation Arrest at the Stationary 

Growth Phase of Trypanosoma cruzi 

Kiaran Kirk 

The Australian National University, Canberra, Australia 

Ion Regulation in the Malaria Parasite: The Target of a New Generation of 

Antimalarials 

Michel Rabinovitch 

Universidade Federal de São Paulo (UNIFESP), Brazil 

Why coinfect cells with non-viral pathogens? 

24

� Keynote Conference 

17h30 Opening Cerimony 

Main Hall Opening Conference 

Elaine Fuchs 

The Rockefeller University, New York, USA 

Skin Stem Cells in Homeostasis, Wound Repair and Cancer 

Chair: Estela Bevilacqua 

� Symposia 

8h45- 10h15 

Room 201 Symp #6 

Membrane Biology 

Chair: José Garcia Abreu 

Thursday, July 26 

Christophe Lamaze 

Institut Curie, Paris, France 

Membrane Dynamics and Mechanics of Signaling: Role of Caveolae 

Derek Toomre 

Yale University School of Medicine, USA 

Studying spatial control of exocytosis at the nanoscale in living cells 

José Garcia Abreu 

Universidade Federal do Rio Janeiro, Brazil 

New inhibitory Wnt/β-catenin mechanisms affecting embryonic head formation 


Signaling in Development 

Chair: Ricardo Guellerman Pinheiro Ramos 

Roeland Nusse 


Wnt Signaling, Stem Cells and Tissue Repair 

Olivier Pourquié 

Institut de genétique et biologie moleculaire et celulaire, INSERM, France 

Formation of the Vertebrate Body Axis 

Matthew Scott 


Hedgehog Signaling in Development and Disease 


Epithelial proliferation and differentiation 

Chair: Mari Sogayar 

Fiona Watt 

CRUK Cambridge Research Institute, Li Ka Shing Centre, UK 

Intrinsic And Extrinsic Regulation Of Epidermal Stem Cell Fate 

25

João Viola 

Program of Cellular Biology, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, 

Brazil. 

Differential roles for NFAT transcription factor isoforms in cell transformation 

Mari Sogayar 

Department of Biochemistry, Chemistry Institute, University of São Paulo, São 

Paulo, Brazil 


Immune Cell Biology 

Chair: Wilson Savino 

Flávio Salazar Onfraya 

University of Chile 

Immunological and Clinical Outcomes of a New DC-Based Vaccine 

Augustin G Zapata 

Faculty of Biology, Complutense University, Spain 

Eph/ephrin-mediated interactions govern functional maturation of developing 

thymocytes in the thymic epitelial 3D network 

Wilson Savino 

Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil 


Cell Biology and Education (ASCB & IFCB Symposium) 

Chairs: Bruce Alberts and Cynthia Jensen 

Cynthia Jensen 

University of Auckland, New Zealand 

Cell Biology and Education 

Marlene Behchimol 

Universidade Santa Úrsula and Fundação CECIERJ, Rio de Janeiro, Brasil 

Teaching at Distance: Interactive Multimedia of the Cell Biology of 

Trypanosoma cruzi 

Kiaran Kirk 

The Australian National University, Canberra, Australia 

Engaging undergraduate students in research 


Glia Club 

Chairs: Vivaldo Moura Neto and Bernardo Castellano 

Arthur Butt 

University of Portsmouth, U.K. 

GSK3β is a profound negative regulator of oligodendrocyte differentiation and 

myelination 

Geoff Pilkington 

University of Portsmouth, UK 

Role of cancer stem cells in adult and paediatric brain neoplasms: hoax or holy 

grail? 


National Institute of Biology, Ljubljana, Slovenia 

Mesenchymal Stem Cells lower proliferation and invasion of Glioblastoma cells, 

exploiting the Immune Response Mediating Chemokines 

26

10h00 – Exhibits open 

10h15- 10h45 – Break 

Bernardo Castellano 

Universidade Autonoma de Barcelona 

Effects of CNS-targeted Il-6 or Il-10 production on microglial activation and 

motor neuron degeneration after facial nerve axotomy 


10h45- 11h45 

Main Hall Douglas Green 

St. Jude Children's Research Hospital, USA 

Cell death 

Chair: Wilson Savino 

� 1 st Poster Session 

11h45- 12h45 

Pavillion 5 (1 st and 2 nd floors) Poster Presentation - even numbers 

12h45- 13h45 

Pavillion 5 (1 st and 2 nd floors) Poster Presentation - odd numbers 

11h45 – IFCB General Assembly – Room 204 

� Symposia- Selected Abstracts 

12h15- 13h45 

Room 201 Special Symposium Professional selected abstracts 

Hiroshi Hosoya,Hiroshima University 

Hinrich P Hansen University Clinic Cologne, Köln, Germany 

Simone Vargas da Silva, Universidade do Estado do Rio de Janeiro 

Danielle Pereira Cavalcanti, Inmetro 

Patricia V. Burgos, Universidad Austral de Chile 

Chairs: Maria Inês Borella, Flávia Lima and Graciela Dutari 

27

Room 202 Special Symposium Graduate students selected abstracts- Session I 

Andrew Oliveira Silva, Universidade Federal do Rio Grande do Sul 

Gabriela Nana Colaneri, Universidade Federal de São Paulo, UNIFESP 

Priscila Teles de Tolêdo Bernardes, UFMG 

Luciana Pescatore, FM USP 

Chair: James Armitage, Sérgio L Felisbino 

� Exhibitors Technical Conferences and Activities 

13h00- 14h00 

Room 205 GE Healthcare 

Room 207 Nikon 

Room 208 Life Technologies 


14h00- 15h00 

Main Hall Bruce Alberts 

University of California, San Francisco, USA 

Science, Biology, and the World’s Future 

Chairs: Wanderley de Souza and Denys Wheatley 

� Lectures 

15h15- 16h15 

Room 201 L# 6 

Juan Bonifacino 

National Institutes of Health, Bethesda, USA 

Signal-Adaptor Interactions that Mediate Polarized Sorting in 

Neurons 

Chair: Luis Lamberti Silva 

Room 202 L# 7 

Anne Eichmann 

Yale University, New Haven, USA 

Guidance of vascular patterning: lessons from the nervous 

system 

Chair: Luiz Eurico Nasciutti 

Room 204 L# 8 

Hans Clevers 

University Medical Centre Utrecht, Utrecht, the Netherlands 

Lgr5 Stem Cells in self-renewal and cancer 

Chair: Vivaldo Moura Neto 

28

Room 205 L# 9 

Mauro Pavão 

Universidade Federal do Rio de Janeiro, Brasil 

Targeting protein-glycan interactions at cell surface during EMT 

and hematogeneous metastasis: consequences on tumor 

invasion and metastasis 

Chair: Marimélia Porcionatto 

Room 207 L# 10 

Alejandro Schinder 

Leloir Institute, Buenos Aires, Argentina 

Adult-born neurons contribute to information processing in the 

dentate gyrus 

Chair: Flávia Gomes 

16h15- 16h45 – Coffee Break 

� Symposia 

16h45- 18h15 


Protein Folding and Assembly 

Chair: Carlos Ramos 

Douglas M Cyr 

UNC-Chapel Hill, USA 

Mechanisms for folding corrector action in rescue of mutant CFTR from 

premature degradation by ER Quality Control 

Alberto Macario 

Istituto Euro- Mediterraneo di Scienza et Tecnologia, Palermo, Italy 

Chaperonopathies: Impact on protein folding and beyond 

Francisco Laurindo 

University of São Paulo, Brazil 

Redox Processes Associated with Physicological Protein Folding and Endoplasmic 

Reticulum Stress 


Vascular cell biology 

Chair: Robson Monteiro 

Joseph H McCarty 

University of Texas, Houston, USA 

Cell Adhesion and Signaling Pathways in Neurovascular Developmen 

Jean Leon Thomas 

Brain and Spinal Cord Institute, Paris, France 

Vascular growth factor signaling in neurogenesis 

Robson Monteiro 

Institute of Medical Biochemistry, UFRJ, Brazil 

Tumor-Derived Microvesicles and their Role in Cancer Progression 

29


Cell cycle control mechanisms 

Chairs: Hugo Armelin and Patricia Gama 

Leslie I Gold 

New York University 

Stabilizing nuclear p27 kip1 with Skp2/Cks1 E3 ligase inhibitors as a potential 

therapeutic intervention for endometrial cancer and other cancers 

Michele Pagano 

New York University, USA 

Cyclin F-mediated degradation of RRM2 (Ribonucleotide Reductase family 

member 2) controls genome integrity and DNA repair 

Guido Lenz 

Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil 

Resveratrol and Temozolomide co-treatment induces mitotic catatrophe and 

senescence in glioma cells through modulation of mitotic regulators 


Migration and regeneration 

Chair: Fernando Costa e Silva Filho 

Mark Ginsberg 

University of California, San Diego, USA 

Inside- out integrin signaling 

Tatiana Coelho-Sampaio 

UFRJ, Rio de Janeiro, Brasil 

Human-laminin mediates axonal regeneration promoted by human adipose 

tissue-derived stromal cells after spinal cord injury in rats 

Fernando Costa e Silva Filho 

UFRJ, Rio de Janeiro, Brasil 

A mechanochenical cross-talking between eukaryotic cells and their surroundings 

instruct cells on what they have to do 


Inflammation 

Chair: Patrícia Bozza 

Niels O S Câmara 

University of Sao Paulo, Brazil 

The intimate link between fibrosis and inflammatory response 

Richard Bucala 


How a Parasite MIF Suppresses T cell Immunity and Influenced the Evolution of 

Macrophage Responsivenes 

Patrícia Bozza 

Instituto Oswaldo Cruz, FIOCRUZ, Brazil 


Glia 

Chair: Flavia A C Gomes 

Arturo Ortega 

Cinvestav-IPN, México DF, Mexico 

GLAST/EAAT1 induces Glutamine release through SNAT3 in cultured chick 

cerebellar Bergmann glial cells 

30

18h00 – Exhibits close 

Frank Pfrieger 

University of Strasbourg, France 

Understanding Neuron-Glia Interactions: Models Matter 

Adan Aguirre 

Department of Pharmacological Sciences, 442 Center for Molecular Medicine, 

Stony Brook University, Stony Brook, NY 11794-5140 


18h30- 19h30 

Main Hall Ruslan Medzhitov 


Inflammation: Physiology, Pathology and Evolution 

Chair: Patricia Bozza 

� Symposia 

8h45- 10h15 


Perspectives in cancer therapies 

Chair: Jörg Kobarg 

Friday, July 27 

Vanderlei Salvador Bagnato 

Universidade de São Paulo, São Carlos, Brazil 

Modern optical techniques for diagnostic and treatment of cancer and 

microorganism 

Atanasio Pandiella 

Universidad de Salamanca, Spain 

Deciphering Neuregulin-HER signaling in breast cancer 

Jörg Kobarg 

Centro Nacional de Pesquisa em Energia e Materiais, Campinas, Brasil 

Prospecting and testing new molecular target proteins for cancer therapy: 

integrating systems and structural biology 


Regulators of neural transmission 

Chairs: Vilma Martins and Roy Larson 

Jeremy M Henley 

University of Bristol 

Regulation of neuronal function and dysfunction by protein SUMOylation 

Christina Joselevitch 


Gain control in the outer retina 

31

Martin Cammarota 

Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, Brazil 


Tissue Regeneration 

Chair: Juan Larrain 

Ken Poss 

HHMI, Duke University Medical Center, Durham, USA 

Cellular and molecular mechanisms of zebrafish heart regeneration 

José Garcia-Arrarás 

University of Puerto Rico 

Cellular and molecular mechanisms of intestinal regeneration in echinoderms 

Juan Larrain 

Pontificia Universidad Catolica de Chile 

Spinal cord regeneration in Xenopus 


Metabolic Programming 

Chair: James A Armitage 

Patricia Lisboa 

State University of Rio de Janeiro, Brazil 

Smoking in the postnatal life and future obesity: the nicotine role on the 

endocrine dysfunctions 

Licio Velloso 

University of Campinas, Brazil 

Diet-induced hypothalamic inflammation in obesity 

James A Armitage 

Monash University, Victoria, Australia 

Maternal obesity, diabetes or high fat intake in pregnancy: Are they all 

independent risk factors for metabolic syndrome in her offspring? 


Mitochondria 

Chairs and Speakers: Enilza Espreafico and Nadja Souza-Pinto 


Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 

SP, Brazil 

Mitochondrial BER activities maintain mtDNA stability and mitochondrial 

function 

Alicia Kowaltowski 

Universidade de São Paulo, Brazil 

Dietary interventions, mitochondria, oxidants and lifespan 

Enilza Espreafico 

Universidade de São Paulo, Ribeirão Preto, Brazil 

Evidence implicating KIAA0090/CG2943 in mitochondrial function 


Cytotoxicity 

Brazilian-Slovenian Meeting 

Chairs: Sandra Azevedo and Tamara Lah Turnsec 

32

10h00- Exhibits open 

10h15- 10h45- Break 

Bojan Sedmak 

National Institute of Biology, Ljubljana, Slovenia 

Cyclic cyanopeptides influence cytoskeleton organization in glial cells 

Gregor Anderluh 

University of Ljubljana, Slovenia 

Equinatoxin effects on cellular membranes 


10h45- 11h45 

Main Hall Daniel St Johnston 

University of Cambridge, UK 

Polarizing perpendicular axes in Drosophila 

Chair: Irene Yan 

� 2 nd Poster Session 

11h45- 12h45 

Pavillion 5 (1 st and 2 nd floors) Poster Presentation - even numbers 

12h45- 13h45 

Pavillion 5 (1 st and 2 nd floor) Poster Presentation - odd numbers 

11h45 – SBBC General Assembly – Room 204 

� Symposia- Selected Abstracts 

12h15- 13h45 

Room 201 Special Symposium Undergrad students selected abstracts 

Wesley Luiz Barros da Silva, Fluminense Federal University 

Luana De Santana Bottas, Biosciences, University of São Paulo, São Paulo, Brazil. 

Lucas Antonio Duarte Nicolau, UFPI 

Brenno Vinícius Martins Henrique, University of Brasília 

Flavio Augusto Rocha Barbosa, Universidade Federal de Santa Catarina 

Chairs: Ivarne Tersariol, Regina Goldenberg 

33

Room 202 Special Symposium Graduate students selected abstracts 

María Eugenia Sabatino, Universidad Nacional de Córdoba, Argentina 

Eugenio Damaceno Hottz, IOC, Fiocruz 

Manuela Weitkunat, Max Planck Institute of Biochemistry 

Clarissa Xavier Resende Valim, FMRP, USP 

Rebeca Piatniczka Iglesia, ICB, Universidade de São Paulo, Brasil 

Chairs: Christina Barja-Fidalgo, Paola Casanello, Giselle Zenker Justo 

� Exhibitors Technical Conferences and Activities 

13h00- 14h00 

Room 205 Carl Zeiss 

Room 207 BD 

Room 208 Roche 

� Lectures 

14h15- 15h15 

Room 201 L# 11 

Miriam Jasiulionis 

Ontogeny and Epigenetics Laboratory, Pharmacology 

Department, Universidade Federal de São Paulo, São Paulo, 

Brazil 

Epigenetic alterations: Linking sustained stress to 

melanocyte malignant transformation 

Chair: James Armitage 

Room 202 L# 12 

Stefan Linder 

University Medical Center Eppendorf, Hamburg 

Regulation of macrophage podosomes by microtubules and 


Chair: Fernando Costa e Silva Filho 

Room 204 L# 13 


Instituto de Biofísica Carlos Chagas Filho, Universidade Federal 

do Rio de Janeiro, UFRJ, Rio de Janeiro, Brasil 

Bone marrow-derived stem cell therapy attenuates lung silicosis 

and lung fibrosis 

Chair: Ken Wu 


34

� Symposia 

15h45- 17h15 


Cancer 

Chair: Renata Pasqualini 

Webster Cavenee 

University of California San Diego, USA 

Tumor Cell to Tumor Cell Interaction Drives Cancer Heterogeneity 

Wadih Arap 

The University of Texas, M D Anderson Cancer Center, USA 

Targeting Adipose Tissue to Prevent Cancer Progression 

Renata Pasqualini 


Integration of in Vivo Phage Display & Targeted nanotechnology and Moleculargenetic 

Imaging 


Cell motility 

Chair: James Sellers 

Paul Selvin 

University of Illinois, USA 

Single Molecule Fluorescence and Optical Trapping Applied to Molecular Motors: 

Two can do it better than one. 

Marie-France Carlier 

Cytoskeleton Dynamics and Motility group, Gif-sur-Yvette, France 

Microfluidics pushes forward microscopy analysis of actin dynamics 

James Sellers 

National Institutes of Health, Bethesda, USA 

A Tale of Two Tails: The Regulation of Myosin-5a and Myosin-7a 


RNA regulation 

Canadian Cell Biology Society 

Chairs and Speakers: Jean-Pierre Perreault and Carla Columbano 

Richard B Pearson 

University of Melbourne, Australia 

Inhibition of RNA Polymerase I as a Strategy to Treat Cancer 

Carla Columbano Oliveira 

Universidade de São Paulo, Brasil 

Identification of proteins regulating the RNA exosome 

Jean-Pierre Perreault 

Université de Sherbrooke, Canada 

Impact of G-quadruplex structures on the human transcriptome 


Maternal interface 

Chair: Estela Bevilacqua 

Felipe Vadillo-Ortega 

Universidad Nacional de Mexico (UNAM), Mexico 

35

Paola Casanello 

Faculty of Medicine, Pontificea Universidad Católica de Chile, Chile 

The placenta as an early marker of genomic, proteomic and epigenetic changes 

involved in vascular diseases 

Graciela Panzetta 

Universidad Nacional de Córdoba, Argentina 

Expression and function of PSG, StarD7 and KLF6 genes in human trophoblast 

cells 


Cells as biosensors 

Chairs: Paulo Saldiva and Glaucia Santelli 

Cecília Verônica Nunez 

Instituto Nacional de Pesquisas da Amazônia, Manaus, Amazonas, Brazil 

Cytotoxic indole alkaloids isolated from Duroia macrophylla (Rubiaceae) 

Paulo Saldiva 


Cellular responses to ambient levels of air pollution 

Glaucia Santelli 


Cell-fiber interactions: effects on cell biology 

Room 208 Special Symposium – Extra Session 

Bárbara Hissa de Carvalho Vieira Couto, Universidade Federal de Minas Gerais, Brasil 

Ana Lúcia Vargas Arigony Corte, Universidade Federal do Rio Grande do Sul, Brasil 

Daniel Moreira Silva, Universidade Federal de Uberlândia, Brasil 

Olga Catarina Lopes Martinho, University of Minho, Portugal 

Rui Manuel Reis, University of Minho, Portugal 

Raphael Silveira Vidal, Universidade Federal do Rio de Janeiro, Brasil 

Chair: Marimelia Porcionatto 


17h30- 18h30 

Main Hall Jennifer Lippincott-Schwartz 

Kennedy Shriver NICHHD, NIH, Bethesda, MD 20892 

Navigating the cellular landscape with new optical probes, 

imaging strategies and technical innovations 

Chair: Nadja Souza-Pinto 

18h00- Exhibits close 

36

� Lectures 

9h00- 10h00 

Saturday, July 28 

Room 201 L# 14 

Rick Horwitz 

Department of Cell Biology, University of Virginia School of 

Medicine 

Mechanosensing Through Myosin II: From Migration to Learning 

and Memory 

Chair: Christina Barja-Fidalgo 

Room 202 L# 15 

Stephen Doxsey 

University of Massachusetts Medical School 

Emerging roles of mitotic centrosomes in asymmetric events 

and cilia disorders 

Chair: Glaucia M M Santelli 

Room 204 L# 16 

Andrzej Bartke 

Department of Internal Medicine, Southern Illinois University 

School of Medicine, Springfield, Illinois, USA 

Growth Hormone and Aging; Benefits of Endocrine Defects 

Chair: Luiz Renato França 

Room 205 L# 17 

Sérgio Teixeira Ferreira 

Institute of Biomedical Sciences, Federal University of Rio de 

Janeiro, Brazil 

Synapse failure induced by Alzheimer's toxic Aβ oligomers 

Chair: Bernardo Castellano 


� Symposia 

10h30- 12h00 


MMPs and TIMPs 

Chair: Ruy Jaeger 

Stanley Zucker 

Stony Brook University, USA 

Membrane Type I- Matrix Metalloproteinase (MMP14): A Multifaceted Cell 

Surface Protease in Cancer 

Rama Khokha 

University of Western Ontario, Canada 

37

Vincent Lagente 

UMR991 INSERM/Université de Rennes 1, France 

Role of matrix metalloproteinases and inflammasome pathway in the 

development of airway inflammation and fibrosis 


Telomeres 

Chair: Maria Isabel Cano 

Maria Teresa Teixeira 

Institut de Biologie Physico-Chimique, France 

Saccharomyces cerevisiae as a model for the study of telomere-mediated 

replicative senescence 

Rodrigo Calado 

Universidade de São Paulo, Ribeirão Preto, Brazil 

Telomere dysfunction in human disease 

Maria Isabel Cano 

UNESP, Botucatu, Brazil 

Searching for a CST-like complex at Leishmania spp. telomeres 


Cancer Stemness 

Taiwan CB Society 

Chair: Ken Wen Wu 

Tariq Enver 

University College London, UK 

Ken Wen Wu 

National Yang-Ming University, Taipei, Taiwan 

SOX2 promotes lung cancer stemness by inducing EGFR and BCL2L1 expression 


Unconventional organelles 

Chair: Marlene Benchimol 

Martin Embley 

Newcastle University, UK 

Reductive evolution and the minimal mitochondria of microsporidian parasites 

Kildare Miranda 

Federal University of Rio de Janeiro, Brazil 

Dynamic control of the contractile vacuole complex and acidocalcisomes and 

their functional role in the mechanisms of regulatory volume decrease in 

Trypanosomatid parasites 

Ulysses Casado Lins 

Federal University of Rio de Janeiro, Brazil 

Cell biology of magnetotactic bacteria and their organelles: the magnetosomes 


Universidade Santa Úrsula, Rio de Janeiro, Brazil 

An unconventional organelle: the hydrogenosome 

38

� Lectures 

14h15- 15h15 

Room 201 L# 18 

Peter Friedl 

Radboud University Nijmegen Medical Centre, The 

Netherlands 

Collective cancer invasion, tissue guidance, and plasticity of 

therapy response 

Chair: Marinilce F Santos 

Room 202 L# 19 

Xavier Belles 

Institute of Evolutionary Biology (CSIC-UPF), Barcelona 

Regulation of insect metamorphosis and the role of microRNAs. 

Nepenthe teams up with Psyche 

Chair: Klaus Hartfelder 

Room 204 L# 20 

Rafael Linden 

UFRJ, Rio de Janeiro, Brazil 

The prion protein as a prototypical cell surface scaffold protein 

Chair: Vilma Martins 


14h15- 15h15 

Main Hall Richard Hynes 

MIT, Cambridge, USA 

Extrinsic influences on tumor progression - platelets and 

extracellular matrix 

Chair: Hernandes F Carvalho 

15h15- Main Hall- Closing Remarks 

39

Scientific Committee 

Travel Awards 

Flavia C A Gomes (Federal University of Rio de Janeiro) 

Milton Moraes (FIOCRUZ) 

Hernandes de Carvalho (State University of Campinas) 

Coordination: Amanda Araujo (Interevent) 

Selected Students Affiliation Country 

Adny H. Silva Universidade Federal de Santa Catarina (UFSC) Brazil 

Amado Quintar Universidad de Córdoba Argentina 

Andrés Nilson Caniuguir Ortega Perinatology Research Laboratory (PRL) Chile 

Anita Mayara Feitosa Santos Universidade Federal do Ceará (UFC) Brazil 

Bernardo Javier Krause Leyton Perinatology Research Laboratory (PRL) Chile 

Carla Evelyn Coimbra Nunez Universidade Estadual de Campinas (UNICAMP) Brazil 

Eder Carlos Schmidt Universidade Federal de Santa Catarina (UFSC) Brazil 

Everton de Brito Oliveira Costa Centro Regional de Hemoterapia de Ribeirão 

Preto 

Brazil 

Flavio Augusto Rocha Barbosa Universidade Federal de Santa Catarina (UFSC) Brazil 

Graziella Anselmo Joanitti EMBRAPA / CENARGEN Brazil 

Luciana Pescatore Alves Centre de Recherche en Oncologie biologique et 

Oncopharmacologie 

France 

Makiko Morita Hiroshima University Japan 

María Eugenia Sabatino Universidad Nacional de Córdoba Argentina 

Mariana Cristina Cabral Silva Universidade Federal de São Paulo (UNIFESP) Brazil 

Olga Catarina Lopes Martinho Life and Health Sciences Research Institute 

(ICVS), School of Health Sciences, University of 

Minho 

Portugal 

Patrícia Renck Nunes Institute of Molecular and Cell Biology Singapore 

Paula Cristina Rodrigues Frade Universidade Federal do Pará (UFPA) Brazil 

Paulo Euzébio Cabral Filho Universidade Federal do Pernambuco (UFPE) Brazil 

Priscila Briseno Frota Universidade Federal do Ceará (UFC) Brazil 

Renata Ottes Vasconcelos Universidade Federal do Rio Grande (FURG) Brazil 

40

Keynote Conferences- Abstracts 

Skin Stem Cells in Homeostasis, Wound Repair and Cancer 

Elaine Fuchs 

Howard Hughes Medical Institute, The Rockefeller University, 

New York, NY, USA 10065 

Embryonic skin begins as a single layer of unspecified epithelial 

cells. During development, these cells receive external cues to 

undergo a series of morphogenetic events which culminate in 

the production of a stratified epidermis replete with hair follicles, 

sebaceous glands and sweat glands. Postnatally, each of these 

tissues undergoes self-renewal which requires stem cells. We’ve 

demonstrated that there are distinct populations of resident 

stem cells within epithelial tissues. How these cells develop and 

how they balance self-renewal and differentiation is of 

fundamental importance to our understanding of normal tissue 

maintenance and wound repair, and to elucidate how the 

balance of growth and differentiation goes awry in cancers, 

particularly squamous cell carcinomas, among the most 

prevalent and life-threatening of human cancers. Using skin as 

our paradigm, we’ve been dissecting how extrinsic signaling to 

stem sets off a cascade of changes in transcription that governs 

the activation of stem cells during tissue development, 

homeostasis, hair cycling and tumorigenesis. Our findings have 

provided us with new insights into our understanding of the 

process of stem cell activation, and in so doing have revealed 

mechanisms which are also deregulated in a variety of different 

human cancers. In this talk, I will review some of our studies that 

implicate a complicated cross-talk between stem cells and their 

niche microenvironment, and how these communication 

circuitries change in normal homeostasis and wound repair and 

in tumor progression. 

Science, Biology, and the World’s Future 

Bruce Alberts 

Professor Emeritus of Biochemistry and Biophysics, University of 

California, San Francisco; Editor-in-chief, Science magazine; 

United States Science Envoy 

There are many exciting challenges ahead for biologists. Living 

organisms are so complicated that we will need new methods of 

analysis to achieve any deep understanding of their molecular 

mechanisms. For example, even when we have determined each 

of the hundreds of different molecular interactions that create 

the actin cytoskeletal system, and know the three-dimensional 

structures and rate constants for the formation and disassembly 

of each of its possible sub-complexes, the challenge of 

computing the outcomes will remain. In the same sense, most of 

the interesting properties of cells and organisms are “emergent 

properties”, resulting from a large network of interactions that 

have non-intuitive outcomes. 

More broadly, the knowledge and the problem-solving skills of 

scientists are critical for every nation – no matter how rich or 

poor. Thus, for example, science has produced a deep 

understanding of the natural world that often enables an 

accurate prediction of the consequences of current actions on 

the future. In addition, every society needs the values of 

science: honesty, generosity, and an insistence on evidence 

while respecting all ideas and opinions regardless of their source 

of origin. To spread such values, science education needs to be 

redefined at all levels, with much less emphasis on the 

memorization of science facts and terms. Instead, we should be 

providing empowering experiences in problem-solving that take 

advantage of the curiosity that children bring to school and 

increase a student’s understanding of the world. Closely related 

changes in the introductory science courses in college, 

emphasizing “science as a way of knowing,” are the key to 

driving these reforms. 

Cell death 

Douglas Green 

St. Jude Children's Research Hospital, USA 

Inflammation: Physiology, Pathology and Evolution 

Ruslan Medzhitov, Ph.D. 

David W. Wallace Professor of Immunobiology 

Investigator, Howard Hughes Medical Institute 

Yale University School of Medicine 

New Haven, CT USA 

Inflammation is an adaptive response to noxious conditions that 

disrupt tissue homeostasis. The inflammatory response alters 

the functional state of target tissues and organs aiming to 

eliminate the inflammatory inducers and to restore homeostasis. 

This unavoidably occurs at the expense of normal tissue function 

thereby creating a potential for pathological alterations. In 

addition, inflammatory control mechanisms are generally 

antagonistic to the homeostatic control mechanisms. Therefore, 

the inflammatory response presents a fundamental trade-off 

between host protection and inflammatory pathology. This 

trade-off was optimized under environmental conditions that are 

no longer present for most modern human populations and was 

shaped by evolutionary priorities that are no longer relevant for 

most humans suffering from inflammatory diseases. 

Understanding the evolutionary and physiological roots of the 

inflammatory response will help to develop prophylactic and 

therapeutic better strategies for the prevention and treatment 

of modern human diseases. 

41

Polarizing perpendicular axes in Drosophila 

Daniel St Johnston 

The Gurdon Institute, University of Cambridge, UK 

Almost all cells in a multicellular organism must be polarized to 

perform their normal functions, while a loss of polarity is a 

hallmark of cancer. Work over the last decade has revealed that 

a conserved set of polarity (PAR) proteins define complementary 

cortical domains in all polarized cell-types examined so far. How 

these complementary domains are established is much less well 

understood, however, with the exception of the C. elegans 

zygote. We have analyzed how the similar PAR domains form in 

the Drosophila oocyte to define the anterior–posterior axis (AP) 

of the embryo. Our results reveal that the oocyte is polarized by 

a different mechanism from the C. elegans zygote that also 

appears to operate in epithelial cells. Nevertheless, the 

organizing principles that underlie polarity seem to be 

conserved. 

The dorsal-ventral (DV) axis is also defined by the polarized 

organization of the oocyte, in this case by the movement of the 

nucleus from the posterior cortex of the oocyte to its 

anterior/lateral border. Although the movement of the oocyte 

nucleus was thought to depend on the prior establishment of AP 

polarity, we have isolated a mutant that separates these two 

processes. More importantly, live imaging reveals a novel 

mechanism of nuclear movement. This reveals that the oocyte 

has two parallel polarity systems and leads to a revised view of 

how orthogonal AP and DV axes form. 

Extrinsic influences on tumor progression - platelets and 

extracellular matrix 

Richard Hynes 

Howard Hughes Medical Institute, Koch Institute, MIT, 

Cambridge, MA 02139, USA. rohynes@mit.edu 

Intrinsic changes in tumor cells contribute to metastatic 

potential, but influences from the surrounding environment also 

play important roles. 

We have shown that platelets actively promote invasive and 

malignant behavior of tumor cells by activating signal 

transduction pathways (TGF- /SMAD and NF B) within the 

tumor cells and enhancing invasive behavior, extravasation and 

metastasis. Platelets form aggregates around tumor cells that 

also recruit leukocytes, which further enhance malignancy. 

Alterations in extracellular matrix (ECM) occur during normal 

development and in pathologies such as fibrosis, skeletal 

diseases and cancer. Despite clear indications that tumor ECM 

and its interactions with cells play important roles in tumor 

progression, we do not have a good picture of ECM composition, 

origins and functions in tumors. One reason lies in the 

biochemical properties of ECM proteins (large size, insolubility, 

cross-linking, etc.) that render attempts to characterize ECM 

composition very challenging. 

We have developed proteomics-based methods coupled with 

bioinformatic definition of the “matrisome” (ECM and ECMassociated 

proteins) to analyze the protein composition of tissue 

extracellular matrices. We have characterized the ECMs of 

normal tissues and of non-metastatic and metastatic tumors. We 

have applied this approach to understand the origins of tumor 

ECM and shown that both tumor cells and stromal cells 

contribute to significant changes in the ECMs of tumors of 

differing metastatic potential. We have begun to apply this 

approach to human patient material to characterize the ECM 

composition of tumors of varying prognosis with the goal of 

developing ECM signatures that may be of diagnostic and/or 

prognostic value. 

Navigating the cellular landscape with new optical probes, 

imaging strategies and technical innovations 

Jennifer Lippincott-Schwartz 

Eugene Kennedy Shriver National Institute of Child Health and 

Human Development, National Institutes of Health, Bethesda, 

MD 20892 

Emerging visualization technologies are playing an increasingly 

important role in the study of numerous aspects of cell biology, 

capturing processes at the level of whole organisms down to 

single molecules. Recent developments in probes, techniques, 

microscopes and quantification are dramatically expanding the 

areas of productive imaging. Photoactivatable fluorescent 

proteins (PA-FPs) have been particular fruitful in this regard. 

They become bright and visible upon being exposed to a pulse of 

UV light. This allows selected populations of proteins to be pulselabeled 

and tracked over time. Used for in cellulo pulse chase 

experiments, the PA-FPs have helped clarify mechanisms for 

biogenesis, targeting, and maintenance of organelles as separate 

identities within cells. PA-FPs have further permitted the 

development of single molecule-based superresolution (SR) 

imaging, which dramatically improves the spatial resolution of 

light microscopy by over an order of magnitude (~10-20 nm 

resolution). Involving the controlled activation and sampling of 

sparse subsets of photoconvertible fluorescent molecules, single 

molecule SR imaging offers exciting possibilities for obtaining 

molecule scale information on biological events occurring at 

variable time scales. Here, I discuss the new fluorescent imaging 

techniques and the ways they are helping researchers navigate 

through the cell to unravel long-standing biological questions. 

42

L#1 

The ribosome-associated E3 ubiquitin ligase, Listerin (Ltn1), is 

implicated in neurodegeneration and mediates a novel 

pathway of protein quality control 


The Scripps Research Institute, La Jolla, CA 

mRNA lacking stop codons ('non-stop mRNA') can arise from 

errors in gene expression, and encode aberrant proteins whose 

accumulation could be deleterious to cellular function. In 

bacteria, these 'non-stop proteins' become co-translationally 

tagged with a peptide encoded by ssrA/tmRNA (transfermessenger 

RNA), which signals their degradation by energydependent 

proteases. How eukaryotic cells eliminate non-stop 

proteins remained unknown. We have recently reported that 

the S. cerevisiae Ltn1 RING-domain-type E3 ubiquitin ligase acts 

in the quality control of non-stop proteins (Bengtson & Joazeiro 

2010. Nature 467:470-3). The Ltn1-mediated process is 

mechanistically distinct but conceptually analogous to that 

performed by ssrA: Ltn1 is predominantly associated with 

ribosomes, and marks nascent non-stop proteins with ubiquitin 

to signal their proteasomal degradation. Ltn1-mediated 

ubiquitylation of non-stop proteins seems to be triggered by 

their stalling in ribosomes on translation through the poly(A) 

tail. The biological relevance of this process is underscored by 

the finding that loss of Ltn1 function confers sensitivity to stress 

caused by increased non-stop protein production. We speculate 

that defective protein quality control may underlie the 

neurodegenerative phenotype that results from mutation of the 

mouse Ltn1 homologue, Listerin. In my talk, I will review these 

data and will present recent findings and further 

characterization of the Listerin/Ltn1 pathway. 

Lectures- Abstracts 

L#2 

Excessive mitochondrial fission mediated by �PKC and by Drp1 

activation; new targets for neuroprotection 

Daria Mochly-Rosen 1 , Marie-Helene 1 Distanik and Xin Qi 1.2 

1 Department of Chemical and Systems Biology, Stanford 

University School of Medicine, Stanford, CA, USA. 2 Current 

address: Department of Physiology, Center for Mitochondrial 

Diseases, Case Western Reserve University School of Medicine, 

Cleveland, OH, USA 

Neuronal cell death in a number of neurological disorders is 

associated with aberrant mitochondrial dynamics and 

mitochondrial degeneration. However, the triggers for this 

mitochondrial dysregulation are not known. We found that 

activation of � protein kinase C (�PKC) induced aberrant 

mitochondrial fragmentation and impaired mitochondrial 

function in neurons in an in vivo rat model of hypertensive 

encephalopathy. We found that �PKC directly bound to Drp1, a 

major mitochondrial fission protein, and phosphorylated it at 

Ser 579, thus increasing mitochondrial fragmentation. 

Importantly, inhibition of �PKC, using a selective �PKC inhibitor 

peptide that we have designed, reduced impaired 

mitochondrial fission and conferred neuronal protection in 

models of hypertensive encephalopathy. We also found that 

this �PKC inhibitor reduced mitochondrial dysfunction in 

models of Parkinsonism. Together, we show that �PKC 

activation dysregulates the mitochondrial fission machinery and 

increases ROS production, thus contributing to at least two 

neurological pathologies by increasing mitochondrial fission, 

fragmentation and dysfunction. Since �PKC may be critical for 

other cellular functions, we next focused on generating an 

inhibitor of Drp1 interaction with Fis1. Applying a rationally 

designed approach, we identified P110, a peptide inhibitor of 

Drp1/Fis1 interaction, and show that this peptide is highly 

effective and selective in inhibiting aberrant mitochondrial 

fission in neurons and cell death induced by neurotoxins, such 

as those associated with Parkinsonism. Therefore, we suggest 

that inhibitors of aberrant mitochondrial fission might be useful 

for treatment of human diseases in which dysregulation of 

mitochondrial dynamics occurs. 

43

L#3 

New approaches for correlated LM and 3D EM applied to 

MULTISCALE CHALLENGES: Bridging Gaps in Knowledge and 

Understanding 

Mark H. Ellisman, Ph.D., 

Professor of Neurosciences and Bioengineering; Director, the 

National Center for Microscopy and Imaging Research (NCMIR) 

(http://www.ncmir.ucsd.edu/) UCSD. 

A grand goal in cell biology is to understand how the interplay 

of structural, chemical and electrical signals in and between 

cells gives rise to tissue properties, especially for complex 

tissues like nervous systems. New technologies are hastening 

progress as biologists make use of an increasingly powerful 

arsenal of tools and technologies for obtaining data, from the 

level of molecules to whole organs, and at the same time 

engage in the arduous and challenging process of adapting and 

assembling data at all scales of resolution and across disciplines 

into computerized databases. This talk will highlight projects in 

which development and application of new contrasting 

methods and imaging tools have allowed us to observe 

otherwise hidden relationships between cellular, subcellular 

and molecular constituents of cells, including those of nervous 

systems. New chemistries for carrying out correlated light and 

electron microscopy will be described, as well as recent 

advances in large-scale high-resolution 3D reconstruction with 

LM, TEM and SEM based methods. Examples of next 

generation cell-centric image libraries and web-based 

multiscale information exploration environments for sharing 

and exploring these data will also be described. 

L#4 

Dynamics of gene expression in real-time measured on single 

genes in single living cells 

Yaron Shav-Tal 

The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan 

University, Ramat Gan, Israel 

How can the transcriptional output of a gene be measured in a 

living cell? One approach is to measure transcriptional kinetics 

on multiple-copy gene-arrays by quantifying the rates at which 

fluorescently tagged mRNA is produced. This technique can 

provide accurate rates of transcription elongation in vivo. 

Another system allows the detection of transcriptional gene 

activity from a single gene, thereby providing the ability to 

analyze the kinetics of gene expression at the single allele level. 

This analysis can discern between endogenous and overexpressed 

states of a gene, and provide spatial and temporal 

information on transcription throughout the cell cycle. 

44

L#5 

PfCBF transcription factor, a new player for signal transduction 

in melatonin-pathways in malaria parasites 

Wania Rezende Lima, Miriam Moraes and Célia R. S. Garcia 

Departamento de Fisiologia, Instituto de Biociências, 

Universidade de São Paulo – São Paulo- Brasil 

The signal transduction pathways controlling malaria parasite 

development remain largely unexplored. It is now accepted that 

Plasmodium senses the environment and exploits calcium and 

cAMP signalling pathways to modulate cellular functions. We 

want to understand how the molecular machinery for signalling 

transduction is put in action in Plasmodium, how second 

messengers are generated and if they play a role in the cell 

cycle. We have reported that potentially important signaling 

molecules from the host cell, the Red Blood Cell (RBCs) such as 

ATP modulates Plasmodium falciparum progression within RBCs 

through the rise of cytosolic Ca 2+ . We have used a cell-permeant 

form of caged-IP3 to investigate the cytosolic IP3 levels under 

physiological conditions in infected RBCs co-loaded with both 

the cell-permeant caged-IP3 and Fluo4-AM. UV flash photolysis 

of caged-IP3 under these conditions elicited a rapid and 

transient increase in intracellular Ca 2+ in RBCs infected with P. 

falciparum. Thereby providing a direct evidence that a classical 

PLC-dependent intracellular Ca 2+ release pathway operates in P. 

falciparum infected RBCs. We provided the first direct evidence 

that the host hormone melatonin elicits a rise in intracellular IP3 

levels in the malaria parasite. We have also found that the 

Plasmodium kinase PfPK7 is central in the downstream 

mechanism for synchronizing the parasite as a P. falciparum 

clone unable to express PfPK7 does not respond to melatonin. 

Taken together these data implicate that melatonin activates 

Phospholipase C (PLC) to generate IP3 and open ER-localized IP3sensitive 

Ca 2+ channels in P. falciparum 

In our search for the molecular effectors of second messenger 

signaling in P. falciparum we have search for the role of the 

PfCBF. The CBF family of transcription factors are involved in 

the regulation of cell cycle of many eukaryotic genes. The 

molecular and functional characterization of transcription 

factors in P. falciparum are yet poorly studied. In order to 

determine the protein and mRNA expression levels of intraerythrocytic 

PfCBF, western-blot and qRT-PCR were performed. 

To localize the CBF protein distribution in the parasite, confocal 

microscopy and subcellular fractionation were carried out. The 

effect cAMP on PfCBF gene and protein expression during intraerythrocytic 

development of the malaria parasites was followed 

by qRT-PCR and western blot analysis. PfCBF is expressed 

throughout the intra-erythrocytic stages but is greatly 

detectable at the schizont stage at both the mRNA and protein 

levels. 

In conclusion, We suggest that PfCBF may have an integral role 

in parasite melatonin responses and the subsequent parasite 

development. Then progress in understanding the function of 

PfCBF transcription factor in the context of the melatonin 

response is likely to provide a better knowledge of the parasite 

biology. 

L#6 

Signal-Adaptor Interactions that Mediate Polarized Sorting in 

Neurons 

Ginny G. Farías, Loreto Cuitino, Xiaoli Guo, Xuefeng Ren, Rafael 

Mattera and Juan S. Bonifacino 

Cell Biology and Metabolism Program, Eunice Kennedy Shriver 

National Institute of Child Health and Human Development, 

National Institutes of Health, Bethesda, Maryland, USA 

Neurons are anatomically and functionally polarized cells that 

conduct nerve impulses in a vectorial fashion. Impulses are 

received by dendrites, propagated through the soma, and 

eventually transmitted to other cells by axons. The plasma 

membrane of each of these neuronal domains has a distinct 

protein composition, but the mechanisms responsible for this 

differential distribution of plasma membrane proteins remain 

poorly understood. By analogy to other protein sorting 

processes, we hypothesized that biosynthetic delivery of 

transmembrane proteins to different neuronal domains could 

be mediated by interaction of sorting signals in the cargo 

proteins with adaptor proteins that are components of protein 

coats. Indeed, we found that a tyrosine-based sorting signal in 

the cytosolic domain of the transferrin receptor (TfR) mediates 

sorting of this protein to the somatodendritic domain in both 

hippocampal and cortical neurons. This signal binds to the 

mu1A subunit of the clathrin-associated, heterotetrameric 

adaptor protein 1 (AP-1) complex. Overexpression of a 

dominant-negative mu1A mutant incapable of binding signals, 

or RNAi-mediated depletion of another subunit of the AP-1 

complex, gamma-adaptin, resulted in missorting of the TfR to 

the axon. Various microscopic techniques revealed that sorting 

occurs at AP-1-coated areas of the TGN through exclusion of the 

TfR from transport carriers bound for the axon. These findings 

demonstrate that interactions of sorting signals with AP-1 

mediate clathrin-dependent sorting of the TfR and other cargos 

to the neuronal somatodendritic domain. Together with recent 

observations in other polarized cell types, our findings support 

the notion that AP-1 is a global regulator of polarized sorting. 

45

L#7 

Guidance of vascular patterning: lessons from the nervous 

system 

Anne Eichmann 

Centre Interdisciplinaire de Recherche en Biologie (CIRB), 

Collège de France, Paris, France, Cardiovascular Research 

Center, Yale University School of Medicine, 300 George Street, 

New Haven, CT 06510-3221, USA 

Anatomical parallels between the nervous and the vascular 

system are readily apparent in peripheral body tissues, where 

blood vessels and nerves ramify throughout nearly all domains 

of the body and are usually aligned. Alignment of nerves and 

blood vessels allows the establishment of a physical relationship 

between them, as larger nerves are vascularized by vasa 

nervorum to ensure their oxygen and nutriment supply, while 

arteries are innervated by autonomic nerve fibers that control 

vascular tone. To orchestrate the formation of their highly 

branched, exquisitely wired networks, nerves and blood vessels 

have developed shared cellular and molecular principles. 

L#8 

Lgr5 Stem Cells in self-renewal and cancer 

Hans Clevers 

Hubrecht Institute, Royal Netherlands Academy of Arts and 

Sciences & University Medical Centre Utrecht, Uppsalalaan 8, 

3584 CT Utrecht, the Netherlands 

The intestinal epithelium is the most rapidly self-renewing 

mammalian tissue. Lgr5 is a gene transcribed in cycling, crypt 

base columnar cells at the crypt base. Using lineage tracing 

experiments the Lgr5 +ve cells were identified as the stem cells of 

the intestinal epithelium. Furthermore, Lgr5 +ve stem cells can 

initiate ever-expanding organoids in vitro. The Lgr5 +ve stem cell 

hierarchy of differentiation is maintained in these organoids. 

Thus, intestinal crypt-villus units can be built from a single stem 

cell in the absence of a non-epithelial cellular niche. 

Although, Lgr5 stem cells persist life-long, crypts drift toward 

clonality quickly. The cellular dynamics are consistent with a 

model in which the stem cells divide symmetrically, and 

stochastically adopt stem or transient amplifying cell fates after 

cell division. 

Lgr5 stem cells are interspersed between differentiated Paneth 

cells, which produce all essential signals for stem-cell 

maintenance. Co-culturing of sorted stem cells with Paneth cells 

dramatically improves organoid formation. Genetic removal of 

Paneth cells in vivo results in the concomitant loss of Lgr5 stem 

cells. 

Intestinal cancer is initiated by Wnt pathway-activating 

mutations in genes such as APC. Deletion of APC in stem cells, 

but not in other crypt cells results in neoplasia, identifying the 

stem cell as the cell-of-origin of adenomas. Moreover, a stem 

cell/progenitor cell hierarchy is maintained in stem cell-derived 

adenomas, lending support to the “cancer stem cell”-concept. 

46

L#9 

Targeting protein-glycan interactions at cell surface during 

EMT and hematogeneous metastasis: consequences on tumor 

invasion and metastasis 

Mauro S. G. Pavao, Eliene O. Kozlowski and Felipe C. O. B. 

Teixeira 

Instituto de Bioquímica Médica, Universidade Federal do Rio de 

Janeiro (UFRJ), Rio de Janeiro, Brasil 

Two critical moments of carcinoma invasion and metastasis are 

the epithelial to mesenchymal transition (EMT), which occurs in 

the primary tumor and the hematogeneous metastasis, which 

occurs in the vascular system. Stromal growth factors and cell 

sulfate heparan sulfate proteoglycans (HSPG) are key mediators 

of EMT, whereas tumor cell surface glycans and P-selectin on 

activated platelets are essential for hematogeneous metastasis. 

Cell surface HSPG are co-receptors for the binding of several 

growth factors to their receptors involved in EMT and tumor 

dissemination. Two families of HSPGs carry the majority of the 

heparan sulfate on cells: glypicans and syndecans. 

Hematogeneous metastasis of cancer cells is a cascade of 

events involving the intravasation of tumor cells into the 

bloodstream, evasion of innate immune surveillance, adhesion 

to vascular endothelium of distant organs and colonization of 

tissues. During this process, the interaction of tumor cell 

surface glycans and platelet P-selectin creates complexes that 

allows tumor cells to evade the immune defenses and 

eventually colonize distant organs. Previous work from our lab 

suggest that the unique glycosaminoglycans from marine 

invertebrates may attenuate the response of tumor cells to 

growth factor–mediated EMT in the primary tumor and Pselectin-mediated 

formation of tumor cell-platelet complex 

during hematogeneous metastasis. As a consequence, tumor 

cell dissemination can be drastically reduced. 

L#10 

Adult-born neurons contribute to information processing in 

the dentate gyrus 

Alejandro F. Schinder 

Laboratory of Neuronal Plasticity, Leloir Institute (IIBBA- 

CONICET), Buenos Aires 

The adult dentate gyrus generates new granule cells (GCs) that 

develop over several weeks and integrate into the preexisting 

network. While adult hippocampal neurogenesis has been 

implicated in learning and memory, the specific role of new GCs 

remains unclear. Is it solely the continuous addition of new 

neurons to the network what is important, or are there unique 

functional properties only attributable to new GCs that are 

relevant to information processing? While developing, 

immature GCs display elevated intrinsic excitability, reduced 

GABAergic inhibition and a capacity to undergo activitydependent 

synaptic potentiation. Such high intrinsic excitability 

would potentially allow immature GCs to be activated by 

entorhinal afferents in spite of their low density of 

glutamatergic inputs. It has thus recently been hypothesized 

that immature GCs might be critical to hippocampal function. 

We have recently examined whether immature adult-born 

neurons contribute to information encoding. Combining 

calcium imaging and electrophysiology in acute slices we found 

that weak afferent activity recruits few mature GCs while 

activating a substantial proportion of the immature neurons. 

These different activation thresholds are dictated by an 

enhanced excitation/inhibition balance that is transiently 

expressed in immature GCs. In addition, immature GCs exhibit 

low input specificity that switches with time towards a highly 

specific responsiveness. Therefore, activity patterns entering 

the dentate gyrus can undergo differential decoding by a 

heterogeneous population of GCs originated at different times. 

47

L#11 

Epigenetic alterations: Linking sustained stress to melanocyte 

malignant transformation 

Miriam Galvonas Jasiulionis 

Ontogeny and Epigenetics Laboratory, Pharmacology 

Department, Universidade Federal de São Paulo, São Paulo, 

Brazil 

As other tumor types, both genetic and epigenetic alterations 

seem to contribute to melanoma genesis. Consistent evidences 

have suggested the key role of epigenetic marks in the genesis 

of pathologies induced by chronic stress. Increased levels of 

reactive oxygen species (ROS), caused for example by chronic 

inflammation, aging or UV radiation, might be responsible for 

abnormal epigenetic marks, which might significantly 

contribute to melanoma development. In this way, the study of 

the relationship among sustained stress, aberrant epigenetic 

marks and melanocyte malignant transformation may help to 

comprehend the mechanisms involved in melanoma genesis 

and, also, open new avenues to the development of new 

therapeutic strategies. Our laboratory established a murine 

model of melanocyte malignant transformation associated with 

sustained stress conditions. Progressive morphological and 

molecular alterations, which lead to the acquisition of 

malignant phenotype, were observed after submitting nontumorigenic 

melanocytes to sequential cycles of anchorage 

blockade. In this way, pre-malignant melanocytes 

corresponding to intermediate phases of malignant 

transformation (1C, 2C, 3C and 4C), and different melanoma 

cell lines, both non-metastatic (4C3- and 4C11-) and metastatic 

(4C3+, 4C11+, Tm1 e Tm5), were obtained from the nontumorigenic 

melanocyte lineage melan-a. Data from our group 

demonstrated that melan-a anchorage blockade results in 

oxidative stress and that increased levels of superoxide anion 

are related to global DNA hypermethylation and increased 

levels of Dnmt1 protein observed in this condition. We have 

been studied molecular mechanisms underlying alterations of 

epigenetic marks by ROS and the impact of this modulation on 

melanocyte malignant transformation. 

L#12 

Regulation of macrophage podosomes by microtubules and 


Stefan Linder 

University Medical Center Eppendorf, Hamburg 

Podosomes are actin-based matrix contacts in a variety of cell 

types, most notably monocytic cells, and are characterized by 

their ability to lyse extracellular matrix material. Besides their 

dependence on actin regulation, podosomes are also contacted 

by microtubule plus ends and are influenced by microtubuledependent 

transport processes. 

This talk will highlight the role of microtubules and motor 

proteins in the regulation of podosome turnover and podosomal 

matrix degradation in primary human macrophages. A particular 

focus will be on the role of kinesin motors and the transport of 

the matrix metalloproteinase MT1-MMP. A further topic will be 

the differential regulation of podosome subpopulations, and 

especially the influence of the actomyosin system in podosome 

turnover. 

48

L#13 

Bone marrow-derived stem cell therapy attenuates lung 

silicosis and lung fibrosis 


Instituto de Biofísica Carlos Chagas Filho, Universidade Federal 

do Rio de Janeiro, UFRJ, Rio de Janeiro, Brasil 

Silicosis is an occupational disease produced by the deposition 

of silica particles in the lungs, which causes respiratory failure 

due to a fibrotic reaction. There is no effective treatment for 

silicosis, other than the cessation of the causative exposure. 

We showed in animal models of silicosis that bone marrow 

stem cell therapy is efficient to prevent the development of 

granulomas and attenuates the inflammatory process. In 

patients we reported the time course of lung perfusion 

scintigraphy of five patients with silicosis treated with 

intrabronchial instillation of autologous bone marrow derived 

mononuclear cells through bronchoscopy and this procedure 

showed to be safe with benefits to the lungs. These results 

open the opportunity for further studies in patients and 

possible use of this new technology for the treatment of lung 

silicosis. 

L#14 

Mechanosensing Through Myosin II: From Migration to 

Learning and Memory 

Rick Horwitz, Miguel Vicente-Manzanares, Lingfeng Chen, 

Jennifer Hodges, Karen Litwa, Kris Kubow, and Alexia Bachir 

Department of Cell Biology, University of Virginia School of 

Medicine 

Myosin II (MII) generates and interprets mechanical cues and 

thereby participates in a signaling loop that regulates diverse 

cellular processes. In cell migration, MII is a downstream target 

of Rho GTPases and major regulator of protrusion, adhesion, 

and polarity. We have recently identified new modes of MII 

regulation - novel tyrosine phosphorylation sites in the 

regulatory light chain and a cluster of phosphorylation sites in 

the tail region of the heavy chain - that modify its contractile 

and bundling properties. Most migration studies have utilized 

αvβ3 or α5β1 integrins, which serve as receptors for vitronectin 

and fibronectin. We have now extended this to other cell types 

and integrins. On the one hand myosin II plays an analogous 

role in the organization of dendritic spines and the postsynaptic 

density in hippocampal neurons during their development and 

response to stimulation. On the other, its role is greatly 

diminished in cells using the α6β1 or αLβ2 integrins. In these 

cells, the apparent affinity between integrin and its ECM leads to 

a novel molecular fluxing of integrins in adhesions. This results 

in reduced force transmission to the substrate, enhanced 

signaling, and increased directional migration. For cells 

migrating in 3D, the role of MII is modulated by the organization 

of the surrounding matrix resulting in the characteristic 

adhesion profiles observed in 3D. Finally, the effect of MII on 

adhesions is being studied using correlation microscopy and 

cryoEM. 

49

L#15 

Emerging roles of mitotic centrosomes in asymmetric events 

and cilia disorders 

Stephen Doxey 

University of Massachusetts Medical School , Department 

Program in Molecular Medicine University of Massachusetts 

Medical School 373 Plantation Street Worcester MA 01605 

Mitosis is a fundamental process required for cell proliferation 

in all multicellular organisms. Much has been learned about 

the underpinnings of this process over the last century, but 

new and unexpected insights continue to be uncovered. Here 

we describe two novel and unanticipated findings associated 

with mitosis. The first is the unexpected identification of 

mitotic functions for proteins long known to function in cilia 

formation and ciliopathies. We show that the cilia proteins 

IFT88, IFT20 and IFT57 play a crucial role in the organization of 

spindle poles. Their depletion disrupts astral microtubules and 

misorients spindles. This has important implications for 

cystogenesis that accompanies ciliopathies. A second study 

shows that the midbody, a singular organelle formed between 

dividing daughter cells, is inherited by one daughter cell rather 

than being lost as a remnant or residual body as previously 

believed. Midbodies are inherited asymmetrically by the 

daughter cell with the older centrosome. Disruption of the 

older centrosome randomizes midbody inheritance. Midbodies 

accumulate in stem cells and cancer ‘stem cells’ but not in 

normal or differentiating cells. In differentiating cells midbodies 

are degraded by receptor-mediated autophagy; stem cells and 

cancer stem cells evade autophagic degradation. Midbody 

enrichment by blocking degradation enhances reprogramming 

to induced pluripotent stem cells and increases in vitro 

tumorigenicity of cancer cells. These results reveal unexpected 

post-mitotic roles for midbodies in stem cells and cancer ‘stem 

cells’. 

L#16 

Growth hormone and aging; benefits of endocrine defects 

Andrzej Bartke 

Department of Internal Medicine, Southern Illinois University 

School of Medicine, Springfield, Illinois, USA 

Growth hormone (GH) levels progressively decline after reaching 

maximal levels in early adulthood and it was suspected that this 

decline may represent one of the causes of aging. Surprisingly, 

mice with mutations that cause GH deficiency and mice with 

targeted deletion of GH receptors live much longer than their 

normal siblings and exhibit symptoms of delayed aging. 

Extended longevity of these mutants is associated with reduced 

growth and adult body size, improved maintenance of 

pluripotent bone marrow stem cells, reduced incidence of 

cancer, increased fibroblast resistance to various cytotoxic 

stressors and various metabolic changes. Circulating levels of 

insulin and glucose are reduced and insulin sensitivity measured 

by insulin tolerance tests is enhanced. In GH receptor deleted 

(GHRKO) mice improved whole animal insulin sensitivity has 

been related to increased levels and phosphorylation of hepatic 

insulin receptors and reduced inhibitory (Serine 307) 

phosphorylation of IRS-1. mTOR signaling likely contributes to 

this change in IRS-1 phosphorylation. Results of surgical 

removal of intraabdominal adipose tissue indicate that 

adiponectin secreted by these fat depots enhances insulin 

sensitivity of long-lived GH-related mutants. Metabolic shifts in 

GH-deficient and GH-resistant mice also include increased 

oxygen consumption and reduced respiratory quotient, implying 

increased reliance on lipids as metabolic fuel. In sum, 

suppression of GH signals slows aging in mice by multiple 

mechanisms. Supported by NIA. 

50

L#17 

Synapse failure induced by Alzheimer's toxic Aβ oligomers 

Sérgio Teixeira Ferreira 

Biomedical Sciences Institute, Federal University of Rio de 

Janeiro (UFRJ), Rio de Janeiro, Brazil 

More than one hundred years after its original description, the 

mechanisms leading to memory loss and progressive cognitive 

impairment in Alzheimer’s disease (AD) remain controversial. 

Considerable evidence accumulated during the past decade 

implicates soluble oligomers of the amyloid-β peptide (Aβ), 

which accumulate in the brains of AD patients, as the proximal 

toxins that attack neurons and cause synapse failure 

culminating with memory impairment. This presentation will 

focus on mechanisms by which Aβ oligomers (AβOs) attack 

synapses and negatively impact the function of neuronal 

receptors important for synaptic plasticity. We recently 

showed that AβOs cause aberrant activation of NMDA 

receptors, which triggers dysregulation of intracellular Ca2+ 

levels, neuronal oxidative stress and receptor internalization. 

Similarly, AβOs induce removal of AMPA receptors from 

synapses. Along with changes in pre-synaptic neurotransmitter 

vesicle release, combined removal of NMDA and AMPA 

receptors from synapses may be part of the mechanism by 

which AβOs inhibit synaptic plasticity. We also demonstrated 

that NMDA receptors play a key role in the binding of Aβ 

oligomers to a neuronal receptor complex that putatively 

comprises additional protein components, among which the 

cellular prion protein. Finally, our recent work has shown that 

A Os inhibit neuronal insulin signaling, essential for neuronal 

survival, synaptic plasticity and memory formation. Elucidation 

of molecular/cellular mechanisms underlying the deleterious 

impact of AβOs on synapses may illuminate the development 

of novel therapeutic approaches to combat memory loss in AD. 

Key words: synaptotoxicity, amyloid- , memory loss 

L#18 

Collective cancer invasion, tissue guidance, and plasticity of 

therapy response 

Peter Friedl 1,2 

1 Radboud University Nijmegen Medical Centre, Nijmegen, The 

Netherlands and 

2 The University of Texas, MD Anderson Cancer Center, 

Houston, TX, USA 

The tumor microenvironment contributes to cancer invasion, 

growth and survival with impact on tumor response to therapy. 

We here employ intravital infrared multiphoton imaging for the 

multi-parameter visualization of cancer invasion, guidance by 

the tumor stroma, and therapy response. The data show 

predominantly collective cancer cell into the host stroma at 

speeds of up to 200 µm per day. Invasion resulted from nondestructive 

contact-guidance type migration exploiting 

preformed tracks of multi-interface topography, including 1D, 

2D and 3D dimensionalities, but was independent of β1 and β3 

integrin-mediated mechanotransduction. Collective invasion 

was coupled to altered survival capability, withstanding highdose 

radiotherapy and forming a resistance niche for 

subsequent relapse of the disease. Albeit invasion was integrinindependent, 

invasion-associated radioresistance was sensitive 

to the β1/β3 integrin targeting by RNAi or antiantibody 

treatment, resulting in anoikis induction and regression 

of both, tumor lesion and invasion strands. In conclusion, 

collective invasion is an important invasion mode in solid tumors 

that receive integrin signals from the tissue microenvironment 

for acquiring an altered phenotype and improved survival. 

51

L#19 

Regulation of insect metamorphosis and the role of 

microRNAs. Nepenthe teams up with Psyche 

Xavier Bellés 

Institute of Evolutionary Biology (CSIC-UPF), Barcelona 

E-mail: xavier.belles@ibe.upf-csic.es 

Insect metamorphosis has fascinated mankind since the time of 

Aristotle, some two thousand years ago. But it was not until 

the decade of 1930 that the studies of Vincent B. Wigglesworth 

showed that insect metamorphosis is regulated by two 

hormones: the molting hormone, which induces the successive 

molts, and the juvenile hormone, which maintains the juvenile 

character of them. Then, a number of transcription factors act 

as mediators of these hormones, as well as a number of target 

genes that codify for proteins, giving the shape and behaviour 

of a juvenile or an adult stage. Working on the cockroach 

Blattella germanica, we found that microRNAs, which are RNAs 

of ca. 22 nucleotides that play a repressing action on mRNA, 

have a key role in metamorphosis. We silenced the expression 

of dicer-1 (a ribonuclease that mediates the maturation of 

microRNAs) in the last nymphal instar and the cockroaches, 

instead of molting to the adult stage, transformed into 

supernumerary nymphs. We presume that there are 

microRNAs that repress the expression of genes that maintain 

the juvenile status quo (like Nepenthe, the drug of 

forgetfulness of the Greeks). This leads to a change of genetic 

program, from juvenile to adult and, within the latter, there 

must be other microRNAs that modulate and refine the 

expression of genes that give rise to the adult animal, thus 

making it all right (like Psyche, the Greek symbol of 

transformation and new life). 

L#20 

The prion protein as a prototypical cell surface scaffold protein. 

Rafael Linden 

Instituto de Biofísica da UFRJ, Rio de Janeiro, Brazil. 

Based on multiple interaction partners and pleiotropic signaling 

properties, we proposed the hypothesis that the prion protein 

(PrPC) is a cell surface scaffold protein, that serves as a dynamic 

platform for the assembly of signaling modules involved in 

widespread systemic functions. Our recent work is focused on 3 

topics: (a) identification and validation of additional molecular 

interactions of PrPC; (b) structural evidence for allosteric 

function of PrPC; (c) functional properties and dysfunction of 

PrPC beyond the nervous system. A phage display screen, 

together with evidence from PrPC-null mice, implicate several 

neurotransmitter receptors and/or transporters in PrPCdependent 

signaling; Biophysical techniques showed that 

interaction of PrPC with its ligand hop/STI1 entails reciprocal 

structural remodeling, and strongly suggest allosteric effects 

that may be involved in the propagation of signals through PrPCmediated 

multiprotein complexes; Beyond the nervous system, 

we found that both peripheral inflammation and behavioral 

stress modulate the content of PrPC at the plasma membrane of 

neutrophils, with consequences upon peroxide-dependent 

cytotoxicity towards vascular endothelial cells. Our studies add 

to the understanding of both allosteric properties of the prion 

protein and systemic control of its expression and function. The 

data are consistent with the scaffold hypothesis that explains 

the multiple roles of the prion protein in physiology and 

pathology, and further suggest that PrPC may be relevant for 

clinically observed associations of stress and anxiety with either 

the severity or the progression of various degenerative/ 

noncommunicable diseases. 

(Supported by CNPq, FAPERJ, CAPES, FAPESP) 

52

Symposia- Abstracts 

Symp#1 Prion protein in physiology and pathology 

Chair Jerson Silva 

Jerson Silva 

Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil 


Neurodegeneration and Cancer: a Crosstalk Between Prion Protein and its Ligand STI1 

Vilma R. Martins 

Hospital A.C. Camargo, International Center for Research, Sao Paulo, Brazil 

Prion protein (PrP C ) is a highly abundant protein in the central nervous system. It’s misfolding is associated with fatal 

neurodegenerative illnesses named prion diseases. PrP C is known to bind to a number of extracellular or membrane 

proteins triggering specific signals that modulate diverse cellular functions. One of these ligands is Stress Inducible protein 

1 (STI1) whose interaction with PrP C promotes neuronal survival, differentiation, neural progenitor/stem self-renewal and 

memory formation. On the other hand, PrP C transduces neurotoxic signals upon binding to A� oligomers, the toxic 

components in Alzheimer’s disease (AD). Our group has been exploring how the toxic signals triggered by PrP C - A� 

oligomers can be impaired by STI1. The results point that at least in vitro the toxicity of A� oligomers can be reverted by 

recombinant STI1. Remarkable, PrP C was described to participate in tumoral processes. Our results show that both PrP C 

and STI1 are highly expressed in human glioblastomas (GBM) and their expression is associated with increased tumor 

proliferation and decreased patient’s survival. In cell culture of GBM and in animal models the inhibition of PrP C -STI1 

binding was able to inhibit the proliferation and also to increase animal survival. Therefore, the complex PrP C -STI1 is an 

important therapeutic target in AD and in GBM. 

Neurotoxic Activities of PrP C in Prion and Alzheimer’s Diseases 

David A. Harris, Brian Fluharty, Jessie A. Turnbaugh, Tania Massignan, Ursula 

Unterberger, and Emiliano Biasini 

Dept. of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA 

There is evidence that alterations in the normal physiological activity of PrP C contribute to prion-induced neurotoxicity, 

and may also play a role in Alzheimer’s disease. This mechanism has been difficult to investigate, however, because the 

normal function of PrP C has remained obscure, and there are no assays available to measure it. We have found that cells 

expressing deletions or disease-associated point mutations in the conserved, central region of PrP exhibit spontaneous 

ionic currents that are likely due to unconventional channels or pores formed by the mutant PrP molecules themselves. 

These currents predispose neurons to excitotoxic death induced by endogenous, glutamatergic synaptic input. Current 

activity depends on the presence of a polybasic amino acid segment at the N-terminus (residues 23-31) that may serve as 

a tethered protein transduction domain capable of transiently permeabilizing the plasma membrane. The sequence 

domains of PrP C that are important for current activity are also critical for binding of oligomeric forms of the Alzheimer’s 

Aβ peptide, suggesting that PrP C may play a general role in mediating neurotoxicity in several neurodegenerative diseases, 

perhaps via abnormal activity of ion channels. 

53

Symp#2 Programs, Genes and Homeostasis 

Chair José Xavier Neto 

Ancient Programs of Gene Expression in Development and Homeostasis 



The origins of vertebrate cardiac chambers among the simpler peristaltic pumps of invertebrate chordates are not 

understood. Peristaltic pumps operate by contractions that originate in the outside of a muscular conduit to squeeze its 

contents inside. Although versatile and adaptable, peristaltic pumps are limited by poor inflow-to-outflow coordination, 

often manifested by backflow, loss of fluid energy by distension, reflection and reversion. By breaking down circulatory 

work into dedicated inflow (reservoirs or atria) and outflow modules (pumps or ventricles), chambered hearts eliminated 

the inflow-to-outflow interference displayed by peristaltic pumps. This chambered mode of operation evolved only in 

vertebrates and in mollusks, which are animals that display simple tubular peristaltic pumps during early phases of their 

ontogenies, suggesting that chambered pumps evolved from ancestral peristaltic pumps. In amniotes such as mice and 

chicken, cardiac progenitors are divided by differential RA signalling into two broad anterior and posterior domains that 

will later give to outflow (ventricles and outflow tract) and inflow (sinus venosa and atria) cardiac tissues. This patterning 

mechanism has been modeled in a two-step process. Early specification signals are first conveyed by paracrine diffusion of 

the morphogen retinoic acid (RA) from posterior mesoderm towards posterior cardiac progenitors. Late determination 

signals are communicated by autocrine RA signaling setup by a caudal to rostral wave of raldh2 (aldh1a2), a gene 

encoding the main RA synthetic enzyme, which transiently confers posterior cardiac precursors with the ability to 

synthesize their own RA. 

Retinoic Acid Signaling in Development and Evolution 

Michael Schubert 

Institut de Génomique Fonctionnelle de Lyon (UMR 5242 du CNRS, Ecole Normale Supérieure de Lyon, Université Claude 

Bernard Lyon 1), Université de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07, France. 

E-mail: Michael.Schubert@ens-lyon.fr 

Extensive research carried out in the course of the last 100 years has established that retinoids, which constitute a group 

of fat-soluble morphogens related to retinol (vitamin A), play crucial roles in early development, organogenesis, tissue 

homeostasis, proliferation, differentiation, and apoptosis. In vertebrates, most, but not all, retinoid functions are 

mediated by retinoic acid (RA) binding to heterodimers of two nuclear receptors: retinoic acid receptor (RAR) and retinoid 

X receptor (RXR). Retinoid signaling was long thought to be vertebrate-specific, but developmental studies in invertebrate 

chordates have revealed roles for retinoids conserved in all chordates. Outside chordates, however, evidence for 

functional roles of retinoids and of the RAR/RXR heterodimer remains scarce, although recent bioinformatic analyses have 

revealed that genes involved in retinoid signaling are present in the genomes of a variety of metazoan animals, including 

echinoderms (sea urchins) and lophotrochozoans (annelids and mollusks). These in silico results suggest that the retinoid 

pathway might have already been present in Urbilateria, the last common ancestor of protostomes and deuterostomes. 

To obtain insights into the diversification of the retinoid signaling cascade during morphological and genomic evolution, 

we have been using both developmental biology and bioinformatic approaches. We have thus addressed the question of 

the evolutionary origins of the retinoid signaling pathway and studied the molecular hierarchy controlled by retinoid 

signaling and its changes during evolution, with particular focus on the diversification of chordates. Altogether, our 

analyses have provided new insights into the origin and functional elaboration of the retinoid signaling pathway in the 

course of evolution. 

Kleber Franchini 


54

Symp#3 Gene Therapy 

Chair Martin Bonamino 

Gene Therapy of Limb Ischemia with GM-CSF 

Sang Won Han 

Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil 

Peripheral arterial diseases (PAD) affect about 1000 per million every year and about 200 of them suffer limb 

amputations. The PAD incidence increases in the case of diabetic patients and people with more than 60 years. Therefore, 

PAD has a high socio-economic and medical impact today. Approximately half of critical limb ischemic patients can be 

treated by vascular surgery, but the remainder depends mainly on the velocity of adaptation of the existing collateral 

vessels, a process known as arteriogenesis. 

Several growth factors, cytokines and proteases are required for arteriogenesis, which is the process of remodeling preexistent 

vessels during the ischemia. The monocytes, attracted by the presence of tumor necrosis 

factor-α and monocyte chemoattractant protein-1 at the inflammatory sites, are the main producers of factors for 

arteriogenesis. The time and concentration of the factors required to complete arteriogenesis varies in each case of PAD, 

consequently the action of the activated monocytes may not be enough to resolve the ischemic problem. One way to 

prolong the life of monocytes is by inhibiting apoptosis by granulocyte-colony-stimulating factor (GM-CSF), which is a 

hematopoietic-stimulator that enhances the survival, proliferation and rate of differentiation of hematopoietic cells. 

In my presentation, therapeutic effects of GM-CSF in limb ischemia by gene therapy will be presented and discussed. 

A Hematopoietic Stem Cell (HSC) Specific microRNA Gives Novel Insights into the Regulation of HSC Homeostasis and 

Allows Safer HSC-based Gene Therapy 

Bernhard Gentner 1,2 , Alice Giustacchini 1,2 , Ilaria Visigalli 1 , Eric Lechman 3 , Peter van Galen 3 , Hidefumi Hiramatsu 3 , Francesco 

Boccalatte 1,2 , Massimo Saini 1 , Silvia Ungari 1,2 , John E Dick 3 , Alessandra Biffi 1 and Luigi Naldini 1,2 . 

1 San Raffaele Telethon Institute for Gene Therapy; 2 Vita-Salute San Raffaele University, San Raffaele Scientific Institute, 

Milan, Italy; 3 Division of Stem Cell and Developmental Biology, University of Toronto, Toronto, Ontario 

We report that miR-126, a microRNA preferentially expressed in Hematopoietic Stem Cells (HSC) among the 

hematopoietic lineage, plays a pivotal role in restraining cell cycle progression of HSC in vitro and in vivo. miR-126 

knockdown expanded functional mouse and human HSC in vivo, without HSC exhaustion. Conversely, enforced miR-126 

expression increased the fraction of phenotypic HSC in G 0. miR-126 control of proliferation is attributable, in part, to 

attenuation of signal transduction by the PI3K/AKT/GSK3β axis. We propose that miR-126 establishes a threshold for HSC 

activation and provides negative feedback aiding the return of stimulated HSC to quiescence. Our results establish that 

the HSC quiescence/activation equilibrium is regulated by miRNAs in a mechanism conserved between mouse and human. 

The discovery of HSC-specific microRNAs also prompted us to design novel vectors for HSC-mediated gene therapy with 

enhanced efficacy and safety. By adding miR-126 target sequences (miRT) to a vector cassette, miR-126 activity was 

harnessed to negatively regulate transgene expression in HSC and target expression to differentiated hematopoietic cells. 

These HSC-off vectors allow delivering a transgene into HSC without affecting its proteome, while achieving sustained 

multi-lineage expression in the progeny. The utility of this new vector was demonstrated for the gene therapy of Krabbe 

disease in the mouse model. miR-126 regulated vectors overcame hematopoietic toxicity associated to unregulated 

galactocerebrosidase (GALC) expression in HSC, while delivering substantial amounts of GALC enzyme in the nervous 

system with improved survival of the affected mice. 

Conditional models for Chimeric Antigen Receptor (CAR) based activation of T lymphocytes 

Martin Bonamino 

Instituto Nacional de Cancer – Rio de Janeiro – Brazil 

The modification of T lymphocytes with Chimeric Antigen Receptors (CARs) represents a promising strategy for combined 

adoptive T cell based immune-gene therapy of cancer. Current CAR molecules are constructed fusing an immunoglobulinderived 

Fab-based antigen recognition domain in the scFv configuration, a transmembrane domain and signaling domains 

promoting T cell activation. Clinical trials based on this strategy have reported impressive hematological responses for 

leukemia and lymphomas for CARs designed against CD19, CD20 or CD30 antigens. 

One potential limitation of this strategy is the off-target effects observed when target antigens are expressed in healthy 

tissues. To circumvent this limitation we are considering conditional activation based on two CARs in a way that only the 

correct antigen combination induces complete T cell activation. This strategy has the potential to expand the panel of 

CAR-targeted antigens, narrowing T cell responses based on CAR mediated antigen recognition and increasing the safety 

of CAR-based immune-gene therapies. 

55

Symp#4 Cell Biology & Reproduction 

Chair Luiz Renato França 

Spermatogonial Stem Cell Niche in Vertebrates 

Luiz R França 

Luiz Renato França,Paulo HA Campos Júnior, Guilherme MJ Costa, Samyra SMSN Lacerda, Gleide F Avelar, Alana L Sousa, 

*Marie-Claude Hofmann 

Laboratory of Cellular Biology, Dept. of Morphology, ICB/UFMG, Belo Horizonte, MG, Brazil. *MD Anderson Cancer Center, 

Dept. of Endocrine Neoplasia and Hormonal Disorders, Houston, TX, USA (email: lrfranca@icb.ufmg.br) 

Spermatogonial stem cells (SSCs) are located in a particular environment called the “niche” that is controlled by the 

basement membrane, key testis somatic cells, and factors originating from the vascular network. Although crucial for SSC 

physiology, the niche is still poorly understood, particularly in non-model vertebrates where the testis cytoarchitecture 

could provide important cues for niche components and regulation. Recently, we demonstrated that A und GFRA1 + cells 

present preferential location (nearby blood vessels) in vertebrate species other than mouse and rat, such as zebrafish, 

bullfrog, turtle and horse. Additionally, we observed that peccaries present a peculiar Leydig cell (LC) distribution, 

whereby these cells situate around lobes of seminiferous tubules. Since the role of LCs as a niche component is not yet 

clearly elucidated, this feature makes the peccary an interesting model for investigating the SSC niche. Subsequently, we 

observed that in peccaries, ~93% of A undspermatogonia are GFRA1 + and that these cells are preferentially located adjacent 

to the interstitium without LCs. Moreover, the expression of CSF-1 was observed in LCs and peritubular myoid cells (PMCs) 

while its receptor was present in LCs and in GFRA1 + A und. In summary, besides reinforcing the fundamental role of Sertoli 

cells in GDNF-GFRA1 signaling for SSC self-renewal in vertebrates, our data suggest that the mechanisms involved in SSC 

physiology may be conserved in vertebrates. However, our peccary findings indicate that, contrary to PMCs, LCs might 

play a minor role in the SSC niche/physiology and that LCs are probably involved in the differentiation of A und toward type 

A1 spermatogonia. 

Fetal Testis Differentiation and Function, its Regulation and its Disorders 

Richard M Sharpe, Rod Mitchell, Afshan Dean, Karen Kilcoyne, Sophie Platts, Ashley Boyle, Sheila Macpherson, Chris 

McKinnell, Richard Anderson, Sander van den Driesche 

MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, University of Edinburgh, UK (contact: 

r.sharpe@ed.ac.uk) 

Differentiation of the testis represents the first step along the pathway to becoming a male. Understanding of the 

processes that regulate testis differentiation have added importance because there is increasing evidence that the 

commonest disorders of human male reproductive health may largely stem form this period in life. Thus the testicular 

dysgenesis syndrome (TDS) hypothesis proposes that subnormal ‘set-up’ of the fetal testis/cell types leads to subnormal 

function (especially of the fetal Leydig cells) which, in turn, leads to male reproductive disorders that manifest at birth 

(cryptorchidism, hypospadias, micropenis) or in adulthood (low sperm count, low-normal testosterone, testis germ cell 

cancer). Direct evaluation of this hypothesis in humans is difficult, so we have used a rat model of TDS (fetal exposure to 

dibutyl phthalate; DBP) to help elucidate key mechanisms and cell-cell relationships in the fetal testis, disruption of which 

leads to TDS disorders. These have helped identify the masculinisation programming window (MPW) within which 

testosterone production by fetal Leydig cells is critical for determining normality and ultimate adult size of all male 

reproductive organs; deficiency in testosterone production in the MPW determines risk of later TDS disorders and can be 

‘measured’ retrospectively by anogenital distance (AGD). Our studies show that DBP-induced focal dysgenesis 

(malformation of seminiferous cords, intratubular Leydig cells, mis-specification of somatic cells) is closely interlinked with 

deficiency in testosterone production in the MPW, even though the dysgenesis manifests after the MPW. The mechanisms 

and factors involved, insofar as they are understood, will be discussed. 

Antimicrobial Proteins Secreted by the Epididymis 

Maria Christina W. Avellar 

Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de São Paulo – Escola Paulista 

de Medicina (UNIFESP-EPM), São Paulo, SP, 04044-020, Brazil. 

This presentation will focus on the expression and regulation of naturally occurring antimicrobial proteins secreted by the 

epididymis. Aspects of the pattern of expression of mRNA and protein for selected genes, highlighting isoforms expressed 

by the beta-defensin SPAG11B gene, in the adult tissue and during development of the rat epididymis will be discussed. 

The effects of androgens, luminal fluid, glucocorticoids and exposure to in vivo bacterial products on their expression and 

immunolocalization will be also presented. Financial Support: FAPESP, CNPq, CAPES and Fogarty International Center 

(subcontract UNIFESP-EPM/University of North Carolina at Chapel Hill, USA). Email: avellar@unifesp.br. 

56

Symp#5 Host Parasite Interaction 

Chair Wanderley de Souza 

Wanderley de Souza 

Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil 

Introductory Notes 

Dephosphorylation of eIF5A is Required for Translation Arrest at the Stationary Growth Phase of Trypanosoma cruzi 

Chung, J.*; Rocha, A. A.*, Tonelli, R. R.;,Castilho, B. A., and Sérgio Schenkman. 

Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, Brazil 

* Both authors contributed equally 

The protein known as eukaryotic initiation factor 5A (eIF5A) has an elusive role in the translation elongation. It has a unique and 

essential hypusine modification on a conserved lysine residue in most eukaryotes. In addition, this protein is modified by 

phosphorylations with unknown functions. Here we found that a phosphorylated state of eIF5A from Trypanosoma cruzi (TceIF5A), 

the protozoan that causes Chagas’ disease, predominates in exponentially growing cells and extensive dephosphorylation occurs in 

cells reaching the stationary growth phase. The phosphorylation was shown to occur mainly at Ser 2, then at Ser 47, homologous to 

yeast eIF5A. In addition, a novel phosphorylation site was identified at Tyr 21. In exponential cells, TceIF5A is partially associated with 

polysomes, compatible with its function as an elongation factor and become relatively enriched in polysomal fractions at stationary at 

stationary phase. TceIF5A overexpression increases the rate of cell proliferation, protein synthesis, and the relative amount of 

polysomes. When Ser 2 is replaced by Asp, but not by Ala, in the overexpressors, the cells still show an increased protein synthesis 

and growth rate. However, the presence of Asp causes cell damage when cultures reach the stationary phase. Wild type, or Ala, but 

not Asp replacing Ser 2 forms of TceIF5A causes protein synthesis arrest and are enriched in polysomal content at the stationary 

phase. We conclude that dephosphorylation of eIF5A has a key role in arresting the protein synthesis under unfavorable conditions, 

indicating that eIF5A phosphorylation/dephosphorylation might control its association with polysomes during translation elongation. 

Ion Regulation in the Malaria Parasite: The Target of a New Generation of Antimalarials 

Kiaran Kirk 

Research School of Biology, The Australian National University, Canberra, ACT, 0200, Australia 

The intraerythrocytic malaria parasite induces novel channels in the membrane of its host erythrocyte. These channels mediate the 

uptake of essential nutrients but, at the same time, allow a net influx of Na + ions, resulting in an elevated Na + concentration in the 

host cell compartment. The intraerythrocytic malaria parasite itself maintains an intracellular Na + concentration some ten-fold less 

than that in its host cell, extruding Na + via a Na + -ATPase on its plasma membrane. Bioinformatic analysis of the genome of the human 

malaria parasite Plasmodium falciparum reveals that the most likely candidate for the parasite’s Na + ATPase is a protein known as 

PfATP4. 

The spiroindolones are a new class of compound that inhibit the in vitro growth of the human malaria parasite, Plasmodium 

falciparum, at nanomolar concentrations. One of the spiroindolones is now in Phase IIa clinical trials, and is the first molecule with a 

novel mechanism of action to enter Phase IIa studies for malaria in the last 20 years. Prolonged exposure of P. falciparum parasites to 

sub-lethal concentrations of spiroindolones leads to the emergence of spiroindolone-resistant parasites, with the resistance 

attributable to mutations in PfATP4. In this talk I will introduce the cell physiology of the intracellular malaria parasite and present 

evidence that the spiroindolones exert their antimalarial effect by inhibiting Na + extrusion via PfATP4, thereby disrupting Na + 

regulation in the intracellular parasite. 

Why coinfect cells with non-viral pathogens? 

Michel Rabinovitch 

Universidade Federal de São Paulo – Escola Paulista de Medicina, Departamento de Microbiologia, Imunologia e Parasitologia, São 

Paulo, Brazil e-mail: michel.rabinovitch3@gmail.com 

Coinfection of E. coli bacteria with mutant bacteriophages in the 1940s spurred the development of molecular virology. Beginning in 

the 1960s, virologists, among them alumni of the CSHL Phage Course, coinfected mammalian cells with virus mutants, strains or 

species and developed the basic procedures and concepts of viral genetics. The AIDS pandemic of the 1980s begot cell coinfections of 

HIV and non-viral pathogens. In the 1990s, impressive horizontal gene exchanges were detected between pathogens sheltered in 

free-living protozoa. In contrast, there are few reports–briefly reviewed in the presentation-of mammalian cells coinfected with 

bacteria or protozoa. Initially, the model permitted the targeting of pathogens to intracellular compartments they normally don’t 

occupy, thanks to C. burnetii’s exceptionally large and hospitable parasitophorous vacuoles. Vacuolar colocalization will probably be 

rare in the world of coinfections. We believe that coinfection, apart from its ludic quality, may uncover unexpected, and hopefully 

interesting, interactions involving (for instance), antagonism via secreted toxins or antibiotics, competition for cell derived nutrients, 

quorum sensing effects, exploitable modulation of host cell gene expression and transduction cascades. We thus argue that 

coinfection with non-viral-pathogens could provide an added tool for mono-infection-entrenched cellular microbiologists. However, 

whereas mono-infections may reflect a dialogue – by proxy - between two genomes, the neo-coinfector may be confronted with a 

livelier dialogue involving three – genomes, besides the potential participation of a fourth, the host cell mitochondrial genome. One 

problem remains: given the number of available microorganisms, how is one to select the most promising pair for coinfection? 

57

Symp#6 Membrane Biology 

Chair José Garcia Abreu 

New Inhibitory Wnt/β-catenin Mechanisms Affecting Embryonic Head Formation 

Jose Garcia Abreu, PhD. 

Instituto de Ciencias Biomédicas – Universidade Federal do Rio Janeiro. Rio de Janeiro – Brazil. 

The establishment of vertebrate embryonic axes involves a series of cellular and molecular events right after 

fertilization. In the frog embryo the dorsal ventral axis relies on accumulation of dorsal beta-catenin which together 

with Nieuwkoop center set the dorsal organizer, also known as Spemann Organizer. Upon the onset of gastrulation a 

number of secreted factors act dorsally preventing dorsal fate from ventral signals. At the same time cells from the 

prechordal plate endomesoderm secrete inhibitors of ventro-lateral Wnt signals setting up the antero-posterior axis. 

Therefore, Wnt/beta-catenin signaling plays major role in the establishment and patterning of embryonic axis. Here, 

we present a new Wnt-beta-catenin inhibitor, expressed in the Spemann Organizer which is essential for proper head 

formation. We also present data on how cholestero-rich membrane microdomains interfere with the morphogentic 

fields in the head organizer, the pre-chordal plate. 

Support: FAPERJ, CNPQ and CAPES. 

Membrane Dynamics and Mechanics of Signaling: Role of Caveolae 

Sinha, B., D. Koster, R. Ruez, P. Gonnord, M. Bastiani, D. Abankwa, R.V. Stan, G. Butler-Browne, B. Vedie, L. Johannes, 

N. Morone, R.G. Parton, G. Raposo, P. Sens, C. Lamaze, and P. Nassoy. 2011. Cells respond to mechanical stress by 

rapid disassembly of caveolae. Cell. 144:402-13. 

Nassoy, P., and Christophe Lamaze. Stressing caveolae new role in cell mechanics. Trends Cell Biol. in press 

Institut Curie, Paris, France 

The functions of caveolae, the characteristic plasma membrane invaginations, has long remained debated. The 

particular abundance of caveolae in endothelial and muscle cells cells, which respectively experience shear stress and 

stretching, led us to investigate the role of caveolae in membrane-mediated mechanical response. Acute mechanical 

stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced 

caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force 

measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the 

primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress. 

Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. We further 

show that mechanosensing through caveolae in endothelial cells involves the Jak/Stat signaling pathway. Caveolae are 

therefore mechanosensors and mechanotransducers which constitute a physiological membrane reservoir that quickly 

accommodates sudden and acute mechanical stresses. 

Studying Spatial Control of Exocytosis at the Nanoscale in Living Cells 

Derek Toomre 

Yale University School of Medicine, USA 

Cells spatially control exocytosis to control a range of biological function – from cell division, migration, invasion and 

the formation of specialized structures such as the primary cilium. Loss of this spatial-temporal control can lead to 

diseases including cancer, diabetes, and polycystic kidney disease. This seminar will focus firstly on new superresolution 

‘nanoscopes’ and their power to visualize subcellular processes with incredible detail. I will then show how 

it to query and even optogenetically manipulate the very last steps of exocystosis, vesicle tethering and fusion. As case 

studies, I will show how this approach has given new insight and lead to new concept in cytokinesis, cell migration, and 

insulin-mediated trafficking of Glut4 in adipocytes. For examples, in adipocytes we see two membrane trafficking 

pathways to the surface and a regulation by insulin on the expansion of the fusion pore. Challenges and potentials of 

these new nanoscopes, with special emphasis to membrane traffic, will be discussed. 

58

Symp#7 Signaling in development 

Chair Ricardo Guelerman Pinheiro Ramos 

Ricardo Guelerman Pinheiro Ramos 

University of São Paulo, Ribeirão Preto, Brazil 


Wnt Signaling, Stem Cells and Tissue Repair 

Roel Nusse, Howard Hughes Medical Institute, Department of Developmental Biology, Lorry I. Lokey Stem Cell 

Research Building. Stanford 

Work from many laboratories has shown that Wnt signals are essential for the control over stem cells. A right balance 

between the number of stem and differentiated cells is essential for the proper function of organs. Locally acting 

signals, including Wnts, are important to maintain this balance in a spatially organized manner and these signals are 

key to understanding the regulation of growth. How this is achieved is far from clear and is the subject of studies in our 

lab, both in vivo and in cell culture. In vivo, a particular question we address is how physiological changes, such as 

those occurring during hormonal stimuli, injury or programmed tissue degeneration have an impact on the selfrenewal 

signals and on stem cell biology. Current research includes: 1) Identifying and tracing Wnt-responsive stem 

cells in tissues; 2) mapping cis-acting transcriptional control elements (enhancers) that control Wnt gene expression in 

normal and injured tissues; 3) the use of active Wnt proteins to maintain stem cells (including embryonic stem cells) in 

cell culture; 4) presenting Wnt protein in a vectorial manner to stem cells to direct asymmetric cell division. 

Formation of the Vertebrate Body Axis 

Olivier Pourquié 

Institut de genétique et biologie moleculaire et celulaire, INSERM, France 

Hedgehog Signaling in Development and Disease 

Matthew Scott 

Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Clark Center 

West Wing W252, 318 Campus Drive, Stanford University School of Medicine, Stanford, California 94305-5439 

Phone 650-725-7680 Fax (650) 725-2952 

Hedgehog (Hh) signaling is important for the development of most organs and tissues. Damage to Hh signal 

transduction components causes birth defects and cancer. We have been exploring four areas of Hedgehog signaling: 

transduction in primary cilia, roles of Neuropilin proteins, identification of direct Hh target genes in the cerebellum and 

medulloblastomas (MBs), and mutations in MB tumor genomes. Neuropilins 1 and 2 (Nrp1, 2) are transmembrane 

proteins with roles in axon guidance and vascular endothelial growth factor (VEGF) signaling. We found that they are 

important positive regulators of Hh signal transduction. Nrps are expressed at times and locations of active Hh signal 

transduction during mouse development. We show that Nrps mediate Hh transduction between activated 

Smoothened (Smo) protein and the negative regulator Suppressor of Fused (SuFu). Nrp1 transcription is induced by 

Hh signaling and Nrp1 over-expression increases maximal Hh target gene activation, indicating the existence of a 

positive feedback circuit. We are testing the importance of Nrps for growth of MB cells. Nrps act upstream of Gli 

proteins, transcription factors that directly control Hh target gene transcription. We have identified direct targets of 

Gli1 in normal mouse cerebellum development and in MBs, and found that Gli1 is located at some common genes in 

the two cell types as well as many locations unique to each cell type. To understand better the properties of MB 

tumor cells we are determining exome sequences of human and mouse tumors. 

59

Symp#8 Epithelial proliferation and differentiation 

Chair Mari Sogayar 

Mari Sogayar 

Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil 

Introductory notes and talk 

Intrinsic And Extrinsic Regulation Of Epidermal Stem Cell Fate 

Fiona M Watt 

CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK 

When an epidermal stem cell divides its progeny can either remain stem cells or undergo terminal differentiation. 

These cell fate decisions are controlled both by intrinsic mechanisms and by external signals from the local 

microenvironment or niche. Interactions between epidermal stem cells and the niche are reciprocal, since stem cells 

are capable of remodelling their environment. My lab is investigating the interplay between specific intrinsic and 

extrinsic signals in regulating stem cell fate in adult epidermis. We find that both in vitro and in vivo approaches are 

informative and conclude that the way that a stem cell behaves is to a large extent determined by extrinsic signals. 

Wellcome Trust Centre for Stem Cell Research , University of Cambridge (CSCR), and the other in Cancer Research UK 

Cambridge Research Institute (CRI) 

Differential roles for NFAT transcription factor isoforms in cell transformation 

João Viola 

Program of Cellular Biology, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil. 

The nuclear factor of activated T cells (NFAT) family of transcription factors are inducible proteins that play a key role 

in gene expression. The NFAT family is composed of four calcium-responsive proteins (NFAT1-4). Each NFAT gene may 

be alternatively spliced into two or more isoforms that differ at the N- and/or C-termini, although the core of the DBD 

and NHR regions remain conserved. Once NFAT is activated, these proteins can bind to their target promoter elements 

and activate the transcription of specific responsive genes, either alone or in combination with other nuclear partners. 

Regardless of their widely known cytokine gene expression properties, NFAT transcription factors have been shown to 

regulate other genes related to cell cycle progression, cell differentiation and apoptosis, unraveling a broader role for 

these proteins in normal cell physiology. Recent studies suggest that the NFAT family of transcription factors plays a 

much broader role in cell proliferation and apoptosis, and their contributions to tumorigenesis are becoming clearer. 

Here, we demonstrate that three of NFAT proteins (NFAT1 and NFAT2 �- and �-isoforms) induce distinct phenotypes 

in NIH3T3 cells and the differential roles for NFAT family members are partially mapped to the transactivation domains 

(TAD) located at the N- and C-terminal end of these proteins. In fact, our results suggest that NFAT1 and NFAT2 �isoform 

act as tumor suppressor genes, mainly by inducing cell death and cell cycle arrest, whereas NFAT2 �-isoform 

act as an oncogene, by protecting cells from apoptosis. Finally, our results support distinct roles for the different 

isoforms of NFAT transcription factors in cell transformation. 

Financial Support: ICGEB, INCT-Cancer, FAPERJ, CNPq and CAPES. 

Contact: jpviola@inca.gov.br 

60

Symp#9 Immune Cell Biology 

Chair Wilson Savino 

Wilson Savino 


Introductory notes and talk 

Immunological and Clinical Outcomes of a New DC-Based Vaccine 

Flavio Salazar-Onfray and Mercedes López 

1 Millennium Nucleus on Immunology and Immunotherapy, Faculty of Medicine, University of Chile. 

We developed an original method for production of therapeutic dendritic-like cells named Tumor Antigen Presenting 

Cells (TAPCells ® ) using an allogeneic melanoma-derived cell lysate (TRIMEL) as activation factor and antigen provider. 

TAPCells-based immunotherapy induced T cell-mediated immune responses and improved long-term survival of stage 

IV patients in studies involving more than 100 individuals (López et al. 2009, J Clin Oncol; Aguilera et al. 2011, Clin 

Cancer Res). Importantly, 61% of tested patients (58 out of 94) showed a Delayed Type Hypersensitivity (DTH) reaction 

against TRIMEL indicating the development of anti-tumor immunological memory that correlates with prolonged 

patient survival. The in vitro analysis of TRIMEL showed that it contains damage associated molecular patterns such as 

HMBG-1 protein, induced by heat shock, capable to improve, through TLR4, the DC maturation and antigen crosspresentation. 

In fact, a TLR4 polymorphism correlates with patient clinical outcome. DTH response against TRIMEL was 

associated with prolonged survival of the stage IV responder melanoma patients (DTH +; 35 months) compared to the 

non-responders (DTH -; 11 months). Furthermore, we observed that DC-vaccination resulted in a three-fold augment 

of Th1 cell population releasing IFN-γ and a two-fold increase of Th17 lymphocyte population capable to produce IL-17 

in the PBL of DTH+ patients respect to DTH- ones. Antibodies against melanoma antigens can be detected in the sera 

from several vaccinated patients, althougth no correlation with clinical responses could be established. Taken 

together, our results indicate that TAPCells immunization resulted in two different pattern of response associated to 

the immunological and clinical outcome. Our study may contribute to the better understanding of clinical 

immunological responses produced by DC-vaccines and to the development of improved DC-based vaccines. 

Supported by Fondecyt 1090238 and 1090243. 

Eph/ephrin-mediated Interactions Govern Functional Maturation of Developing Thymocytes in the Thymic Epitelial 

3D Network 

Agustín G Zapata 1 , Juan J Muñoz 2 , David Alfaro 1 , Javier Gª Ceca 1 , Teresa Cejalvo 2 , Esther Trobajas 1 , Sara Montero 1 

(1) Department of Cell Biology, Faculty of Biology, (2) Centre for Cytometry and Fluorescence Microscopy, 

Complutense University, 28040 Madrid, Spain 

The thymus is a primary lymphoid organ in which a 3D epithelial network supports the functional maturation of 

lymphoid progenitors into T lymphocytes. The process is highly dependent on the migration of developing thymocytes 

to the adequate thymic niche in which thymic epithelial cell (TEC)-thymocyte interactions are critical. In the current 

presentation we report the role played in these processes by Eph and ephrins, a large family of receptors and ligands, 

respectively involved in the organogenenesis and homeostasis of numerous tisssues, regulating cellular 

attachment/detachment. They are extensively expressed in the thymus, partially govern colonization of lymphoid 

progenitors and their migration throughout thymic parenchyma and their lack deeply affects not only T-cell maturation 

but also correct organization of thymic epithelial network, reflecting the relevance of these molecules in the 

thymocyte-TEC interactions that largely modulate the biology of thymus 

61

Symp#10 Cell Biology and Education 

ASCB & IFCB Symposium 

Chairs Bruce Alberts and Cynthia Jensen 

Cell Biology and Education 

Jensen, C.G. 

Department of Anatomy with Radiology 

University of Auckland, Auckland, New Zealand 

Although Cell Biologists have a wide range of research interests, they all have a common interest in teaching cell and 

molecular biology to undergraduate and postgraduate students and in training masters and PhD students and 

postdoctoral fellows in research techniques. The speakers and discussants at this symposium will describe a variety of 

methods of teaching and training in cell biology, including descriptions of special courses and distance teaching. There 

will be an opportunity for discussion, and questions and comments from the audience will be encouraged. 

Teaching at Distance: Interactive Multimedia of the Cell Biology of Trypanosoma cruzi 

Benchimol, M. 1, 2 , Teixeira, D.E. 2 , Crepaldi, P.H. 1,4 3, 4 

; De Souza, W. 

1 

Universidade Santa Úrsula, Rio de Janeiro, RJ, Brasil 

2 

Fundação CECIERJ, Rio de Janeiro, RJ, Brasil. 

3 Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil 

4 INMETRO, Rio de Janeiro, RJ, Brasil 

CECIERJ is a state public foundation focused in education. It includes the CEDERJ arm, which is specialized in teaching 

at distance as university. Our group has developed an intense work producing multimedia material to undergraduate 

students in Biology. The aim of this work was to develop educational materials in the graphical version using threedimensional 

(3D) animations, to visualize the morphology, dynamic processes and basic knowledge of the Cell Biology 

as a whole and here, in special of Trypanosoma cruzi, the causative agent of Chagas´ disease. Parasitic protozoa are 

important agents of human and veterinary diseases not only in Brazil but also all over the world. The life cycle of these 

protozoa is presented in different levels of education, from fundamental school to graduation level. Videos and 

animations include: cell division, endocytosis and flagellar beating; the interaction of the parasite with a vertebrate 

host cell and the behavior of this protozoan in the digestive tract of the invertebrate host. Thus, this material could: (1) 

facilitate the cell biology of parasites learning and teaching, (2) provide good material which can be used by several 

people at different levels, such as lectures, classes, research, thesis, etc. 

Supported by CNPq, FAPERJ and CECIERJ 

Engaging Undergraduate Students in Research 

Kiaran Kirk 

Research School of Biology, The Australian National University, Canberra, ACT, 0200, Australia 

There are many benefits to be gained from engaging high-achieving students in ‘real research’ from as early as possible 

in their undergraduate career. At the Australian National University we offer students the opportunity to do 

laboratory-based ‘Biology Research Projects’ that count as courses towards their Science degree. We have also 

introduced a research-focused (and highly-selected) degree, the ‘Bachelor of Philosophy’, in which a quarter of the 

courses taken over a three year period are in the form of research projects. Our experience with this mode of teaching 

will be discussed. 

62

Symp#11 Glia Club 

Chairs Bernardo Castellano and Vivaldo Moura Neto 

GSK3β is a Profound Negative Regulator of Oligodendrocyte Differentiation and Myelination 

Arthur M. Butt, Andrea Rivera and Kasum Azim 

Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, U.K. 

Oligodendrocytes are the myelinating cells of the central nervous system and are the primary targets of tissue destruction in the 

demyelinating disease multiple sclerosis. The enzyme GSK3β is a target of many receptor-mediated signalling pathways that regulate the 

differentiation of from their precursors (OPCs). We have examined this using a range of small molecular inhibitors of GSK3β in the mouse 

brain. Inhibition of GSK3β stimulates the generation of OPCs from neural precursor cells (NPCs) in the subventricular zone (SVZ), involving the 

canonical Wnt-β-catenin signalling pathway. Significantly, inhibition of GSK3β also dramatically stimulates oligodendrocyte differentiation and 

myelination. A key finding is that GSK3β inhibition has equivalent effects in the adult and stimulates the regeneration of oligodendrocytes and 

remyelination following demyelination in the adult forebrain. Using a genome wide microarray approach, we find that GSK3β inhibition 

regulates oligodendrocyte generation via multiple positive and negative regulatory signalling pathways. GSK3β inhibition significantly upregulated 

Sox10 and Olig2, key positive regulators of oligodendrocyte differentiation, and down-regulated the Wnt and Notch signalling 

pathways, together with helix-loop-helix ID (inhibitor of differentiation), which are dominant negative regulators of oligodendrocyte 

differentiation. This study identifies novel functions for GSK3β as a profound negative regulator of oligodendrocytes at all stages of their 

differentiation in vivo. Moreover, our findings indicated that GSK3β signalling pathways contributed to inefficient regeneration of 

oligodendrocytes and myelin repair in demyelination. 

Role of Cancer Stem Cells in Adult and Paediatric Brain Neoplasms: Hoax or Holy Grail? 

Professor Geoffrey J Pilkington BSc PhD CBiol FSB FRCPath 

Professor of Cellular and Molecular Neuro-oncology, University of Portsmouth, St Michael’s Building, White Swan Road Portsmouth PO1 2DT 

UK 

In the 1970s stem cell-like populations were described in ethylnitrosourea-induced rat glioma and hypothesised as the origin of such tumours. 

These were located around blood vessels and degenerating neurones, sub-ependymally, at the lateral ventricles. More recently cancer stem 

cells (CSCs), reported largely on their expression of CD133, gathered considerable interest in adult and paediatric brain tumours. Initial 

observations that the CD133+ population were the initiators of brain tumours, based upon their ability to produce tumours in xenograft 

models while CD133- failed to do so have, however, been challenged. The value of CD133 (Prominin-1) has therefore been questioned but the 

function of CD133 or its possible link with processes underlying tumour development and progression remains obscure. Adult glioblastoma 

biopsies yield only 1-5% CSCs based upon CD133 immunostaining. We described a low passage paediatric glioblastoma culture where over 

40% of the cells express CD133 and, if transferred to neural basal medium under hypoxic conditions, this elevated to >95% CD133+. Magnetic 

bead immunoseparated CD133+ and CD133- were used for genetic profiling, adhesion, invasion, and proliferation assays in response to 

nuclear- and mitochondrially-acting pro-apoptotic agents. We also investigated the significance of CD133 glycosylation and influence of oxygen 

on such glycosylation. Whether or not CD133 is a marker of CSCs in brain tumours remains controversial but it may be of significance to the 

biology of paediatric brain neoplasms and requires further investigation both in vitro and in tissue sections. Hoax? certainly not, but CD133 

must be put into context and, while the Holy Grail issue remains unresolved, this is an area of intense interest in unravelling the mysteries of 

tumour biology. 

Mesenchymal Stem Cells lower proliferation and invasion of Glioblastoma cells, exploiting the Immune Response Mediating Chemokines 

Tamara T. Lah, Motaln H 1 , Gruden K 2 , Hren M 2 , Primon M 1 and Schichor Ch 3 

1. Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia. 2 Department of Biotechnology and 

Systems Biology, National Institute of Biology, Ljubljana, Slovenia. 3 Klinikum Großhadern, Ludwig-Maximilians-Universität, München, 

Germany. 

Human mesenchymal stem cells (hMSC) are gaining the forefront position in therapies for curing several diseases. The majority of them is 

focused on the improvements in the regenerative medicine, whereas only limited number of studies is addressing the potential use of hMSC 

for anti-cancer therapy, although the findings in several different cancer models are suggesting they could be developed into efficient cellbased 

therapeutics. 

Considering recent in vivo and in vitro reports on hMSCs growth inhibitory effect on most malignant brain tumor – glioblastoma multiforme 

(GBM) we focused here on the cellular processes responsible for this inhibitory effect, such as cell proliferation, invasion and senescence 

which we confirmed in several GBM lines. We performed whole genome mRNA analysis and cytokine profiling of both, the hMSC and the U87- 

MG GBM cells grown in co-cultures. We found that several chemokines may account either for the decrease of both, proliferation and invasion 

of U87-MG, as well as for induced MSCs proliferation and invasion when the two cells were grown in the indirect co-cultures. CCL2/MCP-1 was 

collectively identified as one of the few most significantly up-regulated chemokine responsible for hMSC and U87-MG paracrine signaling and 

we functionally confirmed its role in GBM cell invasion in vitro. 

In conclusion, our results indicate the CCL2/MCP1 to be the key player of paracrine MSC/glioma cell interactions. Several other gene/protein 

putative markers were identified to take part in hMSC/glioma cell communication for the first time. Together with CCL2/MCP-1 those markers 

could be utilized in future, as target genes for cell-based anticancer therapy. 

Effects of cns-targeted il-6 or il-10 production on microglial activation and motor neuron degeneration after facial nerve 

axotomy 

B. Castellano 1, N. Villacampa 1, B. Almolda 1, I.L. Campbell 2 and B. González 1 

1Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences. Universitat Autònoma de Barcelona, Spain. 2School of 

Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia 

Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are key cytokines with an important role in the regulation of the inflammatory and immune 

responses. In the central nervous system (CNS), increased expression of both IL-6 and IL-10 occurs in a wide range of pathological conditions. 

Meanwhile IL-6 has been usually recognized as a cytokine with a dual role acting as a pro-inflammatory or anti-inflammatory signal inducing glial 

activation while IL-10 is mainly involved counteracting the inflammatory response and immune reactions. The objective of the present study was 

to evaluate the effects of local production of either IL-6 or IL-10 in the microglial response, lymphocyte infiltration and neuronal degeneration 

induced by transection of the facial nerve, a sterile neuronal injury model. Facial nerve axotomy (FNA) was performed in transgenic mice with 

astrocyte-targeted production of either IL-6 (GFAP-IL6Tg) or IL-10 (GFAP-IL10Tg) and their corresponding wild-type (WT) littermates. The 

analysis was performed by histology, immunohistochemistry and flow cytometry at different time points, ranging from 3 to 42 days post-lesion. 

Our observations clearly indicate that GFAP targeted expression of either IL-6 or IL-10 exerts a direct impact on the pattern of microglial 

activation and neuronal degeneration/survival or axotomized motor neurons. As will be discussed, changes observed in the expression of 

different molecules such as Iba1, CD11b, CD16/32, MHC class II and some integrins like osteopontin and their receptors (CD44 and �5) may be 

involved in the differential glial activation pattern and lymphocyte recruitment producing a specific outcome of facial nerve axotomy. 

Supportedby Ministerio de Ciencia e Innovación (BFU2008-04407/BFI) (BFU2011-27400) and NH&MRC grant 632754 

63

Symp#12 Protein Folding and Assembly 

Chair Carlos Ramos 

Protein Folding and Assembly 

Carlos Ramos 

Chemistry Institute, UNICAMP, Campinas, Brazil 

Protein folding and assembly have strong biotechnological and medical relevance, and understanding how proteins fold into their 

native structures has long been a major goal for researchers aiming to predict structure from the primary amino acid sequence. 

Protein homeostasis is relevant for several cellular processes, such as aging, neurodegenerative diseases, evolutionary processes, and 

synaptic plasticity. Although failure to reach or maintain the correct folded structure leads to serious consequences, under normal 

circumstances aberrant proteins become eliminated. A correct balance between folding and the degradation of misfolded proteins is 

maintained by a basic cellular phenomenon known as protein quality control (PQC). This correct balance is critical for cell viability, 

particularly when considering macromolecular crowding in the intracellular environment. In this environment, improper associations 

between partially unfolded proteins are enhanced, and mechanisms that prevent incorrect folding or help to eliminate irreversible 

aggregates that may be harmful to cells are necessary. The resulting misfolded proteins may be degraded by proteases or repaired by 

chaperones, but proteins that escape PQC will probably aggregate. In this symposium speakers will discuss recent advances in our 

knowledge of how proteins fold and assembly inside the cell. 

Mechanisms for folding corrector action in rescue of mutant CFTR from premature degradation by ER Quality Control 

Douglas M. Cyr 

Department of Cell Biology, School of Medicine, UNC-Chapel Hill, Chapel Hill, NC, 27599 

CF patients inherit a variety of mutations that cause folding defects in CFTR, which lead to its recognition for premature degradation 

by Hsp70 dependent E3 ubiquitin ligases (RMA1 and CHIP) on the cytoplasmic face of the ER. The folding defects in ΔF508-CFTR, as 

well as defects in other rare mutants, are correctable, but the mechanism of action for folding correctors is unknown. ΔF508 occurs 

in nucleotide binding domain 1 (NBD1) and blocks Cl- channel assembly by hindering interactions of NBD1 with intracellular loops 

exposed by MSD1 and MSD2. Therefore, correction of folding defects in ΔF508-CFTR requires assembly to a conformation to permits 

escape form multiple ERQC machines and may require repair of more than one folding defect. This talk we describe current 

knowledge about the mechanism for recognition of misfolded CFTR by ERQC machines and present information on the mechanism 

for folding corrector action in treatment of CF. Prospects for treatment ΔF508 homozytotes and compound heterozygotes with 

different combinations of folding correctors will be discussed. 

This work is supported by grants from the National Institutes of Health and the North American Cystic Fibrosis Foundation. 

Chaperonopathies: Impact on protein folding and beyond 

Alberto J. L. Macario, a,b and Everly Conway de Macario a 

a Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore, and IMET, Baltimore, MD, 

USA; b Istituto Euro-Mediterraneo di Scienza et Tecnologia (IEMEST), Palermo, Italy. 

Chaperonology encompasses the study of molecular chaperones and heat-shock proteins in all their aspects, normal and abnormal; 

physiological and pathological, including medico-clinical; biochemical; molecular biological; genetic; and biological. A subfield of 

Chaperonology deals with the chaperonopathies, i.e., diseases in which chaperones play a pathogenic role, participating in the 

mechanism of disease as etiologic-pathogenic factors. These diseases can be classified as any other in the Medical textbooks, 

considering genetic features, molecular mechanism, age of onset, clinical manifestations and course, response to treatment, and so 

on. Some are genetic and hereditary while others are acquired and not transmissible, the former are due, for example, to mutations 

in a chaperone gene, whereas the latter are due, for example, to post-translational modifications of the chaperone protein molecule. 

Since this is a new field, only recently defined within Medicine and that is not treated in most textbooks of Medicine or Pathology, the 

presentation will consist of an introductory overview. Various types of genetic and acquired chaperonopathies will be briefly 

discussed, considering that malfunctioning chaperones affect not only protein homeostasis (i.e., the canonical role of chaperones) but 

alto other unrelated cellular functions, pertaining for example, to cancer and autoimmune diseases. Some of these are classified as 

chaperonopathies by mistake or collaborationism. In them, one or more molecular chaperone, even if normal, actively favors disease, 

e.g., certain types of cancer require chaperones for cell growth and dissemination; in this context, data on Hsp60 chaperone 

migrations in cancer will be described. Acknowledgment: AJLM was partially supported by IEMEST. e-mail: 

Ajlmacario@som.umaryland.edu 

REDOX PROCESSES ASSOCIATED WITH PHYSIOLOGICAL PROTEIN FOLDING AND ENDOPLASMIC RETICULUM STRESS 

Francisco R. M. Laurindo 

Vascular Biology Laboratory, Heart Institute(Incor), University of São Paulo School of Medicine. 

Protein folding at the endoplasmic reticulum(ER) lumen involves chaperone-assisted folding, glycosylation and disulfide bond introduction, the later 

consisting in the transfer of oxidizing equivalents to cysteine thiols at their correct location in nascent proteins. The main effectors of disulfide bond 

introduction are protein disulfide isomerase(s), particularly PDIA1 (PDI). ER-based PDI is an abundantly expressed thioredoxin superfamily 

oxidoreductase displaying many interactions with redox and nonredox proteins and several post-translational modifications. PDI family contains >20 

members with some apparent complementary actions. PDI has oxidoreductase, isomerase and chaperone effects, the latter not directly dependent on 

its thiols. PDI is a converging hub for pathways of disulfide bond introduction into ER-processed proteins, via hydrogen peroxide-generating mechanisms 

involving the ER flavooxidase Ero1α, as well as hydrogen peroxide-consuming reactions involving peroxiredoxin IV and novel peroxidases Gpx7/8. A 

situation in which ER-dependent reactive oxygen species (ROS) generation is increased in many cell types is ER stress. PDI is a candidate pathway for 

coupling ER stress to ROS generation. Emerging information suggests a convergence between PDI and Nox family NADPH oxidases. In vascular smooth 

muscle cells, PDI silencing prevents Nox responses to angiotensin-II and inhibits Akt phosphorylation in vascular cells. Also PDI is required for Nox1/ROSdependent 

vascular smooth muscle cell migration through pathways involving small GTPases Rac1 and RhoA, while PDI silencing promotes cytoskeletal 

disruption. PDI overexpression spontaneously enhances Nox activation and expression. During acute ER stress in smooth muscle cells, silencing of either 

Nox4 or PDI abolishes ROS generation, while PDI silencing enhances apoptosis. During sustained ER stress, ROS generation correlates with increased 

apoptosis, but does not induce cell death. At the cell surface, PDI mediates redox-dependent adhesion, coagulation/thrombosis, immune functions and 

virus internalization. The route of PDI externalization remains elusive. Thus, such multiple effects renders PDI(s) putative redox cell signaling adaptors of 

broader significance. Altogether, redox pathways associated with (patho)physiological protein folding are prime candidate regulators of cellular redox 

status in many diseases (Research supported by: FAPESP, CNPq/INCT Redoxoma). 

64

Symp#13 Vascular cell biology 

Chair Robson Monteiro 

Tumor-Derived Microvesicles and their Role in Cancer Progression 

Robson Q. Monteiro 

Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil 

Shedding of phosphatidylserine (PS)-containing microvesicles (MVs) by cancer cells have been correlated with several pro-tumoral 

responses. In addition, the procoagulant properties of MVs suggest their involvement in the establishment of cancer-associated 

prothrombotic states. Comparison of MVs produced by a non-tumorigenic melanocyte-derived cell line (melan-A) with its 

tumorigenic melanoma counterpart, Tm1, showed an increased rate of MVs production upon malignant transformation. Moreover, 

tumor-derived MVs displayed increased levels of the clotting initiator protein, tissue factor (TF). As a result, Tm1 but not melan-aderived 

MVs accelerated thrombosis in vivo. Analysis of plasma obtained from melanoma-bearing mice showed the presence of MVs 

with a similar procoagulant pattern as compared to Tm1 MVs produced in vitro. Remarkably, flow-cytometric analysis demonstrated 

that 60% of ex-vivo MVs are TF-positive and carry the melanoma-associated antigen, demonstrating its tumor origin. These data 

reinforce the possible involvement of tumor-derived MVs in the establishment of cancer-associated hypercoagulant states, indicating 

an important role for TF in this process. Since MVs may horizontally transfer their cargo between different cells, we further 

investigated the exchange of TF-bearing MVs between human breast cancer cell lines with different aggressiveness potential. 

Incubation of low aggressive MCF-7 cells with MVs from the aggressive cell line, MDA-MB-231, rendered a significant gain of TF 

activity. This phenomenon was not observed upon pretreatment of MVs with an anti-TF neutralizing antibody or annexin V, which 

blocks PS sites on MVs surface. These data indicate that TF-bearing MVs can be transferred between different populations of cancer 

cells, and thus may contribute to the propagation of a TF-related aggressive phenotype among heterogeneous cell subsets present in 

the tumor microenvironment. 

This study was supported by the Brazilian agencies CNPq and FAPERJ. 

Cell Adhesion and Signaling Pathways in Neurovascular Development 

Joseph H. McCarty 

Department of Cancer Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, 

U.S.A. 

The mammalian central nervous system contains billions of neurons and glia that are interlaced with an elaborate network of blood 

vessels comprised of endothelial cells, pericytes and vascular basement membranes. During development blood vessels grow and 

sprout along a pre-formed latticework of glial cells; however, the mechanisms by which glial cells control central nervous system 

neovascularization remain enigmatic. We have used Cre-lox strategies in mice to demonstrate that αvβ8 integrin expressed in glial 

cells is essential for neovascularization of the developing central nervous system. Cell type-specific inactivation of αv or β8 integrin 

gene expression in radial glia using a Nestin-Cre transgene leads to the development of hemorrhagic blood vessels that form 

glomeruloid-like tufts in the embryonic brain and the neonatal retina. These pathologies correlate with diminished activation of latent 

TGFβs, which are extracellular matrix-bound protein ligands for αvβ8 integrin. Genetic ablation of canonical TGFβ receptors Alk5 or 

TGFβR2 in vascular endothelial cells during embryogenesis result in brain vascular pathologies that are identical to those in integrin 

conditional knockout mice. Furthermore, tamoxifen-inducible inactivation of TGFβ receptor signaling in retinal endothelial cells also 

leads to defective angiogenesis and intraretinal hemorrhage. Collectively, our data demonstrate that αvβ8 integrin and TGFβ 

receptors are components of a paracrine signaling axis that links glial cells to endothelial cells during central nervous system vascular 

development. 

Vascular growth factor signaling in neurogenesis 

Jean-Léon Thomas #, Anne Eichmann * 

Departments of Neurology # and Cardiovascular Medicine * , Yale School of Medicine, New Haven, CT, USA 

# Brain and Spinal Cord Institute, Paris, France 

In the adult mammalian brain, the potential to generate new neurons is restricted to a limited number of sites called neurogenic 

niches, which are localized in the subventricular zone (SVZ) lining the cerebral ventricles and in the dentate gyrus (DG) of the 

hippocampus. Injury of brain tissue resulting from trauma or pathologies activates neurogenesis in these niches, attesting to an 

endogenous repair potential that is generally not sufficient to allow a complete rescue. To enhance this endogenous neurogenic 

response without negative side effects, it is crucial to characterize the mechanisms which are active in neurogenic niches. 

Functionally, members of the vascular endothelial growth factor (VEGF) family stimulate adult neurogenesis and neuronal plasticity, 

opening potential approaches for repair of neurodegenerative diseases. However, it has been unclear whether VEGFs stimulate 

neurogenesis directly via VEGF receptors (VEGFRs) expressed by neural cells, or indirectly via the release of growth factors from 

angiogenic capillaries. We have reported that the lymphangiogenic growth factor VEGF-C is expressed by neural cells and provides 

trophic support to neural progenitor cells during brain development (Le Bras, Nat Neurosci, 2006). Here, we will discuss our latest 

findings on its receptor VEGFR-3, which is expressed by adult NSCs, and is critical for adult neurogenesis by acting directly in NSCs and 

niche astrocytes, but not endothelial cells (Calvo, Genes Dev., 2011). 

65

Symp#14 Cell cycle control mechanisms 

Chairs Patricia Gama and Hugo Aguirre Armelin 

Stabilizing nuclear p27 kip1 with Skp2/Cks1 E3 ligase inhibitors as a potential therapeutic intervention for endometrial cancer and 

other cancers 

Savvas C. Pavlides, Lily Wu, Kuang-Tzu Huang, Stepahnie V. Blank, Khushbakhat Mittal, Timothy Cardozo, and Leslie I. Gold 

School of Medicine, New York University, USA 

The cell cycle is precisely regulated via the ubiquitin-proteasome system (UPS) by three substrate-specific E3 ubiquitin ligases, APC- 

Cdc20, APC-Cdh1, and SCF-Skp2/Cks1. Inhibitors of specific E3 ligases that degrade proteins involved in cell cycle arrest are significant 

targets to block for cancer therapy and a significant improvement over currently used non-specific proteasome inhibitors. The cyclindependent 

kinase inhibitor, p27 kip1 (p27), is important for cell cycle arrest in G1. SCF-Skp2/Cks1 ubiquitylates nuclear p27 targeting it 

for degradation thereby causing cell cycle progression. In turn, APC-Cdh1 signals Skp2 and Cks1 degradation, maintaining abundant 

levels of p27 for cell cycle arrest. We show perpetual degradation of p27 by the UPS in type I endometrial carcinoma (ECA), an 

estrogen (E2)-induced cancer. Using normal human primary endometrial epithelial cells (EECs), we demonstrate that E2 induces 

MAPK-Erk2-driven ubiquitin-mediated degradation of p27 by its phosphorylation at T187, required for its degradation by SCF- 

Skp2/Cks1. Also, E2 decreases APC-Cdh1 to increase Skp2 and Cks1 levels for p27 degradation. We propose that E2-induced 

degradation is involved in the pathogenesis of ECA because knocking-down Skp2 completely blocks E2-induced p27 degradation and 

growth stimulation. Conversely, progesterone (Pg) and TGF-β, both inhibitors of EEC growth, markedly increase p27 by increasing 

Cdh1 thereby causing destruction of Skp2/Cks1 leaving p27 intact. Accordingly, separately knocking-down Cdh1 and TGF-β obviate 

both Pg- and TGF-β-induced stabilization of nuclear p27 and completely blocks their ability to inhibit growth. These studies suggest 

that preventing p27 degradation is a rational therapeutic strategy for the treatment of type I ECA. Indeed, small molecule inhibitors 

of Skp2 E3ligase activity (Skp2E3LIs) shown in silico to block p27 binding to Skp2-Cks1, inhibit both E2-induced proliferation and 

degradation of p27 in an ECA cell line and in primary ECA cells. Significant progress has been made in vitro showing lack of toxicity 

and that certain Skp2E3LIs specifically block nuclear degradation of p27 where it can inhibit Cdk1 for cell cycle arrest. Skp2E3LIs 

provide tools for understanding the role of the UPS in p27-mediated cell cycle regulation and as a novel approach to treating ECA and 

many other cancers with inverse levels between p27 and Skp2. 

Cyclin F-mediated degradation of RRM2 (Ribonucleotide Reductase family member 2) controls genome integrity and DNA repair 

Vincenzo D’Angiolella 1 , Valerio Donato 1 , Frances M. Forrester 1 , Yeon-Tae Jeong 1 , Claudia Pellacani 1 , Yasusei Kudo 1,2 , Anita Saraf 3 , 

Laurence Florens 3 , Michael P. Washburn 3,4 , and Michele Pagano 1,5 

1 Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, NY 

10016, USA. 2 Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 

Tokushima, Japan. 3 The Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. 4 Department of 

Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, 

USA. 5 Howard Hughes Medical Institute 

F-box proteins are the substrate recognition subunits of SCF ubiquitin ligase complexes. The F-box protein family obtained its name 

from Cyclin F (also known as Fbxo1), in which the F-box motif was first described. Cyclin F is localized both to the centrosomes and 

the nucleus. At the centrosomes, Cyclin F targets CP110 for proteasomal degradation during G2 to limit centrosome duplication to 

once per cell cycle. Instead, the nuclear function of Cyclin F remains elusive. Using purifications and mass spectrometry, we 

identified RRM2 (the ribonucleotide reductase family member 2) as a new interactor of the F-box protein Cyclin F. Ribonucleotide 

reductase (RNR) catalyzes the conversion of ribonucleotides to the deoxyribonucleotides (dNTPs) that are necessary for replicative 

and repair DNA synthesis. Because of this fundamental function, RNR is among the most well-conserved (from prokaryotes to 

eukaryotes) and highly-regulated enzymes. Indeed, an unbalanced and/or increased dNTP pools produce a hypermutator phenotype, 

and decreased dNTP levels interfere with proper DNA replication and repair. We found that, during G2, following CDK-mediated 

phosphorylation of Thr33, RRM2 is degraded via SCF Cyclin F to maintain balanced dNTP pools and genome stability. After DNA damage, 

Cyclin F is downregulated in an ATR-dependent manner to allow accumulation of RRM2. Defective elimination of Cyclin F delays DNA 

repair and sensitizes cells to DNA damage, a phenotype that is reverted by expressing a non-degradable RRM2 mutant. In summary, 

we have identified a novel biochemical pathway that controls the abundance of dNTPs and ensures efficient DNA repair in response 

to genotoxic stress. 

Resveratrol and Temozolomide co-treatment induces mitotic catatrophe and senescence in glioma cells through modulation of 

mitotic regulators 

Eduardo C. Filippi-Chiela and Guido Lenz* 

Department of Biophysics and Center of Biotechnology, 

Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 

Email: lenz@ufrgs.br Phone: 55 51 33087613 

Blockage of the cell cycle is an important strategy in cancer therapeutics. On the other hand, forcing mitosis in cells with high levels of 

DNA damage may also be a good strategy, since it may induce mitotic catastrophe (MC) and senescence. Temozolomide (TMZ), the 

primary therapy used in gliomas, causes DNA damage and G2 arrest. Resveratrol (Rsv) presents additive toxicity with TMZ in several 

glioma cells in vitro and in vivo, but the mechanism of additive toxicity is not clear, which is the aim of the present work. Rsv 

abrogated the TMZ-induced G2 arrest when added together, but not after TMZ. Rsv potentiated the increase in TMZ-induced 

gammaH2AX, but not ATM and Chk2. Abrogation of TMZ-induced cell cycle arrest by Rsv involved a reduction of cyclin D, 

pWee1(S642) and of the Wee1 target site, pCdc2(Y15) and increase of cyclin B. This suggests a state of forced passage through G2 

checkpoint despite large DNA damage, a scenario typical of MC. In order to quantify MC and senescence, we developed a quantitative 

method called nuclear morphometric analysis (NMA). Indeed, after acute treatment with Rsv+TMZ, the proportion of cells with high 

nuclear irregularity increased from 5 to 28% in 48h. Seven days later, a large induction of senescence and reduction in clonogenicity 

was observed. In conclusion, presence of Rsv forced damaged cells treated with TMZ through mitosis due to a reduction of Wee1 and 

pCdc2(Y15), leading to MC and senescence. Funding: CNPQ and FAPERGS. No conflict of interest. 

66

Symp#15 Migration and Regeneration 

Chair Fernando Costa e Silva Filho 

A mechanochenical cross-talking between eukaryotic cells and their surroundings instruct cells on what they have to 

do 

Fernando Costa e Silva Filho 1* , Nathan Bessa Viana 2 , Lilian de Mello Gil 1 , and Débora Barreiros Petrópolis 1,3 

1,2 UFRJ- 1 Instituto de Biofísica Carlos Chagas Filho and 2 Instituto de Física (Brazil), 3 Institute Pasteur (France), 

and INCT- 1,3 Instituto Nacional de Pesquisa Translacional em Saúde e Ambiente da Região Amazonica (Brazil) 

Collagen I (COL) is abundant in the extracellular matrix (ECM) of most of studied animal tissues and one of the most 

widely-used scaffolds for three-dimensional (3D) cell culture and tissue engineering applications, which is partly 

derived from the ability of purified COL monomers to self-assemble into stable, 3D gels at physiological pH. The fiber 

diameter, pore size, and bulk elasticity of reconstituted COL gels can be tuned within modest ranges by changing COL 

concentration, ionic strength, pH, and the temperature of gelation. The last in turn begins with the entropy-driven 

nucleation of triple-helical COL monomers into small aggregates, which subsequently self-assemble into thin filaments 

that laterally crosslink into the well known COL fibers. A 3D COL matrix is then formed via non-covalent entanglement 

of the fibers. As a consequence of this entanglement, reconstituted COL networks or meshes typically exhibit nonaffine 

mechanical properties which means applied stresses are dissipated non-uniformly throughout meshes via 

sliding, slipping, bending, and bucking of individual COL fibers. Given such 3D COL properties which partially mimic the 

mechanical configuration of naturally occurring ECM we have been used COL meshes under different mechanical 

configurations to explore further the responsiveness of some protozoa and mammalian cells to the mechanics of their 

surroundings. Trophozoitic forms of the parasitic protozoan E. histolytica (HM1:IMSS) and human osteoblasts (HOB) 

are cells we have elected to investigate the mechanisms underlying the interaction between eukaryotes and each one 

of 2D (biofilms) and 3D (meshes) COL setups by using biophysical, biochemical, structural and ultrastructural methods 

as well as optical tweezers. Altogether, the resulting data we have obtained clearly show that the early response of a 

protozoan and a mammalian cell to a same mechanochemical environment is quite different: while HM1:IMSS cells 

tend to use COL fibers as migration tracks, HOB cells tend to remodel the mesh at high extent following invasion. 

Inside-out integrin signaling 

Mark Ginsberg 

University of California, San Diego, Department of Medicine, La Jolla, CA 

Integrin activation contributes to leukocyte trafficking, cell migration and extracellular matrix assembly. Deletion of 

talin or point mutations in talin or integrins that disrupt their interaction led to profound defects in integrin 

activation. We reconstructed integrin activation in vitro and found that that talin binding is sufficient for activation. 

Talin interaction with phospholipids is required for its capacity to activate integrins. Nanodiscs bearing a single lipidembedded 

integrin and revealed that talin activates unclustered integrins leading to molecular extension in the 

absence of force or other membrane proteins. Rap1 small GTPases are important in activation of integrins and we 

report that they interact with RIAM (Rap-interacting Adaptor Molecule) to promote talin-dependent activation. RIAM 

connects the membrane targeting sequences in Ras GTPases to talin, thereby recruiting talin to the plasma membrane 

and activating integrins. A minimized 50 residue Rap-RIAM module, containing the talin binding site of RIAM joined to 

the membrane-targeting sequence of Rap1A is sufficient to target talin to the plasma membrane and to mediate 

activation in the absence of Rap1 activity. The structure of the αIIbβ3 transmembrane domain (TMD) reveals how talin 

binding can disrupt the αβ TMD complex and lead to the long range conformational change that results in integrin 

activation. These studies define the molecular mechanisms whereby talin activates integrins and establish a signaling 

roadmap between agonist stimulation and integrin activation. 

Human-laminin mediates axonal regeneration promoted by human adipose tissue-derived stromal cells after spinal 

cord injury in rats 

Tatiana Coelho Sampaio 

Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Histologia e Embriologia, 

Rio de Janeiro, Brasil 

Adipose tissue is a convenient source of adult mesenchymal cells for regenerative therapies. We injected human 

adipose tissue-derived stromal cells (hADSC) after acute spinal cord injury in immunocompetent rats and found that 

they promoted extensive morphological and functional recuperation. In contrast to controls, treated animals 

presented 1) clusters of neural precursors in the spinal parenchyma, 2) blood vessels with double basement 

membranes and 3) abundant deposition of laminin of human origin at the lesion site and spinal midline. These effects 

did not occur upon treatment with conditioned medium, but did occur after injection of hADSC into the non-injured 

cord. Fibers positive for 5-HT, Beta III tubulin or GAP-43 were visible in the tissue surrounding the cystic cavity in close 

association with laminin. We propose that laminin is the main effector of hADSC-induced axonal regeneration and that 

it acts by increasing the amount of local neural precursors. 

67

Symp#16 Inflammation 

Chair Patrícia Bozza 

Patrícia Bozza 



The intimate link between fibrosis and inflammatory response 

Niels Olsen Saraiva Camara 

Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil 

Toll-like receptors (TLRs) are an innate family of receptors that can sense tissue damage and orchestrate a cascade of 

inflammation. Recent reports have shown reduced fibrosis in TLR4-deficient mice. TLR2 and TLR4 signal via the 

intracellular adaptor molecule MyD88, although only few studies implicated a role for MyD88 in fibrosis. TLRs 

modulate the immune system through the production of different cytokines and influence fibrosis. In fact, fibrosis is 

strongly linked with the development of a Th2-biased response (involving IL4, IL5 and IL13). Macrophages are 

considered to play a pivotal role in the development of fibrosis. Recent studies raise the possibility that the effector 

phenotype of the recruited macrophages, rather than their presence, determines the extent of renal parenchymal 

injury. Macrophages are classified in distinct subpopulations according to their response to innate or adaptive immune 

signals. The term “classically activated” has been used to designate the effector macrophages that are produced 

during cell-mediated immune responses. Such macrophages are also designated M1 macrophages and express iNOS, 

CXCL9, CCR7, CXCL11, IL12 and IFNγ. On the other hand, one of the first innate signals released during tissue injury is 

thought to be IL4, an inducer of “alternatively activated” or M2 macrophages. Since collagen deposition is a hallmark 

of all chronic diseases, preceded by the development of sterile inflammation, which can be modulated by the presence 

of cytokines, here, we present data that MyD88-depend pathway could be involved in sensing these tissue alterations 

and in favoring a Th2-prone pro-fibrotic immune response. 

How a Parasite MIF Suppresses T cell Immunity and Influenced the Evolution of Macrophage Responsiveness 

Rick Bucala MD PhD, Yale University, New Haven, CT. 

The inability to acquire protective immunity against Plasmodia is the chief obstacle to malaria control, and an 

inadequate T cell response may contribute to persistent blood stage infection. We observed that high levels of 

inflammatory cytokines inhibit Plasmodium-specific memory T cell development and result in fewer protective 

memory T cells. The Plasmodium ortholog of macrophage migration inhibitory factor (MIF), which is produced during 

infection, is associated with inflammatory sequelae in human malaria and induces high levels of pro-inflammatory 

cytokine expression. Using a genetically targeted strain of P. berghei, the Plasmodium MIF (PMIF) mediated increase in 

inflammatory cytokine expression was found to promote T cell apoptosis, resulting in fewer antigen-experienced CD4 T 

cells that become memory cells. CD4 T cells activated in the presence of PMIF fail to produce robust anti-malaria recall 

responses during a secondary challenge infection and are unable to control parasitemia. These results indicate that 

Plasmodia modulate the adaptive immune response and interfere with the generation of malaria-specific memory CD4 

T cells, thereby facilitating parasite persistence and transmission. The immunoregulatory function of PMIF may 

account for its expression across all Plasmodium spp., its evolutionary conservation in protozoan and helminthic 

parasites, and the prevalence of low expression MIF alleles in many human populations. Targeting PMIF may be a 

useful approach for augmenting natural host immunity and for producing more effective vaccines. 

68

Symp#17 Glia 

Chair Flávia Carvalho Alcântara Gomes 

GLAST/EAAT1 induces Glutamine release through SNAT3 in cultured chick cerebellar Bergmann glial cells 

Angelina Rodriguez 1 and Arturo Ortega 2 

1 Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico., 2 Departamento de Genética y 

Biología Molecular, Cinvestav-IPN, México DF, Mexico. 

Glutamate is the main excitatory neurotransmitter in the vertebrate brain. Once released, its extracellular levels are 

tightly regulated through the action of a family of sodium-dependent glutamate/aspartate transporters profusely 

expressed in glial cells. Once internalized into the glial compartment, it is metabolized by glutamine synthetase to 

glutamine and released to the synaptic space through sodium-dependent neutral amino acid carriers of the N System. 

Glutamine is then taken up by neurons via System A transporters completing the so-called glutamate/glutamine 

shuttle. 

Although this neuronal/glial coupling was described decades ago, it has only been recently that the biochemical 

framework that supports this shuttle has begun to be elucidated. Using the established model of cultured cerebellar 

Bergmann glia cells from chick cerebellum, we characterized the functional and physical coupling of glutamate uptake 

and glutamine release. A time-dependent glutamate transporter-induced glutamine release could be demonstrated. 

Furthermore, D-aspartate, a specific glutamate transporter ligand, was capable to enhance the coimmunoprecipitation 

of the glutamate and glutamine transporters, whereas glutamine tended to reduce this 

association. Our results clearly pointout that glial cells that enwrap glutamatergic synapses act as sensors of neuronal 

activity and through their contribution to the neurotransmitter recycling, could well the rate-limiting step of 

glutamatergic synaptic function. 

Understanding Neuron-Glia Interactions: Models Matter 

Frank W. Pfrieger 

Institute of Cellular and Integrative Neurosciences, CNRS UPR 3212, University of Strasbourg, Strasbourg, France 

Brain development and function depend on interactions of neurons and different type of glial cells. Within the last 

years, we have developed new experimental approaches that allow to study these interactions in vitro and in vivo, 

with a focus on the retina. In my presentation, I will summarize our results, which indicate contributions of astroglial 

cells to synapse development, neuronal volume regulation and cholesterol homeostasis in the brain. 

Adan Aguirre 

Department of Pharmacological Sciences, 442 Center for Molecular Medicine, Stony Brook University, , Stony Brook, 

NY 11794-5140 

69

Symp#18 Perspectives in cancer therapies 

Chair Jörg Kobarg 

Prospecting and testing new molecular target proteins for cancer therapy: integrating systems and structural 

biology” 

Jörg Kobarg, PhD 

LNBio-Laboratório Nacional de Biociências, CNPEM-Centro Nacional de Pesquisa em Energia e Materiais 

Rua Giuseppe Máximo Scolfaro 10.000 Campinas-SP, Brasil, CEP 13083-970 F: 0055-19-3512-1125 

Starting from identified cancer related proteins or candidate proteins we explore and integrate several techniques and 

approaches ranging from structural biology, micro array, proteomics, protein interactome to cellular and molecular 

functional characterization, in order to obtain information on the mechanisms underlying the dysfunction of these 

proteins in cancer and to envision new modes of interference aiming at the target specific therapeutic intervention in 

cancer. Distinct aspects of this approach are exemplified by three different proteins or groups of proteins currently 

under investigation: 1. FEZ1 as a kinesin associated transport adaptor protein that when over-expressed can lead to 

the formation of so called “flower-like nuclei“, a hall mark of certain aggressive sub-types of leukemia. 2. Il-7 Receptor 

Cys insertion mutations that lead to aberrant receptor homo-dimerization and constitutive activation , growth and 

survival of lymphocytes and to tumor formation in the mice model. 3. The 11 human members of the family of NIMA 

(Never in mitosis gene A)-related serine/threonine kinases (Neks) have cell cycle-related functions, were recently 

described as related to pathologies, particularly cancer, and present promissing chemotherapeutic targets. In order to 

understand better the cellular functions of human Nek kinases we performed yeast two-hybrid assays using Nek1, 6, 7 

and 9 as baits to identify their protein interaction partners. Similar studies are currently ongoing for Nek 3, 4, 5, 10 and 

11. We will present a general overview of our results and their implications for these protein kinases functions in the 

context of tumorigenesis. 

Modern optical techniques for diagnostic and treatment of cancer and microorganisms 

Vanderlei S. Bagnato 

Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil 

Solving health problems with photonics techniques is attractive due to its more selective and fast response, minimally 

or non-invasive procedure, and potential low cost instrumentation. These characteristics are especially relevant for 

emergent economy countries, where health care is still deficient for large amount of population. Brazil shows a diverse 

situation along its large territory: it is possible to find the best medicine with the highest technology available and well 

educated personnel, but also a poor health care or even the lack of one. Diagnostics and treatment techniques that are 

effective, low cost, and that requires simple instrumentation may be good solutions for improving health care. This 

presentation will start with the main principles involved in photonics for live science and present the status of 

development for applications in cancer diagnostic and treatmne as well as microbial control. 

Deciphering Neuregulin-HER signaling in breast cancer 

Atanasio Pandiella 

Centro de Investigación del Cancer. CSIC-Universidad de Salamanca, Spain. 

The ErbB/HER receptors and their ligands play important roles in animal physiology, and their deregulation has been 

linked to diseases such as cancer. Activation of the HER receptors may occur by different mechanisms, including ligand 

binding, receptor overexpression, or molecular alterations. In breast cancer, one of the HER family recptors, termed 

HER2, is overexpressed in tumors of 20% of patients, and this has led to the development of therapies against HER2 

which are now routinely used in the breast cancer clinic. While assessment of the levels of HER receptors in breast 

cancer has been extensively analyzed, the role of their ligands has been less well studied. We have explored the 

expression of Neuregulins (NRGs), a subgroup of HER ligands, in breast cancer samples. We observed frequent 

expression of these ligands, and such expression was linked to metastatic dissemination and poor clinical outcome, 

indicating that targeting this ligand system may be therapeutically beneficial. For this reason, we have started a 

program to identify how the NRG-HER signaling system controls the proliferation of breast cancer cells. Genomic as 

well as proteomic strategies have allowed us to identify novel signaling intermediates of the NRG-HER system. Using 

biochemical, genetic, cell biological techniques, as well as xenografted mice, we have elucidated the participation of 

these novel signaling intermediates in NRG-stimulated proliferative responses in breast cancer cells. Pharmacological 

action on some of these intermediates allowed us to evaluate the potential therapeutic value of their targeting in 

breast cancer. 

70

Symp#19 Regulators of neural transmission 

Chairs Vilma R Martins and Roy Larson 

Regulation of neuronal function and dysfunction by protein SUMOylation 

Jeremy M. Henley 

University of Bristol 

The post-translational modification SUMOylation is a major regulator of protein function that plays an important role 

in a wide range of cellular processes. SUMOylation involves the covalent attachment of a member of the small 

ubiquitin-like modifier (SUMO) family of proteins to lysine residues in specific target proteins via an enzymatic cascade 

analogous to, but distinct from, the ubiquitination pathway. The implications for neuronal protein SUMOylation are 

far-reaching in both normal cell function and in neurological and neurodegenerative diseases. I will discuss aspects of 

our work attempting to identify and functionally characterise SUMO substrates; elucidate the molecular mechanisms 

regulating, and consequences of, substrate SUMOylation and deSUMOylation; determine the activity-dependence of 

SUMO and SUMO-specific protease trafficking to synapses; and define how SUMOylation regulates synaptic 

transmission under basal, stimulated and pathological conditions. 

Gain control in the outer retina 

Joselevitch, C. 1,2 , Kamermans, M. 1 

1 - Retinal Signal Processing, The Netherlands Institute for Neuroscience; The Netherlands. 

2 - Department of Experimental Psychology, Universidade de São Paulo, Brazil. 

Gain control mechanisms are present at all retinal layers. They are especially important for cells that receive mixedinput 

from rods and cones, in order to avoid premature saturation as light levels increase. Here we describe a 

mechanism at work in the goldfish retina that modulates the effectiveness of the rod-bipolar cell synapse. Voltageclamp 

recordings of mixed-input ON bipolar cells in retinal slices show that a voltage-gated current is activated during 

the light-induced depolarization at scotopic levels. The activation of this current effectively diminishes the amplitude 

of the bipolar cell rod-driven light response and makes it faster and more transient with increasing light intensity. This 

effect can be abolished by the K + channel blocker TEA, which indicates that the voltage-gated current is mediated by K + 

ions. Mathematical simulations with NEURON suggest that the K + channels are most likely concentrated at the 

dendritic tips of mixed-input ON bipolar cells, close to the site of glutamate release by photoreceptors. Since the 

magnitude of activation of such channels depends directly on the amplitude of the light response, they control the 

gain of the rod bipolar cell synapse and speed up synaptic transmission as light levels increase and rod responses 

themselves inactivate slowly. 

Protein synthesis and memory processing 

Martin Cammarota 

Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, Brazil 

71

Symp#20 Tissue Regeneration 

Chair Juan Larrain 

Spinal cord regeneration in Xenopus 

Rosana Muñoz 1 , Dasfne Lee-Liu 1 Mauricio Moreno 1, , Gabriela Edwards 1 , Leonardo I. Almonacid 2 , Victor Tapia 1 , Karina 

Tapia 1 , Francisco Melo 2 , Juan Larrain 1 

1 Center for Aging and Regeneration and Millenium Nucleus in Regenerative Biology, Department of Cell and Molecular 

Biology, Pontificia Universidad Catolica de Chile; 2 Molecular Bioinformatics Laboratory, Millennium Institute on 

Immunology and Immunotherapy, Department of Molecular Genetics and Microbiology, Pontificia Universidad 

Catolica de Chile. 

Xenopus tadpoles are able to regenerate the spinal cord (SC) after injury, although this capacity is lost when they reach 

metamorphosis. The cellular and molecular mechanisms that explain this differential SC regeneration ability have not 

been unveiled (or are not completely understood). Thus, a deep comparison between the regenerative capacities in 

these two stages of Xenopus life cycle might be crucial to establish why SC regeneration is lost during metamorphosis. 

We have found that spinal cord transection activates proliferation of Sox2 + cells from the ependymal layer in 

regenerative but not in non-regenerative stages. At 6 days post transection (dpt) Sox2 + cells fill the gap between the 

spinal cord stumps and provide a surface for axonal regeneration.To deepen this analysis, we propose that the 

differences in regeneration capacity can be explained at least at the level of gene expression. Thus, we aim to identify 

a group of SC transcripts that are permissive and another non-permissive for regeneration. To demonstrate this we 

performed a high-throughput analysis of the SC transcriptome (RNA-Seq) after injury (transection) in different stages. 

So far, we have found that more than 4000 transcripts show differential expression when comparing regenerative and 

non-regenerative stages. We have successfully validated these differences in a group of them using qRT-PCR. And 

importantly, gene ontology enrichment analyses show that genes belonging to the biological processes ‘cell cycle’ and 

‘immune response’ are differentially regulated after spinal cord injury, amongst others. Considering these preliminary 

results we suggest that the differences in SC regeneration capacities in Xenopus could be explained at least by a 

differential expression of cell cycle and immune response genes. 

Cellular and Molecular Mechanisms of Zebrafish Heart Regeneration 

Ken Poss 

HHMI, Duke University Medical Center, Durham, USA 

Cellular and molecular mechanisms of intestinal regeneration in echinoderms 

Jose E. García-Arrarás 

University of Puerto Rico 

In recent years we have seen a growing interest in determining the cellular and molecular mechanisms involved in the 

process of organ regeneration. This process comprises a sequence of temporal and spatial events that interact to give 

rise to a new organ. We have studied the regeneration of the digestive tract using as a model system the sea cucumber 

Holothuria glaberrima. This echinoderm, like many other holothurians, has the capacity to regenerate most of its 

digestive tract following its loss. We have shown that the new intestinal primordium is a blastema-like structure that 

forms as the mesenterial cells undergo a series of changes that include dedifferentiation, proliferation and apoptosis. 

These cells undergo changes at the molecular level, expressing molecular markers not normally found in the normal 

mesentery. Among the molecular markers that appear to be over-expressed within the epithelial cells during the 

formation of the intestinal rudiment are those associated with signalling pathways such as Wnt 9 and BMP1/TLD, with 

the control of cellular proliferation and cell death such as TCTP, survivin, and mortalin and with the ubiquitinproteasome 

system. The drastic changes observed in the expression profile of the epithelial component suggest that 

these cells are the key players in the regeneration process and provide a target to further explore their role in organ 

regeneration. Thus, as we unravel the cellular and molecular mechanisms associated with intestinal regeneration in 

echinoderms we provide a much-needed insight into the basic biological processes involved in organ regeneration. 

Funded by NIH (1SC1GM084770), NSF (IOS-0842870) and the University of Puerto Rico 

72

Symp#21 Metabolic programming 

Chair James Armitage 

Maternal obesity, diabetes or high fat intake in pregnancy: Are they all independent risk factors for metabolic 

syndrome in her offspring? 

James A Armitage 

Department of Anatomy and Developmental Biology 

Monash University, Victoria, Australia 

In many societies across the globe, more than half of the women of reproductive age are overweight or obese. 

Maternal obesity and diabetes in pregnancy have long been recognised as risk factors for adverse pregnancy 

outcomes, including emergency caesarean section, shoulder dystocia and perinatal complications. 

More recently we have also come to appreciate the fact that maternal obesity or diabetes may also programme 

metabolic, cardiovascular and renal dysfunction in her offspring. Our studies in diabetic mice show that maternal 

hyperglycaemia programmes abnormal fetal growth and a reduction in kidney development, which occurs from the 

earliest time points of kidney development and may result in lifelong alterations in renal function. 

In addition to the obesity epidemic, humans across the globe are consuming diets very high in fats and oils, particularly 

saturated fatty acids. At present it is not known whether consumption of a high fat diet is sufficient to programme 

metabolic cardiovascular or renal disease in the offspring. 

We developed a rodent model to better understand the role of maternal fat intake in pregnancy without the confound 

of maternal obesity and show that high saturated fat intake in pregnancy and suckling programmes offspring 

hypertension and altered renal function independent of maternal or offspring obesity. The mechanisms underlying this 

programming may relate to placental fatty acid transfer and cytokine production in late gestation. 

In conclusion, maternal diabetes and excessive maternal saturated fatty acid intake can programme alterations in 

kidney development and function independent of maternal obesity. Given the preponderance for high saturated fat 

intake, and the increasing prevalence of diabetes in women of reproductive age, these findings offer strong evidence 

for moderation of fat intake in pregnancy and careful management of hyperglycaemia in pregnant women. 

SMOKING IN THE POSTNATAL LIFE AND FUTURE OBESITY: the nicotine role on the endocrine dysfunctions. 

Patricia Cristina Lisboa 

Laboratory of Endocrine Physiology, Department of Physiological Sciences, Biology Institute, State University of Rio de 

Janeiro, RJ. 

Around 40% of children worldwide are exposed to tobacco smoke at home. Children born from smoking mothers 

present several developmental impairment. Environmental changes in a critical window of development, such as 

gestation or lactation, can cause permanent alterations in the metabolism, leading to disease at adulthood; a 

phenomenon called programming or developmental plasticity, which is based on epigenetic alterations (DNA 

methylation and histone acetylation) that change the pattern of expression of several genes involved with the 

metabolism regulation. A histone deacetylase, Sirt1 is inhibited by nicotine and can play an importante role in the 

developmental plasticity. Obesity is a global epidemic and it has been shown an association of maternal smoking with 

the development of obesity in childhood. However, little is known about the early and late effects of the tobacco in 

neonatal life upon adiposity and endocrine function. We studied two models of programming related to smoking that 

produced animals with higher cardiovascular risk and endocrine dysfunction during development: maternal nicotine 

exposure (i) and maternal cigarette smoke exposure (ii), both only during lactation. We evidenced a relationship 

between hyperleptinemia in offspring whose mothers were exposed to nicotine during lactation with the further 

development of leptin and insulin resistance as well as thyroid and adrenal dysfunctions in adulthood. Thus, an 

environment free of smoke during lactation is essential to improve health outcomes in adult life, reducing the risk for 

future diseases. The knowledge about the pathophysiological mechanisms involved in maternal smoking can give new 

insight concerning therapeutic strategies for obesity. 

Diet-induced hypothalamic inflammation in obesity 

Licio A. Velloso 

University of Campinas, Brazil 

Obesity results from the failure of the homeostatic control of caloric intake and energy expenditure. Most of this 

control is exerted by a complex network of hypothalamic neurons that integrate hormone, nutrient and neuronal 

signals involved in the sensing and responsiveness to the fluctuations of the body energy stores. Data obtained in the 

latest fifteen years have placed hypothalamic dysfunction in a central position in the pathogenesis of obesity. Here, we 

will review the seminal work that have contributed to our current knowledge of the mechanisms involved in the 

control of food intake and thermogenesis and also the implications of hypothalamic dysfunction in the development of 

obesity. We will present data from both experimental and human studies showing that saturated fats present in the 

western diet can activate hypothalamic inflammation which results in the defective control of energy homeostasis. 

73

Symp#22 Mitochondria 

Chairs Enilza Espreafico and Nadja Souza-Pinto 

Evidence implicating KIAA0090/CG2943 in mitochondrial function 

ENILZA M ESPREAFICO, RODRIGO R SILVA, CARLOS A COUTO LIMA, ROBERTO A. MOLINA, JOSANE F SOUSA, MILENE M 

LOPES, MAIARO C MACHADO, LUCAS ANHEZINI, RICARDO GP RAMOS 

Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, 

Universidade de São Paulo, 14049-900 - Ribeirão Preto, SP, Brasil 

Human KIAA0090 is an evolutionarily conserved and ubiquitously expressed gene that maps to a chromosomal region (1p36.13) with 

frequent aberrations in cancer. It is a complex gene with cDNA sequences in databases supporting the occurrence of more than 20 

alternative transcripts. The RefSeq transcript is predicted to encode a 993 aa transmembrane protein whose S. cerevisiae ortholog 

(EMC1) was recently proposed to function on transmembrane protein folding in the endoplasmic reticulum (ER). Deletion of the gene 

in yeast and C. elegans leads to slow growth and a number of interactors involved in multiple pathways, including cell cycle, secretory 

pathway, UPR, ERAD, ion transport, cytoskeleton, transcription factors, and mitochondrial electron transfer, have been detected. We 

found KIAA0090 to be upregulated in melanoma cells and nevi. Expression of EGFP-tagged proteins in mammalian cells showed 

pronounced apoptotic cell death and involved alterations in mitochondria and ER. KIAA0090 knockdown also led to an increase of cell 

death rates in melanoma cells. The endogenous protein was primarily localized either to mitochondria or Golgi, depending whether 

the antibody used was to the N- or C-terminal regions. The results shown here corroborate many genetic interactions found in yeast, 

but suggest that KIAA0090 protein has a broader subcellular localization and function than the one proposed for its yeast 

counterpart. To decipher the role of this gene in development, we are beginning to conduct functional studies on the Drosophila 

melanogaster KIAA0090 ortholog, CG2943. Driving an RNAi targeting CG2943 mRNA to skeletal muscle led to high rates of pupal 

lethality and generated offsprings unable to fly and with severe deficiency of locomotion. Ultrastructural analyses of muscle fibers are 

currently being performed to gain insights into the structural basis that accounts for the observed phenotype. 

Financial Support: FAPESP, CNPq, DECIT, CAPES, FAEPA 

Mitochondrial BER activities maintain mtDNA stability and mitochondrial function 


Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil 

The mammalian mitochondrial DNA (mtDNA) codes for 13 polypeptides, all essential components of the electron transfer chain. 

Mutations and deletions of the mtDNA lead to mitochondrial dysfunction, which cause several human syndromes and have been 

implicated in common, multi-factorial diseases such as cancer and neurodegeneration. The mtDNA is closely associated with the inner 

mitochondrial membrane, where reactive oxygen species are generated as byproducts of normal oxidative metabolism. Thus, 

mitochondria rely on DNA repair pathways to maintain mtDNA stability. Among those, the base excision repair has been extensively 

characterized in mammalian mitochondrial. Mitochondrial BER (mtBER) involves 5 enzymatic steps, catalyzed by isoforms of the 

enzymes involved in nuclear BER, which have been biochemically characterized. However, its regulation is still unclear. We 

hypothesized that mtBER activity is modulated by proteins interactions, in a fashion akin to the modulation of nuclear BER. Using in 

vitro assays to measure each BER step independently, we have identified two proteins which strongly affect mtBER activity. The 

repair factor CSB (mutated in Cockayne Syndrome) is involved in maintaining mtBER activities anchored to the inner mitochondrial 

membrane, where the mtDNA is located, and thus, favors mtDNA repair efficiency. On the other hand, the nucleoid protein TFAM 

(Mitochondrial transcription factor A) binds to damaged DNA, diminishing the accesses of repair enzymes. TFAM binding to DNA is 

modulated by p53, allowing the damage to be accessed by the BER enzymes. We propose a model in which CSB, TFAM, p53, and 

others, yet unidentified proteins, modulate mtBER activity in response to stress. 

Dietary interventions, mitochondria, oxidants and lifespan 

Alicia J. Kowaltowski 

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil 

Mitochondrial energy metabolism and mitochondrially-derived oxidants have, for many years, been recognized as central toward the 

effects of aging. Calorie restriction (CR) enhances animal lifespan and prevents age-related diseases, including neurological decline. 

Recent evidence suggests a mechanism involved in CR-induced lifespan extension is NO ● -stimulated mitochondrial biogenesis. We 

examine here the effects of CR on brain mitochondrial content. CR increased eNOS and nNOS and the content of mitochondrial 

proteins in the brain. We established an in vitro system to study the neurological effects of CR using serum extracted from animals on 

this diet. In cultured neurons, CR serum enhanced nNOS expression and increased nitrite levels (a NO ● product). CR serum also 

enhanced the levels of cytochrome c oxidase and increased citrate synthase activity and respiratory rates. CR serum effects were 

inhibited by L-NAME and mimicked by the NO ● donor SNAP. Furthermore, both CR sera and SNAP were capable of improving 

neuronal survival. Since eNOS is the main source of NO ● involved in mitochondrial biogenesis, we investigated the mechanism of NOS 

activation by treating vascular cells with serum from CR rats and found increased Akt and eNOS phosphorylation, in addition to 

enhanced nitrite release. Inhibiting Akt phosphorylation or immunoprecipitating adiponectin (found in high quantities in CR serum) 

completely prevented the increment in nitrite release and eNOS activation. Overall, we demonstrate that adiponectin in the serum 

from CR animals increases NO • signaling by activating the insulin pathway, resulting in enhanced mitochondrial biogenesis and 

neuronal survival. 

Supported by FAPESP, CNPq and INCT/NAP Redoxoma 

74

Symp#23 Cytotoxicity -Brazilian-Slovenian Meeting 

Chairs Sandra Azevedo and Tamara Lah Turnsec 


Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia. 

Cancer initiation and promotion is caused by a number of substances of artificial as well as natural origin that perturb normal cell 

metabolism and in the first case also effect gene structure and expression by direct or indirect effects on cell nuclei. Genetic 

toxicology is the field that describes ad study such events and when these are initiated by environmentally released substances, the 

ecotoxicology may explain its effect is origin, distribution and metabolism as well as the effects on different organisms, including 

humans. 

In this session all these are combined, leading us from ecotoxicology, associated with water organisms that release a number of 

toxins into their environment. Being of structurally very diverse families and sizes (from small peptides of unusual structure, that 

would not be degraded by host proteases (but rather inhibit them) to larger oligomeric protein structures forming pores in the cell 

membranes. These toxic substances may have differential effects, both on the same and other species in their environment. 

After overcoming the cell defence and resistance mechanisms, the toxins either cause autophagy, senescence or apoptosis via a 

number of pathways, which may lead either to cell death or transformation, which primed the cells with the potency to tumour 

progression. By the same token, a number of toxins are also being testing for their effect on eradicating cancer cells and recently 

also cancer stem cells. The problem here, especially in the case of cancer stem cells. The latter in particular have developed a 

number of resistance mechanisms. This being overcome by an appropriate combination of toxins with other strategies to specifically 

attack cancer cells, offer new strategy in cancer treatment that may lead to improved efects at least in certain cancer strategies. 

Also, as cancer tissue is composed of a variety of tumour and normal - stromal cells, the effects on these, as well as on their 

interactions need to be considered in the future. 

Cyclic cyanopeptides influence cytoskeleton organization in glial cells 

Bojan Sedmak 

National Institute of Biology, Ljubljana, Department of Genetic Toxicology and Cancer Biology, Večna pot 111, 1000 Ljubljana, 

Slovenia, EU 

Three basic ways of interaction are possible after cell exposure to biologically active substances; interaction with membrane 

receptors, membrane insertion and cell entrance. The acute toxicity and cytotoxicity of the best known cyanopeptide microcystin 

(MC) is primarily due to its ability to enter mammalian cells misusing the organic anion-transporting polypeptide system. Strong 

protein phosphatase inhibitory activity is believed to be the mechanism by which MC destroys liver cells and consecutively the target 

organ. In terms of genotoxicity brain cells suffer the most damage implying the possibility of MC passage through the blood brain 

barrier. In addition to MCs bloom forming cyanobacteria produce a variety of other non-hepatotoxic cyclic cyanopeptides similar in 

origin structure and activity in considerable amount. 

Our experiments are focused to normal NHA and tumour derived U87 astrocytes to introduce cyanopeptides as research tools and 

feasible lead substances in pharmacology. We have monitored the influence of cyclic cyanopeptides on both morphological and 

genetic level. The effects on cell morphology were studied by pursuing the changes in intermediate filament (IF) organization. The 

target were two IF’s, glial fibrillary protein expressed in many astrocyte cell lines and nestin expressed by many cell types during 

development and does not persist into adulthood. Epifluorescent and confocal microscopy were used to pursue the morphological 

changes while the expression of genes controlling the intracellular scaffolding’s biogenesis, organization, polymerization and 

depolymerization of MF, MT, IF as well as the cytoskeletal regulatory genes, relevant ARF and RHO G-protein members and their 

regulatory factors was assessed with RT 2 Profiler TM PCR Array. 

Equinatoxin effects on cellular membranes 

1 Miša Mojca Cajnko, 1 Maja Marušič, 2 Biserka Bakrač, 1 Simon Caserman, 1,2 Gregor Anderluh 

1 National Institute of Chemistry, Ljubljana, Slovenia 

2 Department of Biology, Biotechnical Faculty, University of Ljubljana, Slovenia 

Disruption of cellular membranes is a very efficient way to alter cellular function and, hence, pore-forming toxins are one of the most 

important groups of natural toxins. The most studied pore forming toxins are bacterial virulence factors. Actinoporins are efficient 

pore-forming toxins produced by sea anemones. They exclusively form pores in membranes that contain sphingomyelin. They are an 

important example of so-called alpha-helical pore-forming toxins, since the final conductive pathway is formed by amphipatic alphahelices. 

The pore formation is a multistep process that involves recognition of the membrane sphingomyelin, firm binding to the 

membrane accompanied with the transfer of the N-terminal region to the lipid-water interface and final pore formation after 

oligomerization of several monomers. We have recently shown that equinatoxin II (EqtII), the most studied representative of 

actinoporins, specifically binds SM, but not other lipids, and described molecular mechanism of SM recognition. By using EqtII as a 

molecular probe we show that sphingomyelin in the Golgi apparatus is exposed to the cytosol of the cell. Due to its unique features, 

EqtII was also used to study sphingomyelin distribution in the plasma membrane. EqtII binding was accompanied by extensive plasma 

membrane reorganization into microscopic domains that resemble coalesced lipid rafts. Pore formation enabled entry of calcium ions 

in the cell, which was followed in number of responses such as hydrolysis of phosphatidylinositol 4,5-bisphosphate, plasma 

membrane blebbing, actin cytoskeleton reorganization, and inhibition of endocytosis. In Caco2 epithelial cells EqtII was found to 

decrease transepithelial electrical resistance. It seems that plasma membrane reorganisation is, at least in part, a killing strategy of 

actinoporins. 

75

Symp#24 Cancer 

Chair Renata Pasqualini 

Integration of in Vivo Phage Display & Targeted nanotechnology and Molecular-genetic Imaging 

Renata Pasqualini, Ph.D. 


Our group has previously reported the design, generation, and construction of AAV/phage (termed AAVP) particles (Hajitou et al. 

2006, Hajitou et al. 2007, Soghomonyan et al. 2007) for targeted molecular-genetic imaging. These hybrid vectors containing 

prokaryotic and eukaryotic cis-genomic elements have the potential to integrate ligand-directed targeting and molecular-genetic 

imaging. In a related line of research, we have used labeled, targeted peptide motifs themselves as imaging tools (Yao et al. 2005, 

Marchiò et al. 2004, Arap et al. 2004, Zurita et al. 2004, Cardó-Vila et al. 2003, Chen et al. 2003, Mintz et al. 2003). In pilot 

experiments, AAVP-based molecular-genetic imaging appears to be superior in side-by-side comparison to standard imaging because 

it provides prediction of therapeutic response in addition to only monitoring (Hajitou et al., PNAS, 2008). Thus, we plan to focus 

primarily on the development of AAVP-based molecular-genetic imaging approaches. Finally, we have also designed and developed 

nanotechnology-based (i.e., bottom-up self-assembled) biocompatible networks of phage-gold as nano-molecular sensors and 

reporters (Souza et al. 2006a, Souza et al. 2006b). This new methodology will be incorporated and will likely prove to be quite 

synergistic with AAVP (Souza et al. 2011). Here we used prototypes of this new class of targeted hybrid vectors for therapy and for 

molecular-genetic imaging, in conjunction to the discovery of new ligand motifs that target human tumor endothelium. AAVP-based 

anti-vascular cancer therapy by targeted TNF in pet dogs with native tumors has also been successful (Paoloni et al. 2009). Ultimately 

to generate an “imaging transcriptome” for human tumors. The incorporation of transcriptional targeting (through tissue-specific or 

radiation-induced promoters) to ligand-directed AAVP-targeting may enable one to determine a gene (or set of genes) status without 

tissue biopsy. 

Tumor Cell to Tumor Cell Interaction Drives Cancer Heterogeneity 

Webster K. Cavenee 

Ludwig Institute for Cancer Research, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0660 USA 

Most efforts to understand the consequences of large-scale genomic mining of data from human tumors have focused on their cellintrinsic 

activities both in vitro and in vivo. Because of this, targeted therapeutic approaches have primarily been directed at features 

of individual tumor cells and their intrinsic mutations. For example, we have for more than a decade functionally dissected the 

amplification and mutation of the epidermal growth factor receptor gene (EGFR), that results in the common and oncogenic EGFRvIII 

(ΔEGFR) variant, a signature pathogenetic event in glioblastoma, the most common intracranial tumor. These analyses have allowed 

us to develop both small molecule- and antibody-based therapeutics that are now in clinical trials. 

Paradoxically, despite its greater intrinsic biological activity than wildtype EGFR (wtEGFR), only a minority of cancer cells in primary 

tumors possesses the hallmark ΔEGFR lesion, while the remainder expresses wtEGFR. We hypothesized that the ΔEGFR-expressing 

subpopulation has an extrinsic activity that provides enhanced tumorigenicity to the entire tumor cell population, perhaps through a 

paracrine mechanism. Using a combination of mixed tumor engraftments and biochemical analysis of paracrine factors and signaling 

pathways activation, we determined that human glioma tissues, glioma cell lines, glioma stem cells and primary mouse astrocytes, 

that express ΔEGFR each secrete IL-6 and/or LIF cytokines. This then prompts a novel interaction between the receptor that is 

common to these cytokines, gp130, and wtEGFR in neighboring cells that express amplified levels of EGFR, resulting in co-receptor 

activation and tumor growth enhancement. Ablating IL-6, LIF or gp130 uncouples this cellular cross-talk and potently attenuates 

tumor growth enhancement. 

These findings demonstrate that the heterogeneity that characterizes GBM, and perhaps other tumors with this feature, does not 

occur stochastically. Instead, it results from both intrinsic and extrinsic activities of driver mutations and can be an actively 

maintained feature. This illuminates for the first time a heterotypic cancer cell interaction of potential therapeutic significance. 

Targeting Adipose Tissue to Prevent Cancer Progression 

Wadih Arap, M.D., Ph.D. 


Human obesity is a leading cause of morbidity and mortality and a financial burden worldwide. Despite efforts in past decades, very 

few drugs have been developed for the treatment of obese patients. The paradigm of obesity treatment currently relies on CNS 

and/or peripheral metabolic mechanisms to suppress appetite and elevate energy expenditure, or inhibition of fat absorption. Only 

two Food FDA-approved drugs for weight loss are currently available in the United States (phentermine and orlistat); most 

unfortunately, placebo-subtracted weight losses are small and concerns over side effects limit their use, hence the great therapeutic 

challenge. Here we evaluated and validated a new conceptual approach against obesity: targeted induction of apoptosis in blood 

vessels supplying white adipose tissue (WAT). Our group is a pioneer in this area and has previously designed and has recently 

established adipotide as a prototype in a new class of drugs that target the vascular endothelium of white fat in pre-clinical models of 

obese rodents and obese non-human primates. We have chosen to pursue a pilot application of adipotide as a strategy to overcome 

the obesity-related tumor-promoting effects of obesity in the context of human prostate cancer progression and recurrence. 

Notably, we have received “safe-to-proceed status” from the FDA for the IND application of adipotide; as such, the start of the firstin-human 

clinical trial in obese prostate cancer patients is imminent. Our Specific Aims are: (i) To define the metabolic and oncologic 

consequences of targeted treatment with adipotide in obese men with prostate cancer. (ii) To lead optimize adipotide derivatives 

and dose-limiting toxicity in rodents and non-human primates. In the short-term, imaging guided studies will enable the rapid 

translation and drug lead optimization of adipotide and will provide the clinical foundation for approval of an entirely new approach 

against human obesity. In the long-term, a successful innovative therapy such as adipotide against human obesity would truly be 

transformative with immense public health impact against not only obesity but also against associated patient co-morbidities 

including diabetes, metabolic syndrome, arterial hypertension, atherosclerosis, and cancer. 

76

Symp#25 Cell motility 

Chair James Sellers 

A Tale of Two Tails: The Regulation of Myosin-5a and Myosin-7a 

James R. Sellers 

National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 USA 

Myosins are a superfamily of molecular motors that can be subdivided into more than 35 classes. Myosins have 

undergone structural and functional adaptations to perform many duties inside cells and in many cases the activity of 

the myosin is tightly regulated. In this talk I will discuss the structure, function and regulation of two myosins, mouse 

myosin-5a and Drosophila myosin-7a. Myosin-5a is a processive cargo transporter in cells which helps move organelles 

from one point to another, whereas myosin-7a appears to be active in areas of very high actin density such as 

stereocelia and other actin bundles. In humans, mutations in myosin-7a lead to deafness and blindness. The enzymatic 

activities of both of these myosins are regulated in vitro through head-tail interactions, but the molecular details of 

these interactions are very different. Myosin-5a is a dimeric motor and the presence of both heads is important to the 

regulation, whereas myosin-7a is monomeric. Each myosin has at least one binding partner that is sufficient to activate 

the myosin from its off state. For myosin-5a this binding partner is termed melanophilin which also interacts with 

Rab27a to form a tripartite complex that connects the melanosome to actin filaments. We discovered a novel protein 

in Drosophila that interacts with myosin-7a to activate its activity. The details of the regulation of these two myosins 

will be discussed. 

Single Molecule Fluorescence and Optical Trapping Applied to Molecular Motors: Two can do it better than one. 

Paul Selvin 

Mindy Tonks Hoffman, Ben H. Blehm, Paul R. Selvin, University of Illinois, Urbana-Champaign 

Kinesin and dynein are molecular motors that move in opposite directions on a microtubule. They often act on the 

same cargo, causing the cargo to frequently switch direction. Whether this back-and-forth motion results from a 

coordinating complex or from a tug-of-war between the two motors is currently unknown. We have applied single 

molecule fluorescence to determine that they are undergoing a synergistic tug-of-war. By synergistic, we mean that 

the combination of the two motors is able to bypass roadblocks along the microtubule. Furthermore, using an in vivo 

optical trap, and by comparing directional stall forces in vivo and in vitro, we found when cargo is going in the positive 

microtubule direction, kinesin and dynein are pulling, with the dynein walking backwards. The net stall force equals 

the stall force of kinesin (≈ 7 pN) minus the stall forces of the number of dyneins (1.1 pN x ND, where ND, = 0 to 6). 

When moving in the negative microtubule direction, the stall force is just equal to a multiple of dynein’s stall force (1.1 

pN x ND), implying that kinesin has fallen off the microtubule. 

Microfluidics pushes forward microscopy analysis of actin dynamics 

Marie-France Carlier 1 , Antoine Jégou 1 , Guillaume Romet-Lemonne 1 , Thomas Niedermayer 2 and Reinhard Lipowsky 2 

1 Cytoskeleton Dynamics and Motility group, CNRS UPR 3280, 91198 Gif-sur-Yvette France 

2 Theory and Biosystems, Max Planck Institute of Colloids and Interfaces, Potsdam Germany 

Cycles of site-directed actin polymerization and depolymerization, associated with ATP hydolysis, drive a large number 

of motile processes in eukaryotic cells. The study of actin dynamics and its control by regulatory proteins has mainly 

relied, for 30 years, on bulk solution kinetic measurements in which the behavior of many filaments is averaged. 

Recently, individual filament dynamics have been approached using Total Internal Reflection Fluorescence (TIRF) 

microscopy. The latter method uniquely allows analysis of fluctuations in length of filaments or their processive 

assembly by formins, but suffers from artifacts resulting from the need to immobilize filaments on a coverslip, the lack 

of spatial and temporal resolution and tedious image analysis. To overcome these problems, we have implemented 

microfluidics in the TIRF method. Two issues have been addressed at the scale of single filaments. First, by switching 

rapidly filaments from polymerizing to depolymerizing conditions, analysis of nucleotide dependent disassembly rate 

demonstrates that the slow release of Pi following rapid cleavage of ATP on a single filament assembling from ATP-Gactin 

occurs via a random mechanism. Second, we show that the reported abrupt switches to very slow filament 

depolymerization, attributed to the structural stabilization of filaments upon ageing (Kue and Mitchison, PNAS 2008, 

Science 2009) are actual pauses in depolymerization, caused by stochastic formation of photo-induced, 

immunodetectable covalent actin dimers within the filaments. Statistic analysis of the frequency of pauses shows that 

pauses represent the slow dissociation of actin dimers. Further developments of microfluidics in the study of actin 

dynamics will be discussed. 

77

Symp#26 RNA regulation - Canadian Society for Cell Biology 

Chairs and speakers Jean Pierre Perrault and Carla Columbano 

Impact of G-quadruplex structures on the human transcriptome 

Jean-Pierre Perreault and Jean-Denis Beaudoin 

Groupe ARN/RNA group, Département de biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 

Sherbrooke, QC, J1H 5N4, Canada (Jean-Pierre.Perreault@USherbrooke.ca) 

Given that greater than 90% of the human genome is expressed, it is logical to assume that post-transcriptional regulatory 

mechanisms must be the primary means of controlling the flow of information from mRNA to protein. Guanine-rich nucleic acid 

sequences can fold into non-canonical, four stranded helical structures called G-quadruplexes. Initially, we have developped a robust 

approach that includes in silico, in vitro and in cellulo experiments permitting an in-depth evaluation of the global impact of Gquadruplexes 

as translational repressors. Briefly, sequences including potential G-quadruplexes were selected within 9 distinct genes 

encoding proteins involved in various biological processes. Six of these sequences were observed to fold into G-quadruplex structures 

in vitro, all of which exhibited translational inhibition in cellulo when linked to a reporter gene. In addition, the impact of single 

nucleotide polymorphism was shown to be important in the formation of G-quadruplexes located within the 5’-untranslated region of 

an mRNA. Subsequently, the same approach was applied in order to study to evaluate the presence of G-quadruplex structures within 

human 3'-UTRs. Specifically, two potential G-quadruplex sequences located in the 3'-UTR of the low density lipoprotein receptorrelated 

protein 5 (LRP5) gene and the fragile X mental retardation autosomal homolog 1 (FXR1) gene were chaarcterized. Both of 

these G-quadruplex structures increases by 2-fold the gene expression of a reporter gene by stimulating the polyadenylation of its 

mRNA throughout an alternative site located downstream of the canonical site of their corresponding 3'-UTR. Sequence analysis, site 

directed mutagenesis, miRNA regulation network analysis and G-quadruplex ligand experiments were performed to define rules 

governing this phenomenon. In light of these results, we suggest that 3'-UTR G-quadruplexes can regulate alternative polyadenylation 

sites, leading to the expression of shorter transcripts, and can interfer with the miRNA regulatory network of a specific mRNA. In light 

of these results, the G-quadruplexes represent a class of RNA motif that is broadly distributed in the cellular transcriptome and have 

important impact on mRNA species. 

Identification of proteins regulating the RNA exosome 

Carla Columbano Oliveira 

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo 

In eukaryotes, many posttranscriptional processing events are necessary for the synthesis of mature RNAs. mRNAs, tRNAs, rRNAs, 

snRNAs and snoRNAs are processed through several steps that involve specific reactions between RNA and proteins. In fact, most 

cellular RNAs are associated with proteins, forming ribonucleoprotein complexes (RNPs), which participate in different aspects of 

gene expression. 

The main focus of our laboratory has been the study of the posttranscriptional control of gene expression through the functional and 

structural characterization of proteins that regulate processing of different types of RNA. We will show the identification and 

functional characterization of Saccharomyces cerevisiae proteins that interact with and regulate the RNA exosome, a protein complex 

involved in processing and degradation of all types of RNA. Nop53p and Nop8p are nucleolar proteins involved in the maturation of 

the large ribosomal subunit and regulate the RNA exosome during this process in different ways. While Nop53p activates the 

exosome, Nop8p inhibits it. These observations led to the hypothesis that the interactions between different proteins and the 

exosome are responsible for directing the complex to its substrates, and for controlling its activity. 

Inhibition of RNA Polymerase I as a Strategy to Treat Cancer 

Megan J. Bywater 1 , Katherine M. Hannan 1 , Gretchen Poortinga 1 , Joanna C. Chan 1 , Elaine Sanij 1 , Nadine Hein 1 , Carleen Cullinane 1 , 

Denis Drygin 2 , William G. Rice 2 , Ricky W. Johnstone 1,3 , Grant A. McArthur 1,3 , Ross D. Hannan 1,3 and Richard B. Pearson 1,3 . 

1 Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic, Australia; 2 Cylene 

Pharmaceuticals Inc., 5820 Nancy Ridge Drive, San Diego, CA 92121, USA; 3 Sir Peter MacCallum Department of Oncology, University 

of Melbourne, Melbourne Australia. 

Morphologic abnormalities of the nucleolus, the site of transcription of the ribosomal genes (rDNA) by RNA Polymerase I (Pol I), have 

been recognized as diagnostic for cancer for more then a century. Furthermore, accelerated ribosome biogenesis is invariably 

associated with malignant transformation. Nevertheless, a critical, unresolved question has been whether the accelerated ribosome 

biogenesis responsible for the nucleolar changes is required for maintenance of the malignant phenotype. 

Here we show that the PI3K/AKT pathway, deregulated in a high proportion of human tumours, is a critical regulator of ribosome 

biogenesis. Constitutively active AKT is sufficient to drive rRNA synthesis, ribosome biogenesis and cell growth. Furthermore, AKT 

cooperates with c-MYC to activate rRNA synthesis and ribosome biogenesis identifying the AKT/mTORC1/MYC network as a master 

controller of cell growth. Consistent with this concept, AKT activity is required for maximal activation of rRNA synthesis and tumour 

formation in the E�-Myc mouse model of Burkitt’s lymphoma (1). Our findings raise the exciting possibility that malignant diseases 

characterized by unrestrained cellular growth may be vulnerable to therapeutic strategies that target ribosome biogenesis. 

To directly test this hypothesis, we used genetic manipulation and a novel selective small molecule inhibitor of Pol I transcription (CX- 

5461) (2), to provide the first definitive evidence that accelerated rDNA transcription and nucleolar integrity are necessary for 

oncogenic activity in hematologic tumour cells. Further, we show that Pol I transcription can be targeted in vivo to therapeutically 

treat tumors in both genetically engineered and xenograft models of lymphoma and leukemia through the non-genotoxic activation 

of p53-dependent apoptosis, while sparing normal cells of hematological lineages. Thus, selective inhibition of Pol I transcription, a so 

called ‘”house keeping” process, can serve as a novel therapeutic strategy for the treatment of cancer (3). 

(1) Chan J.C, et al (2011) Science Signaling 4 (188), ra56, (2) Drygin, D et al., (2011) Cancer Res, 71(4):1418-3 

(3) Bywater, M.J. et al (2012) Cancer Cell (accepted for publication) 

78

Symp#27 Maternal interface 

Chair Estela Bevilacqua 

Felipe Vadillo-Ortega 

Universidad Nacional de Mexico (UNAM), Mexico 

The placenta as an early marker of genomic, proteomic and epigenetic changes involved in vascular diseases 

Paola Casanello, Krause B, Caniuguir A, Muñoz E, Carrasco I. 

Faculty of Medicine Pontificia Universidad Católica de Chile 

Fetal programming resulting from disturbed intrauterine growth induces permanent physiological alterations that 

increase the risk of developing cardiometabolic diseases in the adulthood. Most of the support for this notion has 

come from animal models, and correlations between neonatal data and adult health in humans. Interestingly, human 

placenta seems to represent a good source for the study of this process. There is convincing data showing that 

macroscopic placental characteristics as well as molecular and epigenetic markers in the placenta at term predict adult 

cardiometabolic risk. We have studied the effect of hypoxia on vascular function and endothelial physiology in 

placentae from intrauterine growth restriction (IUGR) fetuses. These studies have shown that endothelial cells from 

IUGR placentae (IUGR-EC) present altered expression patterns at transcriptional and proteomic levels, similar to those 

observed in normal EC exposed to hypoxia, confirmed the idea that endothelial dysfunction can be programmed in 

utero In fact, IUGR-EC present altered expression of eNOS, CAT-1 and arginase-2, which correlate with altered NOSdependent 

vascular relaxation. Moreover, the altered expression of eNOS in IUGR-EC is associated to specific changes 

in the DNA methylation status at NOS3 promoter. Interestingly, eNOS expression in IUGR-EC can be reprogrammed 

preventing the heritance of DNA-methylation patterns by transient silencing of DNMT1. All these data highlight the 

applicability of placental studies in order to predict future health risk in humans, however further efforts are necessary 

to validate the implications of these seminal findings and how these could represent the vascular alterations that take 

place in the fetus. 

Supported by FONDECYT-1120928, CONICYT Anillos ACT-73, AT24100107(Chile). EM & BK hold CONICYT PhD grants. 

Expression and function of PSG, StarD7 and KLF6 genes in human trophoblast cells 

Graciela M Panzetta-Dutari., Racca AC., Camolotto S., Ridano ME., Flores-Martin J., Rena V. & Genti-Raimondi S. 

CIBICI-CONICET. Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas. Universidad Nacional de 

Córdoba. Ciudad Universitaria. Córdoba. Argentina. 

Placenta is intimately related to fetal and maternal health. Villous cytrophoblasts (CTB) differentiate by fusion to form 

the syncytiotrophoblast (STB) layer characterized by a high metabolic and biosynthetic activity. Human pregnancyspecific 

glycoproteins (PSG) are the major STB secreted proteins at term, and low PSG levels have been associated with 

complicated pregnancies. Steroidogenic acute regulatory protein-related lipid transfer domain containing 7 (StarD7) 

has a wide-spread expression in trophoblastic tissues with highest levels in choriocarcinoma cells, and KLF6 knockout 

mice exhibit impaired placental development. In order to further elucidate gene expression control and function of 

these proteins in placental biology, we performed microscopy, qRT-PCR, western-blot, transfection, siRNA, DNAprotein 

interaction and immunoprecipitation assays, among others, in human trofoblastic cell models. We found that 

PSGs are early differentiation markers whose expression precedes that of �hCG and cell fusion. PSG promoter 

activation involves regulation by Sp1, KLF6, acetylation/ deacetylation balance and 5`proximal sequences. Remarkably, 

KLF6 peaks early during the syncytialization process, transactivates PSG and �hCG genes, and KLF6 down-regulation 

inhibits CTB fusion, suggesting it is an essential regulator of trophoblast differentiation. StarD7 expression is regulated 

by SF-1 and Wnt-�-catenin signaling which might have important implications in phospholipid uptake and transport 

contributing to trophoblast development. Finally, as an increased risk of pregnancy alterations has been reported in 

women chronically exposed to pesticides, we investigated chlorpyrifos effect on trophoblast cells. Exposures to 

concentrations which did not alter cell viability and fusion modified KLF6, �hCG, GCM1, ABCG2, and P-gp but not PSG 

and StarD7 gene expression. These studies have provided a better understanding about the molecular players involved 

in trophoblast cell biology and hence in pregnancy maintenance. This study was conducted with the ethics approval 

from the Human Studies Local Committee. It was supported by CONICET, FONCyT, MinCyT of Córdoba and SECyT-UNC 

Listing of authors Panzetta-Dutari GM., gpan@fcq.unc.ed.ar; Racca AC., aracca@fcq.unc.ed.ar; Camolotto S., 

scamolotto@fcq.unc.ed.ar; Ridano ME., mridano@fcq.unc.ed.ar; Flores-Martin J., jflores@fcq.unc.ed.ar; Rena V., 

vrena@fcq.unc.ed.ar; Genti-Raimondi S., sgenti@fcq.unc.ed.ar 

Haya de la Torre y Medina Allende. Ciudad Universitaria. X5000HUA Córdoba, Argentina, 

79

Symp #28 Cells as biosensors 

Chairs Glaucia M Machado Santelli and Paulo Saldiva 

Cytotoxic indole alkaloids isolated from Duroia macrophylla (Rubiaceae). 

Cecilia Veronica Nunez 1 *, Marne Carvalho de Vasconcellos 2 , Vincent Roumy 3 , Sevser Sahpaz 3 , François Bailleul 3 , Thierry Hennebelle 3 . 

1 

Laboratório de Bioprospecção e Biotecnologia, Coordenação de Tecnologia e Inovação, Instituto Nacional de Pesquisas da Amazônia, 

Aleixo, Manaus, Amazonas, 69060-001, Brazil; 

2 

Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas – UFAM, Rua Alexandre Amorim, 330, Aparecida, Manaus, 

Amazonas, 69010-330, Brazil; 

3 

Laboratoire de Pharmacognosie, EA 4481, Université de Lille 2 – Droit e Santé, 59006, Lille, France. 

Duroia macrophylla Huber is a native plant species of the Amazon region. It is known as cabeça-de-urubú, apuruí or puruí-grande-damata 

but no medicinal use is described for it. In our research group bioprospection programm, we collected several Rubiaceae plant 

species, prepare organic and aqueous extracts and assayed to several activities. D. macrophylla extracts were first assayed against 

Artemia salina, to determine their toxicity. The methanolic leaf extracts was toxic against A. salina, with a LD50 of 40.00 µg/mL. Then, 

the methanolic leaf extract was fractionated and 4 alkaloids were isolated: two new roxburguine indole alkaloids plus two other 

known ones. All isolated substances were essayed on tumor cell lines and the new alkaloid 4 showed a cytotoxic activity against HL60 

(human leukemia), APC02 (human gastric adenocarcinoma) and B16F10 (murine melanoma) tumor cell lines (IC50 values of 2.28 

µg/mL, 5.08 µg/mL and 5.11 µg/mL, respectively) and a cytotoxicity of 7.8 µg/mL on normal cell line NHI3T3 (fibroblast murine). The 

alkaloids assayed did not cause membrane disruption in mouse erythrocytes. This is the first chemical study on this species. Our 

findings showed that Amazonian plant species can contain new active substances, even if they do not have popular use. 

Acknowledgments: CT-Agro/CNPq, PPBio/CNPq, FAPEAM, INCT - CENBAM/CNPq. 

Cell-fiber interactions: effects on cell biology 

Glaucia Maria Machado-Santelli 

(glaucia.usp@gmail.com) Department of Cell and Developmental Biology Institute of Biomedical Sciences - University of São Paulo, 

Brazil 

Particle toxicology main subject is to understand their cytotoxic and genotoxic mechanisms. Initial studies focused on the evaluation 

of particles parameters after inhalation such as the diameter, length and biopersistence led to the association of asbestos exposure 

with several health problems including lung cancer and mesothelioma. The low biopersistence of chrysotile, causing it to disintegrate 

and become shorter in the lungs, is the main structural features that lead the chrysotile being less pathogenic than the amphiboles. 

This safety has been controversial since in vitro chrysotile-associated genotoxic potential has been demonstrated. We evaluated the 

induction of micronucleated, poliploid and multinucleated cells in chrysotile exposed cultured cells. These in vitro studies show that 

fibers interfere with mitoses and cytokinesis progression leading to multinucleated and polyploid cells. Cell cycle progression is 

impaired by fibers and multipolar mitosis may be consequence of fiber induced centrosomic amplification. The cell fate was followed 

by pulse-time microscopy, allowing us to establish how the chrysotile treatment acts on cell cycle progression and its possible 

relation with other types of fibers. 

Cellular responses to ambient levels of air pollution 

Paulo Saldiva 

(pepino@usp.br) Department of Pathology Faculty of Medicine – University of São Paulo, Brazil 

The widespread use of fossil fuels has been associated to marked alterations in our environmental. Global climate changes and local 

air pollutants are known to cause adverse health effects in humans. The use of cells as biosensors of adverse effects have provided 

valuable information for the process of evaluating environmental risk associated to air pollution. Respiratory epithelium, 

endothelium, placental trophoblast, cells of seminiferous tubules, endometrium, and cells of reproductive organs of higher plants 

have been extensively used to detect, quantify and explore the mechanisms of pollution induced injury, disclosing new perspectives 

to the process of pollution control, aimed to preserve human health. Effects of air contaminants such as endocrine disruption, 

cardiovascular damage, cancer induction and promotion and persistent inflammation, have been characterized using cellular systems 

or in vivo toxicological approaches. In this context, biomonitoring of air pollution is nowadays as important as the classical chemical 

characterization of the concentration of environmental toxics, opening new areas of research in cell biology. 

80

Symp#29 MMPs and TIMPs 

Chairs Ruy Jaeger 

Membrane Type I- Matrix Metalloproteinase (MMP14): A Multifaceted Cell Surface Protease in Cancer 

Stanley Zucker 

Stony Brook University, USA 

MMP14, an intrinsic plasma membrane proteinase, plays a critical role in digesting basement membrane and 

extracellular matrices and in inducing cancer cell migration, thereby promoting cancer invasion and metastasis. We 

and others have demonstrated that MMP14 is highly expressed in most human cancers and correlates with poor 

clinical outcome. We have evaluated the role of MMP14 in converting quiescent tumor initiating cells (TICs) to 

metastatic cancer cells. Our studies of the hemopexin (PEX) domain of MMP14 have shown that of the 4 outermost 

blades, strands I and IV are essential fo cell migration. Peptides mimicking these outermost strands reduced cancer 

cell migration and angiogenesis in vitro and lung metastasis in vivo. We next examined the effect of cellular hypoxia on 

MMP14 function in TICs. SK-3rd TICs, isolated by passage of human breast cancer cells in immunodeficient mice, 

display enhanced lung metastases. Surprisingly, under normoxic conditions, SK-3rd cells displayed minimal increase in 

cancer invasion. However, when cultured under hypoxic conditions, a dramatic increase in cell invasiveness in 3D 

collagen gels was demonstrated, which coincided with increased localization of MMP14 at the cell surface. These data 

suggest that induction of TIC invasion during hypoxia is caused by enhanced trafficking of MMP14 from the trans Golgi 

network to the plasma membrane. MMP14 also induces the generation of reactive oxygen species in cancer cells, 

leading to enhanced cancer aggressiveness. Our most recent studies incriminated tumor growth factor-beta as a key 

intermediary in MMP14 cell signaling in cancer progression. 

Rama Khokha 

University Western Ontario, Toronto, Canada 

Role of matrix metalloproteinases and inflammasome pathway in the development of airway inflammation and 

fibrosis 

Vincent Lagente 

UMR991 INSERM/Université de Rennes 1, Faculté de Pharmacie, 

2 avenue du Prof Léon Bernard, 35043 Rennes cedex, France 

Matrix metalloproteinases (MMPs) are a major group of proteases known to regulate the turn-over of extracellular 

matrix and so they are suggested to be important in the process of lung disease associated with tissue remodelling. 

Pulmonary fibrosis has an aggressive course and is usually fatal for an average of three to six years after the onset of 

symptoms. Pulmonary fibrosis is associated with deposition of extracellular matrix (ECM) components mainly collagen 

in the lung interstitium. The excessive airway remodeling as a result of an imbalance in the equilibrium of the normal 

processes of synthesis and degradation of extracellular matrix components could be in favor of anti-protease 

treatments. We previously demonstrated a significant inhibition of bleomycin-induced pulmonary fibrosis in mice by 

the MMP inhibitor batimastat. We also reported a correlation of the differences in collagen deposition in the lungs of 

bleomycin-treated mice with a reduced molar pro-MMP-9/TIMP-1 ratio in broncholaveolar lavage fluid, beginning as 

early as the inflammatory events at day 1 after bleomycin administration. The differences in TIMP-1 level, particularly 

at early events after bleomycin administration, suggest that early altered regulation of matrix turnover may be 

involved in the further development of bleomycin-induced pulmonary fibrosis. We also demonstrated that 

Inflammasome-NLRP3 pathway associated with the IL-1R/MyD88 signaling is required in the bleomycin-induced 

increased TIMP-1 level and pulmonary fibrosis in mice. Finally, these observations emphasize those effective therapies 

for these disorders must be given early in the natural history of the disease, prior to the development of tissue 

remodeling and fibrosis. 

81

Symp #30 Telomeres 

Chair Maria Isabel Cano 

Saccharomyces cerevisiae as a model for the study of telomere-mediated replicative senescence 

Maria Teresa Teixeira 

Emilie Fallet, Pascale Jolivet, Julien Soudet, Zhou Xu, Kamar Serhal and Maria Teresa Teixeira 

Institut de Biologie Physico-Chimique, FRE3354 CNRS/UPMC Biologie Moléculaire et Cellulaire des Eucaryotes - 13 rue 

Pierre et Marie Curie, 75005 Paris, France ; ERC-STG-2010 D-END 

In the absence of telomere length maintenance, telomeres shorten progressively with every replication cycle due to 

the DNA-end replication problem. This leads to a permanent cell cycle arrest called replicative senescence. In humans, 

this process is involved in the aging of certain organs and in suppression of cancer. Telomeres can be re-elongated by 

telomerase or more rarely by homologous recombination (HR) in cells that proliferate indefinitely such as unicellular 

eukaryotes, stem cells and cancer cells of multicellular eukaryotes. In telomerase-deficient yeast cells, replicative 

senescence is defined as an arrest in G2/M after 60-80 generations as telomeres shorten 2-4 nt/cell division. Our 

analysis of the DNA-end replication problem formally demonstrate that telomere shortening occurs during the 

synthesis of the leading strand and depends on the length of the 3’-protruding end of chromosomes. Together with 

the study of factors that regulate the resection and the synthesis of the 5’ strand, our data support a precise molecular 

model of the DNA replication of telomeres. Senescence in yeast depends on the DNA damage checkpoints, similar to 

other eukaryotes. A mathematical modeling of the distribution of telomere length and analysis of meiotic products 

suggests that the shortest telomere in a cell may have a determinant role in the onset of senescence. Accordingly, the 

DNA damage checkpoints recognize a very short telomere in senescent cells, triggering a replication fork regression 

and sister chromatid HR. We propose that these pathways counteract the telomere shortening rate allowing a few 

additional cell divisions before definitive arrest 

Telomere dysfunction in human disease 

Rodrigo Calado 

University of São Paulo, Ribeirão Preto, Brazil 

Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects 

in them result in various diseases. Severe deficiencies result in dyskeratosis congenita, a congenital aplastic anemia 

with associated mucocutaneous abnormalities. Mutations in TERT, the catalytic component, and TERC, the RNA 

template, can behave as risk factors for the development of bone marrow failure, pulmonary fibrosis, and hepatic 

cirrhosis. Both penetrance and organ specificity are variable and not well understood. Chromosome instability is a 

result of critical shortening of telomeres and cancer. 

Searching for a CST-like complex at Leishmania spp. telomeres 

Maria Isabel Cano 

Instituto de Biociências, Depto. de Genética, UNESP-Botucatu, São Paulo-Brazil, 18618-970, micano@ibb.unesp.br 

In most eukaryotes telomere binding proteins play crucial roles by interacting with several other regulators to ensure 

proper telomere maintenance and to form high order complexes. The CST complex, mainly formed by RPA-like 

proteins, is being considered a second telomere capping mode occurring from budding yeast to higher eukaryotes. 

The role of CST in chromosome-end protection couples the conventional replication machinery and telomere 

functions and highlights the complexity of the end- protection process. Leishmania spp. telomeres are composed by 

TTAGGG repeats which are maintained by telomerase. The basic Leishmania telomeric complex is formed by the 

proteins RPA-1 and Rbp38, which bind in vitro and in vivo, with high affinity to the G-rich telomeric strand, and by the 

TRF orthologue representing a shelterin component of this protozoan. Using a large scale search on the tri-tryps 

database we were able to confirm that the Leishmania spp. genome, like other trypanosomatids, lacks all of the 

conserved telomere-end-binding proteins found in other eukaryotes, such as the key components of the CST (e.g. 

CDC13 and CTC) and the shelterin (POT1) complexes. Thus, we speculate that the Leishmania RPA-1 homologue may 

play the same roles as POT1/CDC13 at parasite telomeres. In this report we used different approaches to show that 

RPA-1 interacts with both Rbp38 and with telomerase. And also that the putative Leishmania CST-like complex meets 

the TRF orthologue by physical interactions between Rbp38 and TRF. We speculate whether these protein interactions 

reflect the entire telomeric complex or the presence of functionally distinct subcomplexes at parasite telomeres. 

Supported by: FAPESP, CNPq 

82

Symp#31 Cancer Stemness -Taiwan Cell Biology Society 

Chair Ken Wu 

Tariq Enver 

Stem Cell Laboratory, UCL Cancer Institute, University College London, London, UK 

Relapses after therapy-induced complete clinical remissions remain the most significant challenge in cancer therapy. This suggests 

that a proportion of cancer cells at presentation, escape therapy and persist during remission. These cells presumably are the source 

of relapse. Why are these cells chemoresistant? We argue that the answer lies in a combination of genetic and epigenetic 

heterogeneity acting to some degree at the level of 'cancer stem' or 'tumour propagating' cells. We have obtained evidence in 

support of this conceptual framework for cancer resistance in the context or childhood ALL, the commonest cancer of children. Our 

results encourage a re-positioning of the cancer stem cell concept as it relates to disease in patients. 

SOX2 promotes lung cancer stemness by inducing EGFR and BCL2L1 expression 

Cheng-Wen Wu 

Institute of Biomedical Sciences, Academia Sinica; and Program in Molecular Medicine, National Yang-Ming University, Taipei, 

Taiwan, ROC. 

Tumor cells have long been observed to share several biological characteristics with normal stem/progenitor cells; however, the 

molecular mechanisms eliciting cancer stemness features in tumors remain elusive. SOX2 is a key regulator for maintaining stemness 

properties in lung progenitor cells. Here we report the discovery and involvement of SOX2 in the development of lung cancer 

stemness. SOX2 expression was associated with poor prognosis of lung cancer patients. SOX2 was expressed in a subclass of lung 

cancer cells, the self-renewal and proliferation of which was dependent on SOX2 signaling. SOX2 induced EGFR expression via binding 

to the EGFR promoter, and EGFR activation further upregulated SOX2 levels, forming a positive feedback loop. SOX2 overexpression 

promoted chemoresistance, and SOX2 silencing perturbed mitochondrial integrity with marked apoptosis and autophagy. SOX2 

induced BCL2L1 expression through binding its promoter. Ectopic BCL2L1 expression rescued SOX2 silencing–induced apoptosis, 

autophagy, and mitochondrial abnormality. SOX2 overexpression induced tumor formation, and SOX2 knockdown attenuated tumor 

growth in a xenograft mouse model. SOX2, EGFR and BCL2L1 expression was significantly correlated in primary lung tumors. These 

data support the critical role of SOX2 in the development of lung cancer stemness via activation of EGFR and BCL2L1 signaling. 

TBA 

83

Symp#32 Unconventional organelles 

Chair Marlene Benchimol 

Reductive evolution and the minimal mitochondria of microsporidian parasites 

Martin Embley 

Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, UK NE24HH 

Microsporidians are important human pathogens causing chronic diarrhoea in children and the elderly, and infecting 

immunocompromised patients, including those with HIV/AIDS. In addition to their medical importance, microsporidians have 

become models for understanding cellular and genomic reduction in eukaryotes. The adoption of an obligate intracellular lifestyle 

has allowed them to lose metabolic pathways and to simplify the structures and functions of cellular organelles. In my talk I will 

discuss how such reductive evolution has affected the proteome and functions of their minimal mitochondria – now widely referred 

to as mitosomes, and why, despite their reduced nature mitosomes are still essential for parasite viability. 

An unconventional organelle: the hydrogenosome 


Universidade Santa Úrsula, Laboratório de Ultraestrutura Celular - Rio de Janeiro - Brazil 

Hydrogenosomes are spherical or slightly elongated organelles found in non-mitochondrial organisms. Like mitochondria 

hydrogenosomes: (1) are surrounded by two closely apposed membranes and present a granular matrix: (2) divide in three different 

ways: segmentation, partition and the heart form; (3) they may divide at any phase of the cell cycle; (4) produce ATP; (5) participate 

in the metabolism of pyruvate formed during glycolysis; (6) present a relationship with the endoplasmic reticulum; (7) incorporate 

calcium; (8) import proteins post-translationally; (9) present cardiolipin. However, there are differences, such as: (1) absence of 

genetic material, at least in trichomonas; (2) lack a respiratory chain and cytochromes; (3) absence of the F0- F1 ATPase; (4) absence of 

the tricarboxylic acid cycle; (5) lack of oxidative phosphorylation; (6) presence of peripheral vesicles. Hydrogenosomes are considered 

an excellent drug target since their metabolic pathway is distinct from those found in mitochondria and thus medicines directed to 

these organelles will probably not affect the host-cell. The main drug used against trichomonads is metronidazole, although other 

drugs such as β-Lapachone, colchicine, Taxol, nocodazole, griseofulvin, cytochalasins, hydroxyurea, among others, have been used in 

trichomonad studies, showing: (1) flagella internalization forming pseudocyst; (2) dysfunctional hydrogenosomes; (3) 

hydrogenosomes with abnormal sizes and shapes and with an electron dense deposit called nucleoid; (4) intense autophagy in which 

hydrogenosomes are removed and further digested in lysosomes. 

Dynamic control of the contractile vacuole complex and acidocalcisomes and their functional role in the mechanisms of regulatory 

volume decrease in Trypanosomatid parasites 

Kildare Miranda 1 

Wendell Girard-Dias 1 , Wanderley de Souza 1 and Roberto Docampo 2 , 1 Biophysics Institute, Federal University of Rio de Janeiro, 2 

University of Georgia 

Understanding mechanisms involved in osmoregulation control in protozoan parasites has been a challenge for many research 

groups. Among these mechanisms, a cyclic AMP (cAMP) signaling pathway has been shown to play a key role in osmoregulation, 

through a mechanism that involves the activation of an unusual organelle named the contractile vacuole complex (CVC). In 

Trypanosoma cruzi, the CVC is formed by a central vacuole surrounded by interconnected tubules that undergo dynamic changes 

upon osmotic stress and interacts with acidocalcisomes, whose structural organization, chemical properties and physiological activity 

may also vary upon events of osmotic stress. Biochemical and molecular data have shown that the sequence of events that take 

place in cells submitted to hyposmotic stress leads to an increase in cAMP levels, stimulating the traffic of an aquaporin from 

acidocalcisomes to the CVC through a fusion mechanism. Acidocalcisomes contain basic amino acids and high levels of cations and 

polyphosphate, a content that once released within the contractile vacuole, leads to an increase in the osmotic pressure towards the 

lumen of the organelle, stimulating water transport into the CVC. Functional analysis of mutant parasites that overexpress enzymes 

involved in the control of cAMP levels showed alterations in the regulatory volume decrease (RVD), a large and functional CVC and 

were more efficient in volume recovery. Taken together, our data show dynamic changes in the osmoregulatory system of T. cruzi, 

governed by signaling events that involve a unique mechanism of interaction of the CVC with acidocalcisomal components. 

Cell biology of magnetotactic bacteria and their organelles: the magnetosomes 

Ulysses Lins 

Instituto de Microbiologia, UFRJ, Centro de Ciências da Saúde, Bloco I, Avenida Carlos Chagas Filho, 373 - 21941-902, Rio de Janeiro, 

RJ, Brasil 

Historically prokaryotes have been described as simple cells with organization principles distantly related to the more complex 

eukaryotic cells. Recent advances in understanding the cell biology and molecular mechanisms underlying the ultrastructural 

organization of bacterial cells have modified the traditional views used to distinguish eukaryotic from prokaryotic cells. The 

complexity of prokaryotic cells and their similarities to eukaryotes is highlighted by the discovery of cytoskeleton elements in bacteria 

and further by the description of membranous organelles with specialized functions in a number of prokaryotic species. One of these 

organelles, the magnetosome, consists of a nanometer-sized magnetic crystal which is formed in the bacterial cell cytoplasm inside a 

bilayer lipid vesicle containing a unique set of proteins. The magnetosomes are organized as chains within the cell and are 

surrounded by a distinct cytoskeletal network of filaments. Bacteria that produce magnetosomes are called magnetotactic bacteria 

because of their ability to orientate and navigate along magnetic field lines which is a consequence of the magnetic moment 

generated by the chains of magnetosomes. The specific proteins expressed by the cell in the magnetosome membrane modulate the 

biomineralization of the magnetic crystals within the magnetosome vesicle. Consequently, the controlled biomineralization process 

that takes place in magnetosomes produce magnetic crystals with unique morphologies that is dependent on the magnetotactic 

bacterial species. 

84

Poster Sessions 

July 26th (Thursday) Board ID Floor 

Cell Biology A1-A122 1 

Cell Biology and Inflammation C1-C118 1 

Cell Biology in Education E1-E12 2 

Cell Cycle and Proliferation F-1-F27 2 

Cell Differentiation H1-H19 1 

Cell Therapy K1-K16 2 

Cells as Biosensors L1-L7 2 

Cytoskeleton M1-M13 2 

Developmental Biology N1-N51 2 

Epigenetics O1-O18 2 

Gene Therapy Q1-Q5 2 

Host Parasite Interaction R1-R75 2 

Methods in Cell Biology S1-S30 1 

Plant Cell Biology U1-U41 2 

Plasma Membrane and Organelles V1-V10 1 

Proteolysis X1-X10 2 

Stem Cells Z1-Z42 2 

July 27th (Friday) Board ID Floor 

Cell Biology and Cancer B1-B252 1 

Cell Biology and Reproduction D1-D140 2 

Cell Death G1-G39 2 

Cell Migration I1-I13 2 

Cell Signaling J1-J48 1 

Extracellular Matrix P1-P37 2 

Neurobiology T1-T85 2 

85

Presentation guidelines 

Poster Sessions will be held at 1 st and 2 nd floors (Room 203) and will be organized according 

to the different areas. Please check your Board ID above. 

Poster Session I: Thursday, July 26 th 

Set up: Wednesday 15h00- 17h00 and Thursday 9h00- 9h30 

Tear down: until 15h30 

Poster Session II: Friday, July 27 th 

Set up: Thursday 16h30 -18h00 and Friday 9h00- 9h30 

Tear down: 16h00- 16h30 

Author presentation hour for both sessions: 

11h45- 12h45 even numbers 

12h45-13h45- odd numbers 

Poster numbers will identify the boards. Tapes and hangers should be brought to the area 

by presenters. The Organizing Committee will not provide these items and will not collect 

and keep Posters that are left on the Boards. 

We will invite our speakers to select and nominate three best posters according to their 

expertise. Winners and prizes will be announced during the closing cerimony 

86

A – Cell Biology 

A1-A122 

A - 1 EARLY WEANING AFFECTS CORTICOSTERONE LEVELS, CBG 

BINDING CAPACITY AND GLUCOCORTICOID RECEPTOR IN THE GASTRIC MUCOSA 

OF RATS DURING POSTNATAL DEVELOPMENT. HELOISA GHIZONI, PRISCILA 

MOREIRA FIGUEIREDO, MARIE-PIERRE MOISAN, LUCIANA HARUMI OSAKI, CRUZ 

ALBERTO MENDOZA RIGONATI, PATRÍCIA GAMA 

A - 2 NORMAL AND REGENERATION BONE TISSUE ANALYSIS: USE OF 

FOURIER TRANSFORMED SPECTROSCOPY INFRARED (FTIR) FOR IN SITU 

MOLECULAR IDENTIFICATION. TACIANA D. MAGRINI, HERCULANO S. MARTINHO, 

ANA AMÉLIA RODRIGUES, NILZA BATISTA, WILLIAM D. BELANGERO, ARNALDO R. 

SANTOS JR 

A - 3 A NOVEL LEISHMANIA AMAZONENSIS PROTEIN WICH INTERACTS 

HIGHLY SPECIFICALLY WITH THE G-RICH TELOMERIC STRAND. VINICIUS SANTANA 

NUNES, MARIBEL FERNÁNDEZ FERNÁNDEZ, CRISTINA BRAGA DE BRITO LIRA, 

MARIA ISABEL NOGUEIRA CANO 

A - 4 AN EVALUATION OF CHONDROCYTES MORPHOLOGY AND GENE 

EXPRESSION ON SUPERHYDROPHILIC VERTICALLY-ALIGNED MULTI-WALLED 

CARBON NANOTUBES FILMS. ELIANE ANTONIOLI, ANDERSON O. LOBO, DANIELLA 

Z. BUCCI, MARIO FERRETTI, MOISÉS COHEN, EVALDO J. CORAT, VLADIMIR J. 

TRAVA-AIROLDI 

A - 5 ALTERED EXPRESSION OF LEPTIN AND GHRELIN IN THYMUS OF 

ALOXAN-INDUCED DIABETIC MICE. CAROLINA FRANCELIN, IEDA GENISELI, LIANA 

VERINAUD 

A - 6 ANALYSIS OF WNT PATHWAY COMPONENTS IN AN 

EXPERIMENTAL MODEL OF ENDOMETRIOSIS. RÔMULO MEDINA DE MATTOS, 

PAULA RODRIGUES PEREIRA, FÁBIO HECHT CASTRO MEDEIROS, DENISE PIRES DE 

CARVALHO, LUCIANA BUENO FERREIRA, ETEL RODRIGUES PEREIRA GIMBA, FELIPE 

LEITE DE OLIVEIRA, LEANDRO MIRANDA ALVES, LUIZ EURICO NASCIUTTI 

A - 7 INFLUENCE OF BIOMODULATION IN CELL CULTURE GIRARDIA 

TIGRINA (PLATYHELMINTHES, TRICLADIDA). KARLA ANDRESSA RUIZ LOPES, 

ROBERTA CARICATTO BERNARDO PINTO, NÁDIA MARIA RODRIGUES DE CAMPOS 

VELHO, CRISTINA PACHECO SOARES 

A - 8 ACTION OF SULFATED GALACTANS FROM RED ALGAE HYPNEA 

MUSCIFORMIS ON HEMOSTASIS, CELL PROLIFERATION AND CYCLE CELL 

PROGRESSION. MONIQUE GABRIELA DAS CHAGAS FAUSTINO ALVES, CELINA 

MARIA PINTO GUERRA DORE, KAHENA DE QUEVEDO FLORENTIN, LUIZA S.E.P. 

WILL, THUANE DE SOUZA PINHEIRO, HUGO ALEXANDRE DE OLIVEIRA ROCHA, 

EDDA LISBOA LEITE 

A - 9 EFFECT OF RESISTANCE TRAINING ON BLOOD PRESSURE, ARTERIAL 

MORPHOLOGY AND VEGF PROTEIN EXPRESSION ON L-NAME HYPERTENSIVE 

RATS. ANNE CAROLLINE VERÍSSIMO DOS SANTOS, AYSLAN JORGE SANTOS DE 

ARAUJO, KARINE DOS SANTOS SOUZA, MARLÚCIA BASTOS AIRES, EMERSON 

TICONA FIORETTO, VALTER JOVINIANO DE SANTANA-FILHO, MARCIO ROBERTO 

VIANA DOS SANTOS 

A - 10 INTERACTION CELL-CHRYSOTILE IN TWO DIFFERENT CELL LINES: A 

MORPHOLOGICAL APPROACH. LUANA RIBEIRO RICARDI, BEATRIZ DE ARAUJO 

CORTEZ, PAULA REZENDE-TEIXEIRA, GLÁUCIA MARIA MACHADO-SANTELLI 

A - 11 α-A2BP1 MARKS P-BODIES CONTAINING REPRESSOR/DECCAPING 

MRNP COMPLEXES DEVOID OF GW182 IN DROSOPHILA S2 CELLS. GUSTAVO 

BORGES PEREIRA, MARIANA SANTOS DE QUEIROZ, DEISE CRISTINA POLETO 

SCAGLIA, MARIA LUISA PAÇÓ-LARSON 

A - 12 NITRIC OXIDE PRODUCTION BY ASCIDIAN HEMOCYTES AFTER 

HEAVY METALS EXPOSURE. DANIELLY DA FONTE CARVALHO MARTINS, LAURA 

CARRIELLO EMRICH, SILVANA ALLODI, RODRIGO NUNES DA FONSECA, CINTIA 

MONTEIRO DE BARROS 

A - 13 GILL NA+/K+-ATPASE ACTIVITY AND HISTOLOGICAL CHANGES OF 

FISH BATHYGOBIUS SOPORATOR (GOBIIDAE) DURING ACCLIMATION TO 

DIFFERENT SALINITIES AND TIMES. CLÁUDIO A. PIECHNIK, LUCÉLIA DONATTI, 

MARIA ROSA D. PEDREIRO, PRISCILA KREBSBACH, HELENA G. KAWALL 

A - 14 DECREASE OF THE ATAXIN-2 LEVELS SPECIFICALLY IN THE FAT 

BODY INTERFERES WITH GROWTH AND SURVIVAL OF DROSOPHILA. MURILO 

CARLOS BIZAM VIANNA, DEISE CRISTINA POLETO, PAULA FERNANDA GOMES, 

MARIA LUISA PAÇÓ-LARSON 

A - 15 DROSOPHILA ATAXIN-2 RELOCATES TO STRESS GRANULES IN 

RESPONSE TO THERMAL OR OXIDATIVE STRESS. PAULA FERNANDA GOMES, DEISE 

CRISTINA POLETO-SCAGLIA, MARIA LUISA PAÇÓ-LARSON 

A - 16 ASSESSING THE DIFFERENTIATION OF QUAIL TRUNK NEURAL 

CREST CELLS ON A 3D ENVIRONMENT.. FLAVIO AUGUSTO ROCHA BARBOSA, ANA 

RAMOS HRYB, ANDRÉA GONÇALVES TRENTIN, GIORDANO WOSGRAU CALLONI 

A - 17 INFLUENCE OF THE VITAMIN C AND HESPERIDIN ON THE EFFECTS 

OF EXCESSIVE SUCROSE INTAKE IN RATS: A STUDY ABOUT BLOOD GLUCOSE, 

MEMORY, AND DNA DAMAGE IN BLOOD AND HIPPOCAMPAL CELLS. CAMILA 

MAI, PATRÍCIA MOLZ, FERNANDA FLEIG ZENKNER, DEIVIS DE CAMPOS, JOEL 

HENRIQUE ELLWANGER, PAULA FENGLER, LUIZA MÜLLER, DANIEL PRÁ, SILVIA 

ISABEL RECH FRANKE 

A - 18 SPERM MORPHOLOGY IN MICRATHYRIA HESPERIS RIS, 1911 

(ODONATA, ANISOPTERA). ANA PAULA DE ALMEIDA CAIXEIRO, LUIZ FERNANDO 

GOMES, CLÁUDIA VÂNIA MIRANDA DE OLIVEIRA, JOSÉ LINO-NETO 

A - 19 MORPHOLOGY OF THE PERICARDIAL NEPHROCYTES IN TERMITES 

(INSECTA, ISOPTERA). ANA MARIA COSTA LEONARDO, LARA TEIXEIRA LARANJO, 

VANELIZE JANEI, IVES HAIFIG 

A - 20 PRESENILIN 2 REGULATES THE DEGRADATION OF RBP-JK PROTEIN 

VIA P38 MITOGEN-ACTIVATED PROTEIN KINASE: DEGRADATION OF RBP-JK 

INVOLVES BOTH PROTEASOME AND LYSOSOME. SU-MAN KIM, MI-YEON KIM, 

EUN-JUNG ANN, JUNG-SOON MO, JI-HYE YOON, HEE-SAE PARK 

A - 21 LEVELS OF ABSORPTION AND MORPHOLOGICAL ASPECTS IN FETAL 

BONE OF WISTAR RATS TREATED WITH ACETATE LEAD. IURE CARVALHO DE 

SOUZA, ANA PATRÍCIA SANTOS DE OLIVEIRA, RICARDO SCHER, WALDECY DE 

LUCCA JUNIOR, KÁTIA MICHELLE DOS ANJOS BOMFIM, LINCOLN VÍTOR SANTOS, 

VÍCTOR SANTANA SANTOS, JOSÉ ARNALDO VASCONCELOS PALMEIRA, FRANCISCO 

PRADO REIS, CARLOS ALEXANDRE BORGES GARCIA, VERA LÚCIA CORRÊA FEITOSA 

A - 22 LEVELS OF ABSORPTION AND MORPHOLOGICAL ASPECTS IN FETAL 

SKIN OF WISTAR RATS TREATED WITH LEAD ACETATE. ANA PATRÍCIA SANTOS DE 

OLIVEIRA, IURE CARVALHO DE SOUZA, RICARDO SCHER, WALDECY DE LUCCA 

JUNIOR, CARLOS ALEXANDRE BORGES GARCIA, KÁTIA MICHELLE DOS ANJOS 

BOMFIM, LINCOLN VÍTOR SANTOS, VÍCTOR SANTANA SANTOS, JOSÉ ARNALDO 

VASCONCELOS PALMEIRA, FRANCISCO PRADO REIS, VERA LÚCIA CORRÊA FEITOSA 

A - 23 MONOMERIC RECOMBINANT ARTINM ACTIVATES MAST CELLS 

AND BINDS TO CALRETICULIN ON THE MAST CELL SURFACE. VALÉRIA CINTRA 

BARBOSA LORENZI, MARIA CRISTINA ROQUE ANTUNES BARREIRA, MARIA CÉLILA 

JAMUR, CONSTANCE OLIVER 

A - 24 GANGLIOSIDE DEFICIENT MAST CELLS DO NOT EXPRESS GALECTIN- 

1. VIVIAN MARINO MAZUCATO, ADRIANA MARIA MARIANO SILVEIRA E SOUZA, 

MARCELA GIMENEZ, JOSE CESAR ROSA, LUIS LAMBERTI PINTO DA SILVA, MARIA 

CELIA JAMUR, CONSTANCE OLIVER 

A - 25 A NEW PHOSPHORYLATION SITE IN ALPHA-TUBULIN SUGGESTS 

THAT PHOSPHORYLATION MAY BE IMPORTANT TO STABILIZE MICROTUBULES 

DURING CELL DIVISION. MARIANA LEMOS DUARTE, MUNIRA MUHAMMAD ABDEL 

BAQUI, HELIO MIRANDA COSTA-JUNIOR, DENISE APARECIDA BERTI, JULIO CESAR 

BATISTA FERREIRA, TIAGO JOSÉ PASCHOAL SOBREIRA, MARIE-HÉLÈNE DISATNIK, 

DARIA MOCHLY-ROSEN, PAULO SÉRGIO LOPES DE OLIVEIRA, DEBORAH 

SCHECHTMAN 

A - 26 IDENTIFICATION AND CHARACTERIZATION OF THE INTERACTION 

BETWEEN THE KINASE CELL CYCLE REGULATOR KIS AND THE PROLIFERATION 

MARKER CATS. ISABELLA BARBUTTI GONÇALVES, JOÃO AGOSTINHO MACHADO- 

NETO, ADRIANA S. S. DUARTE, FERNANDA SOARES NIEMANN, SARA TERESINHA 

OLALLA SAAD, LETICIA FRÖHLICH ARCHANGELO 

A - 27 A2BP1 IS PRESENT IN MRNP GRANULES CONTAINING THE RNA 

HELICASE ME31B IN DROSOPHILA EYE DISC AND OVARIAN NURSE CELLS. 

MARIANA SANTOS DE QUEIROZ, MAYARA TERRA VILLELA VIEIRA, GUSTAVO 

BORGES PEREIRA, DEISE CRISTINA POLETO SCAGLIA, MARIA LUISA PAÇÓ LARSON 

A - 28 GALECTIN-3 IS IMPORTANT FOR MAST CELLS MIGRATION. VANINA 

DANUZA TOSO, MARIA RITA DE CÁSSIA CAMPOS, DEVANDIR ANTÔNIO DE SOUZA 

JÚNIOR, MARCELO DIAS BARIFFI, MARIA CRISTINA ROQUE ANTUNES BARREIRA, 

CONSTANCE OLIVER, MARIA CÉLIA JAMUR 

A - 29 ANALYSIS OF INTRACELLULAR TRAFFIC MEDIATED BY RAB 

PROTEINS IN HIPPOCAMPUS BEFORE PROTEIN AGGREGATION RELATED TO 

NEURODEGENERATION. THAIANY QUEVEDO MELO, MERARI F. R. FERRARI 

A - 30 COMBINED ACTION OF THE GROWTH HORMONE AND INSULIN- 

LIKE GROWTH FACTOR-1 ON THYMOCYTES IN VITRO. MARVIN PAULO LINS, IANA 

MAYANE MENDES NICÁCIO VIANA, LARISSA FERNANDA ARAÚJO VIEIRA, SALETE 

SMANIOTTO 

A - 31 AEROBIC TRAINING ENHANCES THE REGENERATION PROCESS 

AFTER MUSCLE ATROPHIC STIMULUS. RAQUEL SANTILONE BERTAGLIA, IVAN JOSÉ 

VECHETTI-JUNIOR, PAULO HENRIQUE DO PRADO, HENRIQUE BORGATTO DE 

ALMEIDA DIAS, ROBSON FRANCISCO CARVALHO, MAELI DAL PAI SILVA 

A - 32 CYTOTOXICITY IN PRE-DIABETES. PATRÍCIA MOLZ, CAMILA 

SCHREINER PEREIRA, MORGANA TONET MENDONÇA, THIAGO ALEY BRITES DE 

FREITAS, SHARBEL WEIDNER MALUF, JORGE ANDRÉ HORTA, DANIEL PRÁ, SILVIA 

ISABEL RECH FRANKE 

87

A - 33 MECHANISMS INVOLVED IN THE GASTROPROTECTION INDUCED 

BY EUGENIA DYSENTERICA DC (MYRTACEAE) LEAF EXTRACT IN MICE. LIGIA 

CAROLINA DA SILVA PRADO, ANGÉLICA MARTINS MOREIRA MUNDIM, CAMILA 

RODRIGUES FERRAZ, HUDSON ARMANDO NUNES CANABRAVA, LUIZ BORGES 

BISPO-DA-SILVA 

A - 34 UNDERSTANDING HEPARAN SULFATE /HEPARIN BIOSYNTHESIS. 

CARINA MUCCIOLO MELO, MARIA APARECIDA PINHAL 

A - 35 STUDYING THE INTERACTIONS BETWEEN LEISHMANIA 

AMAZONENSIS TTAGGG REPEAT BINDING FACTOR (LATRF) AND ITS POSSIBLE 

PARTNERS. JOÃO AUGUSTO RIBEIRO, DOUGLAS DIEZ GONÇALVES, ARINA MARINA 

PEREZ, PAULO VINÍCIUS DA MATA MADEIRA, MARCELO SANTOS DA SILVA, MARIA 

ISABEL NOGUEIRA CANO 

A - 36 IDENTIFICATION OF CANDIDATE TRANSCRIPTION FACTORS FOR 

THE REGULATION OF RAT VENTRAL PROSTATE GLAND RESPONSE TO ANDROGEN 

DEPRIVATION AND HIGH DOSE 17BETA-ESTRADIOL ADMINISTRATION. RAFAELA 

DA ROSA RIBEIRO, RAMON OLIVEIRA VIDAL, HERNADES F. CARVALHO 

A - 37 AEROBIC TRAINING HAS ANTI ATROPHY BENEFICIAL AND CARDIAC 

REMODELING EFFECTS IN RATS WITH HEART FAILURE. WARLEN PEREIRA 

PIEDADE, RODRIGO WAGNER ALVES DE SOUZA, LUANA CAMPOS SOARES, DIJON 

HENRIQUE SALOMÉ CAMPOS, PAULA AIELLO TOMÉ DE SOUZA, ANTONIO CARLOS 

CICOGNA, MAELI DAL-PAI-SILVA 

A - 38 AMPHOTERICIN B INDUCES APOPTOSIS ON A CELL LINE OF 

HEPATIC STELLATE CELLS. CAROLINA URIBE CRUZ, FERNANDA OLIVEIRA DOS 

SANTOS, NELSON ALEXANDDRE KRETZMANN, THEMIS REVERBEL DA SILVEIRA, 

URSULA MATTE 

A - 39 EFFECT OF POSACONAZOLE ON THREE-DIMENSIONAL 

CARDIOMYOCYTES CULTURE DURING TRYPANOSOMA CRUZI INFECTION WITH 

EMPHASIS IN EXTRACELLULAR MATRIX PROTEINS AND GAP JUNCTIONS. LÍNDICE 

MITIE NISIMURA, PATRÍCIA MELLO FERRÃO, LAURA LACERDA COELHO, LUCIANA 

RIBEIRO GARZONI 

A - 40 LUEHEA INFUSION OINTMENT IMPROVES WOUNDED EPIDERMAL 

TISSUE HEALING IN WISTAR RATS. PAULO CÉSAR FERREIRA DOS SANTOS, TATIANA 

MORDENTE CLEMENTE, FABRÍCIO CASTRO MACHADO, FERNANDA MIYAGAKI 

SHOYAMA, CLAUDIO VIEIRA DA SILVA 

A - 41 LIVER HISTOLOGY OF THE THREE TELEOST SPECIES CAPTURED IN 

THE ITAPECERICA RIVER, DIVINÓPOLIS, MG, BRAZIL. REGIANNE FERREIRA SILVA, 

CAMILA FERREIRA SALES, MARILIA GABRIELA C AMARAL, HEDER J. RIBEIRO, ROSY I. 

MACIEL AZAMBUJA RIBEIRO, FABRICIO FLÁVIO THEOPHILO DOMINGOS, RALPH 

GRUPPI THOMÉ, HÉLIO BATISTA DOS SANTOS 

A - 42 MASTER SWITCH REGULATORY GENES INVOLVED WITH PROSTATE 

GLAND REMODELING AFTER CASTRATION. UMAR NISHAN, DANILO MARCHETE 

DAMAS DE SOUZA, GUILHERME OLIVEIRA BARBOSA, HERNANDES F. CARVALHO 

A - 43 PLANTS EXTRACTS AND HUMAN PLATELETS MODULATE MAST 

CELLS POPULATION IN SKIN WOUND HEALING. LUCIANA XAVIER PEREIRA, RAÍSSA 

DE OLIVEIRA AQUINO SCHÜFFNER, PATRÍCIA PEREIRA SILVA, HÉLIO BATISTA 

SANTOS, RALPH GRUPPI THOMÉ, HÉLIO CHIARINI GARCIA, ROSSANA CORREA 

NETTO DE MELO, ROSY IARA MACIEL DE AZAMBUJA RIBEIRO, GLEYDES GAMBOGI 

PARREIRA 

A - 44 TOPICAL ANTIMICROBIAL ACTIVITY OF OLEIC AND LINOLEIC ACIDS 

IN WOUNDS. MAYSA BRAGA BARROS SILVA, GILSON MASAHIRO MURATA, RUI 

CURI, ANDREA MARIA SPESSOTO, ELAINE HATANAKA 

A - 45 FEZ1 PROTEIN-PROTEIN INTERACTION NETWORK GIVING CLUES 

TO CELLULAR PROCESSES: THE AUTOPHAGY MACHINERY IN NEUROGENESIS AND 

LEUKEMIA. ARIANE DA SILVA FURLAN, MARCOS RODRIGO ALBORGHETTI, DEIVID 

LUCAS DOS SANTOSMIGUELETI, JÚLIO CÉSAR SILVA, IRIS CONCEPCION LINARES DE 

TORRIANI, HOZANA ANDRADE CASTILLO, JOSE XAVIER NETO, JORG KOBARG 

A - 46 2D-DIGE ANALYSES IN PROTEIN EXPRESSION IN HUMAN 

UMBILICAL VEIN ENDOTHELIAL CELLS: THE EFFECT OF HYPOXIA IN VITRO AND IN 

UTERO. ANDRÉS CANIUGUIR, BERNARDO KRAUSE, ERNESTO MUÑOZ, PAOLA 

CASANELLO 

A - 47 STREPTOMYCIN EFFECTS IN STRETCH-ACTIVATED CHANNEL 

PROTEIN TRPC1 LEVELS AND MYONECROSIS OF MDX MICE. CINTIA YURI 

MATSUMURA, ANA PAULA TIEMI TANIGUTI, LETÍCIA MONTANHOLI APOLINÁRIO, 

HUMBERTO SANTO NETO, MARIA JULIA MARQUES 

A - 48 MIDGUT OF THE DIPLOPOD UROSTREPTUS ATROBRUNNEUS: 

STRUCTURE, FUNCTION AND REDEFINITION OF HEPATIC CELLS. CRISTINA 

MOREIRA DE SOUSA, ALDINEI GONÇALVES JUNIOR, CARMEM SILVIA FONTANETTI, 

MONIKA IAMONTE 

A - 49 DIFFERENTIAL EFFECTS OF CHEMOATTRACTANTS ON MAST CELL 

RECRUITMENT. MARIA RITA DE CÁSSIA CAMPOS, CONSTANCE OLIVER, MARIA 

CELIA JAMUR 

A - 50 RESERVE AND URATE STORAGE IN THE FAT BODY CELLS DURING 

SOLDIER DIFFERENTIATION IN THE TERMITE HETEROTERMES TENUIS (ISOPTERA, 

RHINOTERMITIDAE). LARA TEIXEIRA LARANJO, ANA MARIA COSTA LEONARDO 

A - 51 MORPHOLOGICAL CHARACTERIZATION OF THE EPIDERMIS OF THE 

NEOTROPICAL CATFISH PIMELODELLA CF. LATERISTRIGA LICHTENSTEIN, 1823 

(OSTARIOPHYSI: SILURIFORMES). KARINA MANCINI, EDUARDO MEDEIROS 

DAMASCENO, LUIZ FERNANDO DUBOC, JULIANA CASTRO MONTEIRO 

A - 52 EFFECTS OF YERBA MATÉ (ILEX PARAGUARIENSIS) ON ADIPOSE 

TISSUE OF RATS PROGRAMMED BY EARLY WEANING. NATÁLIA DA SILVA LIMA, 

ANA PAULA SANTOS DA SILVA DE OLIVEIRA, VANESSA S. TAVARES RODRIGUES, 

ANDREA KAEZER, EGBERTO GASPAR DE MOURA, ELAINE DE OLIVEIRA, PATRICIA 

CRISTINA LISBOA 

A - 53 ENTAMOEBA HISTOLYTICA IS ABLE TO INTERNALIZE AND DEGRADE 

TRYPOMASTIGOTES OF T. CRUZI G AND CL STRAINS. FLÁVIA ALVES MARTINS, 

ADELE AUD RODRIGUES, MARIA APARECIDA GOMES, CLAUDIO VIEIRA DA SILVA 

A - 54 AGE EFFECTS ON CHROMATIN SUPRA-ORGANIZATION OF 

CORTICAL NEURONS FROM MICE. HENRIQUE FERREIRA RODRIGUES, TAFAREL 

ANDRADE DE SOUZA, FLAVIA GERELLI GHIRALDINI, MARCELO EMILIO BELETTI, 

MARIA LUIZA SILVEIRA MELLO, ALBERTO DA SILVA MORAES 

A - 55 EXPRESSION AND FUNCTION OF PSG, STARD7 AND KLF6 GENES IN 

HUMAN TROPHOBLAST CELLS. PANZETTA-DUTARI GM, RACCA AC., CAMOLOTTO 

S., RIDANO ME., FLORES-MARTIN J., RENA V., GENTI-RAIMONDI S 

A - 56 CYTOCHEMISTRY OF CLUB CELLS IN THE EPIDERMIS OF THE 

CATFISH PIMELODELLA CF. LATERISTRIGA LICHTENSTEIN, 1823 (OSTARIOPHYSI: 

SILURIFORMES). LUIZ FERNANDO DUBOC, JULIANA CASTRO MONTEIRO, KARINA 

CARVALHO MANCINI, EDUARDO MEDEIROS DAMASCENO 

A - 57 ULTRASTRUCTURE OF CLUB CELLS IN THE EPIDERMIS OF THE 

NEOTROPICAL CATFISH PIMELODELLA CF. LATERISTRIGA LICHTENSTEIN, 1823 

(OSTARIOPHYSI: SILURIFORMES. EDUARDO MEDEIROS DAMASCENO, LUIZ 

FERNANDO DUBOC, JULIANA CASTRO MONTEIRO, KARINA CARVALHO MANCINI 

A - 58 TREATMENT WITH VOCHYSIA SP (VOCHYSIACEAE) EXTRACT IN 

STREPTOZOTOCIN-INDUCED DIABETIC RATS ATTENUATED GLYCEMIA WITHOUT 

ALTERING MORPHOLOGY OF HEPATIC TISSUE. IZABELA BARBOSA MORAES, 

CAMILLA MANZAN MARTINS, NEIRE MOURA DE GOUVEIA, LUCIANA KAREN 

CALÁBRIA, KAREN RENATA NAKAMURA HIRAKI, ALBERTO DA SILVA MORAES, 

FOUED SALMEN ESPINDOLA 

A - 59 STRATEGIES FOR IMMOBILIZATION OF MESENCHYMAL STEM 

CELLS USING SUPER-HYDROPHILIC VERTICALLY ALIGNED CARBON NANOTUBES 

AND DISPERSED MAGNETICALLY ORIENTED CARBON NANOTUBES. ALESSANDRO 

EUSTAQUIO CAMPOS GRANATO, LAYLA TESTA GALINDO, TAÍS ADELITA BARROS, 

MARCELLA BRAGA DA COSTA REIS, PIERO BAGNARESI, LILIAN SIQUEIRA, 

ANDERSON DE OLIVEIRA LOBO, MARIMÉLIA PORCIONATTO 

A - 60 MEDIUM-TERM TREATMENT WITH CYCLOSPORIN A AND 

HETEROPTERYS TOMENTOSA, INVESTIGATED IN HEPATIC TISSUE OF WISTAR 

RATS. KARINE DE MOURA FREITAS, MARIA APARECIDA DA SILVA DIAMANTE, 

JACQUELINE MERIELLEN DE ALMEIDA, NAYARA RUDECK COCK, MARÇAL 

HENRIQUE AMICI JORGE, MARY ANNE HEIDI DOLDER 

A - 61 CLONING, EXPRESSION AND BIOLOGICAL CHARACTERIZATION OF 

A NOVEL PHOSPHOLIPASE-D FROM BROWN SPIDER (LOXOSCELES INTERMEDIA) 

VENOM. GABRIEL OTTO MEISSNER, LARISSA VUITIKA, DILZA TREVIZAN SILVA, 

LUIZA HELENA GRESMKI, OLGA MEIRI CHAIM, MATHEUS REGIS BELISÁRIO, 

ADRIANO MARCELO MORGON, SILVIO SANCHES VEIGA 

A - 62 EFFECT OF ACARBOSE AND PHASEOLAMINE TREATMENTS ABOUT 

LIVER MORPHOLOGY IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. CAMILLA 

MANZAN MARTINS, IZABELA BARBOSA MORAES, KAREN RENATA NAKAMURA 

HIRAKI, NEIRE MOURA GOUVEIA, LUCIANA KAREN CALÁBRIA, FOUED SALMEN 

ESPINDOLA 

A - 63 MELATONIN EFFECTS IN PROSTATE HISTOPHYSIOLOGY OF 

PREPUBERTAL RATS SUBJECTED TO SHORT TERM DIABETES. MARINA 

GUIMARÃES GOBBO, GUILHERME HENRIQUE TAMARINDO, VIVIANE SANCHES 

MASITÉLI, CAROLINA FRANDSEN PEREIRA COSTA, SEBASTIÃO ROBERTO TABOGA, 

REJANE MAIRA GÓES 

A - 64 TOXICITY IN LIVER OF FISH SPECIES OREOCHROMIS NILOTICUS 

(CICHLIDAE) EXPOSED TO NICL2. AMANDA ALFONSO BATISTA, CINTYA A 

CHRISTOFOLETTI, CARMEM S. FONTANETTI 

A - 65 EFFECT OF VOCHYSIA SP. EXTRACT ON THE MORPHOMETRY OF 

THE PAROTID GLAND IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. DOUGLAS 

CARVALHO CAIXETA, FRANCYELLE BORGES ROSA DE MOURA, ALICE VIEIRA DA 

COSTA, LUCIANA KAREN CALÁBRIA, MARCELO EMÍLIO BELETTI, FOUED SALMEN 

ESPINDOLA 

A - 66 IN SILICO ANALYSIS OF BINDING PEPTIDES TO CELL SURFACE FROM 

STAPHYLOCOCCUS AUREUS. FERNANDO VIEIRA RODRIGUES, EMÍLIA REZENDE 

VAZ, CAROLINE FERNANDES REIS, LÉA DUARTE DA SILVA MORAES, YARA CRISTINA 

DE PAIVA MAIA, CARLOS UEIRA VIEIRA, LUIZ RICARDO GOULART, TATIANA 

AMABILE DE CAMPOS 

A - 67 HISTOLOGY AND HISTOCHEMICAL CHARACTERIZATION OF THE 

STOMACH STRUCTURE OF ANTARCTIC FISH NOTOTHENIA ROSSII (RICHARDSON, 

1844) UNDER CONDITIONS OF THERMAL STRESS. PRISCILA KREBSBACH, AXEL H. 

R. COFRÉ, CINTIA MACHADO, MARIA ROSA D. PEDREIRO, FLÁVIA B. V. SILVA, 

88

TÂNIA ZALESKI, LUCIANA B. CETTINA, MARIANA FORGATI, CLÁUDIO A. PIECHNIK, 

LUCÉLIA DONATTI 

A - 68 ASSESSMENT OF SUBCHRONIC ORAL TOXICITY OF ETHANOLIC 

EXTRACT OF MAYTENUS ILICIFOLIA MART. EX REISSEK. IN MALE AND FEMALE 

WISTAR RATS. SILVANE SOUZA ROMAN, CARLA GIANE LOSS, TAÍS REGINA 

FIORENTIN, FABIOLA REGINA BREDA, GABRIELA GUBERT, MORGANA PISTORE, 

JANAINA VIEIRA BELUSSO, MICHELA BIANCHI DE MELLO, ARNO ERNESTO 

HOFMANN JUNIOR 

A - 69 INVESTIGATION OF NTPDASE-2 ROLE IN CELL ADHESION, 

PROLIFERATION AND MIGRATION. FRANCIELE CRISTINA KIPPER, DARLAN 

CONTERNO MINUSSI, GUIDO LENZ, MÁRCIA ROSÂNGELA WINK 

A - 70 THE CHARACTER PROTEIN OF PROSTATE GERBIL: MALE INTACT 

AND FEMALE RECEIVED SUPPLEMENTATION OF TESTOSTERONE. PEDRO 

HENRIQUE GARCIA SOBRINHO, ANA PAULA DA SILVA PEREZ, FÁTIMA PEREIRA DE 

SOUZA, SEBASTIÃO ROBERTO TABOGA 

A - 71 ENDOPLASMIC RETICULUM STRESS IS AN EVOLVING FEATURE OF 

AORTIC DISEASE IN HETEROZYGOUS MARFAN SYNDROME MICE, WHILE NOT 

ACCOUNTED FOR BY FIBRILLIN-1 MUTATION ITSELF. THAYNA MEIRELLES SANTOS, 

MARIA CAROLINA GUIDO, VICTOR DEBBAS, LYGIA DA VEIGA PEREIRA, FRANCISCO 

RAFAEL MARTINS LAURINDO 

A - 72 BIOCOMPATIBILITY EVALUATION OF SOLID LIPID NANOPARTICLES 

TOWARD MOUSE EMBRYO FIBROBLASTS AND ERITHROCYTES. ADNY HENRIQUE 

SILVA, CARINE DAL PIZZOL, FABÍOLA B. FILIPPIN-MONTEIRO, ÂNGELA M. DE 

CAMPOS, TÂNIA B.CRECZYNSKI-PASA 

A - 73 ARREST OF CYTOPLASMIC STREAMING INDUCES ALGAL 

PROLIFERATION IN GREEN PARAMECIA. HIROSHI HOSOYA, EIJI HIRAKI, KOYO 

TETSUKAWA, YOSHIHIKO YAMASHIN, TOSHIYUKI TAKAHASHI, KOZUE HAMAO 

A - 74 NITRIC OXIDE PRODUCTION BY HEMOCYTES OF THE ASCIDIAN 

PHALLUSIA NIGRA. LAURA CARRIELLO EMRICH, DANIELLY DA FONTE CARVALHO 

MARTINS, RODRIGO NUNES DA FONSECA, SILVANA ALLODI, CINTIA MONTEIRO DE 

BARROS 

A - 75 DIPHOSPHORYLATED MYOSIN II REGULATORY LIGHT CHAIN 

LOCALIZES TO THE MIDZONE WITHOUT ITS HEAVY CHAIN DURING CYTOKINESIS. 

TOMO KONDO, KEIJU KAMIJO, KOZUE HAMAO, HIROSHI HOSOYA 

A - 76 COMPARATIVE HISTOLOGY OF THE SPLEEN OF THREE TELEOST 

SPECIES CAPTURED IN THE ITAPECERICA RIVER, DIVINÓPOLIS, MG, BRAZIL. 

MARILIA GABRIELA C AMARAL, REGIANNE FERREIRA SILVA, CAMILA FERREIRA 

SALES, HEDER J. RIBEIRO, ROSY I. MACIEL AZAMBUJA RIBEIRO, FABRICIO FLÁVIO 

THEOPHILO DOMINGOS, RALPH GRUPPI THOMÉ, HÉLIO BATISTA DOS SANTOS 

A - 77 USING A CACO-2 CELL CULTURE MODEL FOR DRUG PERMEATION. 

JULIANNA HENRIQUES DA SILVA, VIVIANE LIONE, RITA DE CASSIA ASCENÇÃO 

BARROS, CARLOS RANGEL RODRIGUES, HELENA CARLA CASTRO, VALERIA P. 

SOUSA, LUCIO MENDES CABRAL, LUIZ EURICO NASCIUTTI 

A - 78 NOREPINEPHRINE DEPRESSES THE NITRIC OXIDE PRODUCTION IN 

THE ASCIDIAN PHALLUSIA NIGRA HEMOCYTES. ANDRESSA DE ABREU MELLO, 

SILVANA ALLODI, CINTIA MONTEIRO DE BARROS 

A - 79 PURINERGIC RECEPTORS ARE INVOLVED IN THE ACTIVATION OF 

MACROPHAGES BY URIC ACID CRYSTALS THROUGH THE NLRP3-INFLAMMASOME 

PATHWAY. THOMAS GICQUEL, TATIANA VICTONI, ALAIN FAUTREL, FLORENCE 

GLEONNEC, CARINE LAMBERT, CARINE LAMBERT, ISABELLE COUILLIN, ELISABETH 

BOICHOT, VINCENT LAGENTE 

A - 80 ADDITIVE EFFECT OF CIGARETTE SMOKE EXTRACT (CSE) AND 

LIPOLYSACCHARIDE (LPS) ON PROINFLAMMATORY CYTOKINE RELEASE 

THROUGH ACTIVATION OF JAK/STAT PATHWAYS IN HUMAN AIRWAY EPITHELIAL 

CELLS. TATIANA VICTONI, MANUELLA LANZETTI, FLORENCE GLEONNEC, LUCIE 

BEAUTRAIS, SAMUEL S. VALENÇA, LUIS CRISTOVÃO PORTO, ELISABETH BOICHOT, 

VINCENT LAGENTE 

A - 81 EFFECTS OF TREATMENTS WITH DIFFERENT ULTRASOUND FIELDS 

IN SKELETAL MUSCLE CELL CULTURES. VIVIANE M. ABRUNHOSA, CAROLINA 

PONTES SOARES, RODRIGO COSTA-FELIX, MANOEL COSTA, CLAUDIA 

MERMELSTEIN 

A - 82 EFFECTS OF ANTIFUNGAL ON SPOROTHRIX SCHENCKII. LUANA 

PEREIRA BORBA DOS SANTOS, KELLY ISHIDA, LEILA MARIA LOPES BEZERRA, SONIA 

ROZENTAL 

A - 83 LIPID DROPLETS INDUCTION IN MURINE MACROPHAGES WITH 

MICE SERUM: POSSIBLE PROTEINACEOUS NATURE OF THE INDUCTION FACTOR. 

THIAGO TORRES DE AGUIAR, LAURA AZEREDO MIRANDA MOTA, SÉRGIO 

HENRIQUE SEABRA, PATRÍCIA TORRES BOZZA, GEÓRGIA CORREA ATELLA, RENATO 

AUGUSTO DAMATTA 

A - 84 HIGH-FAT DIET ENRICHED WITH FISH OIL DECREASES LYMPHOCYTE 

ACTIVATION IN MICE. HELOÍSA HELENA DE OLIVEIRA ALVES, CESAR MIGUEL 

MOMESSO, JARLEI FIAMONCINI, KIM GUIMARÃES CAÇULA, MARIA FERNANDA 

CURY-BOAVENTURA, SANDRO MASSAO HIRABARA, RUI CURI, RENATA GORJÃO 

A - 85 MAINTENANCE OF BIOCHEMICAL PROPERTIES OF CHONDROCYTES 

IN VITRO UNDERGOING CHONDROGENIC MEDIUM RICH IN FACTOR. RICARDO 

SCHMID BOMFIM, CAMILA BASILE CARBALLO 

A - 86 RECOMBINANT PHOSPHOLIPASE-D FROM BROWN SPIDER VENOM 

(LOXOSCELES GENUS) INDUCES CYTOSOLIC CALCIUM INFLUX AND DEGRADATION 

OF PLASMA MEMBRANE PHOSPHOLIPIDS OF B16-F10 CELLS. ANA CAROLINA 

MARTINS WILLE, DANIELLE CHAVES MOREIRA, MARIANA G. MAGNONI, THIAGO 

LOPES DE MARI, LUIZA HELENA GREMSKI, OLGA MEIRI CHAIM, ANDREA SENFF 

RIBEIRO, SILVIO SANCHES VEIGA 

A - 87 DOUBLE STRAND BREAK REPAIR PROTEINS IDENTIFICATION IN 

MAMMALIAN MITOCHONDRIA. VALQUIRIA TIAGO DOS SANTOS, NADJA 

CRISTHINA DE SOUZA PINTO 

A - 88 THE PRESENCE OF THE SYMBIOTIC BACTERIUM INFLUENCES THE 

O2 CONSUMPTION IN ITS HOST CELL, ANGOMONAS DEANEI. ALLAN CÉZAR DE 

AZEVEDO MARTINS, ANA CAROLINA LOYOLA MACHADO, ANTÔNIO GALINA, 

LUCIANE CIAPINA, LUIZ GONZAGA, ANA TEREZA RIBEIRO VASCONCELOS, 

WANDERLEY DE SOUZA, MARCELO EINICKER LAMAS, MARIA CRISTINA MACHADO 

MOTTA 

A - 89 THE TETRASPANIN CD63 IS HIGHLY EXPRESSED BY SECRETORY 

GRANULES IN HUMAN BLOOD EOSINOPHILS. LÍVIA ANDRESSA SILVA DO CARMO, 

KÁTIA BATISTA DO AMARAL, ANN M. DVORAK, PETER F. WELLER, ROSSANA 

CORREA NETTO DE MELO 

A - 90 THE INFLUENCE OF THE SYMBIOTIC BACTERIUM ON RESPIRATION 

OF HOST TRYPANOSOMATIDS STRIGOMONAS CULICIS. ANA CAROLINA LOYOLA 

MACHADO, DALLAN CÉZAR DE AZEVEDO MARTINS, ANTÔNIO GALINA FILHO, 

WANDERLEY DE SOUZA, MARIA CRISTINA MACHADO MOTTA 

A - 91 AGE–RELATED CHANGES IN LIVER MORPHOLOGY: COULD 

HETEROPTERYS TOMENTOSA ALLEVIATE THESE CHANGES? MARIA APARECIDA DA 

SILVA DIAMANTE, FABRICIA DE SOUZA PREDES, ANA MILENA HERRERA, JULIANA 

DE CASTRO MONTEIRO, MARY ANNE HEIDI DOLDER 

A - 92 HISTOPATHOLOGICAL CHANGES IN THE ANTARCTIC FISH 

NOTOTHENIA CORIICEPS AND NOTOTHENIA ROSSII COLLECTED IN KING GEORGE 

ISLAND, ANTARCTIC PENINSULA. MARIA ROSA DMENGEON PEDREIRO, FLÁVIA 

SANT`ANNA RIOS, CINTIA MACHADO, PRISCILA KREBSBACH, CLÁUDIO ADRIANO 

PIECHNIK, TANIA ZALESKI, MARIANA FORGATI, LUCIANA BADELUK CETTINA, 

EDSON RODRIGUES, LUCÉLIA DONATTI 

A - 93 TC95 A HYBRID MOLECULE ON LEISHMANIA AMAZONENSIS: NEW 

CELLULAR TARGETS. JOSEANE LIMA PRADO GODINHO, K. GEORGIKOPOULOU, T. 

CALOGEROPOULOU, WANDERLEY DE SOUZA, JULIANY COLA FERNANDES 

RODRIGUES 

A - 94 BIOLOGY OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN 

THE CONTEXT OF OBESITY IN ADOLESCENTS. BRUNO DIAZ PAREDES, ELIETE 

BOUSKELA, LUIZ GUILHERME KRAEMER DE AGUIAR, VERÔNICA MORANDI, 

MARCELA FERREIRA MARQUES 

A - 95 ULTRASTRUCTURAL AND CYTOGENETIC CHARACTERIZATION OF 

SOME ASPECTS OF SPERMATOGENESIS OF ZAPRIONUS INDIANUS AND 

ZAPRIONUS SEPSOIDES. LETÍCIA DO NASCIMENTO ANDRADE DE ALMEIDA REGO, 

ROSANA SILISTINO DE SOUZA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA, 

LILIAN MADI-RAVAZZI 

A - 96 EVIDENCES OF DEGRANULATION IN HOLOTHURIA GRISEA 

SPHERULOCYTES. PATRICIA LACOUTH, MÁRCIO REIS CUSTÓDIO 

A - 97 CELLULAR RESPONSE OF SKIN FIBROBLAST TO LEISHMANIA 

(LEISHMANIA) AMAZONENSIS INFECTION. CAMILA GUERRA SILVA, ROGER 

MAGNO MACEDO SILVA, CARINA DE LIMA PEREIRA DOS SANTOS, VANESSA 

ALVARO DINIZ, SUZANA CÔRTE-REAL 

A - 98 ADENOHYPOPHYSEAL CELLS IN ADULTS OF SALMINUS 

BRASILIENSIS (TELESOSTEI, CHARACIFORMES): A HISTOCHEMYCAL AND 

IMUNOHISTOCHEMYCAL STUDY. LÁZARO WENDER OLIVEIRA DE JESUS, CHAYRRA 

CHERRADE GOMES, GISELE CRISTIANE DE MELO DIAS, SARA ZAGO GOMES, CRUZ 

ALBERTO MENDOZA RIGONATI, MARIA INÊS BORELLA 

A - 99 EVALUATION OF BME26 CELLS RESISTANCE TO HYDROGEN 

PEROXIDE INDUCED STRESS. BÁRBARA PITTA DELLA NOCE, JORGE LUIS RIBEIRO, 

RENATO AUGUSTO DAMATTA, CARLOS LOGULLO 

A - 100 INSIGHTS ABOUT FIBROCYTES PARTICIPATION IN THE IMMUNE 

RESPONSE OF LEISHMANIASIS. CARINA DE LIMA PEREIRA DOS SANTOS, THAISA 

VIEIRA, VANESSA ALVARO DINIZ, CAMILA GUERRA SILVA, ROGER MAGNO 

MACEDO SILVA, JORGE JOSÉ DE CARVALHO, SUZANA CÔRTE-REAL 

A - 101 THE ROLE OF HISTONE H4 IN THE TRYPANOSOMA CRUZI 

CHROMATIN. THIAGO CESAR PRATA RAMOS, BRUNO DOS SANTOS PASCOALINO, 

SHEILA CRISTINA NARDELLI, SERGIO SCHENKMAN 

A - 102 CELLULAR REDISTRIBUTION OF A PROTEIN KINASE INVOLVED IN 

TRANSLATION CONTROL DURING DIFFERENTIATION OF TRYPANOSOMA CRUZI. 

LEONARDO DA SILVA AUGUSTO, NILMAR SILVIO MORETTI, SERGIO SCHENKMAN 

A - 103 ICK PEPTIDE FROM LOXOSCELES INTERMEDIA VENOMOUS GLAND: 

CLONING, EXPRESSION AND PRODUCTION OF POLYCLONAL ANTIBODIES. 

89

FERNANDO HITOMI MATSUBARA, EDUARDO SOARES CONSTANTINO LOPES, 

GABRIEL OTTO MEISSNER, VALÉRIA PEREIRA FERRER, LUIZA HELENA GREMSKI, 

ANDREA SENFF RIBEIRO, OLGA MEIRI CHAIM, SILVIO SANCHES VEIGA 

A - 104 STUDY OF THE VENTRAL PROSTATE EMBRYOGENESIS IN 

MONGOLIAN GERBIL. BRUNO DOMINGOS AZEVEDO SANCHES, MANOEL 

FRANCISCO BIANCARDI, LUIZ ROBERTO FALLEIROS-JR, FERNANDA CRISTINA 

ALCANTARA DOS SANTOS, SEBASTIÃO ROBERTO TABOGA 

A - 105 TGFB EFFECT IN NUCLEAR TRANSLOCATION OF CLUSTERIN IN 

RWPE-1 TRANSFECTED WITH A CLU-GFP CLONE AND ITS IMMUNOLOCALIZATION 

IN DU145 AND PC3 CELLS. FABIANA KUHNE, GUSTAVO DE MAGALHÃES ALMEIDA, 

HERNANDES F CARVALHO 

A - 106 THYROID HORMONE (T3) MODULATES THE ENTERIC GLIA. ANA 

CARINA BON FRAUCHES OLIVEIRA, SUZANA ASSAD KAHN, ANA LÚCIA TAVARES 

GOMES, PATRÍCIA CASTELUCCI, VIVALDO MOURA NETO 

A - 107 RODLET CELLS IN GILL EPITHELIUM OF CURIMBA (PROCHILODUS 

ARGENTEUS): ULTRASTRUCTURE AND S100 IMMUNOREACTIVITY. MARCELA 

SANTOS PROCÓPIO, HEDER JOSÉ RIBEIRO, SAMYRA MARIA DOS SANTOS NASSIF 

LACERDA, PATRÍCIA MASSARA MARTINELLI, JOSÉ DIAS CORRÊA JUNIOR 

A - 108 HISTOCHEMICAL AND BIOCHEMICAL IDENTIFICATION OF THE 

GLYCOCONJUGATE TYPE IN SECRETION OF THE PAROTOID GLAND OF A 

BRAZILIAN TOAD (RHINELLA ICTERICA). JULIANE SIQUEIRA FRANCISCO, ELIENE 

OLIVEIRA KOZLOWSKI DE FARIAS, MAURO SÉRGIO GOLÇALVES PAVÃO, LYCIA DE 

BRITO GITIRANA 

A - 109 5-HYDROXY-2-HYDROXYMETHYL- �-PYRONE (HMP) AS 

MACROPHAGE ACTIVATOR. ANA PAULA DRUMMOND RODRIGUES, LUIS 

HENRIQUE SEABRA DE FARIAS, ALBERDAN SILVA SANTOS, JOSÉ LUIZ MARTINS DO 

NASCIMENTO, EDILENE OLIVEIRA DA SILVA 

A - 110 EVALUATION OF LEISHMANICIDAL ACTIVITY OF RHIZOPHORA 

MANGLE ON LEISHMANIA MAJOR. KRISIA EMANUELLE FERREIRA DA SILVA, 

ERWELLY BARROS DE OLIVEIRA, MARLLON ALEX NASCIMENTO SANTANA, PAULO 

HENRIQUE CAVALCANTI DE ARAÚJO, ANTÔNIO FERNANDO MORAIS DE OLIVEIRA, 

PALOMA LYS DE MEDEIROS, ELIETE CAVALCANTI DA SILVA, JEYMESSON RAPHAEL 

CARDOSO VIEIRA 

A - 111 EFFECTS OF 5-HYDROXY-2-HYDROXYMETHYL-GAMMA-PYRONE 

(HMP), A SECONDARY METABOLITE OBTAINED FROM ASPERGILLUS FUNGI, ON 

HUMAN NEUTROPHILS. PAULA CRISTINA RODRIGUES FRADE, JOSINEIDE PANTOJA 

DA COSTA, ANA PAULA DRUMMOND RODRIGUES, LUIS HENRIQUE SEABRA 

FARIAS, BRUNO JOSÉ MARTINS DA SILVA, RAQUEL RAICK PEREIRA DA SILVA, 

AMANDA ANASTÁCIA PINTO HAGE, CAROLINE MARTINS ALMEIDA, ALBERDAN 

SILVA SANTOS, EDILENE OLIVEIRA DA SILVA 

A - 112 RST-NEPH PROTEIN FAMILY IN CHICK EMBRYOS. MARA SILVIA 

ALEXANDRE COSTA, FELIPE MONTELEONE VIECELI, LUANA CRISTINA AMISTA, JOSÉ 

EDUARDO BARONEZA, MAIARO CABRAL ROSA MACHADO, IRENE YAN, RICARDO 

GUELERMAN PINHEIRO RAMOS 

A - 113 EFFECTS OF 5-HYDROXY-2-HYDROXYMETHYL-�-PYRONE (HMP) IN 

FILAMENTOUS FUNGAL CURVULARIA PALLESCENS. JORGE AUGUSTO LEÃO 

PEREIRA, ANA PAULA DRUMMOND RODRIGUES, DAVI MARCOS DE SOUZA 

OLIVEIRA, ALBERDAN SILVA SANTOS, EDILENE OLIVEIRA DA SILVA 

A - 114 DIFFERENTIATION OF HUMAN MONOCYTES IN VITRO BY 5- 

HYDROXY-2-HYDROXYMETHYL-GAMMA-PYRONE (HMP), A BIOPRODUCT 

OBTAINED FROM ASPERGILLUS FUNGI. JOSINEIDE PANTOJA DA COSTA, PAULA 

CRISTINA RODRIGUES FRADE, ANA PAULA DRUMMOND RODRIGUES, BRUNO JOSÉ 

MARTINS DA SILVA, ALBERDAN SILVA SANTOS, EDILENE OLIVEIRA DA SILVA 

A - 115 DELETERIOUS EFFECTS OF WATER-SOLUBLE FRACTION (WSF) OF 

PETROLEUM ON BEIJUPIRÁ (RACHYCENTRON CANADUM): HISTOLOGICAL 

EVALUATION. KARINA FERNANDES REZENDE, LÍGIA MARIA SALVO, JULIANA 

CRISTINA TEIXEIRA DE MORAES, DIVINOMAR SEVERINO, JOSÉ ROBERTO 

MACHADO CUNHA DA SILVA 

A - 116 ANALYSIS OF LIPID DROPLETS IN LEISHMANIA (VIANNIA) 

BRAZILIENSIS PROMASTIGOTES IN THE EARLY STATIONARY PHASE OF THE 

GROWTH. AMANDA ANASTÁCIA PINTO HAGE, NUCCIA N. T. DE CICCO, GEORGIA C. 

ATELLA, RAQUEL RAICK PEREIRA DA SILVA, BRUNO JOSÉ MARTINS SILVA, PAULA 

CRISTINA R. FRADE, ANA PAULA DRUMMOND RODRIGUES, EDILENE OLIVEIRA DA 

SILVA 

A - 117 Α6Β1 INTEGRIN IS RELEVANT IN THE FORMATION AND SURVIVAL 

OF DIFFERENTIATED 3D ACINI OF SALIVARY GLANDS CELLS: IMPLICATIONS IN 

SJÖGREN’S SYNDROME. HERY ANDRÉS URRA ZÚÑIGA, DENISSE SEPULVEDA, JUAN 

CORTES, VERONICA BAHAMONDES, ISABEL CASTRO, MARIA JOSE BARRERA, 

SERGIO AGUILERA, CLAUDIO MOLINA, CECILIA LEYTON, CECILIA ALLENDE, SERGIO 

GONZALEZ, MARÍA JULIETA GONZÁLEZ 

A - 118 FURTHER STUDIES OF THE IN SITU CELL STRUCTURE OF CELLS AND 

TISSUES WITH THE ATOMIC FORCE MICROSCOPE. MARÍA DE LOURDES SEGURA- 

VALDEZ, GEORGINA ALVAREZ-FERNÁNDEZ, ALMA ZAMORA-CURA, ASIER GARCÍA 

SENOSIAIN, LOURDES TERESA AGREDANO-MORENO, LUIS FELIPE JIMÉNEZ-GARCÍA 

A - 119 DISTRIBUTION OF AMINOPEPTIDASES IN SUBCELLULAR 

FRACTIONS OF ADIPOCYTES FROM ABDOMINAL FAT IN MONOSODIUM 

GLUTAMATE OBESITY. RAFAELA FADONI ALPONTI, PAULO FLAVIO SILVEIRA 

A - 120 MELANOPSIN ACTIVATES CLOCK GENES IN ZEBRAFISH CELLS. 

BRUNO CESAR RIBEIRO RAMOS, MARIA NATHÁLIA DE CARVALHO MAGALHÃES 

MORAES, LEONARDO HENRIQUE RIBEIRO GRACIANI DE LIMA, ANA MARIA DE 

LAURO CASTRUCCI 

A - 121 HISTOPATHOLOGICAL CHANGES IN THE GILLS OF ARAPAIMA 

GIGAS AFTER BATHS IN FORMALDEHYDE SOLUTION. JOSÉ CARLOS NUNES 

RAULINO, SANNY MARIA DE ANDRADE-PORTO, LUCIANA ARRUDA DINÓLA DE 

OLIVEIRA, JOSE CELSO DE OLIVEIRA MALTA 

A - 122 MUCOUS CELLS IN GILLS OF ARAPAIMA GIGAS EXPOSED TO WHITE 

AND BLACK WATERS AND ITS INFLUENCE ON FISH HOMEOSTASIS. JOSÉ CARLOS 

NUNES RAULINO, JANILSON MORAES SERUDO, ELIZABETH GUSMÃO AFFONSO, 

OSCAR TADEU FERREIRA DA COSTA, WALLICE LUIZ PAXIÚBA DUNCAN, MARISA 

NARCISO FERNANDES, CLEVERSON AGNER RAMOS 

B – Cell Biology and 

Cancer 

B1-B252 

B - 1 NUCLEAR CALCIUM BUFFERING SENSITIZES HUMAN SQUAMOUS 

CELL CARCINOMA TO X-RAYS USING HEAD AND NECK RADIOTHERAPY 

PROTOCOL. LÍDIA MARIA DE ANDRADE, JONY MARQUES GERALDO, OSVALDO 

XAVIER GONÇALVES, MIGUEL TORRES TEIXEIRA LEITE, ANDERSON MIRANDA 

CATARINA, ADRIANA FRANCO PAES LEME, SAMI YOOKO, CARLOS RENATO 

MACHADO, MATHEUS ANDRADE RAJÃO, RODRIGO RIBEIRO RESENDE, CARLA 

JEANE AGUIAR, ELAINE MARIA DE SOUZA FAGUNDES, CARLOS LEOMAR ZANI, 

OLINDO ASSIS MARTINS FILHO, MARIA DE FÁTIMA LEITE 

B - 2 EVALUATION OF GENOTOXICITY OF SOLANUM LYCOCARPUM 

AQUEOUS EXTRACTS UTILIZING ALLIUM CEPA TEST-SYSTEM. VIVIANE MOREIRA 

DE LIMA, JÉSSICA TAMARA DOS SANTOS, JENNIFER VIEIRA GOMES, MARIANA DA 

SILVA DE MELLO, PATRÍCIA FAMPA, HÉLCIO RESENDE BORBA 

B - 3 ASSOCIATION BNP LEVEL WITH CARDIAC DAMAGES INDUCED BY 

IONIZING RADIATION AND CHEMOTHERAPY DRUGS. VERA MARIA ARAÚJO DE 

CAMPOS, CAMILA SALATA, CHERLEY BORBA VIEIRA DE ANDRADE, SAMARA 

CRISTINA FERREIRA MACHADO, ADENILSON DE SOUZA DA FONSECA, ANA LUCIA 

ROSA NASCIMENTO, JORGE JOSÉ DE CARVALHO, CARLOS EDUARDO VELOSO DE 

ALMEIDA 

B - 4 TRICHOSTATIN A, A HISTONE DEACETYLASE INHIBITOR, AFFECTS 

GLIOMA TUMORSPHERES FORMATION AND GROWTH. FELIPE DE ALMEIDA SASSI, 

ANA LUCIA ABUJAMRA, RAFAEL ROESLER 

B - 5 SUPPRESSION OF CLAUDIN-7 EXPRESSION PROMOTES CELL 

PROLIFERATION AND DISRUPTS CELL-MATRIX INTERACTIONS IN HUMAN LUNG 

CANCER CELLS. ZHE LU, QUN LU, LEI DING, YAN-HUA CHEN 

B - 6 MODULATION OF CANONICAL WNT SIGNALING PATHWAY 

DURING EXPERIMENTAL ORAL CARCINOGENESIS. JULIANA GONÇALVES 

CARVALHO, JULIANA NOGUTI, CAROLINA PRADO DE FRANÇA CARVALHO, 

MARCELLO FRANCO, CELINA TIZUKO FUJIYAMA OSHIMA, DANIEL ARAKI RIBEIRO 

B - 7 SCREENING OF PLANTS EXTRACTS OF CERRADO IN NOT CLINICAL 

ASSAYS FOR ANTITUMOR ACTIVITY. CAMILA RAQUEL RODRIGUES BARBOSA, 

HELOÍSA HELENA MARQUES OLIVEIRA, LUCIANA MARIA SILVA, VERA LÚCIA DE 

ALMEIDA, CAROLINA PAULA DE SOUZA MOREIRA 

B - 8 PRELIMINARY STUDIES OF PROSTATE TUMOR CELLS 

INTERACTIONS WITH BRAIN MICROENVIRONMENT. ELIANE GOUVEA DE 

OLIVEIRA, ANTONIO PALUMBO JUNIOR, CELIA YELIMAR PALMERO, LEANDRO 

MIRANDA-ALVES, CHRISTINA MAEDA TAKIYA, VIVALDO MOURA-NETO, LUIZ 

EURICO NASCIUTTI 

B - 9 RAF KINASE INHIBITOR (RKIP) DEPLETION IS ASSOCIATED WITH 

CERVICAL CANCER AGGRESSIVENESS. OLGA CATARINA LOPES MARTINHO, FILIPE 

PINTO, SARA GRANJA, VERA MIRANDA-GONÇALVES, MARISE A.R. MOREIRA, LUIS 

F.J. RIBEIRO, CELSO DI LORETO, MARSHA R. ROSNER, ADHEMAR LONGATTO-FILHO, 

RUI MANUEL REIS 

B - 10 IDENTIFICATION OF NOVEL POTENTIAL PREDICTIVE TARGETS TO 

ANTI-ANGIOGENIC THERAPY RESPONSE IN GLIOBLASTOMAS. OLGA CATARINA 

LOPES MARTINHO, VERA MIRANDA-GONÇALVES, RUI MANUEL REIS 

B - 11 IMMUNOHISTOCHEMICAL EXPRESSION OF BETA-CATENIN, WNT-1 

AND C-MYC IN BASAL CELL ADENOMAS FROM SALIVARY GLAND. JOÃO PAULO 

SILVA SERVATO, ADRIANO MOTA LOYOLA, ANA LÚCIA AMARAL EISENBERG, 

FERNANDO LUIZ DIAS, PAULO ROGÉRIO DE FARIA, SÉRGIO VITORINO CARDOSO 

B - 12 CITOTOXICITY BY SELENIUM IN LUNG ADENOCARCINOMA CELLS. 

LUDMILLA REGINA DE SOUZA DAVID, MAYARA SIMONELLY COSTA DOS SANTOS, 

MARÍLIA CRISTINA ROSA DA COSTA, LUIS ALEXANDRE MUEHLMANN, RICARDO 

BENTES DE AZEVEDO, SÔNIA NAIR BÁO 

90

B - 13 ANTITUMORAL POTENTIAL ABILITY OF EXTRACELLULAR ATP 

AGAINST LEUKEMIC STEM CELLS. ANTONIO CARLOS RIBEIRO FILHO, EDGAR 

JULIAN PAREDES GAMERO, CHRISTIANO MARCELO VAZ BARBOSA, AMANDA 

NOGUEIRA PEDRO 

B - 14 CARDIAC ALTERATIONS INDUCED BY DOCETAXEL AND 

CYCLOPHOSPHAMIDE. VERA MARIA ARAÚJO DE CAMPOS, SAMARA CRISTINA 

FERREIRA-MACHADO, CAMILA SALATA, CAMILA SALATA, NAZARETH NOVAES 

ROCHA, CARLOS ALBERTO MANDARIM-DE-LACERDA, CARLOS EDUARDO 

DEALMEIDA 

B -15 CELL DEATH INDUCED BY RHODIUM (II) CITRATE LOADED 

MAGNETIC NANOPARTICLES IN BREAST CANCER CELLS. NATALIA LEMOS CHAVES, 

JOSÉ RAIMUNDO CORRÊA, MARCELLA LEMOS BRETAS, APARECIDO RIBEIRO DE 

SOUZA, SÔNIA NAIR BÁO 

B -16 LOW-INTENSITY INFRARED LASER EXPOSURE ALTERS EXPRESSION 

OF DNA REPAIR GENES. ADENILSON DE SOUZA DA FONSECA, VERA MARIA 

ARAÚJO DE CAMPOS, SAMARA CRISTINA FERREIRA-MACHADO, ANTÔNIO 

AUGUSTO DE FREITAS PEREGRINO, CARLOS EDUARDO VELOSO DE ALMEIDA, 

ANDRÉ LUIZ MENCALHA, MAURO GELLER, FLÁVIA DE PAOLI 

B -17 CASPASE-3 ACTIVATION AND INCREASED PROCOLLAGEN TYPE I IN 

RADIATION HEART INDUCED LATE EFFECTS. SAMARA CRISTINA FERREIRA- 

MACHADO, CAMILA SALATA, NAZARETH DE NOVAES ROCHA, ALEXANDRE FELIPE 

SILVA CORRÊA, SUZANA CÔRTE-REAL FARIA, VERA MARIA ARAÚJO DE CAMPOS, 

CHERLEY BORBA VIEIRA DE ANDRADE, ANTÔNIO AUGUSTO DE FREITAS 

PEREGRINO, ADENILSON DE SOUZA DA FONSECA, FLÁVIA DE PAOLI, CARLOS 

EDUARDO DEALMEIDA 

B - 18 ACTIVATED WNT SIGNALING PATHWAY IS NOT INFLUENCED BY 

ABSENCE OF GALECTIN-3 IN MICE DURING TONGUE MALIGNANT 

TRANSFORMATION. MARCUS VINÍCIUS RODRIGUES DE SOUZA, MONICA LUIZA 

CAMARGOS LOPES, WANDERSON DE ALMEIDA RAMOS, ROGER CHAMMAS, 

JULIANA MOREIRA DE ALMEIDA SANT’ANA, DANIELLA FERNANDES MENDONÇA, 

ADRIANO MOTA LOYOLA, SÉRGIO VITORINO CARDOSO, PAULO ROGÉRIO DE FARIA 

B - 19 ESTABLISHMENT OF PRIMARY GLIOBLASTOMA CELL CULTURES 

FOR NEW TREATMENT APPROACHES SCREENING. RENATO JOSÉ DA SILVA 

OLIVEIRA, OLGA MARTINHO, CARLOS CLARA, JOSÉ REYNALDO ALMEIDA, RUI 

MANUEL REIS 

B - 20 DNA REPAIR ENZYMES ON PLASMIDS EXPOSED TO LOW-INTENSITY 

INFRARED LASER. KEILA DA SILVA CANUTO, ROBERTA DA SILVA MARCIANO, LUIZ 

PHELIPPE DA SILVA SERGIO, OSCAR ROBERTO GUIMARÃES, GIOVANNI AUGUSTO 

CASTANHEIRA POLIGNANO, MAURO GELLER, FLAVIA DE PAOLI, ADENILSON DE 

SOUZA DA FONSECA 

B - 21 CELLULAR BEHAVIOR OF PROSTATE CANCER IN AN 

INFLAMMATORY MICROENVIRONMENT. AMADO ALFREDO QUINTAR, CAROLINA 

LEIMGRUBER, MARIANA MACCIONI, ANDREAS DOLL, CRISTINA ALICIA 

MALDONADO 

B - 22 ANTITUMOR EFFECT OF RHODIUM(II) CITRATE-LOADED MAGNETIC 

NANOPARTICLES IN MICE BEARING BREAST CANCER. SÔNIA NAIR BÁO, ANA 

LUISA MIRANDA VILELA, RICARDO GUIRELLI SIMÕES DE OLIVEIRA, LUÍS AUGUSTO 

M. TELLES, SÔNIA NAIR BÁO 

B - 23 RESVERATROL AND QUERCETIN INDUCE SENESCENCE-LIKE 

GROWTH ARREST IN GLIOMA CELLS BY INCREASING DNA DAMAGE. LAUREN 

LUCIA ZAMIN, EDUARDO C. FILIPPI-CHIELA, ALESSANDRA PELEGRINI, CHRISTIANNE 

SALBEGO, GUIDO LENZ 

B -24 ANALYSIS OF THE CYTOTOXIC POTENTIAL OF JUÇARA EXTRACTS 

(EUTERPE OLERACEA MART.) IN HUMAN MALIGNANT CELLS. DULCELENA 

FERREIRA SILVA, MARIA DO DESTERRO SOARES BRANDÃO NASCIMENTO, FLÁVIA 

CASTELLO BRANCO VIDAL, JOSÉ ANDRÉS MORGADO DÍAZ, SIMONE FERNANDES, 

PRISCILA DANTAS, DÉBORA SANTOS, MARIA CÉLIA PIRES COSTA, WALBERT EDSON 

MUNIZ FILHO, ROBERTO SOARES DE MOURA 

B - 25 MYOSIN II EXPRESSION AND REGULATION ON ORAL SQUAMOUS 

CELL CARCINOMA. OTÁVIO FRANCISCO GOMES DIAS, BERNARDO SALIM SILVEIRA, 

ALESSANDRA MAGNUSSON, ISABEL DA SILVA LAUXEN, MANOEL SANT'ANA FILHO, 

MARCELO LAZZARON LAMERS 

B - 26 FINASTERIDE TREATMENT DOWNREGULATES FIBRONECTIN- 

INDUCED MMP-2 AND MMP-9 ACTIVITIES IN HUMAN PROSTATIC EPITHELIAL 

CELLS. ANDREI MOROZ, FLAVIA KARINA DELELLA, ELENICE DEFFUNE, SÉRGIO LUIS 

FELISBINO 

B - 27 IN VITRO ANTITUMOR ACTIVITY OF EXTRACTS FROM ENDOPHYTIC 

FUNGI ASSOCIATED WITH CLUSIA SP. ANTONIO CESAR CORRÊA SILVA FILHO, LUIZ 

HENRIQUE ROSA, LUCIANA MARIA SILVA 

B - 28 CYTOTOXIC ACTIVITY OF PYRANONAPHTHOQUINONES AGAINST 

TWO DIFFERENT LEUKEMIA CELL LINES. PATRÍCIA CRISTINA RODRIGUES, SABRINA 

BAPTISTA FERREIRA, VITOR FRANCISCO FERREIRA, FLORIANO PAES SILVA JUNIOR 

B - 29 INTRACELLULAR OXIDATIVE STRESS IS ASSOCIATED WITH NON- 

SMALL CELL LUNG CANCER HUMAN CELL LINES AGGRESSIVENESS. FERNANDA 

STAPENHORST FRANÇA, LEONARDO LISBOA MOTTA, JULIANE BORBA MINOTTO, 

MATHEUS BECKER FREITAS, GUILHERME ANTÔNIO BEHR, ALFEU ZANOTTO-FILHO, 

MELISSA MEDEIROS MARKOSKI, JOSÉ CLÁUDIO FONSECA MOREIRA, FÁBIO KLAMT 

B - 30 SUPEROXIDE ANION MODULATES DNMT1 LEVELS VIA 

RAS/MEK/ERK PATHWAY DURING MELANOCYTE MALIGNANT 

TRANSFORMATION ASSOCIATED WITH SUSTAINED STRESS CONDITION. 

FERNANDA MOLOGNONI, FABIANA HENRIQUES MACHADO DE MELO, TIAGO 

FRANCO DE OLIVEIRA, ANA PAULA DE MELO LOUREIRO, MIRIAM GALVONAS 

JASIULIONIS 

B - 31 LOW-INTENSITY RED LASER DEACRESES SURVIVAL OF PLASMIDS IN 

ESCHERICHIA COLI PROFICIENT AND DEFICIENT ON DNA REPAIR CELLS. ROBERTA 

DA SILVA MARCIANO, LUIZ PHILIPPE DA SILVA SERGIO, OSCAR ROBERTO 

GUIMARÃES, GIOVANNI AUGUSTO CASTANHEIRA POLIGNANO, MAURO GELLER, 

FLAVIA DE PAOLI, ADENILSON DE SOUZA DA FONSECA 

B - 32 HPV INFECTION CORRELATION IN THE PATHOGENESIS OF 

CERVICAL CANCER. KEILA ALVES DA SILVA, SORAYA LOBATO, ANNAMARIA 

RAVARA VAGO 

B - 33 IN VITRO ANTITUMOR ACTIVITY OF SYNTHETIC SCHIFF BASES IN 

HUMAN CELL LINES. MARIANA DE PAULA LAZAROTTI, JOSIANE BARBOSA PIEDADE, 

CLEITON MOREIRA DA SILVA, LEANDRO NUNES SAMPAIO, ANGELO DE FÁTIMA, 

LUCIANA MARIA SILVA 

B - 34 CYTOTOXICITY OF SYNTHETIC ANALOGS OF VISCOSALINE AND 

THEONELLADIN C. JULIANA REY CANUTO SANT”ANA PEREIRA, ALINE BRITO DE 

LIMA, GUSTAVO HENRIQUE RIBEIRO VIANA, LUCIANA MARIA SILVA, FERNANDO DE 

PILLA VAROTTI 

B - 35 THE ROLE OF GPC3 IN CELL PROLIFERATION IN CELL LINES OF 

RENAL CARCINOMA. MARINA CURADO VALSECHI, ANA BEATRIZ BORTOLOZO DE 

OLIVEIRA, MARÍLIA DE FREITAS CALMON, PAULA RAHAL 

B - 36 BIOLOGICAL EFFECTS OF MAGNETIC NANOPARTICLES: STUDIES IN 

VITRO AND IN VIVO FOR POTENTIAL STRATEGIES IN ORAL CARCINOMA. NATALIA 

MARIA CANDIDO, MARILIA DE FREITAS CALMON, ARYANE TOFANELLO SOUZA, 

SEBASTIÃO ROBERTO TABOGA, JOSÉ GERALDO NERY, PAULA RAHAL 

B - 37 ANTI-MRP1 ACTIVITY OF 3B-ACETYL TORMENTIC ACID, A 

PENTACICLIC TRITERPENE FROM CECROPIA LYRATILOBA. GLEICE DA GRAÇA 

ROCHA, RODRIGO RODRIGUES DE OLIVEIRA, MARIA A.C. KAPLAN, CERLI ROCHA 

GATTASS 

B - 38 ANTITUMOR ACTIVITY OF POMOLIC ACID IN GLIOBLASTOMA 

MULTIFORME CELL LINE. LÍVIA PAES TAVARES PACHECO GUIMARÃES, CERLI 

ROCHA GATTASS 

B - 39 EPITHELIAL-MESENCHYMAL TRANSITION IN CERVIX CARCINOMA: 

DONWREGULATION OF E-CADHERIN IN INVASION FRONT. PRISCILA SAMARA 

SARAN, SILVIA VANESSA LOURENÇO, CLÁUDIA MALHEIROS COUTINHO-CAMILLO, 

FERNANDO AUGUSTO SOARES 

B - 40 TUMORSPHERE GROWTH AND CANCER STEM CELL POPULATION 

ARE REDUCED BY EXTRACELLULAR ATP IN GLIOBLASTOMA CELLS. PÍTIA FLORES 

LEDUR, EMILLY SCHLEE VILLODRE, GUIDO LENZ 

B - 41 ANTI-INFLAMMATORY PROTEIN ANNEXIN-1 AND FORMYL PEPTIDE 

RECEPTOR-2 AS THERAPEUTIC TARGETS FOR HUMAN LARYNX CANCER. THAÍS 

SANTANA GASTARDELO, LUCAS RIBEIRO DE AZEVEDO, FLÁVIA CRISTINA 

RODRIGUES LISONI, BIANCA DA CUNHA RODRIGUES, ELOIZA HELENA SILVA 

TAJARA, SÉRGIO LUIS RAPOSO, JOSÉ VICTOR MANIGLIA, PATRÍCIA MALUF CURY, 

SONIA MARIA OLIANI 

B - 42 EVALUATION OF LANGERHANS CELLS DENSITY AND HPV 

INFECTION IN CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS AND INVASIVE 

CANCER. DANIELE DE SOUZA CAMARGOS, ALEXANDRE TAFURI, PAULA ÁVILA 

FERNANDES, MARCELO VIDIGAL CALLIARI, MARCOS XAVIER SILVA, ANNAMARIA 

RAVARA VAGO 

B - 43 CELLULAR PRION-HEAT-SHOCK ORGANIZING PROTEIN 

INTERACTION AS A NOVEL THERAPEUTIC TARGET FOR GLIOBLASTOMAS. LOPES, 

M.H, QUEIROZ-HAZARBASSANOV N.G.T, RODRIGUES, B. R., SANTOS, T. G., CUNHA 

I.W., OBA-SHINJO, S.M, MARIE, S.K.N., MARTINS, V.R. 

B - 44 COMPARATIVE ANTITUMOR EFFECT OF DIGITALIS ON CERVIX AND 

COLON CANCER CELL LINES. SAYONARAH CARVALHO ROCHA, LUIZA DAL-RIOS 

NEVES, MARCO TULIO CORREA PESSOA, SILMARA LUCIA GREGO ALVES, ISABELLA 

VIANA SILVA, LUCIANA MARIA DA SILVA, JOSÉ AUGUSTO FP VILLAR, FABIO VIEIRA 

DOS SANTOS, FERNANDO DE PILLA VAROTTI, LEANDRO AUGUSTO BARBOSA 

B - 45 THE INFLUENCE OF O-GLCNACYLATION IN THE MOTILITY OF 

ALVEOLAR EPHITHELIAL CANCER CELLS. JOANA LAUREANO DONADIO, ANA CLARA 

BRANDÃO MEDINA DOLHER SOUZA, PATRÍCIA DE CARVALHO CRUZ, LEONARDO 

FREIRE-DE-LIMA, ADRIANE REGINA TODESCHINI, WAGNER BARBOSA DIAS 

B - 46 GENETICS OF GLIOMA-ROLE OF A RNA BINDING PROTEIN IN 

MALIGNANCY. KUMAR SOMASUNDARAM 

B - 47 ANTINEOPLASTIC EFFECT OF TWO DIFFERENT APPROACHES OF 

LQB-118 ADMINISTRATION IN MURINE MELANOMA MODEL. EDUARDO 

SALUSTIANO JESUS DOS SANTOS, GABRIEL GONÇALVES DA SILVA SANTOS, 

MATHEUS LOURENÇO DUMAS, ALCIDES JOSÉ MONTEIRO DA SILVA, PAULO 

ROBERTO RIBEIRO COSTA, VIVIAN MARY BARRAL DODD RUMJANEK 

91

B -48 LECTIN OBTAINED OF CAULIFLOWER (BRASSICA OLERACEA VAR. 

BOTRITYS) INHIBITS PROLIFERATION OF CELL LINEAGE OF BREAST CANCER. 

MONISE VIANA ABRANCHES, LORENA NACIF MARÇAL, NATÁLIA CRISTINA SANTOS 

COSTA, SÍLVIA ALMEIDA CARDOSO, SÉRGIO OLIVEIRA DE PAULA, LEANDRO LICURSI 

DE OLIVEIRA 

B - 49 EFFECT OF EPIGENETIC DRUGS IN ANTI-HORMONAL TREATMENT 

OF BREAST TUMOR CELL LINES. DANIELA FILIPPINI IERARDI, GIMENA AGUIAR, 

MIRIAM GALVONAS JASIULIONIS 

B - 50 SURVIVAL PROGENY DERIVED FROM IRRADIATED PARENTAL 

COLORECTAL CANCER CELLS: MORFOLOGICAL AND FUNCTIONAL ANALYSIS. 

PRISCILA GUIMARÃES DE MARCONDES, LÍLIAN GONÇALVES BASTOS, JOSÉ ANDRÉS 

MORGADO DÌAZ 

B - 51 ANALYSIS OF CLASSIC CADHERINS EXPRESSION IN A MURINE 

MELANOMA MODEL. LORENA NACIF MARÇAL, ROSEMAIRY LUCIANE MENDES, 

MARCELO LOBATO MARTINS, ADILSON ARIZA ZACARO 

B - 52 RETINOBLASTOMA (RB) PROTEIN KNOCK-DOWN INCREASES 

APOPTOSIS AND REDUCES ACID VESICLES FORMATION IN GLIOBLASTOMA 

ETOPOSIDE TREATED CELLS. DEBORAH BIASOLI, SUZANA ASSAD KHAN, TAIS 

AZEVEDO, VIVALDO MOURA-NETO, HELENA LOBO BORGES 

B - 53 TRANSGLUTAMINASE 2 ACTIVATES BOTH CASPASE-DEPENDENT 

AND CASPASE-INDEPENDENT APOPTOTIC CELL DEATH VIA CALPAIN/BAX 

SIGNALING PATHWAY IN RESPONSE TO PHOTODYNAMIC THERAPY. JE-OK YOO, 

YOUNG-CHEOL LIM, YOUNG-MYEONG KIM, KWON SOO HA 

B - 54 MINICHROMOSOME MAINTENANCE 7 PROTEIN IS A RELIABLE 

BIOLOGICAL MARKER FOR HUMAN CERVICAL PROGRESSIVE DISEASE. SORAYA 

LOBATO, ALEXANDRE TAFURI, PAULA ÁVILA FERNANDES, MARCELO VIDIGAL 

CALIARI, MARCOS XAVIER SILVA, MARCELO ANTÔNIO PASCOAL XAVIER, 

ANNAMARIA RAVARA VAGO 

B - 55 IMMUNOMODULATORY AND ANTINEOPLASTIC EFFECT OF LQB- 

118, A PTEROCARPANOQUINONE, IN VIVO. VIVIAN MARY BARRAL DODD 

RUMJANEK, EDUARDO SALUSTIANO JESUS DOS SANTOS, ALCIDES JOSE MONTEIRO 

DA SILVA, PAULO ROBERTO RIBEIRO COSTA, VIVIAN MARY BARRAL DODD 

RUMJANEK 

B - 56 TARGETING METNASE TO ENHANCE CHEMOTHERAPY. ANDREI 

LEITÃO, ELIZABETH A. WILLIAMSON, LEAH DAMIANI, CHELIN HU, HELEN 

HATHAWAY, TUDOR I. OPREA, LARRY SKLAR, MONTASER SHAHEEN, JULIE 

BAUMAN, WEI WANG, JAC A. NICKOLOFF, SUK-HEE LEE, ROBERT HROMAS 

B - 57 THE ROLE OF GLUTAMINASE-INTERACTING PROTEIN AND LIVER- 

TYPE GLUTAMINASE ASSOCIATION ON CELL REDOX HOMEOSTASIS. ROBERTA 

CASAGRANDE SAEZ, KALIANDRA DE ALMEIDA GONÇALVES, SANDRA MARTHA 

GOMES DIAS 

B - 58 VEGFR-3 EXPRESSION IN CERVICAL CARCINOMA AS A BIOMARKER 

OF TUMOR RESPONSE TO RADIOCHEMOTHERAPY. IOANA-CARMEN BRIE, 

VIORICA NAGY, NICOLAE TODOR, RARES BUIGA, OVIDIU BALACESCU, LUMINITA 

LELUTIU, CLAUDIA ORDEANU, EVA FISCHER-FODOR 

B - 59 CALLUNA VULGARIS INDUCES APOPTOSIS AND INHIBITS INVASION 

IN A431 HIGHLY METASTATIC EPIDERMOID CARCINOMA CELL LINE. MARIA 

PERDE-SCHREPLER, EVA FISCHER FODOR, CORINA TATOMIR, TIBOR KRAUSZ, CALIN 

PRECUP 

B - 60 EFFECT OF THE COMPOUND A2CN ON THE CYTOTOXITY IN 

LEUKEMIC CELL LINES. CAIO CÉSAR BARBOSA BOMFIM, GLÁUCIA VERÍSSIMO 

FAHEINA MARTINS, BRUNA BRAGA DANTAS, ALETHÉIA LACERDA DA SILVEIRA, 

CLAUDIO GABRIEL LIMA JUNIOR, MÁRIO LUIZ ARAUJO DE ALMEIDA 

VASCONCELLOS, DEMETRIUS ANTONIO MACHADO DE ARAÚJO 

B - 61 IDENTIFICATION OF NOVEL MOLECULAR MARKERS IN HUMAN 

GLIOBLASTOMA WITH THERAPEUTIC POTENTIAL. LAURA BEATRIZ DA SILVA 

CARDEAL, ALINNE LE FOSSE, JUSSARA MICHALOSKI, RAFAEL MALAGOLI, RICARDO 

JOSE GIORDANO 

B - 62 A CASE OF DISSEMINATED NEOPLASIA IN MANGROVE OYSTERS 

CRASSOSTREA GASAR. NATANAEL DANTAS FARIAS, FERNANDO RAMOS 

QUEIROGA, HELENE HÉGARET, PHILIPPE SOUDANT, LUIS FERNANDO MARQUES 

SANTOS, PATRÍCIA MIRELLA DA SILVA SCARDUA 

B - 63 MORPHOLOGICAL FEATURES OF THE MELANOMA B16F10 AND 

B16F0 CELL LINES AND TUMORS. JULIANNA MARIA DA CUNHA DE OLIVEIRA 

SANTOS, EULÓGIO CARLOS CARVALHO, FÁBIO LOPES OLIVARES, WILLIAM 

RODRIGUES FREITAS, LAYLA JANAÍNA HISSA BORGES, MILTON KANASHIRO, LUIS 

OTTONIEL LATORRE, CAMILA CRUZ RIBEIRO, ARNOLDO ROCHA FAÇANHA 

B - 64 IN VITRO STUDY OF ASSOCIATION OF NATURAL COMPOUNDS AND 

CHEMOTHERAPY. AMANDA VALLE PINHATTI, ANA ABUJAMRA, FRANCISCO 

MAIKON CORRÊA DE BARROS, CAROLINE FARIAS BRUNETTO, GILBERTO 

SCHWARTSMANN, GILSANE VON POSER 

B - 65 CYTOPLASMIC DISTRIBUTION OF KAISO IN BLAST CRISIS OF 

CHRONIC MYELOID LEUKEMIA. GREYCE CHRISTINE LISBOA BUENO, JAIME COFRE, 

PIETRO LENTZ MARTINS CANTÚ, JOÃO RICARDO LACERDA DE MENEZES, ELIANA 

ABDELHAY, LUCIANA PIZZATTI 

B -66 LYCOPENE AND BETA-CAROTENE INDUCE GROWTH-INHIBITORY 

AND PROAPOPTOTIC EFFECTS ON PITUITARY TUMOR CELLS. NATÁLIA FERREIRA 

HADDAD, ANDERSON JUNGER TEODORO, FELIPE LEITE DE OLIVEIRA, NATHÁLIA 

SOARES, RÔMULO MEDINA DE MATTOS, RÔMULO DEZONNE, FLÁVIA C. 

ALCÂNTARA GOMES, MÔNICA ROBERTO GADELHA, LUIZ EURICO NASCIUTTI, 

LEANDRO MIRANDA-ALVES 

B - 67 EFFECT FROM A POLYSACHARIDE FROM SARGASSUM VULGARE IN 

ENDOTHELIAL AND TUMORAL CELL LINES: A NEW STRATEGY FOR ANTITUMOR 

AND ANTIANGIOGENIC. CELINA MARIA PINTO GUERRA DORE, MONIQUE 

GABRIELA DAS CHAGAS FAUSTINO ALVES, TIAGO GOMES COSTA, MARÍLIA SILVA 

DO NASCIMENTO, HUGO WESCLEY BARROS ALMEIDA, ALMINO AFONSO DE 

OLIVEIRA PAIVA, LUCIANA GUIMARÃES ALVESFILGUEIRA, EDDA LISBOA LEITE 

B - 68 EGF MODULATES CLAUDIN EXPRESSION INCREASING THE 

TUMORIGENIC POTENTIAL IN COLORECTAL CANCER CELLS. NATALIA FORTUNATO 

DE MIRANDA, WALDEMIR FERNANDES DE SOUZA, BRUNO KAUFMANN ROBBS, 

JOÃO PAULO DE BIASO VIOLA, JOSÉ ANDRÉS MORGADO DÍAZ 

B - 69 SHH SIGNALING PATHWAY IN MODULATING GBM 

PROLIFERATION. TANIA CRISTINA LEITE DE SAMPAIO E SPOHR, INGRID 

ROSENBURG CORDEIRO, JOSÉ MARQUES BRITO NETO, VIVALDO MOURA NETO 

B - 70 DIFFERENTIALLY EXPRESSED STEM CELL MARKERS IN BREAST 

CANCER STEM CELLS. ALINE RAMOS MAIA LOBBA, MARIA FERNANDA FORNI, ANA 

CLAUDIA OLIVEIRA CARREIRA, MARI CLEIDE SOGAYAR 

B - 71 ROLES OF NUP98 IN GENE EXPRESSION REGULATION AND ITS 

LINKS TO CARCINOGENESIS. JULIANA S. CAPITANIO, RICHARD W. WOZNIAK 

B - 72 IN VITRO ANTICANCER ACTIVITY OF N-GLYCAN BIOSYNTHESIS 

INHIBITORS IN COLORECTAL CANCER CELLS. CARLOS ALBERTO FREIRE NETO, 

JULIO CESAR MADUREIRA DE FREITAS JUNIOR, JOSÉ ANDRES MORGADO-DÍAZ 

B - 73 SEX HORMONES EFFECTS ON ADAMTS-1 LEVELS IN NORMAL AND 

TUMORAL BREAST CELLS. SUÉLY VIEIRA DA SILVA, SHEILA CRISTINA ROSAS DE 

ARGÔLO, EMERSON SANTOS, VANESSA MORAIS FREITAS 

B - 74 LAMININ-DERIVED PEPTIDES C16 AND AG73 REGULATE 

EXPRESSION LEVELS OF SPOCK-1 AND MT1-MMP IN BREAST CANCER CELLS. 

BASILIO SMUCZEK, EMERSON DE SOUZA SANTOS, VANESSA M. DE FREITAS, RUY 

GASTALDONI JAEGER 

B - 75 IDENTIFICATION OF CRUDE EXTRACT MOLECULES FROM BEANS 

INVOLVED IN SKIN CANCER PREVENTION. GRAZIELLA ANSELMO JOANITTI, 

EDUARDO FERNANDES BARBOSA, LUCIANO PAULINO SILVA, RICARDO BENTES 

AZEVEDO, SONIA MARIA DE FREITAS 

B - 76 PTEN OVEREXPRESSION REVERTS THE MALIGNANT PHENOTYPE OF 

COLORECTAL CANCER CELLS IN AN EVENT MEDIATED BY THE WNT/B-CATENIN 

PATHWAY. WALLACE MARTINS DE ARAÚJO, PEDRO DANIEL SILVA DE MORAES, 

BRUNO KAUFMANN ROBBS, JOÃO PAULO DE BIASO VIOLA, JOSÉ ANDRES 

MORGADO-DÍAZ 

B - 77 EFFECTS OF HCG AND DERIVETED-ANGIOTENSIN PEPTIDES ON CELL 

VIABILITY AND APOPTOSIS IN TUMORAL (MCF-7) AND NORMAL (MCF10A) 

EPITHELIAL BREAST CELLS. CORREA-NORONHA, SAA, NORONHA, SMR, 

ROZENCHAN, PB, BERNARDO, W, SHIMUTA, SI, NAKAIE, CR, GEBRIM, LH, NAZARIO, 

ACP, SILVA, IDCG 

B - 78 ATYPICAL FUNCTIONS OF THE CELL CYCLE INHIBITOR 

P21WAF1/CIP1: A POSSIBLE ROLE IN SURVIVAL OF MELANOMA CELLS. GABRIELA 

NANA COLANERI, ADRIANA TAVEIRA DA CRUZ, ROBERTA SESSA STILHANO, SANG 

WON HAN, MIRIAM GALVONAS JASIULIONIS 

B - 79 LPA INDUCES CELL PROLIFERATION THROUGH A RHO-ROCK 

SIGNALING IN HCT-116 CELLS. RUBEM JOSÉ PERES MOREIRA, FERNANDA LEVE, 

JOSÉ ANDRÉS MORGADO-DÍAZ 

B - 80 STEPS TOWARD NOVEL ANTI-VEGF THERAPEUTIC AGENTS. 

JUSSARA MICHALOSKI SOUZA, RICARDO JOSÉ GIORDANO 

B - 81 DIFFERENTIAL PROTEINS EXPRESSION IN CANCER CELL LINES 

SKBR3 AND MCF-7 BY 17 BETA-ESTRADIOL (E2), ICI 182,780 AND G1. MILENE 

SCHMIDT LUNA, ANDRÉIA DE SOUZA, CINTIA SCUCUGLIA HELUANY, CATARINA 

SEGRETI PORTO, NORMA YAMANOUYE 

B - 82 APOPTOSIS INDUCTION BY PHORBOL ESTER-RESPONSIVE PKC 

ISOFORMS IN HUMAN EMBRYONIC KIDNEY CELL LINES (HEK 293) DISPLAYING A 

RAS-DEPENDENT MALIGNANT PHENOTYPE. JULIANA GALVÃO DA SILVA, HUGO 

AGUIRRE ARMELIN 

B - 83 THE EFFECT IN VITRO OF ANTI-INFLAMMATORY PROTEIN ANNEXIN 

A1 ON TUBULOGENESIS AND CELL ADHESION. JÉSSICA ZANI LACERDA, THAÍS 

SANTANA GASTARDELO, CARINE CRISTIANE DREWES, SANDRA HELENA POLISELLI 

FARSKY, SONIA MARIA OLIANI 

B - 84 EVALUATION OF CELL ADHESION IN BREAST AND LARYNGEAL 

CANCER CELLS WITH PHOTODYNAMIC THERAPY. GEISA NOGUEIRA SALLES, 

JULIANA MACEDO COSTA COUCEIRO, CRISTINA PACHECO SOARES 

92

B - 85 CONDITIONED MEDIA FROM EPITHELIAL OVARIAN CANCER CELL 

LINES CHRONICALLY EXPOSED TO CISPLATIN IS CAPABLE OF INDUCING 

APOPTOSIS IN NAIVE CELLS. ALICE LASCHUK HERLINGER, CELSO CARUSO NEVES, 

LETICIA BATISTA AZEVEDO RANGEL 

B - 86 SUPER-EXPRESSION OF RAS AND SILENCE OF SYNDECAN-4 IS 

RELATED WITH TUMORIGENESIS. RENAN PELLUZZI CAVALHEIRO, THAIS RUEGGER 

JARROUGE-BOUÇAS, RODRIGO IPPOLITO BOUÇAS, GABRIEL LOPES ARGELLO 

CUNHA, VIVIEN JANE COULSON-THOMAS, TARSIS GESTEIRA FERREIRA, EDUARDO 

HENRIQUE CUNHA DE FARIAS, MARCELO ANDRADE DE LIMA, EDVALDO DA SILVA 

TRINDADE, EDGAR JULIAN PAREDES-GAMERO, JULIANA LUPORINI DREYFUSS, 

CARLA CRISTINA LOPES DE AZEVEDO, HELENA BONCIANI NADER 

B - 87 ATP - INDUCED CELL DEATH BY P2X7 RECEPTOR IN HUMAN 

CERVICAL CARCINOMA CELL LINE. PAOLA DE ANDRADE MELLO, EDUARDO C. 

FILIPPI-CHIELA, ALINE BECKENKAMP, DANIELLE SANTANA BERTODO, JESSICA 

NASCIMENTO, LUCIANA N. CALIL, EMERSON CASALI, ALESSANDRA NEJAR BRUNO, 

JULIANO PACCEZ, LUIZ FERNANDO ZERBINI, MÁRCIA R. WINK, GUIDO LENZ, 

ANDRÉIA BUFFON 

B - 88 PROGRESSION OF HUMAN GLIOBLASTOMA IN THE BRAIN 

PARENCHYMA FROM IMMUNOCOMPETENT MICE. CELINA GARCIA DA FONSECA, 

LUIZ HENRIQUE MEDEIROS GERALDO, LUIZ GUSTAVO DUBOIS, FERNANDA TOVAR- 

MOLL, JOÃO MENEZES, VIVALDO MOURA NETO, FLAVIA REGINA SOUZA LIMA 

B - 89 HUMAN GLIOBLASTOMA CANCER STEM CELLS ARE SENSITIVE TO 

DOXORUBICIN AND TEMOZOLOMIDE. EMILLY SCHLEE VILLODRE, PATRÍCIA 

LUCIANA DA COSTA LOPEZ, GUIDO LENZ 

B - 90 THE ROLE OF P53 IN THE TUMOR-MICROENVIRONMENT 

INTERACTION. MORGANA FERREIRA SOBRINHO, DEBORAH BIASOLI, DYANNA 

GALAXE DE MATOS, VIVALDO MOURA NETO, HELENA LOBO BORGES, FLAVIA 

REGINA SOUZA LIMA 

B - 91 BAUHINIA FORFICATA LECTIN (BFL) INDUCES MITOCHONDRIAL 

CELL DEATH AND INTEGRIN-MEDIATED ANTI-ADHESION ON MCF-7 HUMAN 

BREAST CANCER CELLS. MARIANA CRISTINA CABRAL SILVA, CLÁUDIA ALESSANDRA 

ANDRADE DE PAULA, JOANA GASPERAZZO FERREIRA, EDGAR JULIAN PAREDES- 

GAMERO, RODRIGO DA SILVA FERREIRA, MISAKO UEMURA SAMPAIO, MARIA 

TEREZA DOS SANTOS CORREIA, MARIA LUIZA VILELA OLIVA 

B - 92 MOLECULAR MARKER ANALYSIS IN HEAD AND NECK SQUAMOUS 

CELL CARCINOMA. ELAINE STUR, ELDAMÁRIA DE VARGAS WOLFGRAMM, LIDIANE 

PIGNATON AGOSTINI, LUCAS LIMA MAIA, LYVIA NEVES REBELLO ALVES, IÚRI 

DRUMOND LOURO 

B - 93 INCIDENCE OF HUMAN PAPILOMAVIRUS IN HEAD AND NECK 

SQUAMOUS CELL CARCINOMA IN ESPIRITO SANTO, BRASIL. LIDIANE PIGNATON 

AGOSTINI, MARIANA PENHA DE NADAI SARTORI, ELAINE STUR, ELDAMÁRIA DE 

VARGAS WOLFGRAM, IÚRI DRUMOND LOURO 

B - 94 PROTECTIVE ACTION IN NORMAL CELLS AND APOPTOSIS IN 

HUMAN LIVER CANCER CELLS BY THE PHYLLANTHUS NIRURI DRY EXTRACT. 

HUGO GONÇALO GUEDES, JÉSSICA AQUINO VILAÇA, ANA LUIZA CABRAL DE SÁ, 

AURIGENA ANTUNES DE ARAÚJO, GERLANE COELHO BERNARDO GUERRA, 

RAIMUNDO FERNANDES DE ARAÚJO JÚNIOR 

B - 95 PROGNOSTIC EVALUATION OF S100A4 AND P53 IN CERVICAL 

CANCER CELLS. JÉSSICA NASCIMENTO, REGINA BIASIBETTI, PATRÍCIA NARDIN, 

ALINE BECKENKAMP, DANIELLE BERTODO SANTANA, ALESSANDRA NEJAR BRUNO, 

LUCIANE CALIL, MARIA ISABEL A. EDELWEISS, CARLOS ALBERTO GONÇALVES, 

ANDRÉIA BUFFON 

B - 96 ROLE OF DLG5 IN PROSTATE CANCER PROGRESSION. LUCIA 

TOMIYAMA, TAKUHITO SEZAKI, KAZUMITSU UEDA, NORIYUKI KIOKA 

B - 97 THE ROLE OF LYSOPHOSPHATIDIC ACID IN THE MICROGLIA- 

GLIOBLASTOMA INTERACTION. RACKELE FERREIRA DO AMARAL, TANIA CRISTINA 

LEITE DE SAMPAIO E SPOHR, FABIO DE ALMEIDA MENDES, VIVALDO MOURA 

NETO, FLAVIA REGINA SOUZA LIMA 

B - 98 INTERACTION OF TWO DISINTEGRINS WITH BREAST TUMOR CELLS. 

ARACELI CRISTINA DURANTE, LÍVIA MARA SANTOS, HERNANDES FAUSTINO DE 

CARVALHO, EDWARD SHAW, CHARLOTTE LEDBETTER OWNBY, HELOÍSA SOBREIRO 

SELISTRE-DE-ARAÚJO 

B - 99 MOLECULAR CLONING AND EXPRESSION OF ALTERNAGIN-C, A 

DISINTEGRIN FROM RHINOCEROPHIS ALTERNATUS VENOM. LIVIA MARA 

SANTOS, VERÔNICA ASSALIN ZORGETTO, MÔNICA ROSAS DA COSTA IEMMA, 

ARACELI CRISTINA DURANTE, DULCE HELENA FERREIRA DE SOUZA, HELOISA 

SOBREIRO SELISTRE DE ARAÚJO 

B - 100 EVALUATION OF BREAST CANCER CELL LINES VIABILITY IN 

RESPONSE TO TREATMENT WITH MELATONIN. JULIANA RAMOS LOPES, BRUNA 

VICTORASSO JARDIM, LARISSA BAZELA MASCHIO, THAIZ FERRAZ BORIN, LÍVIA 

CARVALHO FERREIRA, NAIANE DO NASCIMENTO GONÇALVES, CAMILA LEONEL, 

MARINA GOBBE MOSCHETTA, GABRIELA BOTTARO GELALETI, DEBORA AP. PIRES 

DE CAMPOS ZUCCARI 

B - 101 GSH AND GSH-PX EXPRESSION IN PRIMARY CULTURE CELL OF 

CANINE MAMMARY TUMORS AFTER EXPOSURE TO DOXORUBICIN. CAMILA 

LEONEL DA SILVA, GABRIELA BOTTARO GELALETI, BRUNA VICTORASSO JARDIM, 

LÍVIA CARVALHO FERREIRA, JULIANA RAMOS LOPES, MARINA GOBBE MOSCHETTA, 

DEBORA AP. PIRES DE CAMPOS ZUCCARI 

B - 102 TESTING PHAGE CLONES FOR IMPROVE THYROID CANCER 

DIAGNOSTIC. CAROLINA FERNANDES REIS, PATRICIA TIEME FUJIMURA, FABIANA 

DE ALMEIDA ARAÚJO SANTOS, JOÃO PAULO BORGES, CARLOS UEIRA VIEIRA, LUIZ 

RICARDO GOULART, LAURA STERIAN WARD 

B - 103 POTENTIAL PROGNOSTIC VALUE OF CA 15-3 IN MAMMARY 

CANCER. GABRIELA BOTTARO GELALETI, CAMILA LEONEL, MARINA GOBBE 

MOSCHETTA, BRUNA VICTORASSO JARDIM, LARISSA BAZELA MASCHIO, LÍVIA 

CARVALHO FERREIRA, JULIANA RAMOS LOPES, THAIZ FERRAZ BORIN, NAIANE DO 

NASCIMENTO GONÇALVES, DEBORA APARECIDA PIRES DE CAMPOS ZUCCARI 

B - 104 PROLIFERATIVE EFFECTS OF POD1/TCF21 TRANSCRIPTION FACTOR 

IN HUMAN ADRENOCORTICAL TUMOR CELL CULTURES. MONICA MALHEIROS 

FRANÇA, MARIZA GERDULO SANTOS, BRUNO FERRAZ DE SOUZA, ANTONIO M. 

LERARIO, MARIA CANDIDA FRAGOSO, ANA CLAUDIA LATRONICO, BERENICE B. 

MENDONÇA, CLAUDIMARA FERINI PACICCO LOTFI 

B - 105 EFFECTS OF BRAZILIAN PALM TREE EXTRACT ON ACTH-SECRETING 

MOUSE PITUITARY TUMOR CELLS. FLÁVIA MOSCARDINI, NATALIA FERREIRA 

HADDAD, MARIA APARECIDA DE OLIVEIRA DOMINGOS, LÚCIO MENDES CABRAL, 

LEANDRO MIRANDA-ALVES, LUIZ EURICO NASCIUTTI 

B - 106 ROLE OF CANCER STEM CELLS IN GLIOBLASTOMA INVASION OF IN 

THE BRAIN PARENCHYMA. FERNANDO DOS SANTOS ASSUNÇÃO, GABRIELA BASILE 

CARBALLO, GRASIELLA MARIA VENTURA MATIOSZEK, CHARLES VARGAS LOPES, 

CAROLINE MOREIRA, CELINA GARCIA, HERVÉ CHNEIWEISS, ROGERIO ARENA 

PANIZZUTTI, SUZANA ASSAD KAHN, VIVALDO MOURA NETO 

B - 107 C-MYC EXPRESSION IN DYSPLASIAS AND CARCINOMAS 

DEVELOPED IN THE TONGUE FROM GALECTIN-3-DEFICIENT AND WILD-TYPE MICE 

CHALLENGED BY 4NQO. GUSTAVO JOSÉ DE MORAIS GONÇALVES, WANDERSON 

DE ALMEIDA RAMOS, ROGER CHAMMAS, ADRIANO MOTA LOYOLA, SERGIO 

VITORINO CARDOSO, PAULO ROGÉRIO DE FARIA 

B - 108 DIFFERENTIAL EXPRESSION AND ACTIVITY OF THE CD26/DPPIV IN 

HUMAN CERVICAL CARCINOMA CELLS. ALINE BECKENKAMP, DANIELLE BERTODO 

SANTANA, JÉSSICA NASCIMENTO, CAROLINE GUERRA MARANGON, JULIANO 

PACCEZ, LUIZ FERNANDO ZERBINI, MÁRCIA ROSÂNGELA WINK, ALESSANDRA 

NEJAR BRUNO, ANDRÉIA BUFFON 

B - 109 PHOSPHATIDIC ACID INCREASED BY LPP INHIBITION INDUCES 

LIGAND-INDEPENDENT EGFR ENDOCYTOSIS INVOLVING ACTIVATION OF MAPKS. 

CLAUDIA METZ, JUAN JUNG, CAROLINA OTERO, ANDREA SOZA, ALFONSO 

GONZÁLEZ 

B - 110 REGULATION OF FOCAL ADHESION KINASE ACTIVITY IN ORAL 

SQUAMOUS CELL CARCINOMA. BERNARDO SALIM SILVEIRA, OTAVIO FRANCISCO 

GOMES DIAS, ALESSANDRA MAGNUSSON, ISABEL DA SILVA LAUXEN, MANOEL 

SANT’ANA FILHO, MARCELO LAZZARON LAMERS 

B - 111 PHYLLANTHUS NIRURI EXTRACTS AND CISPLATIN HAVE GROWTH 

INHIBITORY EFFECTS ON CANCER CELL LINES. JESSICA AQUINO VILAÇA, 

RAIMUNDO FERNANDES DE ARAÚJO JÚNIOR 

B - 112 MECHANISMS OF FGF2 TOXICITY IN RAS-DRIVEN MALIGNANT 

CELLS: CELL DIVISION BLOCKAGE AND PROTEOTOXIC STRESS. MATHEUS 

HENRIQUE DOS SANTOS DIAS, FÁBIO NAKANO, CECÍLIA SELLA FONSECA, ANDRÉ 

ZELANIS PALITOT PEREIRA, SOLANGE MARIA DE TOLEDO SERRANO, HUGO 

AGUIRRE ARMELIN 

B - 113 EGF PROMOTES CELL MIGRATION IN LUNG CANCER CELL LINES. 

CAMILA LAUAND, PAULA REZENDE TEIXEIRA, EVANDRO LUÍS DE OLIVEIRA NIERO, 

GLÁUCIA MARIA MACHADO SANTELLI 

B - 114 THE SELECTION OF TUBULOGENESIS-DEFECTIVE/HIGHLY 

PROLIFERATIVE ENDOTHELIAL CELLS BY TENASCIN-C IN THE EXTRACELLULAR 

MATRIX OF GLIOMA CELLS INVOLVES THE OPPOSITE MODULATION OF PKC- 

ALPHA AND DELTA ISOFORMS. ALINE OLIVEIRA DA SILVA, TERCIA RODRIGUES 

ALVES, VIVALDO MOURA NETO, VERÔNICA MARIA MORANDI DA SILVA 

B - 115 SEX HORMONES INFLUENCE ADAMTS PROTEASE LEVELS IN 

OVARIAN TUMOR CELLS. MAÍRA DE ASSIS LIMA, VANESSA MORAIS FREITAS 

B - 116 THE EXPRESSION OF STAT3 IN THE NUCLEUS IS ASSOCIATED WITH 

PROLIFERATION IN GLIOBLASTOMA MULTIFORME. BRUNA ROZ RODRIGUES, 

MARILENE HOHMUTH LOPES, ISABELA WERNECK DA CUNHA, VILMA REGINA 

MARTINS 

B - 117 NF-KB COORDINATES EPITHELIAL-MESENCHYMAL TRANSITION 

PROPERTIES IN BREAST CANCER CELLS. BRUNO RICARDO BARRETO PIRES, ANDRE 

LUIZ MENCALHA, AMANDA DE MORAES MAIA, ELIANA SAUL FURQUIM WERNECK 

ABDELHAY 

B - 118 MODULATION OF ENDOTHELIAL CELLS BY HUMAN TUMOR 

MICROENVIRONMENT: A ROLE FOR SYNTHETIC ANALOGUES OF LIPOXINS. 

ANDREZA MAIA VIEIRA, EDWARD HELAL NETO, CAMILA CASTRO FIGUEIREDO, 

THEREZA CHRISTINA BARJA-FIDALGO, IOLANDA M. FIERRO, VERÔNICA MARIA 

MORANDI DA SILVA 

93

B - 119 MALIGNANT HODGKIN CELLS RELEASE CD30 ON MICROVESICLES 

TO FACILITATE CROSSTALK WITH CD30L ON DISTANT IMMUNE CELLS OF THE 

TUMOR MICROENVIRONMENT, IN VITRO. HINRICH P HANSEN, ELKE POGGE-VON- 

STRANDMANN, ADRIANA F PAES LEME, HANNA M ENGELS, VIJAYA L SIMHADRI, 

MARIA DAMS, ROLF SCHUBERT, FABIO QUONDAMATTEO 

B - 120 CELL PROLIFERATION EVALUATION OF THE CUTANEOUS 

SQUAMOUS CELL CARCINOMA IN MICE AFTER PHOTODYNAMIC THERAPY. ANA 

PAULA DA SILVA, FRANCISCO JAVIER HERNANDEZ BLAZQUEZ, DIVINOMAR 

SEVERINO, MAURICIO DA SILVA BAPTISTA, BRUNO COGLIATI, MARIA LÚCIA 

ZAIDAN DAGLI, ELISANGELA DOS ANJOS SILVA, CAMILA LIMA NEVES, JOSÉ 

ROBERTO MACHADO CUNHA DA SILVA 

B - 121 EVALUATION OF PRENEOPLASTIC LESIONS AND CELL 

PROLIFERATION IN EXPERIMENTAL HEPATOCARCINOGENESIS DEVELOPED IN 

CIRRHOTIC MICROENVIRONMENT. TANIA CRISTINA LIMA, CINTIA MARIA 

MONTEIRO DE ARAUJO, VENANCIO AVANCINI FERREIRA ALVES, MARIA LUCIA 

ZAIDAN DAGLI, BRUNO COGLIATI, FRANCISCO JAVIER HERNANDEZ BLAZQUEZ, 

JOSE ROBERTO MACHADO CUNHA DA SILVA 

B - 122 THE ROLE OF FMNL1 IN LEUKEMOGENESIS. PATRICIA MARIA 

BERGAMO FAVARO, JOAO AGOSTINHO MACHADO NETO, MARIANA LAZARINI, 

FABIOLA TRAINA, MATHEUS RODRIGUES LOPES, ELVIRA INFANTE, ANNE RIDLEY, 

FERNANDO FERREIRA COSTA, SARA OLALLA-SAAD 

B - 123 QUERCETIN: POSSIBLE EFFECT ANTI-MDR IN ERYTHROLEUKEMIA 

HUMAN CELL LINES. MAIARA BERNARDES MARQUES, REGINA COIMBRA ROLA, 

ANA PAULA DE SOUZA VOTTO 

B - 124 ANTIPROLIFERATIVE ACTIVITY OF LIPIDIC EXTRACTS OF MARINE 

MICROALGAE ON A MELANOMA CELL LINE: PARTICIPATION OF OMEGA-3 PUFA? 

RENATA OTTES VASCONCELOS, MICHELE MORAES DE SOUZA, ELIANA BADIALE 

FURLONG, PAULO CESAR OLIVEIRA VERGNE DE ABREU, MILENE MEDEIROS DE 

MORAES, JULIANA RAMOS GONZALEZ, ANA PAULA DE SOUZA VOTTO, GILMA 

SANTOS TRINDADE 

B - 125 LAMININ-DERIVED PEPTIDE C16 INDUCES INVASION AND 

INVADOPODIA FORMATION IN ORAL SQUAMOUS CELL CARCINOMA AND 

FIBROSARCOMA CELLS. ADRIANE SOUSA DE SIQUEIRA, MONIQUE PEREIRA PINTO, 

MÁRIO COSTA CRUZ, VANESSA MORAIS FREITAS, RUY GASTALDONI JAEGER 

B - 126 INHIBITION OF HEDGEHOG PATHWAY IN LEUKEMIC CELL LINEAGE 

RESULTS IN CELL CYCLE ARREST, DECREASE IN PROLIFERATION AND CLONOGENIC 

ABILITY WITHOUT INDUCED APOPTOSIS. JULIANA M XAVIER, SARA TEREZINHA 

OLALLA SAAD 

B -127 TUMOR METABOLITES MODULATE THE INTERACTION OF 

ENDOTHELIAL PROGENITOR CELLS AND MATURE ENDOTHELIAL CELLS: ROLE OF 

MATRIX METALLOPROTEASES AND AKT SIGNALING PATHWAY. FERNANDA 

RODRIGUES LANZANA FERREIRA, VERÔNICA MORANDI, CAMILA CASTRO 

FIGUEIREDO 

B - 128 EFFECTS OF FLAVONOIDS ON GLIOBLASTOMA CELLS. JULIANA 

MOREIRA SOARES, ANTONIO GOMES SOARES, VIVALDO MOURA NETO, LUCIANA 

FERREIRA ROMÃO 

B - 129 PARTIAL CHARACTERIZATION AND EVALUATION OF ANTITUMOR 

POTENTIAL OF AN L-AMINO ACID OXIDASE OBTAINED OF BOTHROPS 

JARARACUSSU. NATALIA CRISTINA SANTOS COSTA, MONISE VIANA ABRANCHES, 

LORENA NACIF MARÇAL, GRACIELLE RODRIGUES PEREIRA, HELIOMAR CAZELLI DE 

OLIVEIRA FILHO, RENATO NEVES FEIO, SÉRGIO OLIVEIRA DE PAULA, LEANDRO 

LICURSI DE OLIVEIRA 

B - 130 VINCRISTINE AND CHRYSOTILE INDUCE MULTIPOLAR MITOSIS IN 

LUNG CANCER CELLS BY DIFFERENT MECHANISMS. BEATRIZ DE ARAUJO CORTEZ, 

LUANA RIBEIRO RICARDI, GLAUCIA MARIA MACHADO SANTELLI 

B - 131 INHIBITION OF THE V-TYPE H+-ATPASE AFFECTS THE APOPTOSIS, 

MIGRATION AND INVASION CAPACITIES OF MELANOMA CELL LINES. GILDEÍDE 

APARECIDA COSTA, BRUNNA XAVIER MARTINS, DANIELE SEIPEL DA SILVA, ANDREA 

VETÖ ARNHOLDT, ANNA LVOVNA OKOROKOVA-FAÇANHA, ARNOLDO ROCHA 

FAÇANHA. 

B - 132 CHARACTERIZATION OF THE EXPRESSION OF NA+, K+-ATPASE 

SUBUNITS IN HUMAN BREAST CANCER CELLS. MELINA ALMEIDA DIAS, MÁRCIA 

ALVES MARQUES CAPELLA, ANÍBAL GIL LOPES 

B - 133 EFFECT OF S-NITROSOGLUTATHIONE ON 5-FLUOROURACIL 

INDUCED EXPERIMENTAL ORAL MUCOSITIS AND THE IMPACT OF ORAL 

MUCOSITIS ON BACTERIAL FLORA OF HAMSTERS. MARIA ADRIANA SKEFF DE 

PAULA MIRANDA, ANA PAULA VIEIRA COLOMBO, CARINA MACIEL DA SILVA- 

BOGHOSSIAN, CÍNTIA DE MELO BRAGA, MATHEUS MARTINS CAVALCANTE, 

VIVALDO MOURA NETO, RENATA FERREIRA DE CARVALHO LEITÃO 

B - 134 CELL MIGRATION IN T-CELL LYMPHOBLASTIC 

LEUKEMIA/LYMPHOMA: THE ROLE OF THE SPHINGOSINE-1-PHOSFATE RECEPTOR 

1. CAROLINA VALENÇA MESSIAS RACHID, JULIA PEREIRA LEMOS, WILSON SAVINO, 

DANIELLA ARÊAS MENDES-DA-CRUZ 

B - 135 THE HUMAN METASTATIC MELANOMA CELL LINE, SKMEL147, 

PRESENTS A DIFFERENT NUCLEOTIDE DEGRADATION PROFILE IN COMPARISON 

TO MELANOCYTES. CAROLINE GUERRA MARANGON, JÉSSICA MIETHICKI DA SILVA 

GONÇALVES, JULIANO DOMIRACI PACCEZ, LUIZ ZERBINI, SILVYA STUCHI MARIA 

ENGLER, ANDRÉIA BUFFON, MÁRCIA ROSÂNGELA WINK 

B - 136 ENTEROLOBIUM CONTORTISILIQUUM TRYPSIN INHIBITOR (ECTI), A 

PLANT PROTEINASE INHIBITOR, DECREASES IN VITRO CELL ADHESION AND 

INVASION BY INHIBITION OF SRC-FAK SIGNALING PATHWAYS. CLÁUDIA 

ALESSANDRA ANDRADE DE PAULA, VIVIEN JANE COULSON-THOMAS, JOANA 

GASPERAZZO FERREIRA, PALOMA KOREHISA MAZA, ERIKA SUZUKI, ADRIANA MITI 

NAKAHATA, HELENA BONCIANI NADER, MISAKO UEMURA SAMPAIO, MARIA LUIZA 

VILELA OLIVA 

B - 137 EXPRESSION OF HPSE1 BY PROSTATE CELL LINES AND ITS 

CONTRIBUTION TO TUMOR MICROENVIRONMENT. TAIZE MACHADO AUGUSTO, 

ANA MILENA HERRERA, HERNANDES F CARVALHO 

B - 138 XENOGRAPHIC TUMOR GROWTH USING LNCAP PROSTATE 

CANCER CELL LINE IN IMMUNE COMPETENT MICE. ANA MILENA HERRERA 

TORRES, TAIZE MACHADO AUGUSTO, HERNANDES F CARVALHO 

B - 139 FUCAN B FROM BROWN SEAWEED SPATOGLOSSUM SCHRÖEDERI 

AFFECTS VIABILITY OF DIFFERENT CANCER CELL LINEAGES AND INHIBITS 

ANGIOGENESIS. LEONARDO THIAGO DUARTE BARRETO NOBRE, ARTHUR 

ANTHUNES JÁCOME VIDAL, JAILMA ALMEIDA LIMA, RENAN PELLUZZI 

CAVALHEIRO, EDUARDO HENRIQUE CUNHA DE FARIAS, EDGAR JULIAN PAREDES 

GAMERO, HELENA BONCIANI NADER, HUGO ALEXANDRE DE OLIVEIRA ROCHA 

B - 140 SURVIVIN AND XIAP EXPRESSION MODULATION IS ASSOCIATED 

TO DOCETAXEL-INDUCED CELL DEATH IN BREAST CANCER CELLS. DEBORAH 

DELBUE DA SILVA, GABRIELA NESTAL DE MORAES, RAQUEL CIUVALSCHI MAIA 

B - 141 ACTION OF HEAT SHOCK PROTEINS IN THERAPY PHOTODYNAMIC 

CELLS IN PROSTATE CANCER. ERIANE ELLER DE SIQUEIRA, JULIANA FREIRES 

MANGOLIN, ANDREZA CRISTINA DE SIQUEIRA SILVA, NEWTON SOARES DA SILVA, 

CRISTINA PACHECO SOARES 

B - 142 GENOTOXICITY ASSESSMENT OF PHOTODYNAMIC THERAPY WITH 

CHLORO-ALUMINUM PHTHALOCYANINE AND CHLORO-ALUMINUM 

PHTHALOCYANINE IN DIFFERENT CELL LINES. ANDREZA CRISTINA DE SIQUEIRA 

SILVA, ERIANE ELLER DE SIQUEIRA, JULIANA FREIRES MANGOLIN, NEWTON 

SOARES DA SILVA, ANTONIO CLÁUDIO TEDESCO, ANDREZA RIBEIRO SIMIONI, 

CRISTINA PACHECO SOARES 

B - 143 STUDY OF CANCER STEM CELLS IN INFLAMMATION ASSOCIATED 

COLORECTAL CANCER USING THE AOM-DSS MODEL. DYANNA GALAXE DE 

MATOS, CLAUDIO BERNARDAZZI, LUCAS LOBIANCO DE MATHEO, ANA CAROLINA 

DUDENHOEFFER CARNEIRO, HEITOR SIFFERT PEREIRA DE SOUZA, ROSSANA COLLA 

SOLETTI, HELENA LOBO BORGES 

B - 144 QUANTITATIVE PROTEOME EXPRESSION ANALYSIS OF HUMAN 

BREAST CANCER CELL LINES T47D AND MCF-7. DENISE DE ABREU PEREIRA, 

VANESSA SANDIM SIQUEIRA, ANNELIESE FORTUNA DE AZEVEDO FREIRE DA 

COSTA, ARACI DA ROCHA RONDON, ANA LÚCIA DE OLIVEIRA CARVALHO, MARIA 

ISABEL DORIA ROSSI, DÁRIO ELUAN KALUME, RUSSOLINA BENEDETA ZINGALI 

B - 145 EXTRACT PLANT FROM D.PICTA: A POTENTIAL ANTIPROLIFERATIVE 

AGAINST TUMOR CELLS. CECÍLIO PURCINO DA SILVA SOUZA NETO, ANA CLARA 

QUEIROZ 

B - 146 ANTI-TUMORAL AND ANTI-ANGIOGENIC EFFECTS OF FUCSULF-I, A 

SULFATED FUCAN FROM LYTECHINUS VARIEGATUS. VIVIANE WALLERSTEIN 

MIGNONE DANTAS, ELIENE KOZLOWSKI, MAURO PAVÃO, PAULO MOURÃO, 

CAMILA CASTRO FIGUEIREDO, VERÔNICA MORANDI 

B - 147 EVALUATION OF THE CELL VIABILITY FROM FEMALE CANCER CELL 

LINES AFTER TREATMENT WITH DIFFERENT FRACTIONS OF B. ARTICULATA. 

GABRIEL FERNANDES SILVEIRA, SCHERON RATHKE GIUBEL, KETLEN DA SILVEIRA 

MORAES, CRISTIANE BERNARDES DE OLIVEIRA, GRACE GOSMANN, ANDRÉIA 

BUFFON, ALESSANDRA NEJAR BRUNO 

B - 148 PATTERNS OF PROTEOGLYCANS EXPRESSION IN CACO-2 AND 

HCT116 COLORECTAL CANCER CELLS INDUCED BY VIOLACEIN. GRACE RICHTER 

MOYSÉS, CAROLINA MELONI VICENTE, LENY TOMA, HELENA BONCIANI NADER, 

GISELLE ZENKER JUSTO 

B - 149 THE ROLE OF CELLULAR REDOX POTENTIAL AND THE 

EFFECTIVENESS OF CHEMOTHERAPY IN NON SMALL CELL LUNG CANCER. 

VALESKA AGUIAR DE OLIVEIRA, LEONARDO LISBÔA DA MOTTA, FERNANDA 

MARTINS LOPES, MARCO ANTÔNIO DE BASTIANI, FABIO KLAMT 

B - 150 HIGH TUMORIGENIC CELLS IN HEAD AND NECK CANCER. ANA 

LUÍSA HOMEM DE CARVALHO, LAURA DE CAMPOS HILDEBRAND, ISABEL DA SILVA 

LAUXEN, CARLOS THADEU CERSKI, JACQUES EDUARDO NÖR, MANOEL SANT”ANA 

FILHO 

B - 151 IMMUNOLOCALIZATION OF TIMP-2 DURING TUMOR 

PROGRESSION AZOXYMETHANE INDUCED IN THE LARGE INTESTINE OF ADULT 

RATS. JAIME RIBEIRO FREITAS, ELIAKIN ROBERTO DO CARMO, JESSICA DA SILVA, 

KAMILA CAROLINE CAMARGO, LAÍS COSTA AYUB, PEDRO DUARTE NOVAES, CARLA 

CRISTINE KANUNFRE, MARIA ALBERTINA DE MIRANDA SOARES, JOSÉ ROSA 

GOMES 

94

B - 152 INFLUENCE OF NUCLEOTIDE EXCISION REPAIR IN MITOXANTRONE 

CITOTOXICITY. FRANCIELE FACCIO BUSATTO, JAQUELINE CESAR ROCHA, JENIFER 

SAFFI 

B - 153 DIFFERENTIAL EXPRESSION OF NTPDASES AND ECTO-5’- 

NUCLEOTIDASE IN CERVICAL CARCINOMA CELLS. ALINE BECKENKAMP, DANIELLE 

BERTODO SANTANA, CAROLINE GUERRA MARANGON, ALESSANDRA NEJAR 

BRUNO, EMERSON ANDRÉ CASALI, LUCIANE NOAL CALIL, LUIZ FERNANDO ZERBINI, 

JULIANO PACCEZ, GUIDO LENZ, MÁRCIA ROSÂNGELA WINK, ANDRÉIA BUFFON 

B - 154 ABCB1 EFFECT ON ARSENIC TRIOXIDE RESISTANCE IN CHRONIC 

MYELOID LEUKEMIA CELL LINES. RAPHAEL SILVEIRA VIDAL, NATHALIE HENRIQUES 

SILVA CANEDO, VIVIAN MARY BARRAL DODD RUMJANEK, MARIA DA GLORIA DA 

COSTA CARVALHO 

B - 155 EVALUATION OF NMDA RECEPTOR EXPRESSION AND EFFECT OF 

THE NMDAR ANTAGONISTS ON THE CELL VIABILITY OF CENTRAL NERVOUS 

SYSTEM TUMORS. DÉBORA SCHOENFELD PRUSCH, CAROLINE BRUNETTO DE 

FARIAS, GILBERTO SCHWARTSMANN, ANA LUCIA ABUJAMRA, RAFAEL ROESLER 

B - 156 AUTOPHAGY ACTIVATION IN COLORECTAL CANCER CONTRIBUTE 

TO THE TOLERANCE OF OXALIPLATIN UNDER ENERGY STRESS CONDITIONS. 

DIANA LILIAN BORDIN, MICHELLE DE SOUZA LIMA LIMA, GUIDO LENZ, JOÃO 

ANTONIO PEGAS HENRIQUES 

B - 157 EFFECTS OF AN RGD-DISINTEGRIN IN BREAST CANCER. CARMEN 

LUCIA SALLA PONTES, RADU O MINEA, STEVE SWENSON, FRANCIS MARKLAND JR, 

HELOISA SOBREIRO SELISTRE DE ARAÚJO 

B - 158 METASTATIC MELANOMA: NEW TARGETS FOR DIAGNOSIS AND 

TREATMENT. RAUL FERRAZ ARRUDA, WILLIAM RODRIGUES FREITAS, MILTON 

MASAHIKO KANASHIRO, NADIR FRANCISCA SANNT'ANNA, ARNOLDO ROCHA 

FAÇANHA 

B - 159 EXPRESSION AND FUNCTION OF THE CLOTTING INITIATOR 

PROTEIN, TISSUE FACTOR, CORRELATE WITH CANCER STEM CELLS PHENOTYPE IN 

HUMAN BREAST CANCER CELL LINES. ARACI MARIA DA ROCHA RONDON, 

ANNELIESE FORTUNA DE AZEVEDO FREIRE DA COSTA, ANA PAULA DANTAS NUNES 

DE BARROS, LUIZE GONÇALVES LIMA, ROBSON DE QUEIROZ MONTEIRO, MARIA 

ISABEL DORIA ROSSI 

B -160 CHEMICAL STUDIES AND EVALUATION OF BACCHARIS TRIMERA IN 

CERVICAL CARCINOMA CELL LINE. OLIVEIRA CB, MACIEL ES, GIUBEL SR, MESQUITA 

CB, COMUNELLO LN, SILVEIRA GF, BRUNO AN, BUFFON A, GOSMANN G 

B - 161 STUDY OF REARRANGEMENTS BCR-ABL P190 AND P210 IN ADULT 

ACUTE LYMPHOBLASTIC LEUKEMIA. RUI MILTON PATRÍCIO DA SILVA JÚNIOR, 

JULIANA FERNANDA HOLANDA BEZERRA, AUDREY VIOLETA MARTINS DE 

VASCONCELOS, TÂNIA MARIA ROCHA GUIMARÃES, WASHINGTON BATISTA NEVES, 

FÁRIDA COELI DE BARROS CORREIA MELO, RAUL ANTÔNIO MORAIS MELO 

B - 162 EPITHELIAL OVARIAN CANCER CELL LINE CLASSIFICATION MODEL 

BASED ON MOLECULAR HETEROGENEITY AND CHEMOTHERAPY RESPONSE. 

GUILHERME B FORTES, HAYNNA P KIMIE INADA, JOYCE L MORAES, CINTHYA 

STERNBERG 

B - 163 EVALUATION OF CELL PROLIFERATION IN CANINE MALIGNANT 

MAMMARY TUMORS. CRISTINA MENDES PLIEGO, FRANCIELE BASSO FERNANDES 

SILVA, JULIANA DA SILVA LEITE, MARCELA FREIRE VALLIM DE MELLO, GABRIELLA 

CARVALHO MATTOS FERREIRA, MARIA DE LOURDES GONÇALVES FERREIRA, ANA 

MARIA REIS FERREIRA 

B - 164 EVALUATION OF PROGRAMMED CELL DEATH IN MAMMARY 

CARCINOMAS OF FEMALE DOGS. FRANCIELE BASSO FERNANDES SILVA, CRISTINA 

MENDES PLIEGO, JULIANA DA SILVA LEITE, MARCELA FREIRE VALLIM DE MELLO, 

BETTINA CAMPOS BRITO CUNHA, MARIA DE LOURDES GONÇALVES FERREIRA, ANA 

MARIA REIS FERREIRA 

B - 165 MECHANISMS OF ACETYLEUGENOL NANOCAPSULES ON TOXICITY 

OF MELANOMA CELLS. CARINE CRISTIANE DREWES, LUANA ALMEIDA FIEL, 

ADRIANA R. POHLMANN, SÍLVIA S. GUTERRES, SANDRA HELENA P. FARSKY 

B - 166 P53-DEFICIENT MELANOMA CELLS ARE MORE SENSITIVE TO THE 

CYTOTOXIC EFFECTS OF UVB IRRADIATION: INVOLVEMENT OF DNA REPAIR 

ACTIVATION PATHWAYS AND PEROXIDE PRODUCTION. GUILHERME FRANCISCO, 

TAYNAH IBRAHIM PICOLO DAVID, BRYAN ERIC STRAUSS, ROGER CHAMMAS 

B - 167 LAMININ-DERIVED PEPTIDES AG73 AND C16 REGULATE 

MIGRATION AND INVASION OF A HUMAN PROSTATIC CARCINOMA CELL LINE. 

ADRIANE SOUSA DE SIQUEIRA, TAÍZE M. AUGUSTO, HERNANDES F. CARVALHO, 

RUY GASTALDONI JAEGER 

B - 168 INFLUENCE OF THE ADAMTS-1 BREAST TUMOR 

MICROENVIRONMENT. THAIOMARA ALVES SILVA, ADRIANE S. SIQUEIRA, MÁRIO 

C. CRUZ, RUY G. JAEGER, VANESSA M. FREITAS 

B - 169 VASCULAR ENDOTHELIAL GROWTH FACTOR 936C/T 

POLYMORPHISM IN BRAZILIAN PATIENTS WITH ORAL SQUAMOUS CELL 

CARCINOMA (OSCC). JÚLIA SALLABERRY PINTO, FERNANDA NEDEL, TIAGO VEIRAS 

COLLARES, FABIANA KÖMMLING SEIXAS, SANDRA BEATRIZ CHAVES TARQUINIO 

B - 170 ECTO-ADENOSINE DEAMINASE CHARACTERIZATION ACTIVITY IN 

HUMAN CERVICAL CARCINOMA CELLS. DANIELLE BERTODO SANTANA, ALINE 

BECKENKAMP, JÉSSICA NASCIMENTO, ALESSANDRA NEJAR BRUNO, ANDRÉIA 

BUFFON 

B - 171 ATL-1, A SYNTHETIC ANALOG OF 15-EPI-LIPOXIN A4, MODULATES 

KEY FUNCTION OF TUMOR-ASSOCIATED MACROPHAGE: A POTENTIAL ANTI- 

TUMORAL TOOL. NATÁLIA MESQUITA DE BRITO, RAFAEL LOUREIRO SIMÕES, 

IOLANDA MARGHERITA FIERRO, THEREZA CHRISTINA BARJA FIDALGO 

B - 172 ENHANCED ANTITUMOR EFFECTS OF 3,4-DIHYDROPYRIMIDINE 

DERIVATIVES (DHPMS) ON HUMAN BREAST CANCER CELLS. BRUNA CÂNDIDO 

GUIDO, LUCIANA M. RAMOS, CATHARINE C. NÓBREGA, BRENNO A. D. NETO, JOSÉ 

R. CORRÊA 

B - 173 CELLULAR RESPONSE ANALYSIS IN COLORECTAL CANCER AND 

LUNG CANCER CELLS EXPOSED TO TREATMENT WITH PLATINUM AGENTS IN LOW 

GLUCOSE CONDITIONS. MICHELLE DE SOUZA LIMA, DIANA LILIAN BORDIN, GUIDO 

LENZ, JOÃO ANTÔNIO PEGAS HENRIQUES 

B - 174 ANXA1 SUBCELLULAR LOCALIZATION AND CELL PROLIFERATION. 

LARA VECCHI, LARISSA PRADO MAIA, BRUNA FRANÇA MATIAS, LUIZ RICARDO 

GOULART FILHO 

B - 175 IMMUNOHISTOCHEMICAL STUDY OF FIBROBLAST GROWTH 

FACTOR-2 (FGF-2) IN MALIGNANT AND BENIGN SALIVARY GLAND TUMORS. 

DÉBORA OLIVEIRA SANTOS, TAMIRIS SABRINA RODRIGUES, SERGIO VITORINO 

CARDOSO, KAREN RENATA NAKAMURA HIRAKI 

B - 176 SECRETOME: A RESERVOIR OF BIOACTIVE MOLECULES. REBECA 

KAWAHARA, ANNELIZE Z.B. ARAGÃO, RAFAEL R. CANEVAROLO, GABRIELA V. 

MEIRELLES, FERNANDO M. SIMABUCO, RONEI J. POPPI, ISADORA L. FLORES, 

RICARDO D. COLETTA, NICHOLAS E. SHERMAN, ADRIANA F. PAES LEME 

B - 177 ANALYSIS OF THE EFFECT OF CYCLOOXYGENASE ON THE 

EXPRESSION AND ACTIVITY OF MULTIPLE DRUG RESISTANCE PROTEINS (MDRP) 

IN HUMAN GLIOMA. FERNANDA DE OLIVEIRA SERACHI, ALISON COLQUHOUN 

B - 178 ANALYSIS OF THE EFFECT OF PROSTAGLANDIN E2 AND IBUPROFEN 

ON CELL NUMBER AND EXTRACELLULAR MATRIX SYNTHESIS IN U87MG AND 

U251MG HUMAN GLIOMA CELL LINES. FABIO FEITOZA, ALISON COLQUHOUN 

B - 179 FUNCTIONAL CHARACTERIZATION OF THE LEUKEMIC STEM CELL IN 

THE ACUTE PROMIELOCYTIC LEUKEMIA. LUCIANA MARIA FONTANARI KRAUSE, 

ALEXANDRE KRAUSE, HELDER HENRIQUE PAIVA, EDUARDO MAGALHÃES REGO 

B - 180 EVALUATION OF THE CYTOTOXIC ACTIVITY OF NEW 

NITROFURANTOIN DERIVATIVES. JEYCE KELLE FERREIRA DE ANDRADE, MARIA DO 

DESTERRO RODRIGUES, LARISSA CARDOSO CORRÊA DE ARAÚJO, PAULO BRUNO 

NORBERTO DA SILVA, DALCI JOSÉ BRONDANI, MANOEL ADRIÃO GOMES FILHO, 

GARDENIA CARMEN GADELHA MILITÃO, TERESINHA GOLÇALVES DA SILVA 

B - 181 THE ROLE OF CD73 IN THE PROGNOSIS OF HUMAN 

MEDULOBLASTOMA CELL LINES. CAPPELLARI, A.R., DIETRICH, F., ROCKEMBACH, 

L., CLARIMUNDO, V., BRAGANHOL, E., ABUJAMRA , A.L., ROESLER, R., HENNING, 

U., BATTATASTINI, A.M.O. 

B - 182 ACTION OF PHOTODYNAMIC THERAPY IN THE EXPRESSION OF 

ADHESION PROTEINS. CAROLINA GENÚNCIO DA CUNHA MENEZES COSTA, KAREN 

CRISTIANE MARTINEZ DE MORAES, NEWTON SOARES DA SILVA, CRISTINA 

PACHECO SOARES 

B - 183 ANALISYS GENETIC AND MICROSCOPIC OF FIBROPAPILLOMATOSIS 

IN CHELONIA MYDAS. SAMARA MAFTOUM COSTA, CAROLINA GENÚNCIO DA 

CUNHA MENEZES COSTA, CRISTINA PACHECO SOARES 

B - 184 ROLE OF DERMCIDIN IN TOMORIGENESIS OF MELANOMAS. 

BEATRIZ SANGIULIANO, MARCELA PEREZ, ALINE CADURIN, ANDREW AGUIAR, JOSÉ 

BELIZÁRIO 

B - 185 MODULATION OF ENDOTHELIAL CELL ADHESION AND 

TUBULOGENESIS IN A MODEL OF GLIOMA CELLS SILENCED FOR TENASCIN-C (TN- 

C) EXPRESSION. LAILA RIBEIRO FERNANDES, ADELAIDE CRISTINA DA SILVA 

MONTEIRO, KELLI CRISTINA MICOCCI, ALINE OLIVEIRA DA SILVA, TERCIA 

RODRIGUES ALVES, HELOISA SOBREIRO SELISTRE DE ARAUJO, VIVALDO MOURA 

NETO, VERÔNICA MARIA MORANDI DA SILVA 

B - 186 ALKALINE PHOSPHATASE EXPRESSION IN INTESTINAL EPITHELIUM 

OF RATS INJECTED WITH AZOXYMETHANE. LAÍS COSTA AYUB, JAIME RIBEIRO 

FREITAS, KAMILA CAROLINE CAMARGO, PEDRO DUARTE NOVAES, MARIA 

ALBERTINA DE MIRANDA SOARES, CRISTINA LÚCIA SANT”ANA COSTA AYUB, NÁDIA 

FAYEZ OMAR, JOSÉ ROSA GOMES 

B - 187 CYTOTOXIC EFFECTS ON ORAL SQUAMOUS CELL CARCINOMA 

(OSCC) INDUCED BY EXTRACTS FROM THE ARISTOLOCHIA GENUS. NAYARA 

SANTOS DE MATOS, ANDREA BARRETTO MOTOYAMA 

B - 188 EVALUATION OF THE ROLE OF CISPLATIN AS SENSITIZER TO TRAIL 

IN BREAST CANCER CELL LINES. VIVIANE ALVES MONTEIRO, CARLOS GIL FERREIRA, 

CINTHYA STERNBERG 

B - 189 INVESTIGATION OF ANTITUMOR ACTIVITY OF 1,3-THIAZIN-2,4- 

DIONES AGAINST MELANOMA CELLS. LAURA SARTORI ASSUNÇÃO, MISAEL 

95

FERREIRA, FABIOLA FILIPPIN MONTEIRO, MARCUS MANDOLESI SÁ, TANIA BEATRIZ 

CRECZYNSKI-PASA 

B - 190 VIOLACEIN INDUCES SPECIFIC ALTERATIONS IN PROTEOGLYCANS 

PROFILE IN CHRONIC MYELOID LEUKEMIAS. MARCELLY VALLE PALLADINO, MARIA 

APARECIDA DA SILVA PINHAL, JULIANA LUPORINI DREYFUSS, ELSA YOKO 

KOBAYASHI, HELENA BONCIANI NADER, GISELLE ZENKER JUSTO 

B - 191 DUAL ROLE OF TGFBETA DURING COLORECTAL CANCER 

PROGRESSION. PEDRO HENRIQUE SCHUMANN LIMA, MARCELO NEVES TANAKA, 

BRUNO K. ROBBS, JOÃO PAULO DE BIASO VIOLA, JOSÉ ANDRÉS MORGADO-DÍAZ 

B -192 INHIBITION OF MELANOMA CELL MIGRATION BY CINNAMIC ACID: 

AN IN VITRO STUDY ANALI DEL MILAGROS BERNABE GARNIQUE, GLÁUCIA MARIA 

MACHADO-SANTELLI, EVANDRO LUÍS DE OLIVEIRA NIERO 

B - 193 SPARC/OSTEONECTIN EXPRESSION MEDIATES CHEMOSENSITIVITY 

TO DOCETAXEL IN MCF-7 BREAST CANCER CELLS. ÚRSULA URIAS, MARIA 

APARECIDA NAGAI 

B - 194 CHARACTERIZATION OF TUMOR STEM CELLS IN HUMAN 

GLIOBLASTOMA. ROSENILDE CARVALHO DE HOLANDA AFONSO, SUZANA ASSAD 

KAHN, DENISE DA SILVEIRA LOBO, DIANA MATIAS, JANE CRISTINA DE OLIVEIRA 

FARIA, LUCIANA FERREIRA ROMÃO, CELINA GARCIA DA FONSECA, GRASIELLA 

MARIA VENTURA MATIOSZEK, ALINE MARIE FERNANDES, STEVENS REHEN, JORGE 

MARCONDES DE SOUZA, VIVALDO MOURA NETO 

B - 195 ASSOCIATION OF THYMIDYLATE SYNTHASE AND METHYLENE- 

TETRAHYDROFOLATE REDUCTASE POLYMORPHISMS IN PATIENTS WITH 

ASTROCYTIC TUMORS IN A POPULATION OF NORTHERN BRAZIL. MARIANA DINIZ 

ARAÚJO, WALLAX AUGUSTO SILVA FERREIRA, SYMARA RODRIGUES-ANTUNES, 

MARICELE BAIA DOS SANTOS, JOSÉ REGINALDO NASCIMENTO BRITO, DOUGLAS 

VASCONCELOS, NILSON PRAIA ANSELMO, ROMMEL MARIO RODRIGUEZ 

BURBANO, MARIA LÚCIA HARADA, BÁRBARA DO NASCIMENTO BORGES 

B - 196 EXPRESSION OF NEUROMEDIN B AND ITS AGONIST IN HUMAN 

MEDULLOBLASTOMA. MARIANE DA CUNHA JAEGER, CAROLINA NOR, CAROLINE 

BRUNETTO DE FARIAS, ANA LUCIA ABUJAMRA, GILBERTO SCHWARTSMANN, 

ALGEMIR LUNARDI BRUNETTO, RAFAEL ROESLER 

B - 197 COULD NARINGIN PROTECT THE LIVER OF WISTAR RATS 

INOCULATED WITH WALKER 256 CARCINOSARCOMA? MARIA APARECIDA DA 

SILVA DIAMANTE, CAMILA DE ANDRADE CAMARGO, FABRICIA DE SOUZA PREDES, 

HIROSHI AOYAMA, MARY ANNE HEIDI DOLDER 

B - 198 THE ROLE OF MTOR IN THE CISPLATIN RESISTANT PHENOTYPE IN 

OVARIAN CANCER LINEAGE. TACIANE LADISLAU, DÉBORA SILVA, KLESIA PIROLA 

MADEIRA, RENATA DALMASCHIO DALTOÉ, ALICE LASCHUK HERLINGER, IAN 

VICTOR SILVA, LETICIA BATISTA AZEVEDO RANGEL 

B - 199 CLINICOPATHOLOGICAL SIGNIFICANCE OF ADAMTS-1 AND 

VERSICAN IN OVARY CANCER. JOSÉ ANTONIO ORELLANA TURRI, SUELI 

NONOGAKI, MARCILEI BUIM, JOEMA FELIPE LIMA, CYNTHIA APARECIDA BUENO DE 

TOLEDO OSÓRIO, FERNADO AUGUSTO SOARES, VANESSA MORAIS FREITAS 

B - 200 MUTATIONAL STATUS OF THE TP53 GENE IN CANINE MAMMARY 

TUMORS. THAMIRYS ALINE SILVA FARO, WALLAX AUGUSTO SILVA FERREIRA, 

SUELLEN DA GAMA BARBOSA MONGER, LUCIEN ROBERTA VALENTE MIRANDA DE 

AGUIRRA, WASHINGTON LUIZ ASSUNÇÃO PEREIRA, MARIA LÚCIA HARADA, 

BÁRBARA DO NASCIMENTO BORGES 

B - 201 IMPACT OF TUMOR-DERIVED EXTRACELLULAR MATRIX ON 

ENDOTHELIAL CELL FUNCTIONS AND ITS ASSOCIATION WITH TUMOR- 

ASSOCIATED ANGIOGENESIS. RENATA MACHADO BRANDÃO COSTA, EDWARD 

HELAL NETO, ROBERTA FERREIRA GOMES SALDANHA DA GAMA, THEREZA 

CHRISTINA BARJA-FIDALGO, VERÔNICA MARIA MORANDI DA SILVA 

B - 202 ANTIPROLIFERATIVE ACTIVITY OF NOVEL 3- 

TRIFLUOR(OXO)PYRIMIDO[1,2-A]BENZIMIDAZOLES COMPOUNDS. CASSIANA 

MACAGNAN VIAU, NATÁLIA LEGUISAMO, DÉBORA CORREA ESPIÑA, SIMONE 

SCHNEIDER AMARAL, JENIFER SAFFI 

B - 203 IN VITRO ANTIPROLIFERATIVE ACTIVITY OF (3Β,6Β,16Β- 

TRIHYDROXY-LUP-20(29)-ENE) TRITERPENE AGAINST BREAST CANCER CELLS. 

CASSIANA MACAGNAN VIAU, NATÁLIA LEGUISAMO, DÉBORA CORREA ESPIÑA, 

JENIFER SAFFI 

B - 204 PARP INHIBITION EXERTS SYNERGISTIC EFFECT ON THE 

CARDIOTOXICITY OF TOPOISOMERASE II INHIBITORS. ROBERTO MARQUES 

DAMIANI, MARIANA LUZZATTO, BRUNA CASTILHOS, DINARA JAQUELINE MOURA, 

JOÃO ANTONIO PÊGAS HENRIQUES, JENIFER SAFFI 

B - 205 GENOTOXIC ACTIVITY OF EXTRACTS OF MARINE ALGAE FROM THE 

COAST OF ALAGOAS – BRAZIL. BRUNNO HENRIQUE DA SILVA, ISA RAFAELLA 

ROCHA BRITO, ÉLICA AMARA CECÍLIA GUEDES, ANTÔNIO EUZÉBIO GOULART 

SANT’ANA, RENATO S. RODARTE 

B - 206 CYTOTOXIC EFFECT OF THE ISATIN DERIVATES ON LEUKEMIC CELL 

LINES. GLAUCIA VERÍSSIMO FAHEINA MARTINS, CAIO CÉSAR BARBOSA BOMFIM, 

BRUNA BRAGA DANTAS, CLAUDIO GABRIEL L. JÚNIOR, MÁRIO L.A.A. 

VASCONCELOS, DEMETRIUS A.M. ARAÚJO 

B -207 ANALYSIS OF THE LEPTIN SIGNALING PATHWAY COMPONENTS OF 

THYROID PAPILLARY CARCINOMA OF CHILDREN AND ADOLESCENTS BY 

IMMUNOSTAINING. ARIO LUCIO CORDEIRO ARAUJO JUNIOR, VIVIANE YOUNES- 

RAPOZO, NAYARA PEIXOTO-SILVA, ELAINE DE OLIVEIRA, PATRÍCIA CRISTINA 

LISBOA, ROSSANA CORBO, MARCELLI GATTO, ALBANITA VIANA DE OLIVEIRA, 

EGBERTO GASPAR DE MOURA 

B - 208 APOPTOSIS INDUCTION BY A NEW DERIVATIVE OF 

PODOPHYLLOTOXIN IN HL-60 CELLS. GLAUCIA VERÍSSIMO FAHEINA MARTINS, 

ALETHÉIA LACERDA DA SILVEIRA, BRUNA BRAGA DANTAS, DEMETRIUS ANTONIO 

MACHADO DE ARAÚJO 

B -209 A NEW FAB INHIBITS CELL PROLIFERATION IN MCF7 BREAST 

CARCINOMA CELLS. THAISE GONÇALVES ARAÚJO, CLÁUDIA MENDONÇA 

RODRIGUES, BRUNA FRANÇA MATIAS, YARA C.PAIVA MAIA, ANGELA A.S. SENA, 

CAROLINA FERNANDES REIS, CARLOS UEIRA VIEIRA, LUIZ RICARDO GOULART 

B - 210 INDUCTION OF APOPTOSIS IN HUMAN LUNG ALVEOLAR 

CARCINOMA EPITHELIAL CELLS (A549) BY THE METALLIC COMPLEX CIS- 

TETRAAMMINE(OXALATO)RUTHENIUM(III) DITHIONATE. ELISÂNGELA DE PAULA 

SILVEIRA-LACERDA, FLÁVIA DE CASTRO PEREIRA, ALINY PEREIRA DE LIMA, 

WANESSA CARVALHO PIRES, CESAR AUGUSTO SAM TIAGO VILANOVA-COSTA 

B - 211 BREAST CANCER STEM CELL-LIKE PHENOTYPE OF A 

SUBPOPULATION DERIVED FROM A LUMINAL CELL LINE. ANNELIESE FORTUNA DE 

AZEVEDO FREIRE DA COSTA, ANA PAULA DANTAS NUNES DE BARROS, CAMILA 

MARIA LONGO MACHADO, ARACI MARIA DA ROCHA RONDON, ANDREA 

CORDOVIL PIRES, HÉLIO DOS SANTOS DUTRA, RADOVAN BOROJEVIC, ELIENE 

OLIVEIRA KOZLOWSKI, MAURO SÉRGIO GONÇALVES PAVÃO, ROGER CHAMMAS, 

MARIA ISABEL DORIA ROSSI 

B - 212 UNDERSTANDING THE ROLE OF GENETIC INSTABILITY IN BASAL 

CELL CARCINOGENESIS THROUGH ANALYSIS OF POLYMORPHIC REPETITIVE DNA 

SEQUENCES. JULIANA S. CAPITANIO, MARCOS A. R. MARTINEZ, GUILHERME 

FRANCISCO, CYRO FESTA-NETO, ITAMAR R. G. RUIZ 

B - 213 IN VITRO ANTITUMOR ACTIVITY OF TRETINOIN-LOADED LIPID- 

CORE NANOCAPSULES ON HUMAN LUNG ADENOCARCINOMA EPITHELIAL CELL 

LINE (A549). EDUARDA SCHULTZE, VIRGINIA YURGEL, KARINE RECH BEGNINI, 

ALINE FERREIRA OURIQUE, RUY CARLOS RUVER BECK, STANISÇUAKI GUTERRES, 

ADRIANA RAFFIN POHLMANN, FABIANA SEIXAS, TIAGO COLLARES 

B - 214 MODULATION OF MELANIN SYNTHESIS BY PLATINUM COMPLEXES 

(II) WITH HYDANTOIN DERIVATIVE AS A NOVEL ROUTE FOR CYTOTOXICITY IN 

MELANOMA CELLS. FERNANDA BRANCO FILIPPIN, SUELY LINS GARDINO, MARIA 

DO CARMO ALVES DE LIMA, IVAN DA ROCHA PITTA, SILVYA STUCHI MARIA- 

ENGLER 

B - 215 B16F10 MELANOMA CELLS GROWN ON COLLAGEN MATRIX 

EXHIBITED BEHAVIOR SIMILAR TO IN VIVO TUMOR. PAULA MEDEIROS SABINO, 

BRUNO PIVA, BRUNO LOURENÇO DIAZ 

B - 216 STRUCTURAL AND ULTRASTRUCTURAL DESCRIPTION OF THE 

METAPLASIC AND NEOPLASIC PROCESSES IN RAT PROSTATE EPITHELIAL CELLS 

AFTER SEX STEROIDS-INDUCED CARCINOGENESIS. JAQUELINE DE CARVALHO 

RINALDI, HELOISA BORTOLIN BRUNO, LIVIA MARIA LACORTE, FLAVIA KARINA 

DELELLA, LUIS ANTONIO JUSTULIN JUNIOR, SERGIO LUIS FELISBINO 

B - 217 FREQUENCY OF HPV INFECTION IN HEAD AND NECK SQUAMOUS 

CELL CARCINOMA AND ITS INFLUENCE IN CELL CYCLE RELATED PROTEINS TOP2A 

AND MCM2. ANA CAROLINA LAUS, NAIARA CORRÊA NOGUEIRA DE SOUZA, 

ADHEMAR LONGATTO FILHO, CRISTOVAM SCAPULATEMPO NETO, ANDRÉ LOPES 

CARVALHO 

B - 218 KNOCKDOWN OF XIAP COOPERATES WITH THE OVEREXPRESSION 

OF P53 IN REDUCING CELL PROLIFERATION AND ENHANCING CELL DEATH IN 

GLIOMAS. ANDREW OLIVEIRA SILVA, MICHELE HÜTTEN, PATRÍCIA LUCIANA DA 

COSTA LOPEZ, GUIDO LENZ 

B - 219 THE ROLE OF CELLULAR ADHESION STATE IN REGULATING 

NUCLEAR AKT/PKB LOCALIZATION IN HUMAN MELANOMA CELL LINES 

HARBORING DISTINCT ONCOGENC MUTATIONS. SARAH FRANCO FIGUEIRA, 

RENATA PASCON, MARCELO AFONSO VALLIM, JOEL MACHADO JR. 

B - 220 MICROARRAY ANALYSIS OF DIFFERENTIALLY EXPRESSED GENES IN 

ADENOID CYSTIC CARCINOMA CELLS (CAC2) TREATED WITH LAMININ-DERIVED 

PEPTIDES C16 OR AG73. MICAEL DE PAIVA OLIVEIRA, EMERSON S. SANTOS, 

VANESSA M. FREITAS, BASILIO SMUCZEK, RUY G. JAEGER 

B - 221 THE FLAVONOID ISOQUERCITRIN MODULATE PATHWAY WNT/Β- 

CATENIN THROUGH SPHINGOSINE KINASE IN HUMAN GLIOBLASTOMA CELLS IN 

VITRO. FERNANDA MIRANDA, DÉBORA MALTA CERQUEIRA, RAFAEL LINDOSO, 

MARCELO EINICKER-LAMAS, VIVALDO MOURA NETO, JOSÉ GARCIA ABREU 

B - 222 PRPC AND HOP EXPRESSION AND SECRETION IN COLON AND 

RECTUM TUMORS ARE ASSOCIATED WITH INVASION. TONIELLI CRISTINA SOUSA 

DE LACERDA, MARCOS VINICIUS SALLES DIAS, CLEITON FAGUNDES MACHADO, 

BRUNO COSTA SILVA, VILMA REGINA MARTINS 

B - 223 EVALUATION OF THE CYTOTOXIC ACTIVITY OF NEW 4- 

THIAZOLIDINONE. MARIA DO DESTERRO RODRIGUES, SANDRINE MARIA ARRUDA 

DE LIMA, JEYCE KELLE FERREIRA DE ANDRADE, LARISSA CARDOSO CORRÊA DE 

ARAÚJO, ERALDO ANTUNES GUIMARÃES NETO, JOSÉ GILDO DE LIMA, ALEXANDRE 

96

JOSÉ DA SILVA GÓES, TERESINHA GONÇALVESDA SILVA, GARDENIA CARMEN 

GADELHA MILITAO, SILENE CARNEIRO DO NASCIMENTO 

B - 224 MODULATION OF AUTOPHAGY PATHWAY GENE EXPRESSION 

AFTER CROTAMINE TREATMENT OF TUMOR CELL LINE. MÁRCIA NEIVA, CAMILA 

M YONAMINE, MARCELA B NERING, EDUARDO B OLIVEIRA, DANIELE Y SUNAGA, 

MIRIAN A F HAYASHI 

B - 225 AUXOTROPHIC RECOMBINANT BCG OVEREXPRESSING AG85B AS 

AN ALTERNATIVE THERAPY FOR SUPERFICIAL BLADDER CANCER. KARINE RECH 

BEGNINI, CAROLINE RIZZI, VINICIUS FARIAS CAMPOS, EDUARDA SCHULTZE, 

VIRGINIA CAMPELLO YURGEL, TIAGO COLLARES, ODIR DELLAGOSTIN, FABIANA 

KOMMLING SEIXAS 

B - 226 RUTHENIUM COMPLEX COORDENATED WITH LAPACHOL IS 

CYTOTOXIC FOR DIFFERENT TUMOR CELL LINES AND INHIBITS TUMOR CELL 

ADHESION. JULIANA UEMA RIBEIRO, MARÍLIA IMACULADA FRAZÃO BARBOSA, 

MÁRCIA REGINA COMINETTI, ALZIR AZEVEDO BATISTA 

B - 227 EVALUATION OF GENOTOXIC EFFECTS IN LYMPHOCYTES OF MICE 

FROM LEAF EXTRACTS ZIZIPHUS JOAZEIRO MARTIUS (RHAMNACEAE). ISA 

RAFAELLA ROCHA BRITO, BRUNNO HENRIQUE DA SILVA, CLÁUDIA CAVALCANTE 

DE MATOS RODARTE, ANTÔNIO EUZÉBIO GOULART SANT’ANA, RENATO S. 

RODARTE 

B - 228 CONSTRUCTION OF A RECOMBINANT TAT-HA FUSOGENIC 

MYOSIN-VA FRAGMENT COVERING THE BINDING MOTIF OF DLC2: EVALUATION 

OF CELL PENETRATING AND PRO-APOPTOTIC PROPERTIES. ENILZA MARIA 

ESPREAFICO, CLEIDSON DE PÁDUA ALVES, ENILZA MARIA ESPREAFICO 

B - 229 EVALUATION OF CITOTOXIC ACTIVITY OF RHIZOPHORA MANGLE 

ON HELA CELLS. MARLLON ALEX NASCIMENTO SANTANA, ELIANE ALVES 

BANDEIRA DE CARVALHO, ERWELLY BARROS DE OLIVEIRA, KRÍSIA EMANUELLE 

FERREIRA DA SILVA, PAULO HENRIQUE CAVALCANTI DE ARAÚJO, ELIETE 

CAVALCANTI DA SILVA, ANTÔNIO FERNANDO MORAIS DE OLIVEIRA, JEYMESSON 

RAPHAEL CARDOSO VIEIRA 

B - 230 THE INFLUENCE OF A SELECTIVE INHIBITOR OF THE TYROSINE 

PROTEIN KINASE ACTIVITY OF THE TRK FAMILY ON THE VIABILITY OF SH-SY5Y 

HUMAN NEUROBLASTOMA CELLS. BÁRBARA KUNZLER SOUZA, CAROLINE 

BRUNETTO DE FARIAS, GILBERTO SCHWARTSMANN, ALGEMIR LUNARDI 

BRUNETTO, ANA LUCIA ABUJAMRA, RAFAEL ROESLER 

B - 231 EFFECTS OF A GASTRIN-RELEASING PEPTIDE RECEPTOR 

ANTAGONIST ON THE VIABILITY OF SH-SY5Y HUMAN NEUROBLASTOMA CELLS. 

BÁRBARA KUNZLER SOUZA, CAROLINE BRUNETTO DE FARIAS, GILBERTO 

SCHWARTSMANN, ALGEMIR LUNARDI BRUNETTO, ANA LUCIA ABUJAMRA, RAFAEL 

ROESLER 

B - 232 EFFECT OF NOVEL RATIONALLY DESIGNED NAPHTOQUINONES- 

DERIVED DRUGS ON LUNG CANCER CELL LINES. ALICE LASCHUK HERLINGER, IURI 

CORDEIRO VALADAO, RENATA DALMASCHIO DALTOÉ, KLESIA PIROLA MADEIRA, 

JOÃO FRANCISCO ALLOCHIO FILHO, LUCAS CUNHA DIAS DE REZENDE, MURILO 

FANCHIOTTI CERRI, SARAH FERNANDES TEIXEIRA, PAULO CILAS MORAIS LYRA 

JUNIOR, SANDRO JOSÉ GRECO, LETICIA BATISTA AZEVEDO RANGEL 

B - 233 CITOTOXIC EFFECTS OF ANTHRACYCLINES IN HUMAN FIBROBLASTS 

DEFICIENT IN NUCLEOTIDE EXCISION REPAIR. LARISSA MILANO DE SOUZA, 

TEMENOUGA NIKOLOVA GUESHEVA, GUIDO LENZ, JENIFER SAFFI 

B - 234 NEW BENZOTHIAZOLE INDUCES GENOTOXICITY IN GASTRIC 

CANCER CELL LINE BUT NOT IN NORMAL CELLS. BRUNO MOREIRA SOARES, 

LEILANE DE HOLANDA BARRETO, JORGE AMANDO BATISTA RAMOS, SIVANNE 

BRAGA DE ALMEIDA, VITOR FRANCISCO FERREIRA, NOGUEIRA, A.F., AZEVEDO, 

E.C., ROMMEL MARIO RODRIGUÉZ BURBANO, TATIANA VASCONCELOS, MARNE 

CARVALHO DE VASCONCELLOS, RAQUEL CARVALHO MONTENEGRO 

B - 235 STUDY THE INVOLVEMENT OF METAL PEPTIDASE PHEX IN 

SQUAMOUS CELL CARCINOMA. RAQUEL LEÃO NEVES, DANIELA B. ZANATTA, 

LARISSA P. COPPINI, BRYAN E. STRAUSS, JOÃO B. PESQUERO, FÁBIO D. 

NASCIMENTO, IVARNE L. TERSARIOL, HELENA B. NADER, ADRIANA K. CARMONA, 

NILANA M. T. BARROS 

B - 236 IONIZING RADIATION INDUCES AKT PHOSPHORYLATION AND MIR- 

210 EXPRESSION IN A RADIORESISTANT GLIOBLASTOMA CELL LINE. PAULA 

SABBO BERNARDO, GISELLE PINTO DE FARIA, RAQUEL CIUVALSCHI MAIA 

B - 237 UPREGULATION OF APE/REF-1 EXPRESSION INDUCED BY 

ENDOPLASMIC RETICULUM STRESS. CLARISSA LEAL DE OLIVEIRA MELLO, LUCIANA 

BARRETO CHIARINI 

B - 238 EVALUATION OF THE CELLULAR RESPONSE OF SPECIES CEBUS 

APELLA EXPOSED TO CARCINOGEN N-METHYL-N-NITROSOUREA (MNU) AND 

TREATED WITH CANOVA®. DANIELLE CRISTINNE AZEVEDO FEIO, JOSÉ AUGUSTO 

PEREIRA CARNEIRO MUNIZ, ROMMEL MÁRIO RODRIGUEZ BURBANO, LACY 

CARDOSO DE BRITO JUNIOR, PATRÍCIA DANIELLE LIMA DE LIMA 

B - 239 LIPID DROPLETS ARE SITES OF THE MTOR PATHWAY IN COLON 

CANCER CELLS. NARAYANA FAZOLINI BASTOS, JOÃO PAULO DE BIASO VIOLA, 

PATRÍCIA TORRES BOZZA, CLARISSA MENEZES MAYA-MONTEIRO 

B - 240 EHMT1 AND EHMT2 METHYLTRANSFERASES EXPRESSION 

ANALYSIS IN BREAST CANCER CELL LINES. MARTHA SILVA ESTRELA, CAROLINA 

AMARO DE MOURA, LUÍS HENRIQUE TOSHIHIRO SAKAMOTO, ANDREA BARRETTO 

MOTOYAMA, FÁBIO PITTELLA SILVA 

B - 241 EFFECT OF KIAA0090 KNOCKDOWN IN SOME ASPECTS OF 

MELANOMA DEVELOPMENT, MAINTENANCE AND PROGRESSION. RODRIGO 

RIBEIRO DA SILVA, CARLOS ANTONIO COUTO LIMA, ROBERTO AUGUSTO SILVA 

MOLINA, NOEMI YASUKO OTSUKA, CIBELE CARDOSO, CRISTIANO GONÇALVES 

PEREIRA, ENILZA MARIA ESPREAFICO 

B - 242 EXPRESSION PROFILE OF SUPPRESSOR OF VARIEGATION (SUV) 

GENE FAMILY IN BREAST CANCER CELL LINES. BRENNO VINÍCIUS MARTINS 

HENRIQUE, CAROLINA AMARO DE MOURA, ANDREA BARRETO MOTOYAMA, 

ROSÂNGELA VIEIRA DE ANDRADE, FÁBIO PITTELLA SILVA 

B -2 43 KIAA0090, A NEW HUMAN GENE IS INVERSELY CORRELATED WITH 

HER2 EXPRESSION AND ASSOCIATED WITH BREAST CANCER PROGRESSION. 

ROBERTO AUGUSTO SILVA MOLINA, DANIEL TIEZZI, CIBELE CARDOSO, RODRIGO 

RIBEIRO DA SILVA, NOEMI Y. OTSUKA, ENILZA MARIA ESPREAFICO 

B - 244 CROSSTALK BETWEEN C6 GLIOMA CELLS AND MESENCHYMAL 

STEM CELLS THROUGH SOLUBLE FACTORS AFFECTS THE PURINERGIC SYSTEM. 

PAULA ANDREGHETTO BRACCO, SILVIA MULLER MOURA, GIOVANA RAVIZZONI 

ONZI, LUANA DIMER HAINZENREDER, ADRIANO MARTIMBIANCO DE ASSIS, PEDRO 

ROOSEVELT TORRES ROMÃO, MÁRCIA ROSÂNGELA WINK 

B - 245 THE NOVEL CYTOKINE PANDER/FAM3B AFFECTS CELL GROWTH 

AND INHIBITS APOPTOSIS IN MDA-MB-231 BREAST TUMOR CELLS. LIBNAH LEAL, 

IZABELA CALDEIRA, HUMBERTO MIGUEL GARAY MALPARTIDA 

B - 246 PROFILING OF DIFFERENTIALLY EXPRESSED APOPTOSIS-RELATED 

GENES IN T47D BREAST CANCER CELLS TREATED WITH ANGIOTENSIN-(1-7). 

CHERYL ALECRIM SANTOS, SILVANA APARECIDA ALVES CORREA DE NORONHA, 

SAMUEL RIBEIRO DE NORONHA, SUMA IMURA SHIMUTA, CLOVIS RYUICHI NAKAIE, 

ISMAEL DALE COTRIM GUERREIRO DA SILVA 

B - 247 FUNCTIONAL CHARACTERIZATION OF A NOVEL GENE ASSOCIATED 

WITH MELANOMA PROGRESSION AND BRAF V600E. CRISTIANO G PEREIRA, 

RODRIGO R SILVA, CIBELE CARDOSO, ENILZA MARIA ESPREAFICO 

B - 248 INVOLVEMENT OF MYOSIN-VA IN FOCAL ADHESION FORMATION 

AND SURVIVAL UNDER SUBSTRATE DETACHMENT CONDITIONS. ANELISA 

RAMÃO, CARMEN LUCIA SALLA PONTES, CLEIDSON PADUA ALVES, ENILZA MARIA 

ESPREAFICO 

B - 249 CHARACTERIZATION OF NEW MELANOMA-RESTRICTED GENES 

ASSOCIATED WITH MAPK PATHWAY. CIBELE CARDOSO, CRISTIANO GONÇALVES 

PEREIRA, RODRIGO RIBEIRO DA SILVA, ROBERTO AUGUSTO SILVA MOLINA, 

GUILHERME AUGUSTO SILVA DOS SANTOS, EDUARDO MAGALHÃES REGO, ENILZA 

MARIA ESPREAFICO 

B - 250 ANTI-FGF2 MONOCLONAL ANTIBODY AS AN IMAGING AND 

ANTITUMOR APPROACH FOR MURINE MELANOMA B16-F10. RODRIGO BARBOSA 

DE AGUIAR, CAROLINA BELLINI PARISE, ROGER CHAMMAS, JANE ZVEITER DE 

MORAES 

B - 251 CELL DEATH AND IN VIVO MELANOMA TUMOR GROWTH 

REMISSION DETERMINED BY A SNAKE TOXIN WITH SPECIFICITY FOR ACTIVELY 

PROLIFERATING CELLS. MIRIAN A F HAYASHI, FABIO D NASCIMENTO, LUCIE 

SANCEY, ALEXANDRE PEREIRA, EDUARDO B OLIVEIRA, HELENA B NADER, IVARNE 

LS TERSARIOL, JEAN-LUC COLL, IRINA KERKIS 

B - 252 MT1-MMP AS A MOLECULAR MARKER DURING THE FIRST STAGES 

OF PROGRESSION OF THE COLON CANCER IN RATS. ELIAKIN ROBERTO DO 

CARMO, ROSIANE CRISTINA ALVES, JAIME RIBEIRO FREITAS, JÉSSICA DA SILVA, 

KAMILA CAROLINE CAMARGO, PEDRO DUARTE NOVAES, CARLA CRISTINE 

KANUNFRE, MARIA ALBERTINA DE MIRANDA SOARES, JOSE ROSA GOMES 

C – Cell Biology and 

Inflammation 

C1-C118 

C - 1 EFFECTS OF ANTI-CD3 MONOCLONAL ANTIBODY IN SALIVARY 

GLANDS OF SPONTANEOUSLY DIABETIC MICE. EBER EMANUEL MAYORAL, 

GABRIEL MORETTI DOMINGUES, ALAN TELLES FERRI, RAFAEL DIAS MANCIO, 

FERNANDA ALVAREZ ROJAS, LUIS ANTONIO PERONI, EDMIR AMERICO LOURENÇO, 

EDUARDO JOSE CALDEIRA 

C - 2 MELANOMACROPHAGES IN THE SPLEEN OF EUPEMPHIX 

NATTERERI (ANURA: LEIUPERIDAE): RESPONSES TO LPS. LILIAN FRANCO-BELUSSI, 

GABRIELA BARONI LEITE, JULIANE SILBERSCHIMDIT FREITAS, CLASSIUS DE 

OLIVEIRA 

C - 3 FPR RECEPTOR MEDIATES THE ANTI-INFLAMMATORY ACTIONS OF 

ANNEXIN A1 PROTEIN IN ENDOTOXIN-INDUCED UVEITIS. ANA PAULA GIROL, 

CRISTIANE DAMAS GIL, SONIA MARIA OLIANI 

97

C - 4 DNA DAMAGE IN BLOOD OF THE COPD PATIENTS BY COMET 

ASSAY. HELEN TAIS DA ROSA, ANDRÉA LÚCIA GONÇALVES DA SILVA, MARTIELE 

BIZARRO, EDUARDA BENDER, PAULO RICARDO DA ROSA, CLARA FORRER 

CHARLIER, MIRIAM SALVADOR, DINARA JAQUELINE MOURA, ANDRÉIA ROSANE DE 

MOURA VALIM, NIKOLOVA TEMENOUGA GUECHEVA, JOÃO ANTONIO PEGAS 

HENRIQUES 

C - 5 RU486 IMPROVES CUTANEOUS WOUND HEALING IN MICE 

SUBMITTED TO PSYCHOLOGICAL STRESS. TAIS FONTOURA DE ALMEIDA, ANDRÉA 

MONTE ALTO COSTA 

C - 6 MODULATION OF PROSTATE SMOOTH MUSCLE CELL RESPONSE TO 

BACTERIAL LPS BY TESTOSTERONE. CAROLINA LEIMGRUBER, AMADO QUINTAR, 

CRISTINA ALICIA MALDONADO 

C - 7 ANALYSIS OF THE INFLAMMATORY PROFILE IN TYPE 1 AND 2 IN 

BLOOD AND LESIONS OF MOUSE INFECTED WITH AMERICAN CUTANEOUS 

LEISHMANIASIS. FLÁVIA PERRIM DE MELO, FÁBIO RIBEIRO QUEIROZ, ANA 

CRISTINA CARVALHO DE BOTELHO, JOSIANE BARBOSA PIEDADE, LUCIANA MARIA 

SILVA 

C - 8 INFLUENCE OF CYCLOOXYGENASE-2 INHIBITION ON 

INTRAMEMBRANOUS AND ENDOCHONDRAL BONE GRAFTS INCORPORATION: 

IMUNOHISTOCHEMISTRY ANALYSIS. CLÁUDIA CRISTINA BIGUETTI, EDUARDO 

MORESCHI, LEANDRO DE ANDRADE HOLGADO, APARÍCIO FIUZA DE CARVALHO 

DEKON, PAULO DOMINGOS RIBEIRO JUNIOR, MARIZA AKEMI MATSUMOTO 

C - 9 INCREASE OF TRYPTASE MAST CELL LEADS TO DENERVATION IN 

INFECTED INDIVIDUALS WITH AND WITHOUT CHAGASIC MEGAESOPHAGUS. 

PATRÍCIA ROCHA MARTINS, RODOLFO DUARTE NASCIMENTO, JACQUELINE 

GARCIA DUARTE, SHEILA ADAD, DÉBORA D’ÀVILA REIS 

C - 10 TRAINING EFFECTS ON THE GOBLET CELLS NUMBER AND 

INTESTINAL ALKALINE PHOSPHATASE EXPRESSION IN GMS OBESE RATS.JAIME 

RIBEIRO FREITAS, MARIA ALBERTINA DE MIRANDA SOARES, NAYARA DE 

CARVALHO LEITE, SABRINA GRASSIOLLI, JOSÉ ROSA GOMES 

C - 11 THE INFLUENCE OF PROTEIN MALNUTRITION ON THE IL-1Β 

PRODUCTION BY MACROPHAGES STIMULATED WITH TNF-Α. DALILA CUNHA DE 

OLIVEIRA, ALEXANDRA SIQUEIRA MELLO, JACKELINE SOARES OLIVEIRA BELTRAN, 

ED WILSON DOS SANTOS, PRIMAVERA BORELLI, RICARDO AMBRÓSIO FOCK 

C - 12 CAFFEIC ACID PHENETHYL ESTER (CAPE) IMPROVES THIRD-DEGREE 

BURNS HEALING IN RATS. JEANINE SALLES DOS SANTOS, ANDRÉA MONTE-ALTO 

COSTA 

C - 13 NEUTROPHIL RECRUITMENT TO THE SKELETAL MUSCLE AFTER 

EXERCISE TO FATIGUE IS ASSOCIATED TO PRODUCTION OF ROS. ALBENÁ NUNES 

DA SILVA, PRISCILA TELES DE TOLEDO BERANARDES, BARBARA MAXIMINO 

REZENDE, FERNANDO LOPES, MAURO MARTINS TEIXEIRA, VANESSA PINHO 

C - 14 LEPTIN EFFECTS ON LEUKOCYTES ON OBESE MICE. GLAUCIA SOUZA 

ALMEIDA, SALLY LIECHOCKI, LOHANNA PALHINHA DO AMARAL, PATRICIA TORRES 

BOZZA, CLARISSA M. MAYA-MONTEIRO 

C - 15 CXCR2 AND FPR1 ACTIVATION STIMULATE NEUTROPHIL- 

MEDIATED INJURY DURING ACETAMINOPHEN-INDUCED ACUTE LIVER FAILURE. 

PEDRO ELIAS MARQUES, SYLVIA STELLA AMARAL, DANIELE ARAUJO PIRES, LAURA 

LOPES NOGUEIRA, MAURO MARTINS TEIXEIRA, GUSTAVO BATISTA MENEZES 

C - 16 ESTABLISHMENT OF THE OPTIMAL CONDITIONS TO 

DIFFERENTIATE THE HUMAN U937 CELLS INTO M1 OR M2 MACROPHAGES TO BE 

USED AS IN VITRO EXPERIMENTAL MODEL FOR BIOMEDICAL STUDIES. MARCO 

ANTÔNIO DE BASTIANI, MATHEUS BECKER FREITAS, LEONARDO LISBÔA DA 

MOTTA, FERNANDA FRANÇA, FÁBIO KLAMT, MELISSA MARKOSKI, CAROLINA 

BEATRIZ MÜLLER 

C - 17 EXPRESSION PATTERN OF PRO-INFLAMMATORY CYTOKINES IN 

MSCS FROM GALLUS GALLUS. GABRIHEL STUMPF VIEGAS, RAQUEL CALLONI, 

PATRICK TÜRCK, DIEGO BONATTO, ELVIRA CORDEIRO 

C - 18 INDUCTION OF EOSINOPHIL APOPTOSIS BY HYDROGEN PEROXIDE 

PROMOTES THE RESOLUTION OF ALLERGIC INFLAMMATORY RESPONSE. 

ALESANDRA CORTE REIS, RAYSSA MACIEL ATHAYDE, THIAGO VINICIUS ÁVILA, 

JULIANA PRISCILA VAGO, MILENE ALVARENGA RACHID, MAURO MARTINS 

TEIXEIRA1, VANESSA PINHO 

C - 19 EVALUATION OF LACTOCOCCUS LACTIS SECRETING OR NOT HSP 65 

TREATMENT AS STRATEGY OF FOOD ALLERGY IMMUNOMODULATION. DENISE 

ALVES PEREZ, DÉBORA MOREIRA ALVARENGA, NATHÁLIA VIEIRA BATISTA, 

RAFAELA VAZ DE SOUZA PEREIRA, ROBERTA CRISTELLI FONSECA, ANA CRISTINA 

GOMES SANTOS, ANA MARIA CAETANO DE FARIA, ANDERSON MIYOSHI, GUSTAVO 

BATISTA DE MENEZES, DENISE CARMONA CARA 

C - 20 EFFECTS OF CHLOROQUINE TREATMENT ON THE MOUSE IMMUNE 

SYSTEM. RODOLFO THOMÉ, ALESSANDRO DOS SANTOS FARIAS, FÁBIO TRINDADE 

MARANHÃO COSTA, LIANA VERINAUD 

C - 21 EFFECT OF LOW LEVEL LASER THERAPY ON THE VIABILITY OF 

MACROPHAGES ACTIVATED WITH LPS. LUIZA GABRIELA BARROS, NADHIA HELENA 

COSTA SOUZA, JANE PATRÍCIA DE MELO HAYASHI, RAQUEL AGNELLI MESQUITA 

FERRARI, SANDRA KALIL BUSSADORI, KRISTIANNE PORTA SANTOS FERNANDES 

C - 22 SENSING ENDOPLASMIC RETICULUM STRESS BY PROTEIN KINASE 

RNA-LIKE ENDOPLASMIC RETICULUM KINASE PROMOTES ADAPTIVE 

MITOCHONDRIAL DNA BIOGENESIS AND CELL SURVIVAL VIA HEME OXYGENASE- 

1/CARBON MONOXIDE ACTIVITY. HUN TAEG CHUNG, MIN ZHENG, SEUL-KI KIM, 

YEONSOO JOE, SUNG HOON BACK 

C - 23 INHIBITION OF ROCK PROMOTES RESOLUTION OF INFLAMMATION 

BY ENHANCING NEUTROPHIL APOPTOSIS. RAYSSA MACIEL ATHAYDE, ALESANDRA 

CORTE REIS, VANESSA PINHO DA SILVA, MAURO MARTINS TEIXEIRA 

C - 24 NANOCOMPOSITE TREATMENT REDUCES THE SEVERITY OF THE 

INFLAMMATORY RESPONSE ASSOCIATED WITH ACUTE GRAFT VERSUS HOST 

DISEASE (GVHD) IN MICE. PRISCILA TELES DE TOLÊDO BERNARDES, BÁRBARA 

MAXIMINO REZENDE, MARINA GOMES MIRANDA E CASTOR ROMERO, DANIELLE 

SOUZA G, MAURÍCIO VELOSO BRANT PINHEIRO, VANESSA PINHO, MAURO 

MARTINS TEIXEIRA 

C - 25 EFFECTS OF HIGH-CARBOHYDRATE DIET IN THE INCREASED 

EPIDIDYMAL ADIPOSE TISSUE AND THE RECRUITMENT OF INFLAMMATORY CELLS 

IN MICE. PRISCILA TELES DE TOLÊDO BERNARDES, BÁRBARA MAXIMINO REZENDE, 

MAURO MARTINS TEIXEIRA, VANESSA PINHO, ADALIENE VERSIANI MATOS 

C - 26 ANNEXIN A1 PROMOTES RESOLUTION OF ACUTE INFLAMMATION 

BY INDUCING NEUTROPHIL APOPTOSIS. JULIANA PRISCILA VAGO DA SILVA, 

CAMILA RODRIGUES CHAVES NOGUEIRA, LUCIANA PÁDUA TAVARES, THAÍS ROLLA 

DE CAUX, FREDERICO MARIANETTI SORIANI, FERNANDO LOPES, REMO DE CASTRO 

RUSSO, VANESSA PINHO, MAURO MARTINS TEIXEIRA, LIRLÂNDIA PIRES DE SOUSA 

C - 27 EFFECTS OF THE SYMPATHETIC-PERIPHERAL CRH-HISTAMINE AXIS 

IN THE IMMUNOLOGICAL FUNCTION OF MACROPHAGES. PATRÍCIA RENCK 

NUNES, PAULO IVO HOMEM DE BITTENCOURT JÚNIOR 

C - 28 DETRIMENTAL ROLE OF INTERLEUKIN-4 IN ACETAMINOPHEN- 

INDUCED ACUTE LIVER FAILURE. DANIELE ARAÚJO PIRES, PEDRO ELIAS MARQUES, 

SYLVIA STELLA MARQUES, JAYANE LAÍS QUINTÃO, LINDSLEY FERREIRA GOMIDES, 

GUSTAVO BATISTA MENEZES 

C - 29 EVALUATION OF IMMUNOGENICITY OF THE CANDIDATE PHAGES 

TO USE IN PHAGE THERAPY AND ANALYSIS OF CROSS-REACTION BY SPECIFIC 

ANTIBODIES. ROBERTO SOUSA DIAS, VINÍCIUS DUARTE SILVA, FLÁVIA DE OLIVEIRA 

SOUZA, LÍVIA CARNEIRO FIDÉLIS SILVA, LEANDRO LICURSI DE OLIVEIRA, EDUARDO 

DE ALMEIDA MARQUES SILVA, CYNTHIA CANEDO SILVA, SÉRGIO OLIVEIRA DE 

PAULA 

C - 30 EFFECTS OF THE STIMULATION OF INFLAMMATION AND 

TREATMENT WITH ANXA1 PROTEIN IN THE HUMAN RETINAL PIGMENT 

EPITHELIAL CELLS. LAILA TONIOL CARDIN, NATHÁLIA MARTINS SONEHARA, 

KALLYNE KIOKO MIMURA, LAÍS SOBRAL, ANDRÉIA MACHADO LEOPOLDINO, SONIA 

MARIA OLIANI, FLÁVIA CRISTINA RODRIGUES LISONI 

C - 31 OXIDIZED-LDL AND PARAOXONASE-1 IN THE ASSOCIATION 

BETWEEN CORONARY ARTERY DISEASE AND SLEEP DISORDERED BREATHING. 

FERNANDA SCHÄFER HACKENHAAR, DENIS MARTINEZ, TÁSSIA MACHADO 

MEDEIROS, CRISTINI KLEIN, PAULO V.G. ALABARSE, MARA S. BENFATO 

C - 32 OBESITY AS AN ADDITIONAL COMPLICATION FACTOR IN SEPSIS 

INDUCED PULMONARY INFLAMMATION. THAIS PINEDA FUNGARO, RICARDO 

COSTA PETRONI, SUELEN JERÔNYMO SOUZA DE OLIVEIRA, DENISE FREDIANE 

BARBEIRO, FRANCISCO GARCIA SORIANO, THAIS MARTINS DE LIMA-SALGADO 

C - 33 INFLAMMATORY CELLS PROFILE IN CARDIAC MUSCLE OF CALOMYS 

CALLOSUS INFECTED WITH TRYPANOSOMA CRUZI IN THE CHRONIC PHASE OF 

INFECTION. NOEMI NOSOMI TANIWAKI, VANESSA GALDENO FREITAS, CIBELE 

RODELLA ALMEIDA, DEBORAH YAMAZAKI HUKUDA, MARIA CRISTINA RODRIGUES 

MEDEIROS, ANGELA BATISTA GOMES DOS SANTOS 

C - 34 FEMALE MICE SHOW INCREASED LEUKOCYTE RECRUITMENT IN 

ADIPOSE TISSUE THAN MALE MICE IN A FOOD ALLERGY MODEL. RAFAELA VAZ 

SOUSA PEREIRA, NATHÁLIA VIEIRA BATISTA, ROBERTA CRISTELLI FONSECA, DENISE 

ALVES PEREZ, DÉBORA MOREIRA ALVARENGA, DENISE CARMONA CARA 

C - 35 TEMPORAL EVALUATION OF THE METABOLIC AND 

IMMUNOLOGICAL CONSEQUENCES IN AN EXPERIMENTAL MODEL OF FOOD 

ALLERGY. NATHÁLIA VIEIRA BATISTA, RAFAELA VAZ SOUSA PEREIRA, ROBERTA 

CRISTELLI FONSECA, ADALIENE VERSIANI MATOS FERREIRA, DENISE CARMONA 

CARA 

C - 36 INFLUENCE OF PANCREATIC ACINAR CELL NECROSIS ON STELLATE 

CELL PROLIFERATION IN VITRO. BURKHARD KRUEGER, KRISTINA GEISSLER 

C - 37 PARTICIPATION OF PROINFLAMMATORY CYTOKINES AND CELL 

MIGRATION IN THE ANTI-INFLAMMATORY EFFECTS OF A SULFATED 

POLYSACCHARIDE FRACTION EXTRACTED FROM THE MARINE ALGAE GRACILARIA 

CAUDATA IN MICE. LUCAS ANTONIO DUARTE NICOLAU., RENAN OLIVEIRA SILVA, 

LARISSE TAVARES LUCETTI, ANA PAULA MACEDO SANTANA, ANDRE LUIZ DOS REIS 

BARBOSA, KAROLINE SABÓIA ARAGÃO, RONALDO DE ALBUQUERQUE RIBEIRO, 

MARCELLUS HENRIQUE LOIOLA PONTE DE SOUZA, JAND-VENES ROLIM MEDEIROS 

C - 38 NITRIC OXIDE REDUCES ALENDRONATE-INDUCED GASTRIC 

DAMAGE IN RATS: ROLE OF CYTOKINES AND OXIDATIVE STRESS. LUCAS ANTONIO 

DUARTE NICOLAU., RENAN OLIVEIRA SILVA, NATÁLIA RODRIGUES D’ARC COSTA, 

LARISSE TAVARES LUCETTI, ANDRE LUIZ DOS REIS BARBOSA, ANA PAULA MACEDO 

98

SANTANA, KAROLINE SABÓIA ARAGÃO, RONALDO DE ALBUQUERQUE RIBEIRO, 

MARCELLUS HENRIQUE LOIOLA PONTE DE SOUZA, JAND-VENES ROLIM MEDEIROS 

C - 39 HOW DOES THE PLATELET-ACTIVATING FACTOR ACT IN FOOD 

ALLERGY? ROBERTA CRISTELLI FONSECA, NATHÁLIA VIEIRA BATISTA, RAFAELA VAZ 

SOUSA PEREIRA, DENISE ALVES PEREZ, DÉBORA MOREIRA ALVARENGA, VANESSA 

PINHO, DENISE CARMONA CARA 

C - 40 IMPROVEMENT OF SKIN WOUND HEALING BY PARENTERAL 

INJECTION OF TOLERATED PROTEINS INTO ORALLY TOLERANT MICE. RAQUEL 

ALVES COSTA, LIANA BIAJOLLI O. MATOS, GREGORY THOMAS KITTEN, NELSON 

MONTEIRO VAZ, CLÁUDIA ROCHA CARVALHO 

C - 41 EFFECTS OF LOW LEVEL LASER THERAPY ON THE CREATINE KINASE 

ACTIVITY IN C2C12 CELLS. JEAN LUCAS PARPINELLI BARBOSA, MIKAELE TAVARES 

SILVA, PAOLA PELEGRINELI ARTILHEIRO, KRISTIANNE PORTA SANTOS FERNANDES, 

SANDRA KALIL BUSSADORI, RAQUEL AGNELLI MESQUITA-FERRARI 

C - 42 MOLECULAR FEATURES OF ANEMIA AND OBESITY. THAÍS DA 

FONTE FARIA, SIMONE VARGAS DA SILVA, THEREZA CHRISTINA BARJA FIDALGO, 

MARTA CITELLI DOS REIS 

C - 43 IMPROVEMENT OF SKIN WOUND HEALING BY PARENTERAL 

INJECTION OF A REGULAR DIET COMPONENT (ZEIN). THIAGO CANTARUTI 

ANSELMO, RAQUEL ALVES COSTA, NELSON MONTEIRO VAZ, CLAUDINEY 

MELQUIADES RODRIGUES, KÊNIA SOARES DE SOUZA, CLAUDIA ROCHA CARVALHO 

C - 44 ALPHA-MELANOCYTE STIMULATING HORMONE REDUCE 

INFLAMMATORY CELL COUNT AFTER EXCISIONAL CUTANEOUS WOUND. KÊNIA 

SOARES DE SOUZA, GERALDO MAGELA DE AZEVEDO JUNIOR, RAQUEL ALVES 

COSTA, CLAUDINEY MELQUIADES RODRIGUES, THIAGO CANTARUTI ANSELMO, 

NELSON MONTEIRO VAZ, CLÁUDIA ROCHA CARVALHO 

C - 45 TOLL LIKE RECEPTORS 2 AND 4 LEAD TO CARDIOMYOCYTE 

HYPERTROPHY IN VITRO. FERNANDA GAISLER DA SILVA, MARCELA SORELLI 

CARNEIRO RAMOS 

C - 46 RENAL ISCHEMIA/REPERFUSION INDUCED CARDIAC HYPERTROPHY 

IN MICE: INCREASED GENE EXPRESSION OF HSP 60 AND 70, TOLL-LIKE RECEPTOR 

LIGANDS. MAYRA TRENTIN SONODA, MARCELA SORELLI CARNEIRO RAMOS 

C - 47 EFFECTS OF OLEIC AND LINOLEIC ACIDS ON KERATINOCYTES. 

GILSON MASAHIRO MURATA, RUI CURI, ELAINE HATANAKA 

C - 48 IMPACT OF PERIODONTAL STATUS ON MUSCLE REPAIR PROCESS 

OF SEDENTARY AND TRAINED WISTAR RATS. BÁRBARA CAPITANIO DE SOUZA, 

MARCELO LAZZARON LAMERS, ALESSANDRA MAGNUSSON, MARCELO EKMAN 

RIBAS, ANDRÉ LUIZ LOPES, BRUNO COSTA TEIXEIRA 

C - 49 APOLIPOPROTEIN E COG 133 MIMETIC PEPTIDE ATTENUATES 5- 

FLUOROURACIL-INDUCED INTESTINAL MUCOSITIS IN VITRO AND IN VIVO. 

ORLEÂNCIO GOMES RIPARDO DE AZEVEDO, JARDLON ALBINO COSTA, CELINA 

VIANA DE ARAÚJO, HERENE BARROS MIRANDA LUCENA, ROBERTO CÉSAR P. LIMA- 

JÚNIOR, RENATO ANDRÉ C. OLIVEIRA, BRUNA CASTRO OLIVEIRA, MICHEL P. VITEK, 

RICHARD L. GUERRANT, RONALDO ALBUQUERQUE RIBEIRO, DEYSI VIVIANA T. 

WONG, TIÊ BEZERRA COSTA, SNJEZANA ZALA-MILATOVIC, REINALDO BARRETO 

ORIÁ 

C - 50 EFFECTS OF ZINC SUPPLEMENTATION ON GROWTH, INTESTINAL 

BACTERIAL TRANSLOCATION, AND PRO-INFLAMMATORY CYTOKINES IN WISTAR 

RATS CHALLENGED BY UNDERNUTRITION AND LACTOSE-INDUCED OSMOTIC 

DIARRHEA. ANITA MAYARA FEITOSA SANTOS, CAMILA DE ALBUQUERQUE 

ALMEIDA, PRISCILA BRISENO FROTA, SAID GONÇALVES DA CRUZ FONSECA, ÍTALO 

LEITE FIGUEIREDO, KAROLINE SABOIA ARAGÃO, CARLOS EMANUEL C. 

MAGALHÃES, CIBELE BARRETO MANO DE CARVALHO, REINALDO BARRETO ORIÁ 

C - 51 INFLIXIMAB ATTENUATES BONE RESORPTION AND 

INFLAMMATORY OSTEOLYSIS IN A MODEL OF EXPERIMENTAL PERIODONTITIS IN 

WISTAR RATS. RAKEL DE CASTRO EVANGELISTA, DAVI DA CUNHA GONÇALVES, 

ANITA MAYARA FEITOSA SANTOS, RAFAEL REIS DA SILVA, GERLY ANNE DE CASTRO 

BRITO, RENATA DE CARVALHO LEITÃO, REINALDO BARRETO ORIÁ 

C - 52 MACROPHAGE EFFECTS IN THE NEPHROTOXICITY PROCESS 

CAUSED BY IMMUNOSUPPRESSANT CYCLOSPORINE A: EXPRESSIONS OF TNF- 

ALFA AND ANNEXIN A1. AYLA BLANCO POLTRONIERI, CARLA PATRÍCIA CARLOS, 

EMMANUEL DE ALMEIDA BURDMANN, SONIA MARIA OLIANI 

C - 53 A SNAKE VENOM SECRETED PHOSPHOLIPASE A2 CROSSTALKS 

WITH INTRACELLULAR PHOSPHOLIPASES TO INDUCE MAST CELLS (MCS) 

DEGRANULATION. MARLOS CORTEZ SAMPAIO, BRUNO LOMONTE, JOSÉ MARIA 

GUTIERREZ, CATARINA TEIXEIRA 

C - 54 EVALUATION OF MACROPHAGE INFILTRATION IN ADIPOSE TISSUE 

OF EX-OBESE PATIENTS AND ROLE OF MESENCHYMAL STROMAL CELLS ON THE 

IMMUNOPHENOTYPE OF MACROPHAGES. DAIANA VIEIRA LOPES, CESAR S. 

CLÁUDIO-DA-SILVA, MARCELO C.A. SOUZA, MORENA P. DIAS, HÉLIO DOS SANTOS 

DUTRA, RADOVAN BOROJEVIC, CHRISTINA MAEDA TAKIYA, M. ISABEL DORIA 

ROSSI 

C - 55 COMPARATIVE EFFECTS OF EPA AND DEFLAZACORT ON 

DYSTROPHIN-DEFICIENT MUSCLE FIBERS OF THE MDX MICE. LETICIA 

MONTANHOLI APOLINARIO, SAMARA CAMAÇARI DE CARVALHO, HUMBERTO 

SANTO NETO, MARIA JULIA MARQUES 

C - 56 EFFECT OF PHOTOBIOMODULATION USING DIFFERENT ENERGY 

DENSITIES ON PROLIFERATION OF C2C12 SKELETAL MUSCLE CELLS DURING 

DIFFERENTIATION PROCESS. MIKAELE TAVARES DA SILVA, JEAN LUCAS PARPINELLI 

BARBOSA, PAOLA PELEGRINELI ARTILHEIRO, SANDRA KALIL BUSSADORI, 

KRISTIANNE PORTA SANTOS FERNANDES, RAQUEL AGNELLI MESQUITA-FERRARI 

C - 57 A PHOSPHOLIPASE A2 (CBR) ISOLATED FROM VENOM OF 

CROTALUS DURISSUS RURUIMA INDUCES LIPID BODY (LB) FORMATION IN 

MACROPHAGES. ANA EDUARDA ZULIM DE CARVALHO, KARINA CRISTINA 

GIANNOTTI, ELBIO LEIGUEZ JUNIOR, MÁRCIO HIDEKI MATSUBARA, CONSUELO 

LATORRE FORTES DIAS, MARIA CRISTINA DOS SANTOS, CATARINA TEIXEIRA 

C - 58 EFFECT OF ACTIVATION ON THE VIABILITY OF J774 

MACROPHAGES. JANE PATRICIA DE MELO HAYASHI, NADHIA HELENA COSTA 

SOUZA, LUIZA GABRIELA BARROS, RAQUEL AGNELLI MESQUITA FERRARI, SANDRA 

KALIL BUSSADORI, KRISTIANNE PORTA SANTOS FERNANDES 

C - 59 LIPID BODIES FORMATION INDUCED BY A SNAKE VENOM 

PHOSPHOLIPASE A2 (CB) IS RELATED TO INCREASED PGE2 BIOSYNTHESIS IN 

MACROPHAGES. KARINA CRISTINA GIANNOTTI, ELBIO LEIGUEZ JUNIOR, NEIDE 

GALVÃO DO NASCIMENTO, ANA EDUARDA ZULIM DE CARVALHO, CONSUELO 

LATORRE FORTES-DIAS, RENATA HAGE, CATARINA TEIXEIRA 

C - 60 EFFECTS OF EICOSAPENTAENOIC ACID (EPA) ON M1 AND M2 

MACROPHAGE POPULATIONS IN SKELETAL MUSCLES OF THE MDX MICE. 

SAMARA CAMAÇARI DE CARVALHO, LETÍCIA MONTANHOLI APOLINÁRIO, 

HUMBERTO SANTO NETO, SELMA MARIA MICHELIN MATHEUS, MARIA JÚLIA 

MARQUES 

C - 61 THE DEVELOPMENT OF ENDOMETRIOTIC LESIONS IN 

HETEROLOGOUS MODEL USING MICE THAT EXPRESS A GREEN FLUORESCENT 

PROTEIN (GFP): ANALYSIS OF THE ANGIOGENESIS PROCESSES. JOÃO MARCOS 

PEREIRA SANTOS, THAIS ANGELI GAMBA, KARINA CRISTINA RODRIGUEZ BAPTISTA, 

ANTÔNIO PALUMBO, LEONARDO BOLDRINI, RÔMULO MEDINA MATOS, JAMILA 

ALESSANDRA PERINI, LUIZ EURICO NASCIUTTI, DANIEL ESCORSIM MACHADO 

C - 62 EFFECT OF LOW LEVEL LASER THERAPY ON THE PROLIFERATION OF 

INFLAMMATORY MACROPHAGES. NADHIA HELENA COSTA SOUZA, LUIZA 

GABRIELA BARROS, JANE PATRÍCIA DE MELO HAYASHI, RAQUEL AGNELLI 

MESQUITA FERRARI, DANIELA DE FÁTIMA TEIXEIRA DA SILVA, SANDRA KALIL 

BUSSADORI, KRISTIANNE PORTA SANTOS FERNANDES 

C - 63 DEVELOPMENT OF IN VITRO ALTERNATIVE METHODS TO PREDICT 

ALLERGENIC POTENTIAL OF CHEMICAL AGENTS. JANE ZVEITER DE MORAES, 

VANESSA M. SÁ-ROCHA, JANE ZVEITER DE MORAES 

C - 64 STUDY OF ANTI-INFLAMMATORY ACTIONS OF METHYL GALLATE. 

TATIANA ALMEIDA PÁDUA, BIANCA SUELEN DA SILVA CRUZ DE ABREU, MARCIA 

VIDAL DE CARVALHO, MARIA RAQUEL FIGUEREIDO, MARIA DAS GRAÇAS 

HENRIQUES, ELAINE CRUZ ROSAS 

C - 65 INCREMENT OF MAST CELLS, NEOVASCULARIZATION AND 

ACTIVATION OF NFΚB IN THE ACHILLES TENDON OF RATS WITH EXPERIMENTAL 

DIABETES. RODRIGO RIBEIRO DE OLIVEIRA, YURI RODRIGUES ROCHA, ALLYSSON 

BRUNO RAPHAEL BRAGA, GERLY ANNE DE CASTRO BRITO, LUIZ EURICO NASCIUTTI 

C - 66 AMYLOID FIBRILS INDUCE NEUTROPHIL EXTRACELLULAR TRAPS 

(NETS) FORMATION BY HUMAN NEUTROPHILS AND ARE DIGESTED BY ELASTASE. 

ANDERSON GUIMARÃES BAPTISTA COSTA, ESTEFÂNIA PEREIRA CARDOSO 

AZEVEDO, GUILHERME TOREZANI, CAROLINA AZEREDO BRAGA, FERNANDO LUCAS 

PALHANO, JEFFERY KELLY, ELVIRA SARAIVA, DEBORA FOGUEL 

C - 67 ATTRACTING CHEMOKINES EXPRESSION FOR 

POLYMORPHONUCLEAR CELLS IN WHITE ADIPOSE TISSUE FROM CANCER 

CACHEXIA RATS. FELIPE HENRIQUES, FELIPE FRANCO, PAMELA KNOB, KALTINAITE 

BENETON, RODRIGO XAVIER, CLAUDIO SHIDA, ROGERIO SERTIÉ, SIDNEY PERES, 

MIGUEL BATISTA JR 

C - 68 BOTHROPIC TOXIN MODULATES INFLAMMATORY ANGIOGENESIS 

IN MICE. PUEBLA CASSINI VIEIRA, AMANDA VIEIRA, SAULO ANTONIO GOMES 

FILHO, SIMONE RAMOS DECONTE, FABIO DE OLIVEIRA, FERNANDA DE ASSIS 

ARAÚJO 

C - 69 ATLA, AN ASPIRIN-TRIGGERED LIPOXIN A4 SYNTHETIC ANALOG, IN 

THE TREATMENT OF FIBROTIC EFFECTS OF BLEOMYCIN-INDUCED LUNG 

DAMAGE. RAFAEL DE FREITAS GUILHERME, DEBORA GONÇALVES XISTO, PATRICIA 

RIEKEN MACEDO ROCCO, IOLANDA MARGHERITA FIERRO, CLAUDIO DE AZEVEDO 

CANETTI, CLAUDIA FARIAS BENJAMIM 

C - 70 THE ROLE OF LAMININ POLYMER IN SPLENIC DENDRITIC CELLS. 

LEANDRO LADISLAU ALVES, AMANDA REGINA DA FÉ, STEVEN L KUNKEL, THEREZA 

CHRISTINA BARJA FIDALGO, WILSON SAVINO, CLAUDIA FARIAS BENJAMIM 

C - 71 ANTI-INFLAMMATORY EFFECTS OF GALECTIN-1 PROTEIN ON 

LIPOPOLYSACCHARIDE-CHALLENGED CULTURED HUMAN RETINAL PIGMENT 

EPITHELIAL CELLS. NATHÁLIA MARTINS SONEHARA, LAILA TONIOL CARDIN, 

CRISTIANE DAMAS GIL, SONIA MARIA OLIANI 

C - 72 INVESTIGATION OF MAST CELL HETEROGENEITY AND EXPRESSION 

OF ANTI-INFLAMMATORY PROTEIN ANNEXIN A1 IN ENDOMETRIOSIS. RUBENS DE 

PAULA JUNIOR, POATAN DA SILVA PINOTI, ANTONIO HELIO OLIANI, DENISE 

CRISTINA MOS VAZ, SOLANGE CORREA GARCIA P D”AVILA, SONIA MARIA OLIANI, 

CRISTIANE DAMAS GIL 

99

C - 73 EFECT OF STEROID AND NON-STEROID ANTI-INFLAMMATORY 

COMPOUNDS ON S100B SECRETION IN PRIMARY ASTROCYTE CULTURES 

EXPOSED OR NOT TO LPS. ELISA NEGRI, CAROLLINA FRAGA DA RÉ, FABIANA 

GALLAND, MARIA CRISTINA GUERRA, MARINA CONCLI LEITE, CARLOS ALBERTO 

GONÇALVES 

C - 74 LOVASTATIN DECREASES NEUROINFLAMMATION AND PREVENTS 

COGNITIVE IMPAIRMENT AFTER CEREBRAL MALARIA. PATRICIA ALVES REIS, 

TATHIANY IGREJA DA SILVA, EDSON FERNANDES DE ASSIS, PATRICIA TORRES 

BOZZA, FERNANDO AUGUSTO BOZZA, HUGO CAIRE DE CASTRO FARIA NETO 

C - 75 UNRAVELING A NEW CELLULAR MECHANISM BEHIND 

TRANSTHYRETIN-RELATED LEPTOMENINGEAL AMYLOIDOSIS USING AS MODEL A 

HIGHLY UNSTABLE TRANSTHYRETIN MUTANT. ESTEFANIA PEREIRA CARDOSO 

AZEVEDO, FERNANDO PALHANO, MORGANA SOBRINHO, LUCIANA ROMÃO, 

FLÁVIA LIMA, VIVALDO MOURA NETO, DÉBORA FOGUEL 

C - 76 SRC KINASE RELAYS INFLAMMATORY INFORMATION TO EXERT A 

FINE-TUNED CONTROL OF MICROGLIA ACTIVATION. RENATO SOCODATO, 

CAMILA CABRAL PORTUGAL, VIVIAN COREIXAS, ERICK CORREIA LOIOLA, FILIPA 

DOMINGUES, ANA RAQUEL SANTIAGO, ROBERTO PAES DE CARVALHO, JOÃO B 

RELVAS, FRANCISCO AMBRÓSIO 

C - 77 LIPID-LADEN MULTILOCULAR CELLS: DISTRIBUTION, 

MORPHOLOGICAL AND PHENOTYPICAL CHARACTERIZATION OF A NEGLECTED 

CELL COMPONENT IN THE THYMIC MICROENVIRONMENT OF AGING MICE. 

LARISSA GUTMAN PARANHOS LANGHI, LEONARDO RODRIGUES DE ANDRADE, 

RADOVAN BOROJEVIC, VALÉRIA DE MELLO COELHO 

C - 78 SODIUM VITAMIN C CO-TRANSPORTER-2 (SVCT-2) 

INTERNALIZATION UNDER PRO-INFLAMMATORY CONDITIONS IS ASSOCIATED 

WITH MICROGLIA ACTIVATION. CAMILA CABRAL PORTUGAL, RENATO SOCODATO, 

VIVIAN COREIXAS, ERICK CORREIA LOIOLA, ANA RAQUEL SANTIAGO, ROBERTO 

PAES DE CARVALHO, FRANCISCO AMBRÓSIO 

C - 79 OBATOCLAX DECREASES NEUTROPHILS IN THE MODEL OF 

ANTIGEN-INDUCED ARTHRITIS (AIA) IN MICE. WILLIAM ANTÔNIO GONÇALVES, 

FERNANDO LOPES, MAURO MARTINS TEIXEIRA, VANESSA PINHO 

C - 80 EXPRESSION OF PLIN2 AND FORMATION OF LIPID BODIES 

INDUCED BY DISTINCT SPECIES OF BOTHROPS SNAKE VENOM IN LEUKOCYTES. 

NEIDE GALVÃO DO NASCIMENTO, ELBIO LEIGUEZ, KARINA CRISTINA GIANNOTTI, 

MARIANA VIANA, CATARINA TEIXEIRA 

C - 81 LITHOTHAMNION MUELLERI: A RED ALGAE WHICH REDUCES THE 

INFLAMMATORY RESPONSE ASSOCIATED WITH GRAFT-VERSUS-HOST DISEASE 

WITHOUT IMPAIR THE BENEFICIAL RESPONSE OF GRAFT-VERSUS-LEUKEMIA. 

BARBARA M. REZENDE, PRISCILA T. T. BERNARDES, CAROLINA B. RESENDE, LÍVIA 

BARROSO, ROSA M. E. ARANTES, DANIELLE G. SOUZA, MAURO M. TEIXEIRA, 

MARINA G. M. CASTOR, VANESSA PINHO 

C - 82 BAP1 METALLOPROTEINASE STIMULATES B TYPE SYNOVIOCYTES 

TO PRODUCE PGE2 AND REQUIRES COX-2 AND EP4 RECEPTORS TO THIS EFFECT. 

MARIANA DO NASCIMENTO VIANA, CRISTINA MARIA FERNANDES, ELBIO LEIGUEZ 

JUNIOR, MÁRCIO HIDEKI MATSUBARA, JOSE MARIA GUTIÉRREZ, CATARINA DE 

FÁTIMA PEREIRA TEIXEIRA 

C - 83 HIGHER ACTIVATED POPULATION OF T LYMPHOCYTES AND 

DECREASED T REGULATORY CELL POPULATION IN DMD PATIENTS. LUCIANA 

RODRIGUES CARVALHO BARROS, FERNANDA PINTO MARIZ, MARIANA FERREIRA 

VEGAS, ALEXANDRA QUEIROZ PRUFER ARAUJO, MARCIA RIBEIRO, MARIA DO 

CARMO SOARES CUNHA, WILSON SAVINO 

C - 84 ANTI-INFLAMMATORY EFFECTS OF MAYTENUS ILICIFOLIA MART. 

EX REISSEK IN SWISS MICE. JANAÍNA VIEIRA BELUSSO, FABÍOLA REGINA BREDA, 

CARLA GIANE LOSS, ARNO ERNESTO HOFMANN JUNIOR, SILVANE SOUZA ROMAN 

C - 85 ROLE OF CHEMOKINE RECEPTOR CCR4 AND REGULATORY T CELLS 

IN WOUND HEALING IN MICE. JANAINA DE BARROS FIGUEIREDO, PAULA 

ALVARENGA BORGES, ARIANE RENNÓ BROGLIATO, JANAINA LIMA GEORGII, 

CYNTIA PECLI E SILVA, STEVEN L. KUNKEL, CLAUDIA FARIAS BENJAMIM 

C - 86 INVOLVEMENT OF IMMUNE RESPONSE IN THE RENAL INJURY 

INDUCED BY SEVERE SEPSIS IN MICE. AMANDA REGINA DA FÉ, LEANDRO 

LADISLAU ALVES, CYNTIA PECLI E SILVA, RAFAEL DE FREITAS GUILHERME, STEVEN 

L. KUNKEL, CLAUDIA FARIAS BENJAMIM, IOLANDA MARGHERITA FIERRO 

C - 87 WOUND-HEALING ASSESSMENT OF RUTA GRAVEOLENS L. 

(ARRUDA) EXTRACT IN WISTAR RAT SKIN. JANAÍNA VIEIRA BELUSSO, LUANA 

RORIG GALLI, CAMILA ZANELLA, GABRIELA GIORDANA LORENZON ALVES, 

ROGÉRIO LUIS CANSIAN, SILVANE SOUZA ROMAN 

C - 88 PULMONARY FUNCTION, OXIDATIVE STRESS AND INFLAMMATORY 

MARKERS IN LPS-INDUCED ACUTE LUNG INJURY: DIFFERENTIAL EFFECTS OF 

ATORVASTATIN, PRAVASTATIN AND SIMVASTATIN. ADRIANA CORREA MELO, 

LARISSA A. SILVA NETO, JACKSON N. ALVES, MARINA V. BARROSO, DENISE M. 

CARDOSO, ALAN A. LOPES, RÔMULO PINTO, RENATA T. NESI, EDUARDO TAVARES 

L. TRAJANO, GIOVANNA M. CARVALHO, WALTER ARAÚJO ZIN, LUIS CRISTÓVÃO 

PORTO, SAMUEL SANTOS VALENCA 

C - 89 THE ANTI-INFLAMMATORY ROLE OF ANNEXIN A1 PROTEIN IN 

HUMAN RETINAL PIGMENT EPITHELIUM (ARPE-19) AFTER ENDOTOXEMIA. 

KALLYNE KIOKO MIMURA, CRISTIANE DAMAS GIL, SONIA MARIA OLIANI 

C - 90 IMPAIRMENT HEALING OF DIABETIC WOUNDS IS IMPROVED BY 

ORAL ADMINISTRATION OF ANTIOXIDANTS. ANA FLÁVIA MARÇAL PESSOA, 

JULIANA DA COSTA FLORIM, HOSANA G RODRIGUES, MARCELO L LAMERS, RUI 

CURI, MARINILCE FAGUNDES DOS SANTOS 

C - 91 CELL-CELL INTERACTIONS BETWEEN CHONDROCYTES AND 

SYNOVIOCYTES LIKE CELLS. SAMYLLA MIRANDA MONTE, CAMILA BASILE 

CARBALLO 

C - 92 CELLULAR AND MOLECULAR MECHANISMS OF ANTI- 

INFLAMMATORY EFFECT OF THE SIARESINOLIC ACID. ALMAIR FERREIRA DE 

ARAÚJO, JAMYLLE NUNES DE SOUZA FERRO, ANDERSON MARQUES DE OLIVEIRA, 

LÚCIA MARIA CONSERVA, EMILIANO DE OLIVEIRA BARRETO 

C - 93 ANALYSIS OF RETINOBLASTOMA PHOSPHORYLATION AND 

NUCLEAR Β-CATENIN ACCUMULATION HELPS THE DIFFERENTIAL DIAGNOSIS 

BETWEEN CROHN’S DISEASE AND ULCERATIVE COLITIS. ROSSANA COLLA SOLETTI, 

NATHASSYA ACCIOLY LINS VIDAL RODRIGUES, DEBORAH BIASOLI, VIVALDO 

MOURA NETO, HEITOR SIFFERT PEREIRA DE SOUZA, HELENA LOBO BORGES 

C - 94 PRO-INFLAMMATORY EFFECTS OF THE P2X7 RECEPTOR IN SEPSIS. 

PATRICIA TEIXEIRA SANTANA, LUIZ EDUARDO BAGGIO SÁVIO, CLÁUDIA FARIA 

BENJAMIM, CHRISTINA MAEDA TAKIYA, ROBSON COUTINHO SILVA 

C - 95 INHIBITORY EFFECT OF CURINE ON EOSINOPHIL ACTIVATION AND 

AIRWAY HYPER-RESPONSIVENESS. JAIME RIBEIRO FILHO, ADRIANA VIEIRA-DE- 

ABREU, ANDREA SURRAGE CALHEIROS, JULIANA ALVES AZEREDO, CELIDARQUE DA 

SILVA DIAS, MÁRCIA REGINA PIUVEZAM, PATRÍCIA TORRES BOZZA 

C - 96 STEM CELL FACTOR INDUCES PIECEMEAL DEGRANULATION IN 

HUMAN EOSINOPHIL. KENNEDY BONJOUR DE OLIVEIRA FERREIRA, FELIPE FERRAZ 

DIAS, ANN M. DVORAK, PETER F. WELLER, ROSSANA CORREA NETTO MELO 

C - 97 INVOLVEMENT OF PPARGAMMA ON LIPID BODY FORMATION 

AND HOST IMMUNE RESPONSE DURING INFECTION BY TRYPANOSOMA CRUZI. 

LÍVIA TEIXEIRA, HELOÍSA D'ÁVILA, CÉLIO GERALDO FREIRE DE LIMA, ROSSANA 

CORREA NETTO DE MELO, PATRÍCIA TORRES BOZZA 

C - 98 IMPACT OF THE ABSENCE OF GALECTIN-3 ON THE COURSE OF 

EXPERIMENTAL INFECTION WITH TRYPANOSOMA CRUZI. DANIELLE SILVA DOS 

SANTOS, JULIANA BARRETO DE ALBUQUERQUE, LUIZ RICARDO BERBERT, LANDI 

V.C. GUILLERMO, WILSON SAVINO, JULIANA DE MEIS, DÉA M. S. VILLA-VERDE 

C - 99 HEMATOLOGICAL PARAMETERS OF CHICKENS TREATED WITH 

NITRIC OXIDE INHIBITOR AND INFECTED WITH PLASMODIUM GALLINACEUM. 

BARBARELLA DE MATOS MACCHI, FARLEN JOSÉ BEBBER MIRANDA, FERNANDA 

SILVA DE SOUZA, EULÓGIO CARLOS QUEIROZ DE CARVALHO, ANTÔNIO PEIXOTO 

ALBERNAZ, JOSÉ LUIZ MARTINS DO NASCIMENTO, RENATO AUGUSTO DAMATTA 

C - 100 NEUROPROTECTIVE EFFECTS OF MELATONIN SYNTHESIZED BY 

CEREBELLAR GRANULE CELLS CULTURES. DAIANE GIL FRANCO, ADRIESSA 

APARECIDA DOS SANTOS, REGINA P. MARKUS 

C - 101 ANTIOXIDANT AND CHEMICAL PROFILE OF BRAZILIAN PROPOLIS: 

AN IN VITRO STUDY. ALAN DE AGUIAR LOPES, LARISSA ALEXSANDRA SILVA-NETO, 

THIAGO DOS SANTOS FERREIRA, KARLA MARIA PEREIRA PIRES, MANUELLA 

LANZETTI, RENATA TISCOSKI NESI, ARI MIRANDA SILVA, ANTONIO JORGE RIBEIRO 

DA SILVA, SAMUEL DOS SANTOS VALENÇA, LUÍS CRISTÓVÃO DE MORAES SOBRINO 

PÔRTO 

C - 102 BLOCKAGE OF EXTRACELLULAR ATP/ADP SIGNALING REDUCES 

ACETAMINOPHEN-INDUCED LIVER DAMAGE. JAYANE LAIS DIAS QUINTÃO, SYLVIA 

STELLA AMARAL, PEDRO ELIAS MARQUES, DANIELE ARAÚJO PIRES, GUSTAVO 

BATISTA MENEZES 

C - 103 CARDIAC HYPERTROPHY INDUCED RENAL 

ISCHEMIA/REPERFUSION: GENE EXPRESSION ANALYSIS OF INFLAMMATORY 

CELLS PROLIFERATION IN HEART TISSUE. KARINA KAORI NAKAMA, MARCELA 

SORELLI CARNEIRO RAMOS 

C - 104 A SNAKE VENOM SECRETED PHOSPHOLIPASE A2 INDUCES PPAR-Γ 

AND –Β EXPRESSION AND ACTIVATION IN MACROPHAGES: IMPLICATION IN 

PLIN2 PROTEIN EXPRESSION. ELBIO LEIGUEZ, KARINA CRISTINA GIANNOTTI, JOSÉ 

MARIA GUTIÉRREZ, BRUNO LOMONTE, CATARINA TEIXEIRA 

C - 105 AMYLOID-BETA PEPTIDE TRIGGERS NUCLEAR FACTOR KAPPA B 

SIGNALING PATHWAY IN RAT PINEAL GLANDS. ERIKA CECON, PEDRO AUGUSTO 

CARLOS MAGNO FERNANDES, EDUARDO KOJI TAMURA, REGINA PEKELMANN 

MARKUS 

C - 106 EVALUATION OF THE EFFECT OF PROPIONIBACTERIUM ACNES ON 

THE SURVIVAL OF ANIMALS WITH LETHAL SEPSIS. SAMARA KELLY MENDONÇA DE 

OLIVEIRA, JOSÉ BRUNO NUNES FERREIRA DA SILVA, LARISSA CARDOSO CORRÊA DE 

ARAÚJO, JACIANA DOS SANTOS AGUIAR, TERESINHA GONÇALVES DA SILVA 

C - 107 MECHANISMS INVOLVED IN LIPID BODY FORMATION AND 

AUTOPHAGY DURING EXPERIMENTAL INFECTION BY MYCOBACTERIUM BOVIS 

BCG IN MICE. HELOISA D`AVILA DA SILVA BIZARRO, NATÁLIA ROBERTA ROQUE, 

ALINE APARECIDA ASSIS, DOUGLAS MOREIRA DE ARAÚJO, GABRIEL SANTOS CRUZ 

RODRIGUES, SÍLVIA LUCENA LAGE, PATRÍCIA ELAINE ALMEIDA, ROSSANA. CORREA 

NETTO MELO, HUGO C. CASTRO-FARIA-NETO, CLARISSA MAYA MONTEIRO, 

PATRÍCIA TORRES BOZZA 

100

C - 108 ROLE OF CAVEOLIN-1 IN THE REGULATION OF PRODUCTION OF 

INFLAMMATORY MEDIATORS IN PERITONEAL MACROPHAGES.CECÍLIA JACQUES 

GONÇALVES DE ALMEIDA, CAROLINA DA PAZ ZAMPIER, MICHAEL P. LISANTI, 

PATRÍCIA T. BOZZA 

C - 109 EARLY AND LATE ACUTE LUNG INJURY AND ITS ASSOCIATION 

WITH DISTAL ORGAN DAMAGE IN EXPERIMENTAL MALARIA. MARIANA 

CONCEIÇÃO DE SOUZA, JOHNATAS DUTRA SILVA, TATIANA ALMEIDA PADUA, VERA 

LUIZA CAPELOZZI, PATRICIA R. M. ROCCO, MARIA DAS GRAÇAS HENRIQUES 

C - 110 SNAKE VENOM TOXIN BMOOMP-ALFA-I INHIBITS ANGIOGENESIS 

IN MURINE MODELS. SAULO ANTONIO GOMES FILHO, PUEBLA CASSINI VIEIRA, 

SIMONE RAMOS DECONTE, AMANDA VIEIRA, FABIO DE OLIVEIRA, FERNANDA DE 

ASSIS ARAÚJO 

C - 111 NO AND IL-1Β PRODUCTION BY MURINE MACROPHAGES TREATED 

WITH LECTINS CMOL AND WSMOL. LARISSA CARDOSO CORRÊA DE ARAÚJO, 

JACIANA DOS SANTOS AGUIAR, MARIA DO DESTERRO RODRIGUES, JEYCE KELLE 

FERREIRA DE ANDRADE, LUANA CASSANDRA BREITENBACH BARROSO COELHO, 

TERESINHA GONÇALVES DA SILVA, PATRÍCIA MARIA GUEDES PAIVA 

C - 112 DOWN-MODULATION OF ACTIVATED HUMAN NEUTROPHIL BY 

LMW-FUCOIDAN. JOÃO ALFREDO DE MORAES, ANA CLARA FRONY, GENILSON 

RODRIGUES, CATHERINE BOISSON-VIDAL, CHRISTINA BARJA-FIDALGO 

C - 113 DIESEL PARTICLES (DEP) INDUCE MELATONIN SYNTHESIS BY 

MACROPHAGES THROUGH NF-KB ACTIVATION. CLAUDIA EMANUELE CARVALHO 

DE SOUSA, SANDRA MARCIA MUXEL, ALESSANDRA STRANIERI, MARIANGELA 

MACCHIONE, PAULO HILARIO NASCIMENTO SALDIVA, REGINA PEKELMANN 

MARKUS 

C - 114 CHARACTERIZATION OF GENE EXPRESSION IN CD14+CD16-, 

CD14+CD16+ AND CD14DIMCD16++ MONOCYTE SUBSETS IN OBESITY. MARIANA 

RENOVATO MARTINS, ESTELLE DEVEVRE, ELISE DALMAS, JEAN-LUC BOUILLOT, 

ARNAUD BASEDEVANT, WOLF-HERMAN FRIDMAN, THEREZA CHRISTINA BARJA- 

FIDALGO, KARINE CLÉMENT, CATHERINE SAUTÈS-FRIDMAN, ISABELLE CREMER, 

CHRISTINE POITOU 

C - 115 EVALUATION OF THE EFFECT OF 5 AZA CYTIDINE ON THE WOUND 

HEALING IN WISTAR RATS. FABIANA DE SOUZA GOMES, LÍCIO AUGUSTO VELLOSO, 

CARLA EVELYN COIMBRA NUÑEZ, GABRIELA FREITAS PEREIRA DE SOUZA, MARIA 

HELENA MELO LIMA, RAFAEL DE MORAES PEDRO, ELIANA PEREIRA DE ARAÚJO 

C - 116 THE ROLE OF PURINERGIC P2X7 RECEPTORS IN MURINE SILICOSIS. 

LEONARDO MONÇÃO RIBEIRO, PATRICIA TEIXEIRA SANTANA, RADOVAN 

BOROJEVIC, CHRISTINA MAEDA TAKIYA, ROBSON COUTINHO SILVA 

C - 117 INCREASED LEPTIN RESPONSE AND INHIBITION OF APOPTOSIS IN 

THYMIC CELLS FROM YOUNG OFFSPRING SUBMITTED TO MATERNAL PROTEIN 

DEPRIVATION DURING LACTATION. SIMONE VARGAS DA SILVA, CAROLINA 

SALAMA, MARIANA RENOVATO MARTINS, EDWARD HELAL NETO, MARTA CITELLI, 

WILSON SAVINO, CHRISTINA BARJA-FIDALGO 

C - 118 SHORT- TERM TREATMENT WITH IL-10-PRODUCING LACTOCOCCUS 

LACTIS REDUCES SYSTEMIC IL-17 BUT DO NOT IMPROVE THE CLINICAL SIGNALS 

OF COLITIS.LUÍSA LEMOS DOS SANTOS, ANA CRISTINA GOMES-SANTOS, THAIS 

GARCIA MOREIRA, BERNARDO COELHO HORTA, ANDERSON MIYOSHI, DENISE 

CARMONA CARA, ANA MARIA CAETANO DE FARIA 

D – Cell Biology and 

Reproduction 

D1-D140 

D - 1 STRUCTURAL AND ULTRASTRUCTURAL ANALYSIS OF THE 

PLACENTA IN PREGNANT RATS FED WITH PROTEIN RESTRICTION DIET. HÉRCULES 

JONAS REBELATO, MARCELO AUGUSTO MARRETTO ESQUISATTO, PAULO PINTO 

JOAZEIRO, ROSANA CATISTI 

D - 2 HYPERTHERMIC STRESS AFFECTS SPERMATOGENESIS EUPEMPHIX 

NATTERERI (ANURA: LEIUPERIDAE) GABRIELA BARONI LEITE, JULIANE 

SILBERSCHIMDIT FREITAS, LIA RAQUEL SOUZA DOS SANTOS, LILIAN FRANCO- 

BELUSSI, CLASSIUS DE OLIVEIRA 

D - 3 CHRONIC CAFFEINE INTAKE INCREASES ANDROGENIC STIMULI, 

EPITHELIAL CELL PROLIFERATION AND HYPERPLASIA IN RAT VENTRAL PROSTATE 

SÉRGIO LUIS FELISBINO, CAROLINA SAROBO, LIVIA MARIA LACORTE, MARCELA 

MARTINS, JAQUELINE CARVALHO RINALDI, IVAN JOSÉ VERCHETTI JUNIOR, ANDREI 

MOROZ, WELLERSON RODRIGO SCARANO, FLAVIA KARINA DELELLA 

D - 4 SPERMATOGENESIS IN EUPEMPHIX NATTERERI (ANURA: 

LEIUPERIDAE): LATE RESPONSE TO LPS LARA SALGUEIRO DE GREGORIO, LILIAN 

FRANCO-BELUSSI, GABRIELA BARONI LEITE, JULIANE SILBERSCHMIDT FREITAS, 

CLASSIUS DE OLIVEIRA 

D - 5 TESTES MORPHOLOGY AND SPERMATOGENESIS IN TELCHIN LICUS 

LICUS (LEPIDOPTERA: CASTNIIDAE) MONIQUE CAMPOS PEREIRA, DANIELA 

CARVALHO DOS SANTOS, ELTON LUIZ SCUDELER, ANA SILVIA GIMENES GARCIA, 

REINALDO JOSÉ DA SILVA 

D - 6 REPRODUCTIVE DEVELOPMENT OF THE MALE OFFSPRING FROM 

RATS TREATED WITH CARBAMAZEPINE DURING PREGNANCY SAMARA URBAN DE 

OLIVA, TAIZA STUMPP, SANDRA MARIA MIRAGLIA 

D - 7 EVALUATION OF THE EFFECTS OF ABLATION OF TESTOSTERONE IN 

PROSTATIC COMPLEX OF ARTIBEUS PLANIROSTRIS (CHIROPTERA: 

PHYLLOSTOMIDAE). CINTIA CRISTINA ISICAWA PUGA, MATEUS RODRIGUES 

BEGUELINI, FABIANE FERREIRA MARTINS, ELIANA MORIELLE VERSUTE, PATRICIA 

SIMONE LEITE VILAMAIOR, SEBASTIÃO ROBERTO TABOGA 

D - 8 EFFECT OF CARNITINE AND OF ETOPOSIDE ON SPERMATOGONIAL 

STEM/PROGENITOR CELLS OF RATS TREATED IN THE PREPUBERTAL PHASE. 

FATIMA KAZUE OKADA, TAIZA STUMPP, SANDRA MARIA MIRAGLIA 

D - 9 COMPARATIVE STUDY OF BATS IN DORSAL PROSTATE 

REPRESENTATIVES OF THE SUBFAMILIES: GLOSSOPHAGINAE, CAROLLINAE E 

PHYLLOSTOMINAE (CHIROPTERA-PHYLLOSTOMIDAE) FABIANE FERREIRA 

MARTINS, CINTIA ISICAWA PUGA, MATEUS RODRIGUES BEGUELINI, PATRICIA 

SIMONE LEITE VILAMAIOR, ELIANA MORIELLE-VERSUTE, SEBASTIÃO ROBERTO 

TABOGA 

D - 10 INVOLVEMENT OF ABCB1 AND ABCC1 PROTEINS IN SEA URCHIN 

FERTILIZATION PROCESS. HELENA LIMA DA SILVA NETA, TALITTA DANTAS DE 

ARRUDA, ELIS TORREZAN GONÇALVES RAMALHO NITÃO, LUIS FERNANDO 

MARQUES-SANTOS 

D - 11 GERM CELLS RECOVERY IN IRRADIATED RAT TESTIS AFTER 

TREATMENT WITH ACYLINE - A GNRH ANTAGONIST - AND FLUTAMIDE – AN 

ANDROGEN RECEPTOR ANTAGONIST AMANDA VASCONCELOS DE 

ALBUQUERQUE, MARVIN L. MEISTRICH, GUNAPALA SHETTY, FERNANDA F.R.C.L. 

ALMEIDA, HÉLIO CHIARINI GARCIA 

D - 12 CHARACTERIZATION OF INTERCELLULAR JUNCTIONS IN 

FIBROBLASTS OF MOUSE PUBIC SYMPHYSIS DURING PREGNANCY AND 

POSTPARTUM VIVIANE DE SOUZA ROSA, SÍLVIO ROBERTO CONSONNI, MONICA 

MOREIRA, BIANCA CASTELUCCI, PAULO PINTO JOAZEIRO 

D - 13 CHANGES OF THE MOUSE INTERPUBIC TISSUE THROUGHOUT THE 

MIDST OF PREGNANCY GABRIELA TOGNINI SABA, GIULLIANA PETRI, JULIANA 

MORA VERIDIANO, OLGA MARIA DE TOLEDO CORREA 

D - 14 MORPHOMETRICAL, STEREOLOGICAL AND ULTRASTRUCTURAL 

STUDY OF GREEN PROPOLIS EFFECTS ON RAT EPIDIDYMIS CRISTINA CAPUCHO, 

FABRÍCIA DE SOUZA PREDES, JULIANA DE CASTRO MONTEIRO, RENATA BARBIERI, 

MARY ANNE HEIDI DOLDER, GRASIELA DIAS DE CAMPOS SEVERI-AGUIAR 

D - 15 EXTENSIVE MONONUCLEAR INFILTRATION AND POSTPARTUM 

MOUSE PUBIC SYMPHYSIS RECOVERY BIANCA GAZIERI CASTELUCCI, SÍLVIO 

ROBERTO CONSONNI, VIVIANE DE SOUZA ROSA, PAULO PINTO JOAZEIRO 

D - 16 HETEROCHROMATIN PATTERNS IN TRIATOMA WILLIAMI 

(HEMIPTERA, TRIATOMINAE) NATHÁLIA PAIVA PERERIA, PRISCILA PASQÜETTO 

MENDONÇA, KAIO CESAR CHABOLI ALEVI, ANNA CLAUDIA CAMPANER LIMA, JOÃO 

ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 17 LONG-TERM EFFECTS OF DEVELOPMENTAL EXPOSURE TO 

BISPHENOL A (BPA) ON THE PROSTATE OF ADULT RATS: CHEMOPROTECTIVE 

EFFECT OF INDOLE-3-CARBINOL (I3C) JOYCE ZALOTTI BRANDT, LÍVIA TERESA 

RIBEIRO DA SILVEIRA, TONY FERNANDO GRASSI, WAGNER JOSÉ FÁVARO, RAQUEL 

FANTIN DOMENICONI, JANETE A. ANSELMO-FRANCI, JOSÉ EDUARDO BOZANO, 

LUIS FERNANDO BARBISAN, WELLERSON RODRIGO SCARANO 

D - 18 C-HETEROCHROMATIN PATTERN AND NUCLEOLAR ACTIVITY IN 

HOLOCENTRIC CHROMOSOMES OF TRIATOMA LENTI (HEMIPTERA: REDUVIIDAE) 

KAIO CESAR CHABOLI ALEVI, PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA 

PEREIRA, ANNA CLAUDIA CAMPANER LIMA, JOÃO ARISTEU DA ROSA, MARIA 

TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 19 COMPARATIVE CYTOGENETIC STUDY BETWEEN TRIATOMA 

VANDAE E TRIATOMA WILLIAMI (HEMIPTERA, TRIATOMINAE) NATHÁLIA PAIVA 

PERERIA, PRISCILA PASQÜETTO MENDONÇA, KAIO CESAR CHABOLI ALEVI, ANNA 

CLAUDIA CAMPANER LIMA, JOÃO ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE 

AZEREDO OLIVEIRA 

D - 20 NUCLEOLAR ACTIVITY IN SPERMATOGENESIS OF RHODNIUS 

BRETHESI (HEMIPTERA, TRIATOMINAE) PRISCILA PASQÜETTO MENDONÇA, KAIO 

CESAR CHABOLI ALEVI, NATHÁLIA PAIVA PEREIRA, ANNA CLAUDIA CAMPANER 

LIMA, JOÃO ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 21 STUDY OF SPERMATOGENESIS OF TRIATOMA SHERLOCKI 

(HEMIPTERA, TRIATOMINAE) ANNA CLAUDIA CAMPANER LIMA, KAIO CESAR 

CHABOLI ALEVI, PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA PEREIRA, 

JOÃO ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 22 NUCLEOLAR CYCLE IN TRIATOMA WILLIAMI (HEMIPTERA, 

TRIATOMINAE) NATHÁLIA PAIVA PEREIRA, PRISCILA PASQÜETTO MENDONÇA, 

KAIO CESAR CHABOLI ALEVI, ANNA CLAUDIA CAMPANER LIMA, JOÃO ARISTEU DA 

ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

101

D - 23 QUANTITATIVE EVALUATION AND SPATIAL LOCALIZATION OF 

SPONTANEOUS AND MNU-INDUCED PROSTATE TUMORS IN GERBILS BIANCA 

FACCHIM GONÇALVES, SILVANA GISELE PEGORIN DE CAMPOS, CAMILA HELENA 

FACINA, LUIZ ROBERTO FALLEIROS JR, SEBASTIÃO ROBERTO TABOGA 

D - 24 MELATONIN: MITIGATING DAMAGES IN STREPTOZOTOCIN- 

DIABETIC RAT TESTIS CAROLINA FRANDSEN PEREIRA DA COSTA, MARINA 

GUIMARÃES GOBBO, MARIA ETELVINA PINTO, EDUARDO ALVES DE ALMEIDA, 

REJANE MAIRA GÓES 

D - 25 SERTOLI CELL INDEX IN THE FRUGIVOROUS BAT STURNIRA LILIUM 

DANIELLE BARBOSA MORAIS, SÉRGIO LUIS PINTO DA MATTA 

D - 26 SPERMATIC RESERVE IN THE TESTIS OF THE INSECTIVOROUS BAT 

MOLOSSUS MOLOSSUS DANIELLE BARBOSA MORAIS, SÉRGIO LUIS PINTO DA 

MATTA 

D - 27 EFFECTS OF THE INSECTICIDE ENDOSULFAN ON LEYDIG CELLS OF 

THE BIG FRUIT-EATING BAT ARTIBEUS LITURATUS (OLFERS,1818) DANIELLE 

BARBOSA MORAIS, ALESSANDRO BRINATI, SÉRGIO LUIS PINTO DA MATTA, 

MARIELLA BONTEMPO DUCA DE FREITAS, JULIANA SILVA ROCHA, SENDY MOREIRA 

REIS, JULIANA MATTOS SOUZA LIMA, MICHELE OLIVEIRA SANTOS 

D - 28 LONG-TERM SERTOLI CELL RESISTANCE IN TESTIS OF ADULT 

WISTAR RATS EXPOSED TO A SINGLE CADMIUM IP INJECTION. RODRIGO PAULA 

LEITE, MARY ANNE HEIDI DOLDER 

D - 29 ENVIRONMENTALLY REALISTIC HIGH DOSE OF CADMIUM 

INCREASES LIPID PEROXIDATION IN WISTAR RAT TESTIS: IS THE 

HEMATOTESTICULAR BARRIER A MAJOR TARGET OF FREE RADICALS? MARY 

ANNE HEIDI DOLDER, MARY ANNE HEIDI DOLDER, FERNANDA RAMOS GADELHA, 

LUÍS HENRIQUE GONZAGA RIBEIRO 

D - 30 TIME-DEPENDENT EFFECTS OF CADMIUM ON BLOOD VESSEL 

ENDOTHELIUM - HISTOPATHOLOGICAL AND STEREOLOGICAL ANALYSIS. 

RODRIGO PAULA LEITE, FERNANDA RAMOS GADELHA, MARY ANNE HEIDI DOLDER 

D - 31 SPERMATOGENIC EFFICIENCY OF WILD RODENT OLIGORYZOMYS 

NIGRIPES (RODENTIA, MURIDAE) MAYTÊ KOCH BALARINI, ANA CAROLINA TORRE 

MORAIS, TATIANA PRATA DE MENEZES, DANIELLE BARBOSA MORAIS, MICHELE 

OLIVEIRA SANTOS, FAUSTO FERRAZ, SÉRGIO LUIS PINTO DA MATTA 

D - 32 COMPARATIVE STUDY OF APOPTOTIC PROFILE ACTIVATED BY 

INTRINSIC AND EXTRINSIC PATHWAYS IN VENTRAL PROSTATE OF AGING RATS 

AMANDA CRISTINA REIS GONZAGA, MÔNICA MORAIS SANTOS, JÚNIA DAYRELL DE 

MOURA CORDEIRO, GERMÁN ARTURO BOHÓRQUEZ MAHECHA, CLEIDA 

APARECIDA OLIVEIRA 

D - 33 ACTIONS OF AÇAÍ PULP (EUTERPE EDULLIS) ON THE EPIDIDYMAL 

CAPUT REGION HISTOMORPHOMETRY OF WISTAR RATS EXPOSED TO CADMIUM 

CHLORIDE (CDCL2) ANA CLÁUDIA FERREIRA SOUZA, GRAZIELA DOMINGUES DE 

ALMEIDA LIMA, TATIANA PRATA MENEZES, MARLI DO CARMO CUPERTINO, 

SÉRGIO LUÍS PINTO DA MATTA, MARIANA MACHADO NEVES 

D - 34 EFFECTS OF AÇAÍ PULP (EUTERPE EDULLIS) ON CADMIUM 

CHLORIDE-INDUCED DAMAGE IN EPIDIDYMAL CAPUT REGION OF ADULT RATS: A 

MORPHOMETRIC STUDY GRAZIELA DOMINGUES DE ALMEIDA LIMA, TATIANA 

PRATA MENEZES, VIVIANE SILVEIRA GORETE MOURO, RAFAEL REIS DOMINGUES, 

NAYARA MAGALHÃES GONÇALVES, MARLI DO CARMO CUPERTINO, SÉRGIO LUÍS 

PINTO DA MATTA SERGIO, MARIANA MACHADO NEVES 

D - 35 NO LEVEL AS AN INDICATOR OF SICKNESS BEHAVIOR AND UTERINE 

MORPHOPHYSIOLOGICAL CHANGES IN LPS-TREATED PREGNANT MICE BRUNO 

ZAVAN, ELIANA MARA OLIVEIRA LIPPE, ALEXANDRE GIUSTI-PAIVA, AUREO 

TATSUMI YAMADA, VALDEMAR ANTONIO PAFFARO JUNIOR 

D - 36 EFFECTS OF THE MUTATION IN THE FOXN1 GENE IN THE ADULT 

MICE TESTIS STRUCTURE AND FUNCTION CAROLINA FELIPE ALVES DE OLIVEIRA, 

GLEIDE FERNANDES AVELAR, LUIZ RENATO DE FRANÇA 

D - 37 PROTEIN UNDERNUTRITION MODIFIES THE EPITHELIUM- 

MESENCHYME INTERACTION AND DELAYS THE PROSTATE DIFFERENTIATION IN 

NEONATAL RATS CRISTIANE FIGUEIREDO PINHO, PATRÍCIA FERNANDA FELIPE 

PINHEIRO, RAQUEL FANTIN DOMENICONI, BRUNO CÉSAR SCHIMMING, WAGNER 

JOSÉ FAVARO, SÉRGIO PEREIRA, SILVANA GISELE PEGORIN DE CAMPOS, 

SEBASTIÃO ROBERTO TABOGA, PATRÍCIA ALINE BOER, WELLERSON RODRIGO 

SCARANO 

D - 38 STROMAL CHANGES IN THE VENTRAL PROSTATE OF LONG- TERM 

OBESE RATS ARE ASSOCIATED TO INCREASED MMP-9 ACTIVITY AND HIGH VEGF 

CONTENT SILAS AMÂNCIO SILVA, RENATO SIMÕES CORDEIRO, TATIANA CARLA 

TOMIOSSO, SEBASTIÃO ROBERTO TABOGA, REJANE MAIRA GÓES, DANIELE LISBOA 

RIBEIRO 

D - 39 THE SIZE OF THE SPERM FOLLOWS THE SIZE OF THE INDIVIDUALS 

WHO PRODUCE IN CLOSELY RELATED SPECIES? HELEN CRISTINA PINTO SANTOS, 

GLENDA DIAS, RAQUEL APARECIDA COSTA, JOSÉ LINO NETO 

D - 40 VEGF PROTEIN EXPRESSION IN THE PLACENTA OF ALLOXAN 

INDUCED DIABETIC RATS KARINE DOS SANTOS SOUZA, PRISCILLA SILVA FARIAS, 

WALDECY DE LUCCA JUNIOR, ANDERSON CARLOS MARCAL, MARCIO ROBERTO 

VIANA DOS SANTOS, THIAGO ALVES BRAGA, EMERSON TICONA FIORETTO, 

MARLÚCIA BASTOS AIRES 

D - 41 GESTATIONAL EXPOSURE OF GERBILS TO ETHINYLESTRADIOL 

REDUCES THE NUMBER OF GONOCYTES AT BIRTH. MARIANA PULEGIO, ANA 

PAULA DA SILVA PEREZ, MARIA ETELVINA PINTO, REJANE MAIRA GÓES 

D - 42 MORPHOLOGICAL CHANGES IN THE PLACENTA OF ALLOXAN 

INDUCED DIABETIC RATS PRISCILLA SILVA FARIAS, KARINE DOS SANTOS SOUZA, 

ANDERSON CARLOS MARCAL, MARCIO ROBERTO VIANA DOS SANTOS, EMERSON 

TICONA FIORETTO, MARLÚCIA BASTOS AIRES 

D - 43 RELATION BETWEEN SPERM LENGTH AND SIZE OF THE INDIVIDUAL 

WHO PRODUCES GLENDA DIAS, HELEN PINTO SANTOS, JOSÉ LINO-NETO 

D - 44 GERM CELLS DEVELOPMENT IN THE DOURADO SALMINUS 

FRANCISCANUS LIMA & BRITSKI, 2007 FROM THE SÃO FRANCISCO RIVER BASIN: 

A HISTOLOGICAL AND ULTRASTRUCTURAL STUDY LEONARDO JOSÉ ALVES DE 

FREITAS, PAULA SUZANNA PRADO, KLEBER B. SANTIAGO, MARCOS VINICIUS TELES 

GOMES, NILO BAZZOLI, ELIZETE RIZZO 

D - 45 BISPHENOL A (BPA) AND INDOLE-3-CARBINOL (I3C): EFFECTS ON 

THE MALE RATS PROSTATE DEVELOPMENT LÍVIA TERESA RIBEIRO DA SILVEIRA, 

JOYCE ZALOTTI BRANDT, TONY FERNANDO GRASSI, WAGNER JOSÉ FAVARO, 

RAQUEL FANTIN DOMENICONI, PATRÍCIA FERNANDA FELIPE PINHEIRO, LUIS 

FERNANDO BARBISAN, WELLERSON RODRIGO SCARANO 

D - 46 REPRODUCTION AND SPAWNING OF DOURADO SALMINUS 

FRANCISCANUS LIMA & BRITSKI, 2007 IN THE SÃO FRANCISCO RIVER, TRÊS 

MARIAS, MINAS GERAIS, BRAZIL LEONARDO JOSÉ ALVES DE FREITAS, PAULA 

SUZANNA PRADO, KLEBER B. SANTIAGO, MARCOS VINICIUS TELES GOMES, NILO 

BAZZOLI, ELIZETE RIZZO 

D - 47 EXPRESSION OF THE ESTROGEN RECEPTOR ERBETA IN THE 

VENTRAL AND DORSAL PROSTATE OF AGING RATS MÔNICA MORAIS SANTOS, 

RACHEL PIRES REIS, AMANDA CRISTINA REIS GONZAGA, ANDRÉ GUSTAVO 

OLIVEIRA, GERMÁN ARTURO BOHORQUEZ MAHECHA, MARIA CHRISTINA AVELLAR, 

CLEIDA APARECIDA DE OLIVEIRA 

D - 48 EFFECTS OF THE HERBICIDE ATRAZINE IN THE EXPRESSION OF 

P450-AROMATASE IN THE TESTIS, EPIDIDYMIS AND PROSTATE OF ADULT MALE 

RATS ELISÂNGELA MARTINS DOS SANTOS, CRISTIANO GUIMARÃES PIMENTA, 

POLLYANA RABELO NUNES CAMPOS, GERMÁN ARTURO BOHORQUEZ MAHECHA, 

CLEIDA APARECIDA OLIVEIRA 

D - 49 REPRODUCTIVE AND HISTOLOGICAL PARAMETERS OF ADULT RATS 

EXPOSED TO SIBUTRAMINE GABRIELA MISSASSI, CIBELE DOS SANTOS BORGES, 

RAQUEL FRENEDOSO DA SILVA, JULIANA ELAINE PEROBELLI, MARCIANA 

SANABRIA, THAIS PETROCHELLI BANZATO, MARIANA MACÊDO DE OLIVEIRA, 

WILMA DE GRAVA KEMPINAS 

D - 50 EVALUATION OF REPRODUCTIVE AND HISTOLOGICAL 

PARAMETERS ON TESTIS AND EPIDIDYMIS OF ADULT MALE RATS EXPOSED TO 

SIMVASTATIN. THAIS PETROCHELLI BANZATO, MARIANA MACÊDO OLIVEIRA, 

JULIANA ELAINE PEROBELLI, MARCIANA SANABRIA, CIBELE DOS SANTOS BORGES, 

RAQUEL FRENEDOSO DA SILVA, GABRIELA MISSASSI, WILMA DE GRAVA KEMPINAS 

D - 51 NUCLEUS OF PROSTATIC EPITHELIAL CELL OF SENESCENT GERBILS 

AS A TARGET ORGANELLE OF STUDY AFTER HORMONE DEPRIVATION SILVANA 

GISELE PEGORIN DE CAMPOS, BIANCA FACCHIM GONÇALVES, WELLERSON 

RODRIGO SCARANO, LUIZ ROBERTO FALLEIROS JÚNIOR, SEBASTIÃO ROBERTO 

TABOGA 

D - 52 EXTRAORDINARY DIVERSITY OF SPERM MORPHOLOGY AMONG 

MARINE BIVALVES OF THE SUPERFAMILY TELLINOIDEA (MOLLUSCA): 

SPERMATOZOA RANGING FROM ECT-AQUASPERM TO THOSE WITH SCREW-LIKE 

HEAD, AND UNCOMMON PARASPERMATIC FEATURES GISELE ORLANDI INTROÍNI, 

LENITA DE FREITAS TALLARICO, FLÁVIO DIAS PASSOS, SUGURU UJINO, SHIRLEI 

MARIA RECCO-PIMENTEL 

D - 53 HIGH-FAT DIET ACT AS A PROMOTIONAL AGENT ON PROSTATE 

CARCINOGENESIS OF GERBILS. CAMILA HELENA FACINA, BIANCA FACCHIM 

GONÇALVES, LUIZ ROBERTO FALLEIROS JR, SEBASTIÃO ROBERTO TABOGA 

D - 54 EFFECT OF EXTRACTS FROM THE SEED OF NEEM(AZADIRACHTA 

INDICA A JUSS) ON THE MORPHOMETRY SEMINIFEROUS TUBULES OF WISTAR 

RATS. FERNANDA CAROLINA RIBEIRO DIAS, ALLUANAN ADELSON NASCIMENTO, 

JESSICA SANTANA, OLAVIO CAMPOS JUNIOR, SIMONE CABRAL, WOLFGANG 

HARAND, ELIZABETH NEVES DE MELO 

D - 55 ADMINISTRATION OF AN ANDROGEN COMPOUND TO FEMALE 

WISTAR RATS DURING GESTATIONAL AND LACTATIONAL PERIODS AND THE 

ASSESSMENT OF THE EFFECTS ON THE UTERUS OF THE FEMALE OFFSPRING 

MARINA TREVIZAN GUERRA, RAQUEL FRENEDOSO DA SILVA, MARCIANA 

SANABRIA, GAIL GROSSMAN, PETER PETRUSZ, WILMA DE GRAVA KEMPINAS 

D - 56 EXPRESSION OF GLYCOCONJUGATES IN THE UTERINE NATURAL 

KILLER CELLS FROM GENETICALLY MODIFIED MOUSE. ÉVILA DA SILVA LOPES 

SALLES, PAULO FERNANDO DE SOUZA JÚNIOR, ANDRÉA MOLLICA DO AMARANTE 

PAFFARO, BARBARA ANNE CROY, AÚREO TATSUMI YAMADA, VALDEMAR 

ANTÔNIO PAFFARO JÚNIOR 

D - 57 OXIDATIVE STRESS IN THE KIDNEY OF FEMALE RATS WITH OR 

WITHOUT REPRODUCTIVE ACTIVITY DURING AGING JORDANA SALETE PUTTI, 

ANA CAROLINA ALMEIDA DA SILVA, TIAGO BOEIRA SALOMON, CAMILE SAUL 

BEHLING 

102

D - 58 VITELLOGENIN AND ZONA RADIATA PROTEINS 

IMMUNODETECTION IN LIVER OF LAMBARI ASTYANAX FASCIATUS FROM THE 

FURNAS RESERVOIR, GRANDE RIVER, BRAZIL PAULA SUZANNA PRADO, ANA 

PAULA BARBOSA PINHEIRO, ELIZETE RIZZO 

D - 59 LIVER IGF-I E IGF-II IMMUNOCHEMICAL QUANTIFICATION IN 

ASTYANAX FASCIATUS FROM ESTROGEN CONTAMINATED AREAS FROM THE 

FURNAS RESERVOIR, GRANDE RIVER, BRAZIL PAULA SUZANNA PRADO, ANA 

PAULA BARBOSA PINHEIRO, ELIZETE RIZZO 

D - 60 FECUNDITY AND VITELLOGENIC OOCYTE DIAMETER ASSESSMENT 

OF LAMBARI ASTYANAX FASCIATUS INHABITING EDCS CONTAMINATED WATERS 

IN FURNAS RESERVOIR, GRANDE RIVER, BRAZIL ANA PAULA BARBOSA PINHEIRO, 

PAULA SUZANNA PRADO, JÉSSICA FIGUEIREDO ABREU, ELIZETE RIZZO 

D - 61 STRUCTURAL AND ULTRASTRUCTURAL ANALYSES OF OOCYTES OF 

THE DANIO RERIO EXPOSED TO GLYPHOSATE NEIDE ARMILIATO, EVELISE MARIA 

NAZARI, DIB AMMAR, YARA MARIA RAUH MÜLLER 

D - 62 MORPHOLOGICAL AND CYTOCHEMICAL STUDIES OF PREGNANT 

MOUSE UTERUS FROM NORMAL AND GENETIC MODIFIED MOUSE AFTER 

EMBRYONIC LESION RAQUEL MEZZALIRA RUANO, ÉVILA DA SILVA LOPES SALLES, 

ANDREA MOLLICA DO AMARANTE PAFFARO, BARBARA ANNE CROY, ÁUREO 

TATISUMI YAMADA, VALDEMAR ANTONIO PAFFARO JUNIOR 

D - 63 PLACENTAL INDOLEAMINE 2,3-DIOXYGENASE (IDO) ACTIVITY IN 

RENAL-TRANSPLANTED PREGNANT WOMEN KAREN MATIAS DO PRADO, SIMONE 

CORREA DA SILVA, LEANDRO GUSTAVO OLIVEIRA, SILVANA SANDRI, LARISSA DE SÁ 

LIMA, MELISSA CAVALHEIRO TOURINO, ANA CAMPA, CRISTOFORO SCAVONE, 

NIELS OLSEN SARAIVA CAMARA, ESTELA BEVILACQUA 

D - 64 SPERM MORPHOLOGY OF RHYZOPERTHA DOMINICA 

(COLEOPTERA: BOSTRICHIDAE) GLENDA DIAS, HELEN PINTO SANTOS, JOSÉ LINO- 

NETO 

D - 65 IMMUNOLOCALIZATION OF HOMOGALACTURONAN PECTINS, 

ARABINOGALACTAN PROTEINS AND HEMICELLULOSES IN THE FILIFORM 

APPARATUS OF PITCAIRNIA ENCHOLIRIOIDES L.B.SM. (BROMELIACEAE) SIMONE 

PETRUCCI MENDES, ALEXANDRA A. MASTROBERTI, JORGE E. A. MARIATH, 

RICARDO C. VIEIRA, KAREN L. G. DE TONI 

D - 66 POLYMORPHISM OF SPERMATOZOA IN THE INSECT TRYPOXYLON 

(HYMENOPTERA: CRABRONIDAE) LUIZ FERNANDO GOMES, UYRÁ ZAMA, HELEN 

PINTO SANTOS, JOSÉ LINO-NETO 

D - 67 AQUAPORIN-9 LOCALIZATION IN THE GERBIL EPIDIDYMIS DURING 

POSTNATAL DEVELOPMENT CARLA DE MORAES MACHADO, WELLERSON 

RODRIGO SCARANO, PATRICIA FERNANDA FELIPE PINHEIRO, WAGNER JOSÉ 

FÁVARO, RAQUEL FANTIN DOMENICONI 

D - 68 SPERMATOGONIAL STEM CELL NICHE IN THE SEXUALLY MATURE 

BULLFROG (LITHOBATES CATESBEIANUS) LUIZ HENRIQUE DE CASTRO ASSIS, 

FERNANDA VIEIRA DA SILVA CRUZ, TÂNIA MARA SEGATELLI, LUIZ RENATO DE 

FRANÇA 

D - 69 MATERNAL OBESITY AND POSTNATAL OVERNUTRITION IMPAIRS 

LEYDIG CELLS FUNCTION IN ADULT RATS MARIA ETELVINA PINTO, THIAGO FERES 

PISSOLATO, DANIELE LISBOA RIBEIRO, REJANE MAIRA GÓES 

D - 70 DURATION OF SPERMATOGENESIS IN THE SPINY-RAT, 

PROECHIMYS GUYANNENSIS (RODENTIA: ECHIMYIDAE) NATHÁLIA DE LIMA E 

MARTINS LARA, IVAN CARLOS DOS SANTOS, GUILHERME MATTOS JARDIM COSTA, 

PAULO HENRIQUE ALMEIDA CAMPOS-JUNIOR, ANA PAULA MADUREIRA, MARCOS 

SANTOS ZANINI, LUIZ RENATO DE FRANÇA 

D - 71 FECUNDITY, OOCYTE DIAMETER, GONADAL MATURATION AND 

GONADOSSOMATIC INDEX OF THE CURIMBATÁ PROCHILODUS LINEATUS IN 

THREE SECTIONS OF THE GRANDE RIVER BASIN, DOWNSTREAM FROM THE 

PORTO COLOMBIA DAM. VIOLETA DA ROCHA PERINI, CLÁUDIA KELLY FERNANDES 

CRUZ, NILO BAZZOLI, ELIZETE RIZZO 

D - 72 COLLARED PECCARY (TAYASSU TAJACU) SPERMATOGENESIS 

PROGRESSION AND DE NOVO TESTIS MORPHOGENESIS FROM TESTIS TISSUE 

AND CELL SUSPENSION ECTOPICALLY XENOGRAFTED IN IMMUNODEFICIENT 

MICE PAULO HENRIQUE DE ALMEIDA CAMPOS JUNIOR, G. M. J. COSTA, S. M. S. N. 

LACERDA, G. F. AVELAR, D. A. A. GUIMARÃES, P. R. KAHWAGE, L. R. FRANÇA 

D - 73 SELF-RENEWAL AND EXPANSION OF NILE-TILAPIA (OREOCHROMIS 

NILOTICUS) SPERMATOGONIAL STEM CELLS IN CULTURE SAMYRA MARIA DOS 

SANTOS NASSIF LACERDA, MARIANA DE ARAÚJO DA SILVA, GUILHERME MATTOS 

JARDIM COSTA, PAULO HENRIQUE ALMEIDA CAMPOS-JÚNIOR, TÂNIA MARA 

SEGATELLI, LUIZ RENATO DE FRANÇA 

D - 74 DEVELOPMENT OF A CRYOPRESERVATION PROTOCOL FOR 

SPERMATOGONIAL STEM CELL IN HORSES GUILHERME MATTOS JARDIM COSTA, 

G. F. AVELAR, J. V. REZENDE-NETO, S. M. S. N. LACERDA, P. H. A. CAMPOS- JÚNIOR, 

F. G. P. MARTINS, L. R. FRANÇA 

D - 75 DISTRIBUTION OF ESTROGEN RECEPTORS ERALPHA AND ERBETA 

IN THE PROSTATE AND AMPULLARY GLANDS OF BIG FRUIT-EATING BAT 

ARTIBEUS LITURATUS DURING THE ANNUAL REPRODUCTIVE CYCLE. GABRIEL 

HENRIQUE CAMPOLINA SILVA, REGIANA LUCIA DE OLIVEIRA, JOSÉ CARLOS 

NOGUEIRA, GERMÁN ARTURO BOHORQUEZ MAHECHA, CLEIDA APARECIDA DE 

OLIVEIRA 

D - 76 INVESTIGATION OF AQUAPORIN-9 IN THE EFFERENT DUCTULES 

AND EPIDIDYMIS OF BIG FRUIT-EATING BAT ARTIBEUS LITURATUS DURING THE 

ANNUAL REPRODUCTIVE CYCLE REGIANA LUCIA DE OLIVEIRA, JOSÉ CARLOS 

NOGUEIRA, GERMÁN ARTURO BOHORQUEZ MAHECHA, CLEIDA APARECIDA DE 

OLIVEIRA 

D - 77 EFFECT OF NEEM OIL (AZADIRACHTA INDICA A. JUSS) ON 

MORPHOLOGY OF THE TESTIS OF CERAEOCHRYSA CLAVERI (NAVÁS, 1911) 

(NEUROPTERA: CHRYSOPIDAE) ANA SILVIA GIMENES GARCIA, ELTON LUIZ 

SCUDELER, MONIQUE CAMPOS PEREIRA, PATRICIA FERNANDA FELIPE PINHEIRO, 

DANIELA CARVALHO DOS SANTOS 

D - 78 THE OOGENESIS PROCESS DURING THE REPRODUCTIVE CYCLE OF 

LOXOSCELES INTERMEDIA (ARANEAE: SICARIIDAE). EVERTON FOGAÇA, CLAUDIA 

FEIJÓ ORTOLANI-MACHADO 

D - 79 ASSESSMENT OF SPERMATOGENESIS AND DIAMETER OF 

SEMINIFEROUS TUBULES IN THE LAMBARI ASTYANAX FASCIATUS FROM 

CONTAMINATED SITES IN FURNAS RESERVOIR, GRANDE RIVER, BRAZIL ANA 

PAULA BARBOSA PINHEIRO, PAULA SUZANNA PRADO, FABRÍCIO FLÁVIO 

THEOPHILO DOMINGOS, ELIZETE RIZZO 

D - 80 SPERMATOGENIC CYCLE LENGTH AND SPERM PRODUCTION IN A 

FRESHWATER TURTLE KINOSTERNONSCORPIOIDES ALANA LISLEA DE SOUSA, 

PAULO HENRIQUE ALMEIDA CAMPOS- JUNIOR, GUILHERME MATTOS JARDIM 

COSTA, LUIZ RENATO DE FRANÇA 

D - 81 EXTENUATING EXERCISE INCREASES THE UNK CELLS NUMBER AND 

DECREASES EMBRYO VIABILITY IN PREGNANT MOUSE YAN TEIXEIRA FELBER, 

KAMILA LEITE RODRIGUES, CAMILA A BRAGA, ANDREA MOLLICA AMARANTE 

PAFFARO, VALDEMAR ANTONIO PAFFARO JUNIOR 

D - 82 TYPE A SPERMATOGONIA DISTRIBUTION IN THE TESTIS OF 

SEXUALLY MATURE NILE-TILAPIA (OREOCHROMIS NILOTICUS) PEDRO MANUEL 

APONTE GARCIA, TÂNIA MARA SEGATELLI, LUCAS SANTOS E SOUZA, LUIZ RENATO 

DE FRANÇA 

D - 83 CIRCADIAN PROTEINS CLOCK AND BMAL1 IN THE CHROMATOID 

BODY, A RNA GRANULE OF MALE GERM CELLS RITA LUIZA PERUQUETTI, PAOLO 

SASSONE-CORSI 

D - 84 ETHNOMEDICINES USED IN ALFENAS (BRAZIL) FOR FEMALE 

REPRODUCTIVE DISORDERS JULIANE DE LIMA PASSOS, FERNANDO FELICIONI, ANA 

FLÁVIA GONTIJO PIMENTA, GIOVANA BARBARINE LONGATO, VALDEMAR 

ANTÔNIO PAFFARO JÚNIOR, ANDRÉA MOLLICA DO AMARANTE PAFFARO 

D - 85 EFFECTS OF THE FUNGICIDE TEBUCONAZOLE ON LEYDIG CELLS 

FROM THE FRUGIVOROUS BATS ARTIBEUS LITURATUS (OLFERS, 1818) DIANE DA 

CRUZ MIRANDA, ÉRICA RITA DOS SANTOS LEITE, TÚLIO FIORINI CARVALHO, 

RAQUEL ARMINDA CARVALHO MACHADO, DANIELA VALENTE DE ANDRADE, 

MIRLAINE SOARES BARROS, ALESSANDRO BRINATI, MARIANA MACHADO NEVES, 

MARIELLA BOMTEMPO DUCA DE FREITAS, SÉRGIO LUIS PINTO DA MATTA 

D - 86 KARYOTYPE OF TRIATOMA MELANOCEPHALA (HEMIPTERA: 

REDUVIIDAE) CAMILA HELENA FACINA, KAIO CESAR CHABOLI ALEVI, MARIA 

TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 87 ARTEMISININ INCREASES UTERINE NATURAL KILLER CELL NUMBER 

AND CAUSES EMBRYO LOSS DURING MOUSE PREGNANCY FERNANDO FELICIONI, 

KAMILA LEITE RODRIGUES, VALDEMAR ANTÔNIO PAFFARO JÚNIOR, ANDRÉA 

MOLLICA DO AMARANTE PAFFARO 

D - 88 ANALYSIS OF VIMENTIN EXPRESSION IN MICE CHORIOALLANTOIC 

PLACENTAL TROPHOBLAST GIANT CELLS PEDRO LUIZ ANDRADE SCHERHOLZ, DIVA 

DENELLE SPADACCI-MORENA, SIMA GODOSEVICIUS KATZ 

D - 89 ACUTE EFFECT OF THE FUNGICIDE MANCOZEB ON LEYDIG CELLS 


CRUZ MIRANDA, ÉRICA RITA DOS SANTOS LEITE, TÚLIO FIORINI CARVALHO, 

RAQUEL ARMINDA CARVALHO MACHADO, DANIELA VALENTE DE ANDRADE, 

MIRLAINE SOARES BARROS, ALESSANDRO BRINATI, MARIANA MACHADO NEVES, 

MARIELLA BONTEMPO DUCA DE FREITAS, SÉRGIO LUIS PINTO DA MATTA 

D - 90 ANNUAL REPRODUCTIVE CYCLE OF MALES OF THE FLAT-FACED 

FRUIT-EATING BAT, ARTIBEUS PLANIROSTRIS (CHIROPTERA: PHYLLOSTOMIDAE) 

MATEUS RODRIGUES BEGUELINI, CINTIA CRISTINA ISICAWA PUGA, SEBASTIÃO 

ROBERTO TABOGA, ELIANA MORIELLE VERSUTE 

D - 91 SENESCENCE AND PROSTATE: FIBROBLASTIC GROWTH FACTORS, 

ANDROGEN AND PROLACTIN INTERACTIONS. AMANDA CIA HETZL, FABIO 

MONTICO, LARISSA AKEMI KIDO, RAISA MISTIERI LORENCINI, EDUARDO MARCELO 

CÂNDIDO, VALÉRIA HELENA ALVES CAGNON 

D - 92 BIOCHEMICAL CHARACTERIZATION OF THE NUCLEAR ANNULUS OF 

BULL SPERM AND ITS ASSOCIATION WITH CHROMATIN MOLINE SEVERINO 

LEMOS, PRISCILA FERREIRA MOREIRA, ALBERTO DA SILVA MORAES, FÁBIO DE 

OLIVEIRA, ROMUALDO MORANDI FILHO, MARCELO EMÍLIO BELETTI 

D - 93 CYTOTOXIC EFFECTS OF SODIUM ARSENITE ON MICE SPERM CELLS 

MARIA DE LOURDES GOMES PEREIRA, FERNANDO GARCIA E COSTA 

103

D - 94 REPRODUCTIVE PARAMETERS OF DIABETIC RATS TREATED WITH 

BRAZIL NUT EXTRACT OR SODIUM SELENITE LEONARDO PARREIRA SILVA 

NASCIMENTO, VANESSA CARDOSO PIRES, DANIEL ARAKI RIBEIRO, ANDREA 

PITTELLI BOIAGO GOLLUCKE, LUIS FILIPE DE OLIVEIRA FIGLIOLINO, HIROCHI 

YAMAMURA, NATÁLIA MANZATTI MACHADO ALENCAR, ODAIR AGUIAR JUNIOR 

D - 95 AGING ALTERATIONS IN TESTIS AND EPIDIDYMIS: COULD 

HETEROPTERYS TOMENTOSA IMPROVE THESE CHANGES? FABRICIA DE SOUZA 

PREDES, MARIA APARECIDA DA SILVA DIAMANTE, JULIANA CASTRO MONTEIRO, 

HEIDI DOLDER 

D - 96 PROSTATIC STROMA FEATURES IN THE SENESCENCE AND 

FOLLOWING ANTI-ANGIOGENIC THERAPY X STROMAL REACTIVITY DURING 

CANCER PROGRESSION IN THE TRANSGENIC ADENOCARCINOMA OF MOUSE 

PROSTATE (TRAMP) MODEL FABIO MONTICO, AMANDA CIA HETZL, EDUARDO 

MARCELO CÂNDIDO, LARISSA AKEMI KIDO, RAÍSA MISTIERI LORENCINI, VALÉRIA 

HELENA ALVES CAGNON 

D - 97 DI-N-BUTYL-PHTHALATE (DBP) EFFECTS ON THE PROSTATE OF 

ADULT RATS EXPOSED FROM THE FETAL PERIOD AND INITIATED BY MNU: 

BIOMETRICAL, HORMONAL AND STEREOLOGICAL PARAMETERS TALITA MELLO 

SANTOS, ANDRÉ REBELLO PEIXOTO, JOYCE ZALOTTI BRANDT, LEONARDO DE 

OLIVEIRA MENDES, JOSÉ EDUARDO BOZANO, WAGNER JOSÉ FAVARO, RAQUEL 

FANTIN DOMENICONI, JANETE A. ANSELMO-FRANCI, WELLERSON RODRIGO 

SCARANO 

D - 98 ANTIANGIOGENIC THERAPIES AND MOLECULAR RESPONSE OF THE 

VENTRAL PROSTATE MICROENVIRONMENT IN ELDERLY MICE. LARISSA AKEMI 

KIDO, AMANDA CIA HETZL, EDUARDO MARCELO CÂNDIDO, FABIO MONTICO, 

RAÍSA MISTIERI LORENCINI, VALÉRIA HELENA ALVES CAGNON 

D - 99 INCIDENCE OF LESIONS AND MAPK/AKT PATHWAY EVALUATION 

IN THE ADULT RATS PROSTATE EXPOSED FROM THE FETAL PERIOD TO DI-N- 

BUTYL-PHTHALATE (DBP) ANDRÉ REBELO PEIXOTO, TALITA DE MELLO SANTOS, 

WAGNER JOSÉ FAVARO, PATRÍCIA FERNANDA F. PINHEIRO, RAQUEL FANTIN 

DOMENICONI, SILVANA GISELE PEGORIN DE CAMPOS, SÉRGIO LUIS FELISBINO, 

SEBASTIÃO ROBERTO TABOGA, WELLERSON RODRIGO SCARANO 

D - 100 CHARACTERISTICS OF INTERACTION BETWEEN ESTROGEN AND 

PROGESTERONE ON THE GERBIL PROSTATE RICARDO ALEXANDRE FOCHI, JULIA 

QUILLES ANTONIASSI, LUIZ ROBERTO FALLEIROS JÚNIOR, SEBASTIÃO ROBERTO 

TABOGA 

D - 101 INFUSION AND EXTRACT OF ARTEMISIA VULGARIS IMPAIR MOUSE 

PREGNANCY FERNANDO FELICIONI, PAULO SÉRGIO DE SOUZA PRIZMIC KIMAR, 

VALDEMAR ANTÔNIO PAFFARO JÚNIOR, ANDRÉA MOLLICA DO AMARANTE 

PAFFARO 

D - 102 EFFECT OF PUNICA GRANATUM HIDROALCOHOLIC EXTRACT IN 

MICE PAULO FERNANDO DE SOUZA JR, DANIELE ABUD QUAGLIANO, CAMILA 

MIRANDA PERNAMBUCO, ALEXANDRE GIUST PAIVA, ANDREA MOLLICA DO 

AMARANTE PAFFARO 

D - 103 CONTRACEPTIVE POTENTIAL OF SUBCHRONIC ETHANOLIC 

EXTRACT OF MAYTENUS ILICIFOLIA MART. EX REISSEK. IN FEMALE WISTAR RATS 

SILVANE SOUZA ROMAN, CARLA GIANE LOSS, ASSIS ECKER, BRUNA CLAUDIA 

COPPE, TAÍS REGINA FIORENTIN, ARNO ERNESTO HOFMANN JUNIOR 

D - 104 MORPHOLOGICAL ASPECTS OF THE INITIAL STAGES OF 

TOXOPLASMA GONDII INVASION IN THE HUMAN CHORIONIC VILLI SARA HISSAE 

HIRAIWA, LETÍCIA DE SOUZA CASTRO FILICE, BRENO COSTA LANDIM, PRISCILA 

SILVA FRANCO, ELOISA AMÁLIA VIEIRA FERRO, JULIANA GONZAGA DE OLIVEIRA 

D - 105 ANTIANGIOGENIC THERAPY AND STEM CELL REACTIVITY OF THE 

TRANSGENIC ADENOCARCINOMA OF MOUSE DORSOLATERAL PROSTATE 

(TRAMP) MODEL VALÉRIA HELENA ALVES CAGNON, FABIO MONTICO, AMANDA 

CIA HETZL, RAÍSA MISTIERI LORENCINI, LARISSA AKEMI KIDO, WAGNER JOSÉ 

FÁVARO, MARCUS A. F. CORAT, DELMA P. ALVES, LUIZ A.C. PASSOS 

D - 106 EFFECT OF SYZYGIUM CUMINI HIDROALCOHOLIC EXTRACT IN MICE 

PREGNANCY RODOLFO CABRAL MARCELINO, WESLEY FERNANDES FONSECA 

D - 107 DETERMINATION OF (AG ↓ CT) SEQUENCES IN T. TIBIAMACULATA 

THROUGH RESTRICTION ENDONUCLEASE ALUI NAYARA FERNANDA DA COSTA 

CASTRO, ADAUTO DE OLIVEIRA BORGUETI, ROSANA SILISTINO-SOUZA, LARISSA 

CENTURION GANDOLPHI, MARIA TERCÍLIA VILELA DE AZEREDO-OLIVEIRA 

D - 108 ANALYSIS WITH RESTRICTION ENDONUCLEASE HAEIII IN 

TRIATOMINAE (HETEROPTERA, REDUVIIDAE) LARISSA CENTURION GANDOLPHI, 

ADAUTO DE OLIVEIRA BORGUETI, ROSANA SILISTINO-SOUZA, NAYARA FERNANDA 

DA COSTA CASTRO, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 109 GERM CELLS DIFFERENTIATION IN VITRO: EXPLORING THE ROLE OF 

EXTRACELLULAR MATRIX. MARISTELA TALIARI PIMENTA, CATARINA SEGRETI 

PORTO, MARIA DE FÁTIMA MAGALHÃES LAZARI 

D - 110 PRESENCE OF URETHRAL CORPUS SPONGIOSUM AND PROSTATE 

(SKENE’S PARAURETHRAL GLANDS) IN FEMALE COATI THELMA MICHELLA SADDI, 

FLÁVIO DE REZENDE GUIMARÃES, MANOEL FRANCISCO BIANCARDI, EUGÊNIO 

GONÇALVES DE ARAÚJO, SEBASTIÃO ROBERTO TABOGA, WILIA MARTA ELSNER 

DIEDERICHSEN DE BRITO, FERNANDA CRISTINA ALCANTARA DOS SANTOS 

D - 111 MATERNAL BEHAVIOR IN PREGNANCY AFTER TREATMENT WITH 

HYDROALCOHOLIC EXTRACT OF CASSIA ANGUSTIFOLIA DURING EMBRYO 

IMPLANTATION PERIOD RAFAELA SILVA DOS SANTOS, BRUNO ZAVAN, VALDEMAR 

ANTÔNIO PAFFARO JÚNIOR, ANDRÉA MOLLICA DO AMARANTE PAFFARO 

D - 112 HISTOLOGICAL DESCRIPTION OF THE OOGENESIS OF HYPOSTOMUS 

FRANCISCI (LÜTKEN, 1874) (SILURIFORMES, LORICARIIDAE) CAPTURED IN THE 

ITAPECERICA RIVER, DIVINÓPOLIS, MG, BRAZIL. CAMILA FERREIRA SALES, 

REGIANNE FERREIRA SILVA, MARILIA GABRIELA C AMARAL, ROSY I. MACIEL 

AZAMBUJA RIBEIRO, FABRICIO FLÁVIO THEOPHILO DOMINGOS, RALPH GRUPPI 

THOMÉ, HÉLIO BATISTA DOS SANTOS 

D - 113 STUDY OF SPERMATOGENESIS OF TRIATOMA JUAZEIRENSIS 

(HEMIPTERA, REDUVIIDAE) KAIO CESAR CHABOLI ALEVI, PRISCILA PASQÜETTO 

MENDONÇA, NATHÁLIA PAIVA PEREIRA, NAYARA FERNANDA DA COSTA CASTRO, 

LARISSA CENTURION GANDOLPHI, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 114 EFFECT OF INFUSION OF RUTA GRAVEOLENS IN THE PRE- 

IMPLANTATIONAL AND IMPLANTATIONAL PERIOD OF MICE PREGNANCY CAMILA 

ALVARES BRAGA, WESLEY FERNANDES FONSECA, VALDEMAR ANTÔNIO PAFFARO 

JÚNIOR, ANDRÉA MOLLICA DO AMARANTE PAFFARO 

D - 115 DESCRIPTION OF SOMATIC AND GERM CELLS IN TESTIS OF 

ARMORED CATFISH HYPOSTOMUS FRANCISCI (LÜTKEN, 1874) COLLECTED IN THE 

PARAOPEBA RIVER, SÃO FRANCISCO RIVER BASIN, BRAZIL NATÁLIA RIBEIRO 

ALVES, CAMILA FERREIRA SALES, FABRÍCIO FLÁVIO THEOPHILO DOMINGOS, RALPH 

GRUPPI THOMÉ, FÁBIO PEREIRA ARANTES, YOSHIMI SATO, HÉLIO BATISTA DOS 

SANTOS 

D - 116 FECUNDITY AND OOCYTE DIAMETER OF THREE SPECIES FROM THE 

GRANDE RIVER BASIN, DOWNSTREAM FROM THE PORTO COLOMBIA DAM: AN 

COMPARATIVE ANALYSIS IN TWO SITES CLÁUDIA KELLY FERNANDES DA CRUZ, 

VIOLETA DA ROCHA PERINI, ALESSANDRO PASCHOALINI LOUREIRO, NILO BAZZOLI, 

ELIZETE RIZZO 

D - 117 SPERMIOGENESIS ANALYSIS IN TWO CRYPTIC SPECIES OF 

TRIATOMINES IN BRASILIENSIS SUBCOMPLEX KAIO CESAR CHABOLI ALEVI, 

PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA PEREIRA, BRUNNO BOTELHO 

BORGES, ANNA CLAUDIA CAMPANER LIMA, MARIA TERCÍLIA VILELA DE AZEREDO 

OLIVEIRA 

D - 118 HETEROCHROMATIN PATTERN IN HOLOCENTRIC CHROMOSOMES 

OF TRIATOMA LENTI AND T. SHERLOCKI (HEMIPTERA: REDUVIIDAE) KAIO CESAR 

CHABOLI ALEVI, PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA PEREIRA, 

BRUNNO BOTELHO BORGES, ANNA CLAUDIA CAMPANER LIMA, MARIA TERCÍLIA 

VILELA DE AZEREDO OLIVEIRA 

D - 119 EFFECTS OF EXPERIMENTAL DIABETES IN INTERSTITIAL TISSUE AND 

LEYDIG CELLS OF ADULT WISTAR RATS ALLUANAN ADELSON DO NASCIMENTO 

SILVA, JESSICA SANTANA DE OLIVEIRA, OLÁVIO CAMPOS JÚNIOR, FERNANDA 

CAROLINA RIBEIRO DIAS, RODRIGO RIBEIRO DE OLIVEIRA, SÍLVIA REGINA ARRUDA 

DE MORAES, ELIZABETH NEVES DE MELO 

D - 120 STROMAL CELL DERIVED FACTOR-2 (SDF-2) AT MATERNAL-FETAL 

INTERFACE ALINE RODRIGUES LORENZON, SHAKER CHUCK FARAH, SUSAN J 

FISHER, ESTELA BEVILACQUA 

D - 121 CARUNCULES AND BOVINE ANTIGEN LEUKOCYTE (BOLA) DURING 

PREGNANCY MARCELO EMÍLIO BELETTI, JULIANA MARTINS DA SILVA GALLO, 

PATRÍCIA TERRA ALVES, SABRINA VAZ DOS SANTOS E SILVA, CARLOS UEIRA-VIEIRA 

D - 122 BOLA (BOVINE ANTIGEN LEUKOCYTE) TRANSCRIPTS IN BOVINE 

BLASTOCYSTS AND COTYLEDONS MARCELO EMÍLIO BELETTI, JULIANA MARTINS 

DA SILVA GALLO, CARLOS UEIRA-VIEIRA, PATRÍCIA TERRA ALVES, SABRINA VAZ 

DOS SANTOS E SILVA 

D - 123 ALTERATIONS IN WISTAR RATS FERTILITY BY RESTRICTION OF 

PARADOXICAL SLEEP. ROMUALDO MORANDI FILHO, LARA IZABELLA FRANCO 

MARIANO, ADRIANO LARA ZUZA, MOLINE SEVERINO LEMOS, MARCELO EMILIO 

BELETTI 

D - 124 STUDY OF THE NUCLEOLAR CYCLE OF TRIATOMA JUAZEIRENSIS 

(HEMIPTERA: TRIATOMINAE) KAIO CESAR CHABOLI ALEVI, PRISCILA PASQÜETTO 

MENDONÇA, NATHÁLIA PAIVA PEREIRA, NAYARA FERNANDA DA COSTA CASTRO, 

LARISSA CENTURION GANDOLPHI, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA 

D - 125 GENE TWO OF NON-CLASSICAL BOVINE ANTIGEN LEUKOCYTE 

(BOLA) TRANSCRIPTS QUANTIFICATION IN FETAL BOVINE PLACENTA LAYS 

OLIVEIRA ROCHA, JULIANA MARTINS DA SILVA GALLO, CARLOS UEIRA-VIEIRA, 

PATRÍCIA TERRA ALVES, SABRINA VAZ DOS SANTOS E SILVA, MARCELO EMÍLIO 

BELETTI 

D - 126 EFFECTS OF STRESS BY PARADOXICAL SLEEP RESTRICTION ON 

WISTAR RATS’ TESTIS. LARA IZABELLA FRANCO MARIANO, ROMUALDO MORANDI 

FILHO, ADRIANO LARA ZUZA, MARCELO EMILIO BELETTI 

D - 127 RELATIONSHIP BETWEEN TUMOR NECROSIS FACTOR ALPHA AND 

BOVINE BLASTOCYSTS PRODUCED IN VITRO ROMUALDO MORANDI FILHO, 

JULIANA MARTINS DA SILVA GALLO, CARLOS UEIRA-VIERA, PATRÍCIA TERRA ALVES, 

MARCELO EMÍLIO BELETTI 

D - 128 COMPONENT OF BIRTH CONTROL PILL ADMINISTERED DURING 

GESTATION AND PUBERTY ALTERS THE MORPHOPHYSIOLOGY OF MALE AND 

104

FEMALE PROSTATE OF SENIL GERBIL ANA PAULA DA SILVA PEREZ, MANOEL 

FRANCISCO BIANCARDI, LUIZ ROBERTO FALLEIROS JUNIOR, FERNANDA CRISTINA 

ALCÂNTARA DOS SANTOS, SEBASTIÃO ROBERTO TABOGA 

D - 129 DIABETES AND GLYCEMIC CONTROL: STEM CELL REACTIVITY IN 

THE PROSTATIC MICROENVIRONMENT RAÍSA MISTIERI LORENCINI, AMANDA CIA 

HETZL, EDUARDO MARCELO CÂNDIDO, FABIO MONTICO, LARISSA AKEMI KIDO, 

WAGNER JOSÉ FÁVARO, VALÉRIA HELENA ALVES CAGNON 

D - 130 MORPHOLOGICAL CHARACTERIZATION OF TOROIDAL STRUCTURES 

IN SPERM CHROMATIN OF BULL, TURKEY, AND HUMAN ADRIANO LARA ZUZA, 

ELISSON TERÊNCIO SOUZA, ROMUALDO MORANDI FILHO, MARCELO EMÍLIO 

BELETTI 

D - 131 ROLE OF THE ENTHESIS ON PUBIC SYMPHYSIS RECOVERY DURING 

POSTPARTUM BIANCA GAZIERI CASTELUCCI, SÍLVIO ROBERTO CONSONNI, VIVIANE 

DE SOUZA ROSA, HENRIQUE MARQUES-SOUZA, PAULO PINTO JOAZERIO 

D - 132 EFFECT OF LOW PROTEIN DIET (CASEIN 8%) DURING THE 

INTRAUTERINE AND LACTATIONAL PERIODS ON TUBULAR LUMENATION AND 

GERM CELLS DEVELOPMENT IN THE TESTIS OF IMMATURE WISTAR RATS JESSICA 

SANTANA DE OLIVEIRA, ALLUANAN ADELSON DO NASCIMENTO SILVA, OLÁVIO 

CAMPOS JUNIOR, FERNANDA CAROLINA RIBEIRO DIAS, CAROLINA PEIXOTO 

MAGALHÃES, SANDRA LOPES SOUSA, ELIZABETH NEVES DE MELO 

D - 133 EXPOSURE TO TESTOSTERONE DURING PRENATAL LIFE INCREASES 

THE SUSCEPTIBILITY TO THE DEVELOPMENT OF PROSTATIC LESIONS IN OLD 

FEMALE GERBIL (MERIONES UNGUICULATUS) MANOEL FRANCISCO BIANCARDI, 

ANA PAULA SILVA PEREZ, LUIZ ROBERTO FALLEIROS-JR, FERNANDA CRISTINA 

ALCANTARA DOS SANTOS, REJANE MAIRA GÓES, SEBASTIÃO ROBERTO TABOGA 

D - 134 ACUTE EFFECT OF THE FUNGICIDE MANCOZEB ON DIAMETER OF 

THE NUCLEUS AND NUMBER OF ESPERMATOGENIC CELLS AND SERTOLI CELLS 


CRUZ MIRANDA, TÚLIO FIORINI CARVALHO, RAQUEL ARMINDA CARVALHO 

MACHADO, DANIELA VALENTE DE ANDRADE, MIRLAINE SOARES BARROS, 

ALESSANDRO BRINATI, MARIANA MACHADO NEVES, MARIELLA BONTEMPO DUCA 

DE FREITAS, SÉRGIO LUIS PINTO DA MATTA 

D - 135 EFFECT OF THE FUNGICIDE TEBUCONAZOLE ON DIAMETER OF THE 

NUCLEUS AND NUMBER OF ESPERMATOGENIC CELLS AND SERTOLI CELLS FROM 

THE FRUGIVOROUS BATS ARTIBEUS LITURATUS (OLFERS, 1818) DIANE DA CRUZ 

MIRANDA, TÚLIO FIORINI CARVALHO, RAQUEL ARMINDA CARVALHO MACHADO, 

DANIELA VALENTE DE ANDRADE, MIRLAINE SOARES BARROS, ALESSANDRO 

BRINATI, MARIANA MACHADO NEVES, MARIELA BONTEMPO DUCA DE FREITAS, 

SÉRGIO LUÍS PINTO DA MATTA 

D - 136 USING FLUORESCENT MARKERS FOR ASSESSING SPERM DAMAGE 

IN COLLARED PECCARIES (TAYASSU TAJACU) CAUSED BY SEMEN 

CRYOPRESERVATION MARIANA DE ARAÚJO DA SILVA, GISLAYNE CHRISTIANNE 

XAVIER PEIXOTO, THIBÉRIO DE SOUZA CASTELO, MOACIR FRANCO DE OLIVEIRA, 

GABRIELA LIBERALINO LIMA, JOSÉ ARTHUR BRILHANTE BEZERRA, ALEXANDRE 

RODRIGUES SILVA 

D - 137 PROLONGED BISPHENOL-A EXPOSURE STIMULATES EPITHELIAL 

PROLIFERATION WHICH LEADS TO THE DEVELOPMENT OF A HYPERPLASIC 

GLAND IN THE ADULT FEMALE GERBIL MÔNICA SOUSA CAMPOS, MANOEL 

FRANCISCO BIANCARDI, ANDRÉ VILELA GALVÃO, RODRIGO FERNANDES DE LIMA, 

JOSIANE FAGANELLO, MARA RÚBIA MARQUES, FERNANDA CRISTINA ALCÂNTARA 

DOS SANTOS, LUIZ ROBERTO FALLEIROS-JR, SEBASTIÃO ROBERTO TABOGA 

D - 138 REPRODUCTIVE TOXICITY OF MULTI-WALLED CARBON 

NANOTUBES IN MICE. ALEXANDRA NAVA, SOLANGE CRISTINA DA SILVA MARTINS 

HOELZEL, SILVANE SOUZA ROMAN 

D - 139 EXPRESSION OF CHEMOKINE (C-C MOTIF) LIGAND 25 DURING 

MOUSE EMBRYO IMPLANTATION RODRIGO BARBANO WEINGRILL, M. S. 

HOSHIDA, C. D. MARTINHAGO, E. BEVILACQUA 

D - 140 DEVELOPMENT OF A CHIMERIC EQUID TESTIS USING THE CELL 

AGGREGATE XENOGRAFTING APPROACH G.F. AVELAR, G.M.J. COSTA, J.V. 

REZENDE-NETO, S.M.S.N. LACERDA, P.H.A. CAMPOS-JÚNIOR, B.S.C. ANDRADE, L.R. 

FRANÇA 

E – Cell Biology and 

Education 

E1-E12 

E -1 CONSTRUCTION OF DIDACTIC-PEDAGOGICAL MODELS FOR CELL 

BIOLOGY TEACHING JOÃO PAULO FERREIRA SCHOFFEN, ISABELLA MARIA DIAS 

PAYÃO ORTIZ, JEAN LUCAS KREMER, PRISCILA EUNICE DA SILVA, MATHEUS 

EDUARDO LEME, ANA CAROLINA CORREIA AMBRÓSIO, FRANCIELY PALIARIN, 

CARLOS VINÍCIUS DALTO DA ROSA, KARLA FERNANDA FERRAZ, LUCILENE CRISTINA 

DA SILVA, ALINE NAZARENO 

E -2 CONSTRUCTION OF DIDACTIC-PEDAGOGICAL MODELS FOR 

EMBRYOLOGY TEACHING JOÃO PAULO FERREIRA SCHOFFEN, CRISTINA ALVES 

FONSECA, ISABELLA MARIA DIAS PAYÃO ORTIZ, YURI FUJIMORI, BEATRIZ MAYARA 

LIMA OKISHI, TAYEME CRISTINA PIVA, ROSANA CAMPOS PASCHOALINO, JULIANA 

HADDAD, FABIANA APARECIDA MARTINS, LUIZ EDUARDO LOURENÇO SOUZA 

E -3 THREE-DIMENSIONAL CELL MODELS AS A TEACHING TOOL FOR 

CELL BIOLOGY COURSE IN THE BACHELOR IN SCIENCE AND TECHNOLOGY (BC&T) 

AT UNIVERSIDADE FEDERAL DO ABC (UFABC) ARNALDO R. SANTOS JR., RENATA 

SIMÕES, MARCELLA P. MILAZZOTTO, CHRISTIANE B. LOMBELLO 

E -4 CELL BIOLOGY IN THE PROCESSES OF SCIENTIFIC RESEARCH IN 

PUBLIC HIGH SCHOOL TATIANE DA AQUINO, PAULO RICARDO DA ROSA, JULIANE 

MEILI, TANIA BERNHARD 

E -5 DESCRIPTION OF A PEDAGOGICAL EXPERIMENT ON BUILDING 

UNDERGRADUATE STUDENTS’ CLINICAL THINKING COUPLED UP WITH CELLULAR 

PROCESSES AND BIOCHEMISTRY UNDERSTANDING LETICIA VARGAS DE 

MESQUITA, CAROLINA ÁVILA DE ALMEIDA, CARLOS EDUARDO ABBUD HANNA 

ROQUE, RICARDO FELIPE ALVES MOREIRA, CRISTIANE BARBOSA ROCHA 

E -6 IN VIVO OR IN CITO: CAN THE CELL REPLACE THE ANIMAL? – A 

DOCUMENTARY BEATRIZ LOUREIRO DE SOUZA, RÓBER BACHINSKI, LETÍCIA 

APARECIDA BARBOSA HUMMEL, GUTEMBERG GOMES ALVES 

E -7 PRACTICAL LESSONS IN THE LABORATORY AS A PROPOSAL TO 

BETTER TEACH CELL BIOLOGY TO HIGH SCHOOL STUDENTS FERNANDA SILVA DE 

SOUZA, LACI GONÇALVES VIANA, RENATO AUGUSTO DAMATTA 

E -8 OPINION ON THE USE AND IMPORTANCE OF PRACTICAL LESSONS 

AND THE EFFECT OF A CONTINUOUS EDUCATION COURSE IN CELL BIOLOGY 

CONCEPTS TO HIGH SCHOOL TEACHERS FROM THE NORTHERN STATE OF RIO DE 

JANEIRO. ALINE BRANDÃO ALVES LIMA, FERNANDA SILVA DE SOUZA, RENATO 


E -9 AN INTEGRATED PRACTICAL COURSE ON CELL BIOLOGY BASED ON 

A BIOMATERIAL CYTOCOMPATIBILITY PROJECT FOR HEALTH/BIOLOGY 

UNDERGRADUATE STUDENTS DANIELA COSTA SILVA, JULIANA ALVES CÔRTES, 

ROBER FREITAS BACHINSKI, GUILHERME LECHUGAR, CAROLINA NASCIMENTO 

SPIEGEL, GUTEMBERG GOMES ALVES 

E -10 GETTING OUT OF THE CAMPUS! PRESENTING THE PROGRESS OF 

RESEARCH IN CELL BIOLOGY FOR HIGH SCHOOL TEACHERS BÁRBARA CAPITANIO 

DE SOUZA, ANNA CHRISTINA MEDEIROS FOSSATI, LENIR ORLANDI PEREIRA, 

SIMONE MARCUZZO, RUI FERNANDO FELIX LOPES, TATIANA LUFT, EMERSON 

CASALI, MARCELO LAZZARON LAMERS 

E -11 EDUCATION WITH TECHNOLOGY: THE USE OF AN ADAPTIVE 

INTERFACE FACILITATES THE TEACHING AND LEARNING OF CELL BIOLOGY. 

MAYARA LUSTOSA DE OLIVEIRA, HERNANDES FAUSTINO DE CARVALHO 

E -12 “CELLULAR DOMINATION”: A POWERFUL TOOL FOR TEACHING 

CELL BIOLOGY KRISIA EMANUELLE FERREIRA DA SILVA, THAÍS PRISCILA DE SOUZA 

TORRES, MARLLON ALEX NASCIMENTO SANTANA, JÉSSICA ANDRÉIA PEREIRA 

BARBOSA, JEYMESSON RAPHAEL CARDOSO VIEIRA 

F – Cell Cycle and 

Proliferation 

F1-F27 

F - 1 PMA ANTAGONISTIC EFFECTS ON PROLIFERATION OF 

IMMORTALIZED HUMAN HACAT KERATINOCYTES: STIMULATION OF NORMAL 

AND INHIBITION OF H-RASV12-TRANSFORMED CELLS JULIANNA DIAS ZEIDLER, 

HUGO AGUIRRE ARMELIN 

F - 2 P53, KI-67, COX-2 EXPRESSION IN RAT TONGUE EXPOSED TO 

STEROIDS RENAN POZZI, KELLY ROSSETTI FERNANDES, CAROLINA FOOT GOMES 

MOURA, ANA CLAUDIA MUNIZ RENNO, DANIEL ARAKI RIBEIRO 

F - 3 EFFECT OF UVA AND UVB ON THE NEURONS’ CELL CYCLE OF THE 

CENTRAL OLFACTORY SYSTEM OF THE CRAB UCIDES CORDATUS. GABRIELA 

HOLLMANN, GABRIELLE DE JESUS FERREIRA, ÁLVARO LETÃO, RAFAEL LINDEN, 

SILVANA ALLODI 

F - 4 THE INSULIN RECEPTOR TRANSLOCATES TO THE NUCLEUS TO 

REGULATE CELL PROLIFERATION AND LIVER REGENERATION. CLAUDILENE 

R.CHAVES, MARIA JIMENA AMAYA, MARISA C.F. CASTELUBER, DOUGLAS L. 

ALMEIDA, MAURO C.X. PINTO, LILIAN A.M. ARANTES, LIDIA MARIA ANDRADE, ANA 

C.N. PINHEIRO, EMERSON A. FONSECA, GUSTAVO B. MENEZES, ANA MARIA DE 

PAULA, RODRIGO RIBEIRO RESENDE, MICHAEL H. NATHANSON, MARIA DE FÁTIMA 

LEITE 

F - 5 EFFECTS OF LOW INTENSITY RED LASER ON BACTERIAL GROWTH 

AND PLASMIDS DNA JULIANA NOGUEIRA DOS SANTOS, CAMILA ROOS, FLAVIA DE 

105

PAOLI, OSCAR ROBERTO GUIMARÃES, MAURO GELLER, ADENILSON DE SOUZA DA 

FONSECA 

F - 6 GENOTOXIC EFFECTS ON ERYTHROCYTES OF TILAPIA 

(OREOCHROMIS NILOTICUS) EXPOSED CADMIUM AND AFTER DEPURATION 

JULIANA MOREIRA MENDONÇA GOMES, HEDER JOSÉ RIBEIRO, MARCELA SANTOS 

PROCÓPIO, JOSÉ DIAS CORRÊA JUNIOR 

F - 7 POSSIBLE ACTIVATION OF THE WNT/BETA-CATENIN SIGNALING 

PATHWAY IN HYPERPLASIC PANCREATIC ISLETS OF PRE-DIABETIC MICE DANIELA 

APARECIDA MASCHIO, RICARDO BELTRAME OLIVEIRA, CAROLINA PRADO DE 

FRANÇA CARVALHO, CARLA BEATRIZ COLLARES-BUZATO, MARIANE RODRIGUES 

DOS SANTOS 

F - 8 DECREASED CX36 ISLET CONTENT AND IMPAIRED COMPENSATORY 

BETA CELL FUNCTION AND GROWTH IN RESPONSE TO HIGH FAT DIET IN LDL 

RECEPTOR KNOCKOUT MICE RICARDO BELTRAME OLIVEIRA, CAROLINA PRADO DE 

FRANÇA CARVALHO, DANIELA APARECIDA MASCHIO, ANTÔNIO CARLOS 

BOSCHERO, HELENA COUTINHO FRANCO DE OLIVEIRA, CARLA BEATRIZ COLLARES- 

BUZATO 

F - 9 DIFFERENTIAL LIPID ACCUMULATION IN BONE MARROW 

STROMAL CELLS AND ITS INFLUENCE ON HEMATOPOIESIS IN VITRO. GABRIEL 

FERRAZ DA SILVA, ANDERSON JUNGER TEODORO, GEORGIA CORREA ATELLA, 

MARCELO EINICKER LAMAS, ALEX BALDUINO DE SOUZA, RADOVAN BOROJEVIC, 

MARCIA CURY EL-CHEIKH 

F - 10 IL-4 MODULATES THE PROLIFERATIVE EFFECT OF EGF IN RETINAL 

CELLS GUSTAVO MATARUNA DA SILVA, LUIS EDUARDO GOMES BRAGA, ELIZABETH 

GIESTAL DE ARAUJO 

F - 11 EVALUATION OF IRON SUPPLEMENTED MEDIA CULTURE IN THE 

CELLULAR VIABILITY AND GENOMIC STABILITY OF CELL LINES – MRC5 AND 

HEPG2 ANA LÚCIA VARGAS ARIGONY CORTE, LARISSA MILANO, MICHELLE LIMA, 

ANDRE JUNCHEM, CRISTIANO TRINDADE, MIRIANA MACHADO, DIANA BORDIN, 

EDUARDO FILIPPI-CHIELA, GUIDO LENZ, DANIEL PRA, JOÃO ANTONIO PÊGAS 

HENRIQUES 

F - 12 SIGNS OF CELLULAR SENESCENCE IN ESTROGEN-INDUCED 

PITUITARY HYPERPLASIA MARÍA EUGENIA SABATINO, JUAN PABLO PETITI, LILIANA 

DEL VALLE SOSA, SILVINA GUTIÉRREZ, ALEXANDRA SUSANA LATINI, ALICIA INÉS 

TORRES, ANA LUCÍA DE PAUL 

F - 13 THE EFFECTS OF CAMPTOTHECIN AND BERENIL ON 

ULTRASTRUCTURE OF TRYPANOSOMA CRUZI EPIMASTIGOTE FORM ALINE 

ARAUJO ZUMA, MARIA CAROLINA ELIAS, WANDERLEY DE SOUZA, MARIA CRISTINA 

MACHADO MOTTA 

F - 14 TRANSFORMING GROWTH FACTOR BETA1 PROMOTES P27KIP1 

POST-TRANSCRIPTIONAL REGULATION IN GASTRIC CELLS OF SUCKLING RATS ANA 

PAULA ZEN PETISCO FIORE, EUNICE RIBEIRO DE ANDRADE SÁ, LUCIANA HARUMI 

OSAKI, CRUZ ALBERTO MENDOZA RIGONATTI, PATRICIA GAMA 

F - 15 EVALUATION OF GASTRIC CANCER CELL PROLIFERATION AND 

ADHESION IN CELL CULTURE PLATES SUBMITTED TO CORONA AND GLOW 

DISCHARGE (PLASMA) PROCESSING WITH DIFFERENT N2/H2 RATIO RAQUEL 

AYRES, FERNANDO BONATTO, DIEGO BONATTO 

F - 16 CONSTITUTIVELY ACTIVE CDK1 TRIGGERS DNA DAMAGE AND CELL 

CYCLE ARREST PATRÍCIA RENCK NUNES, KASIM DIRIL, PHILIPP KALDIS 

F - 17 GHRELIN AND GROWTH HORMONE SECRETAGOGUE RECEPTOR 

DISTRIBUTION IN THE GASTRIC MUCOSA OF EARLY WEANED RATS: EFFECTS ON 

EPITHELIAL CELL PROLIFERATION. DANIELA OGIAS, NATALIA BITTAR RODRIGUES, 

LUCIANA HARUMI OSAKI, CRUZ ALBERTO MENDOZA RIGONATTI, PATRICIA GAMA 

F - 18 THE LEISHMANIA (L.) AMAZONENSIS CELL CYCLE: WHO 

DUPLICATES FIRT, KINETOPLAST OR NUCLEUS? MARCELO SANTOS DA SILVA, 

JOMAR PATRÍCIO MONTEIRO, ARINA MARINA PEREZ, MARIA CAROLINA ELIAS, 

MARIA ISABEL NOGUEIRA CANO 

F - 19 ACTIVATION OF C-JUN N-TERMINAL KINASE (JNK) DURING 

MITOSIS IN RETINAL PROGENITOR CELLS. VINICIUS DE TOLEDO RIBAS, BRUNO DE 

SOUZA GONÇALVES, RAFAEL LINDEN, LUCIANA BARRETO CHIARINI 

F - 20 7-EPI-CLUSIANONE EXERTS A NEGATIVE EFFECT ON CELL CYCLE 

PROGRESSION IN LUNG CARCINOMA CELLS TATIANE HELENA BATISTA, NATHALIE 

NUNES DIAS, EVANDRO LUIS DE OLIVEIRA NIERO, MARISI GOMES SOARES, 

GLAUCIA MARIA MACHADO-SANTELLI, MARCELO HENRIQUE DOS SANTOS, 

MARISA IONTA 

F - 21 LEISHMANIA AMAZONENSIS RBP38 IS PROBABLY INVOLVED IN 

DNA DAMAGE RESPONSE IN THE NUCLEUS AND IN THE KINETOPLAST ARINA 

MARINA PEREZ, MARCELO SANTOS DA SILVA, PAULO VINICIUS DA MATA 

MADEIRA, BÁRBARA MORAES SOUZA, JULIA P. C. DA CUNHA, MARIA ISABEL 

NOGUEIRA CANO 

F - 22 CYTOTOXIC ACTIVITY OF 7-EPI-CLUSIANONE, A TETRAPRENYLATED 

BENZOPHENONE, ON BREAST CANCER CELL LINES. NATALIA GABRIELE HOSCH, 

IARA AUANA SALES, EVANDRO LUÍS DE OLIVEIRA NIERO, GLAUCIA MARIA 

MACHADO-SANTELLI, MARCELO HENRIQUE DOS SANTOS, MARISA IONTA 

F - 23 SIGNALING TRIGGERED BY THE NEUROPEPTIDE PACAP AND SHH 

INTERACT IN THE CONTROL OF CELL PROLIFERATION IN THE DEVELOPING RETINA 

THALINE DAIANNE FARIAS ALVES DE LIMA, BRIAN NJAINE, RAFAEL LINDEN, 

MARIANA SOUZA DA SILVEIRA 

F - 24 DOES 5-BROMO-2'-DEOXYURIDINE (BRDU) INFLUENCE THE 

POSTNATAL DEVELOPMENT IN RATS? LÍVIA CLEMENTE MOTTA TEIXEIRA, SILVIA 

HONDA TAKADA, VITOR YONAMINE LEE, MARIA INÊS NOGUEIRA, GILBERTO 

FERNANDO XAVIER 

F - 25 ENDOSYMBIOSIS IN TRYPANOSOMATIDS: THE SYMBIOTIC 

BACTERIUM UNDERGOES COORDINATED DIVISION WITH THE HOST CELL 

STRUCTURES. CAROLINA MOURA COSTA CATTA PRETA, FELIPE LOPES BRUM DA 

SILVEIRA, CAMILA CRISTINA DA SILVA, SERGIO SCHENKMAN, MARIA CAROLINA 

ELIAS, LUCIANA CIAPINA, LUIZ GONZAGA, ANA TEREZA VASCONSELOS, 

WANDERLEY DE SOUZA, MARIA CRISTINA MACHADO MOTTA 

F - 26 BALANCE OF ADIPOGENESIS AND APOPTOSIS MARKERS IN 

MESENTERIC ADIPOSE TISSUE DURING THE DEVELOPMENT OF CANCER 

CACHEXIA FELIPE DE OLIVEIRA FRANCO, FELIPE DOS SANTOS HENRIQUES, 

KALTINAITIS BENETON NUNES HYPOLITO DOS SANTOS, PÂMELA VIEGAS KNÖBL, 

RODRIGO XAVIER DAS NEVES, ROGERIO ANTONIO LAURATO SERTIÉ, CLAUDIO 

SABURO SHIDA, SIDNEY BARNABÉ PERES, MIGUEL LUIZ BATISTA JÚNIOR 

F - 27 THE EFFECTS OF 7-EPI-CLUSIANONE ON PROLIFERATIVE BEHAVIOR 

OF HEPG2 CELLS IZABELLA LUIZ SUZUKI, EVANDRO LUÍS DE OLIVEIRA NIERO, 

GLAUCIA MARIA MACHADO SANTELLI, MARCELO HENRIQUE DOS SANTOS, 

MARISA IONTA 

G – Cell Death 

G1-G38 

G - 1 MITOCHONDRIAL ENERGY UTILIZATION IN YOUNG AND OLD 

WORKER HONEYBEES (APIS MELLIFERA) HSU CHIN-YUAN, YU-LUNG CHUANG 

G - 2 CELLULAR DEGRADATION ACTIVITY IN YOUNG AND OLD WORKER 

HONEYBEES (APIS MELLIFERA) CHAN YU-PEI, CHUANG YU-LUNG, HSU CHIN-YUAN 

G - 3 EFFECTS OF DISTURBED ENVIRONMENTS IN THE LIVER OF 

PROCHILODUS LINEATUS BRUNO FIORELINI PEREIRA, JOSÉ ALGUSTO SENHORINI, 

RITA DE CÁSSIA GIMENES DE ALCÂNTARA ROCHA, FLAVIO HENRIQUE CAETANO 

G - 4 CHARACTERIZATION OF DUAL EFFECTS INDUCED BY 

ANTIMICROBIAL PEPTIDES: REGULATED CELL DEATH OR MEMBRANE 

DISRUPTION EDGAR JULIAN PAREDES GAMERO, MARTA NC MARTINS, FÁBIO AM 

CAPPABIANCO, JAIME S IDE, ANTIONIO DE MIRANDA 

G - 5 THE PARACRINE SIGNALING BY ATP/ ADP IS DETRIMENTAL 

DURING THE STERILE CELL DEATH INDUCED BY ACETAMINOPHEN SYLVIA STELLA 

AMARAL, PEDRO ELIAS MARQUES PEREIRA SILVA, LAURA LOPES NOGUEIRA PINTO, 

DANIELE ARAÚJO PIRES, LÍDIA MARIA DE ANDRADE, MARIA DE FÁTIMA LEITE, 

GUSTAVO BATISTA DE MENEZES 

G - 6 TRICHOMONAS VAGINALIS: ULTRASTRUCTURAL ALTERATIONS 

INDUCED BY BPQ-OH COMPARED TO METRONIDAZOLE AND EVALUATION OF ITS 

CYTOTOXICITY IN MAMMALIAN CELLS DEBORA ROCHA AFONSO SILVA, IVONE 

ROSA DE ANDRADE, WANDERLEY DE SOUZA, JULIO URBINA, MARLENE 

BENCHIMOL 

G - 7 ANTI-APOPTOTIC HSP27 AND ITS TRANSCRIPTION FACTOR HSTF1 

ARE UP-REGULATED BY PROLACTIN IN HUMAN PANCREATIC ISLETS ROSANGELA 

APARECIDA WAILEMANN MANSANO, LETÍCIA FERREIRA TERRA, MARI CLEIDE 

SOGAYAR, LETÍCIA LABRIOLA 

G - 8 CRUDE EXTRACT OF ANNONA MUCOSA (ANNONACEAE) CAUSES 

CHANGES IN CELLS OF THE GUT OF AEDES AEGYPTI LARVAE (DIPTERA: 

CULICIDAE) JAMILE FERNANDA SILVA COSSOLIN, MARILZA DA SILVA COSTA, JOSÉ 

EDUARDO SERRÃO, MÔNICA JOSENE BARBOSA PEREIRA 

G - 9 MORPHOLOGICAL ASPECTS OF THE GUT REPLACEMENT IN 

BRADYSIA HYGIDA (DIPTERA: SCIARIDAE) DURING METAMORPHOSIS THAYLISE 

DE CASSIA SANTOS PRZEPIURA, JOSÉ ROSA GOMES, CRISTINA LÚCIA SANT’ANNA 

COSTA-AYUB, MARIA ALBERTINA DE MIRANDA SOARES 

G - 10 ANALYSIS OF PROTEIN EXPRESSION AFTER PHOTODYNAMIC 

THERAPY IN THE PROTOZOAN PARASITE TRITRICHOMONAS FOETUS SUSANE 

MOREIRA MACHADO, CRISTINA PACHECO SOARES, CRISTIANE APARECIDA 

FERREIRA PIRES, FERNANDA ROBERTA MARCIANO, ANDERSON OLIVEIRA LOBO, 

NEWTON SOARES DA SILVA 

G - 11 GOLD NANOPARTICLES DO NOT INDUCE CYTOTOXICITY IN THE 

ALVEOLAR TYPE-II CELL LINE CAROLINA DA SILVA GOUVEIA PEDROSA, TALÍRIA 

SILVA LOPES, KARINA RIBEIRO DA SILVA, LEANDRA SANTOS BAPTISTA, PRISCILA 

FALAGAN LOTSCH, GUSTAVO CONDE MENEZES, RADOVAN BOROJEVIC, JOSÉ 

MAURO GRANJEIRO 

106

G - 12 APOPTOSIS INDUCTION IN TUMOR CELLS BY A NATURAL 

INTRACELLULAR PEPTIDE CHRISTIANE BEZERRA DE ARAUJO, EDNA T. KIMURA, 

EMER SUAVINHO FERRO 

G - 13 EFFECTS OF THE BOTHROPOIDES INSULARIS VENOM (AMARAL, 

1921) ON RENAL TUBULAR CELLS. CLARISSA PERDIGÃO MELLO, LOUISE 

DONADELLO TESSAROLO, ALBA FABÍOLA COSTA TORRES, RAMON RÓSEO PAULA 

PESSOA BEZERRA DE MENEZES, GUSTAVO JOSÉ DA SILVA PEREIRA, ISABEL 

CRISTINA OLIVEIRA DE MORAIS, DÂNYA BANDEIRA LIMA, JÁDER ALMEIDA 

CANUTO, ALICE MARIA COSTA MARTINS, SORAYA SOUBHI SMAILI 

G - 14 THE EFFECT OF EARLY WEANING ON APOPTOSIS IN THE GASTRIC 

EPITHELIUM OF RATS IN POSTNATAL DEVELOPMENT CAMILA KAMLA 

MARTINATTI, PATRÍCIA GAMA, CRUZ ALBERTO MENDONZA RIGONATI, LUCIANA 

HARUMI OSAKI 

G - 15 ANALYSIS OF GOLD NANOPARTICLES TOXICITY IN HUMAN FETAL 

LUNG FIBROBLAST (MRC5) CELL CULTURE TALÍRIA SILVA LOPES, PRISCILA 

FALAGAN LOTSCH, CAROLINA DA SILVA GOUVEIA PEDROSA, KARINA RIBEIRO DA 

SILVA, LEANDRA SANTOS BAPTISTA, GUSTAVO CONDE MENEZES, JOSE MAURO 

GRANJEIRO 

G - 16 PHENOTHIAZINE-INDUCED HEPG2 CELL DEATH: STRUCTURE- 

ACTIVITY RELATIONSHIP AND MITOCHONDRIAL INVOLVEMENT PRISCILA AFONSO 

DE FARIA, FELIPE SAMUEL PESSOTO, EDGAR JEAN PAREDES-GAMERO, TIAGO 

RODRIGUES 

G - 17 EFFECT OF PROTEIN MALNUTRITION IN THE MECHANISMS OF 

APOPTOSIS, NECROSIS AND AUTOPHAGY IN MARROW HYPOPLASIA. JACKELINE 

SOARES DE OLIVEIRA BELTRAN, GRAZIELA BATISTA DA SILVA, DALILA CUNHA DE 

OLIVEIRA, ED WILSON DOS SANTOS, PRIMAVERA BORELLI 

G - 18 DENGUE INFECTION RESULTS IN CELL DEATH OF HUMAN BRAIN 

MICROVASCULAR ENDOTHELIAL CELLS MICHELLE PREMAZZI PAPA, LUCIANA 

BARROS DE ARRUDA 

G - 19 THE PROTECTIVE EFFECT AGAINST PHOTODAMAGE OF ALOE 

BARBADENSIS MIL IN HUMAN KERATINOCYTES ANA CLAUDIA VIOTTO, NAYRA 

FERNANDES SANTOS, CLEIDIANE SOUZA, DIVINOMAR SEVERINO, MAURÍCIO SILVA 

BAPTISTA, WALESKA KERLLEN MARTINS 

G - 20 INVOLVEMENT OF AUTOPHAGY IN THE PHENOTHIAZINE-INDUCED 

APOPTOSIS IN K562 CELLS VIVIAN MATSUKURA DOS SANTOS, FABIO D. 

NASCIMENTO, GISELLE ZENKER JUSTO, IVARNE LUIS DOS SANTOS TERSARIOL, 

TIAGO RODRIGUES 

G - 21 IN THE SEARCH FOR SPECIFIC MECHANISMS OF PHOTO-INDUCED 

CELL DEATH NAYRA FERNANDES SANTOS, ISABEL DE OLIVEIRA LIMA BACELLAR, 

ANA CLÁUDIA VIOTTO, CHRISTIANE PAVANI, WALESKA KERLLEN MARTINS, 

MAURÍCIO DA SILVA BAPTISTA 

G - 22 EFFECTS OF BOTHROPS MARAJOENSIS SNAKE VENOM AND ITS 

FRACTION PHOSPHOLIPASE A2 ON RENAL TUBULAR CELLS AND MURINE 

MACROPHAGES GDAYLLON CAVALCANTE MENESES, JÁDER ALMEIDA CANUTO, 

LOUISE DONADELLO TESSAROLO, LÍVIA CORREIA FERNANDES, ALBA FABÍOLA 

COSTA TORRES, TICIANA PRACIANO PEREIRA, JOSIANE S. QUETZ, HELENA SERRA 

AZUL MONTEIRO, ALICE MARIA COSTA MARTINS 

G - 23 PALLADACYCLE-INDUCED CASPASE-DEPENDENT APOPTOSIS IN 

K562 LEUKEMIA CELLS IS ASSOCIATED TO THIOL OXIDATION AND 

MITOCHONDRIAL DEPOLARIZATION VIVIAN WERLOGER RODRIGUES DE MORAES, 

EDGAR JULIAN PAREDES-GAMERO, TIAGO RODRIGUES 

G - 24 POLYMERIC MICELLAR SYSTEM POTENTIATES THE ANTITUMOR 

ACTIVITY OF PHENOTHIAZINES IN HUMAN K562 LEUKEMIA CELLS JOYCE CRISTINE 

DE MELLO, DEYSE CARDOSO DE SILVA, DANIELE RIBEIRO DE ARAÚJO, TIAGO 

RODRIGUES 

G - 25 NEEM SEED OIL EXHIBITS CONCENTRATION DEPENDENT DUAL 

EFFECTS ON HEPG2 CELL VIABILITY: PROTECTION AGAINST OXIDATIVE STRESS 

AND INDUCTION OF CELL DEATH PALOMA CAROLINE RIBEIRO, TIAGO RODRIGUES 

G - 26 RENAL EFFECTS OF DINOPONERA QUADRICEPS VENOM ALBA 

FABIOLA COSTA TORRES, JÁDER ALMEIDA CANUTO, LOUISE DONADELO 

TESSAROLO, TICIANA PRACIANO PEREIRA, ANTONIO RAFAEL COELHO JORGE, 

MILEYDE PONTE PORTELA, YVES PATRIC QUINET, HELENA SERRA AZUL MONTEIRO, 

ALICE MARIA MARTINS 

G - 27 PLUMBAGIN-INDUCED CELL DEATH IN LEUKEMIA MODEL IS 

PROMOTED BY CELLULAR OXIDATIVE UNBALANCE MAYARA KAORI KISAKI, TIAGO 

RODRIGUES 

G - 28 SEX-RELATED DIFFERENCES ON HIPPOCAMPAL MITOCHONDRIAL 

PROFILE INDUCED BY NEONATAL HYPOXIA-ISCHEMIA INJURY ANA PAULA 

TONIAZZO, SIMONE NARDIN WEIS 

G - 29 SEX-SPECIFIC EFFECTS OF AUTOPHAGY CELL DEATH IN NEONATES 

FOLLOWING HYPOXIA-ISCHEMIA SIMONE NARDIN WEIS, ANA PAULA TONIAZZO, 

BRADLEY P. ANDER, XINHUA ZHAN, MILO CAREAGA, PAUL ASHWOOD, FRANK RAY 

SHARP, ANGELA TEREZINHA DE SOUZA WYSE, CARLOS ALEXANDRE NETTO 

G - 30 CYTOTOXICITY OF PHENOLIC COMPOUNDS ON HUMAN SKIN CELL 

LINES. ANDRÉA COSTA FRUET, SILVYA STUCHI MARIA-ENGLER, SILVIA BERLANGA 

DE MORAES BARROS 

G - 31 APOPTOTIC RATES IN WISTAR RAT KIDNEYS TREATED WITH 

CYCLOSPORIN A AND HETEROPTERYS TOMENTOSA. KARINE MOURA FREITAS, 

MARIA APARECIDA DA SILVA DIAMANTE, JACQUELINE MERIELLEN DE ALMEIDA, 

NAYARA RUDECK OLIVEIRA STHEL COCK, FABRICIA DE SOUZA PREDES, MARÇAL 

AMICE JORGE, HEIDI DOLDER 

G - 32 REDUCTION OF COLLAGEN FIBERS AND CELL DEATH BY APOPTOSIS 

IN THE LAMINA PROPRIA DURING STAGES OF TOOTH ERUPTION JOSÉ PAULO DE 

PIZZOL JÚNIOR, ESTELA SASSO CERRI, PAULO SÉRGIO CERRI 

G - 33 PROGRAMMED CELL DEATH IN AQUATIC BACTERIA IN TWO 

TROPICAL AQUATIC ECOSYSTEMS MODELS THIAGO PEREIRA DA SILVA, JULIANA 

GAMALIER, VICTOR ZARANTONELLO, FÁBIO ROLAND, ROSSANA CORREA NETTO DE 

MELO 

G - 34 IMPAIRED ENDOPLASMIC RETICULUM STRESS RESPONSE IN 

LYMPHOCYTES FROM PATIENTS WITH BIPOLAR DISORDER BIANCA 

PFAFFENSELLER, BIANCA WOLLENHAUPT DE AGUIAR, GABRIEL RODRIGO FRIES, 

GABRIELA DELEVATI COLPO, RENAN KUBIACHI BURQUE, GIOVANA BRISTOT, 

PÂMELA FERRARI, KEILA MENDES CERESÉR, FÁBIO KLAMT, FLÁVIO KAPCZINSKI 

G - 35 IN VITRO ANTI-APOPTOTIC ACTIVITY OF OIL FROM SALVIA 

LACHNOTASCHYS IN LYMPHOCYTES AND MACROPHAGES OF MUS MUSCULUS 

LUCAS WAGNER GORTZ, MARCELO BETTEGA, LUIZA FERNANDA SCHIER, OSVALDO 

MALAFAIA, CLAUDIA CONSUELO DO CARMO OTA 

G - 36 ANTI-APOPTOTIC EFFECT OF A PROTEIN ISOLATED FROM PODALIA 

SP (LEPIDOPTERA: MEGALOPYGIDAE) HEMOLYMPH IN VERO AND SF-9 CELLS 

NATHALIA DELAZERI DE CARVALHO, ROBERTO HENRIQUE PINTO MORAES, RITA 

MARIA ZUCATELLI MENDONÇA, RONALDO ZUCATELLI MENDONÇA 

G - 37 IN VITRO ANTI-APOPTOTIC ACTIVITY OF OIL FROM COPAIFERA 

LANGSDORFFII IN LYMPHOCYTES AND MACROPHAGES OF MUS MUSCULUS 

MARCELO BETTEGA, LUCAS WAGNER GORTZ, LUIZA FERNANDA SCHIER, OSVALDO 

MALAFAIA, CLAUDIA CONSUELO DO CARMO OTA 

G - 38 DC-SIGN MEDIATES DENGUE VIRUS-INDUCED PLATELET 

ACTIVATION, MITOCHONDRIAL DYSFUNCTION AND CELL DEATH EUGENIO 

DAMACENO HOTTZ, MARCUS FERNANDES OLIVEIRA, ROGÉRIO VALLS DE SOUZA, 

ANDRÉA THOMPSON DA POIAN, ANDREW S. WEYRICH, GUY A. ZIMMERMAN, 

PATRÍCIA TORRES BOZZA, FERNANDO AUGUSTO BOZZA 

G – 39 NFAT1 COOPERATES WITH RAS/RAF/MEK/ERK PATHWAY IN THE 

INDUCTION OF APOPTOTIC AND NECROTIC CELL DEATH IN FIBROBLASTS. ROBBS, 

B.K., VIOLA, J.P.B. 

H – Cell Differentiation 

H1-H19 

H - 1 THE INFLUENCE OF CORTICOSTERONE IN THE MATURATION OF 

RAT GASTRIC MUCOSA DURING EARLY WEANING JULIANA GUIMARÃES ZULIAN, 

CRUZ ALBERTO MENDOZA RIGONATI, PATRÍCIA GAMA 

H - 2 CHOLESTEROL DEPLETION ALTERS THE EXPRESSION OF ADHESION 

PROTEINS AND CELL MIGRATION IN MYOBLASTS ANA CLAUDIA BATISTA 

POSSIDONIO, CAROLINA PONTES SOARES, DÉBORA MORUECO PORTILHO, JULIANA 

LOURENÇO ABRANTES, VICTOR DO VALLE PEREIRA MIDLEJ, MARLENE 

BENCHIMOL, CLÁUDIA DOS SANTOS MERMELSTEIN 

H - 3 2D AND 3D-ORGANIZED CARDIAC CELLS SHOWS DIFFERENCES IN 

CELLULAR MORPHOLOGY, ADHESION JUNCTIONS, PRESENCE OF MYOFIBRILS 

AND PROTEIN EXPRESSION CAROLINA PONTES SOARES, VICTOR MIDLEJ, MARIA 

EDUARDA WESCHOLLEK DE OLIVEIRA, MARLENE BENCHIMOL, MANOEL LUIS 

COSTA, CLÁUDIA DOS SANTOS MERMELSTEIN 

H - 4 HIGH LEVELS OF CIRCULATING TRIIODOTHYRONINE INDUCES 

PLASMA CELL DIFFERENTIATION IN MICE FLAVIA FONSECA BLOISE, FELIPE 

OLIVEIRA, ALBERTO FÉLIX NÓBREGA, ALINE CORDEIRO, LUCIANA DE SOUZA PAIVA, 

DENNIS D TAUB, RADOVAN BOROJEVIC, CARMEN CABANELAS PAZOS-MOURA, 

VALÉRIA DE MELLO-COELHO 

H - 5 EFFECT OF THE LIPID-RAFT DISORGANIZATION ON THE MUSCULAR 

CELL DIFFERENTIATION IN ZEBRAFISH MODEL EDUARDO ANDRÉS RÍOS MORRIS, 

LAISE CAMPOS, CLAUDIA MERMELSTEIN, MANOEL LUÍS COSTA 

H - 6 CHARACTERIZATION OF HEMATOPOIETIC STEM/PROGENITOR 

CELLS OBTAINED IN VITRO FROM HUMAN EMBRYONIC STEM CELLS IN CO- 

CULTURE SYSTEM WITH MOUSE EMBRYONIC FIBROBLASTS EVERTON DE BRITO 

OLIVEIRA COSTA, MARISTELA DELGADO ORELLANA, DANIELLE APARECIDA ROSA 

DE MAGALHÃES, VIRGÍNIA MARA DE DEUS WAGATSUMA, LILIAN FIGUEIREDO 

MOREIRA, SIMONE KASHIMA HADDAD, DIMAS TADEU COVAS, APARECIDA MARIA 

FONTES 

107

H - 7 RHOA GTPASES IS IMPORTANT FOR CELL DIFFERENTIATION IN 

ORAL SQUAMOUS CELL CARCINOMA NANCI MENDES PINHEIRO, MARCO AURÉLIO 

DE OLIVEIRA MARINHO, DOUGLAS CÔBO MICHELLI, BEATRIZ MARTINS TAVAREZ 

MURTA, ANA CRISTINA DE ARAÚJO LEMOS, EURÍPEDES DE OLIVEIRA MARINHO, 

MICHELLE TILLMMAN BIZ, VIRGÍNIA OLIVEIRA CREMA 

H - 8 INDUCTION OF CELLULAR DIFFERENTIATION AND THE MULTIDRUG 

RESISTANCE PHENOTYPE MICHELE CARRETT DIAS GARCIA, LEDA KARINE DE 

ALMEIDA, REGINA COIMBRA ROLA, ANA PAULA DE SOUZA VOTTO, GILMA SANTOS 

TRINDADE 

H - 9 ASSESSMENT OF MINERALIZATION ON PRIMARY HUMAN BONE 

CELLS HARVESTED FROM ARTHROPLASTY EXPLANTS WESLEY LUIZ BARROS DA 

SILVA, MELLODY JESSICA BALLARD ARAGÃO, EMANUELLE STELLET LOURENÇO, 

VINICIUS SCHOTT GAMEIRO, GUTEMBERG GOMES ALVES, JOSÉ MAURO 

GRANJEIRO, ADRIANA BRANDÃO RIBEIRO LINHARES 

H - 10 THE COMBINED USE OF RETINOIC ACID AND CAMP IS EFFECTIVE IN 

INDUCING DIFFERENTIATION OF HEPG2 CELLS DEBORAH ELZITA DO CARMO 

CORRÊA, CAMILLA CRISTINA MORI, PAULA REZENDE TEIXEIRA, GLAUCIA MARIA 

MACHADO SANTELLI, MARISA IONTA 

H - 11 B LYMPHOCYTES DIFFERENTIATE INTO PLASMA CELLS AFTER 

TRIIODOTHYRONINE STIMULATION IN VITRO AND EXPRESS TRBETA1 HUILA 

LUIZA SANTOS DA FONSECA, FLAVIA FONSECA BLOISE, ALINE CORDEIRO, 

ALESSANDRA GRANATO, ALBERTO FÉLIX NÓBREGA, CARMEN CABANELAS PAZOS- 

MOURA, VALÉRIA DE MELLO-COELHO 

H - 12 PS20 AFFECTS UPA SECRETION AND THE BEHAVIOR OF 

ENDOTHELIAL CELLS SILVIA BORGES PIMENTEL DE OLIVEIRA, HERNANDES F 

CARVALHO 

H - 13 EVALUATION OF THE NEUROTOXIC/NEUROPROTECTIVE ROLE OF 

ORGANOSELENIDES USING DIFFERENTIATED HUMAN NEUROBLASTOMA SH-SY5Y 

CELL LINE CHALLENGED WITH 6-HYDROXYDOPAMINE LEONARDO LISBOA DA 

MOTTA, FERNANDA MARTINS LOPES, GIOVANA FERREIRA LONDERO, LIANA 

MARENGO DE MEDEIRO, GUILHERME ANTONIO BEHR, VALESKA AGUIAR DE 

OLIVEIRA, MOHAMED IBRAHIM, JOSÉ CLÁUDIO FONSECA MOREIRA, LISIANE DE 

OLIVEIRA PORCIÚNCULA, JOÃO BATISTA TEXEIRA DA ROCHA, FÁBIO KLAMT 

H - 14 ROLE OF STROTIUM RANELATE ON PROLIFERATION AND 

OTEOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STROMAL CELLS 

RHAYRA BRAGA DIAS, DANIELLE C. BONFIM, RADOVAN BOROJEVIC, MARCOS 

FARINA, MARIA ISABEL DORIA ROSI 

H - 15 ROS INDUCES DIFFERENTIATION OF NORMAL AND LEUKEMIC 

HEMATOPOIETIC CELLS AMANDA NOGUEIRA PEDRO, THALYTA APARECIDA 

CESÁRIO MUNHOZ, CHRISTIANO MARCELLO VAZ BARBOSA, CAROLINA CARVALHO 

DIAS, EDGAR JULIAN PAREDES-GAMERO, ALICE TEIXEIRA FERREIRA 

H - 16 ESTABLISHMENT OF HEMOBLAST CULTURE FROM THE 

HEMATOPOIETIC SITE OF THE SEA SQUIRT STYELA PLICATA ISADORA SANTOS DE 

ABREU, SILVANA ALLODI, CÍNTIA MONTEIRO DE BARROS 

H - 17 BOVINE TENDON EXTRACT SUPPORTS THE DIFFERENTIATION OF 

ADULT HUMAN MESENCHYMAL STEM CELLS INTO TENOCYTE-LIKE CELLS. LÍVIA 

MARIA MENDONÇA AUGUSTO, F. A. MENDES, M. I. D. ROSSI, A. S. BALDUINO, P. L. 

CASADO, A. S. CAVALCANTE, V. F. VIANNA, D. C. BONFIM, J. F. M. BARCELLOS, M. 

E. L. DUARTE 

H - 18 EFFECT OF POLYAMINES ON THE CELLULAR MORPHOLOGY OF 

YARROWIA LIPOLYTICA ANTONIO JESUS DORIGHETTO COGO, ARNOLDO ROCHA 

FAÇANHA, ANNA LVOVNA OKOROKOVA FAÇANHA 

H - 19 IN VITRO OSTEOBLASTIC DIFFERENTIATION ON BIOACTIVE GLASS- 

BASED MATERIALS GABRIELA CAROLINE ALONSO, OLÍVIA CHERUBIN ALVES, 

FABÍOLA SINGARETTI DE OLIVEIRA, ROGER RODRIGO FERNANDES, OSCAR PEITL, 

EDGAR DUTRA ZANOTTO, MÁRCIO MATEUS BELOTI, ADALBERTO LUIZ ROSA, 

PAULO TAMBASCO DE OLIVEIRA 

I – Cell Migration 

I1-I13 

I - 1 MORPHOLOGICAL AND BIOCHEMICAL ASPECTS OF A SUBACUTE 

LESION IN THE PROTOCEREBRAL TRACT OF THE CRAB UCIDES CORDATUS 

CLYNTON LOURENÇO CORREA, PAULA CHAVES DA SILVA, SILVANA ALLODI 

I - 2 PLASMIN AND UROKINASE PROMOTES CELL MIGRATION VIA 

MEK/ERK CASCADE BRUNO ROCHA CORDEIRO COSTA, ALINE ALVES FORTUNATO 

DO CARMO, LEONARDO CAMILO DE OLIVEIRA, CAMILA RODRIGUES CHAVES 

NOGUEIRA, JULIANA PRISCILA VAGO DA SILVA, LUIZA OLIVEIRA PERUCCI, BRUNO 

DOS SANTOS ALVES FIQUEIREDO BRASIL, CLÁUDIO ANTÔNIO BONJARDIM, MAURO 

MARTINS TEIXEIRA, LIRLÂNDIA PIRES DE SOUSA 

I - 3 EVALUATION OF RECOMBINANT CXCL12(5-67) CHEMOTACTIC 

ACTIVITY ON CXCR4+ CELLS IN VITRO TAÍS ADELITA DE ALMEIDA BARROS, 

ROBERTA SESSA STILHANO, SANG WON HAN, GISELLE ZENKER JUSTO, MARIMÉLIA 

PORCIONATTO 

I - 4 CHONDROITIN SULFATE IMPAIRS NEURAL STEM CELL MIGRATION 

IN VITRO LAYLA TESTA GALINDO, PIERO BAGNARESI, MARINILCE FAGUNDES DOS 

SANTOS, MARIMÉLIA APARECIDA PORCIONATTO 

I - 5 HEAT STRESS INFLUENCES ON IMMUNE PARAMETERS IN TROPICAL 

SEA URCHIN LYTECHINUS VARIEGATUS PAOLA CRISTINA BRANCO, MAÍRA 

ESTANISLAU SOARES DE ALMEIDA, RENATA STECCA IUNES, MARINILCE FAGUNDES 

DOS SANTOS, JOÃO CARLOS SHIMADA BORGES, JOSÉ ROBERTO MACHADO CUNHA 

DA SILVA 

I - 6 IMMUNE SYSTEM CELLS OF THE RAT VENTRAL PROSTATE 

QUANTIFICATION BY HEALTHY, CASTRATED AND ESTROGENIZED ANIMALS 

JULIETE APARECIDA FRANCISCO DA SILVA, DAGMAR RUTH STACH-MACHADO, 

HERNANDES FAUSTINO DE CARVALHO 

I - 7 THE ENDOPLASMIC RETICULUM CHAPERONE PROTEIN DISULFIDE 

ISOMERASE (PDI) IS REQUIRED FOR PDGF-INDUCED RHOGTPASE ACTIVATION 

AND NOX1 NADPH OXIDASE-DEPENDENT VASCULAR SMOOTH MUSCLE CELL 

MIGRATION LUCIANA PESCATORE ALVES, DIEGO BONATTO, FABIO LUIS FORTI, 

AMINE SADOK, HERVÉ KOVACIC, FRANCISCO RAFAEL MARTINS LAURINDO 

I - 8 LTB4 AS CHEMOATTRACTANT FACTOR IN THE REGULATORY T 

CELLS MIGRATION CYNTIA PECLI E SILVA, RAPHAEL MOLINARO, MARC PETERS- 

GOLDEN, STEVEN L. KUNKEL, CLAUDIO CANETTI, CLAUDIA FARIAS BENJAMIM 

I - 9 HYPERGLYCEMIA IMPAIRS 2-D AND 3-D MIGRATION OF SKIN 

FIBROBLASTS, ALSO AFFECTING CELL ADHESION AND INTEGRINS SURFACE 

DISTRIBUTION MAÍRA ESTANISLAU SOARES DE ALMEIDA, KELLY SALZMANN 

MONTEIRO, SANDRA COCCUZZO SAMPAIO VERSSONI, TÁRCIO TEODORO BRAGA, 

NIELS OLSEN SARAIVA CÂMARA, MARCELO LAZZARON LAMERS, MARINILCE 

FAGUNDES DOS SANTOS 

I - 10 CHARACTERIZATION OF THE IMPAIRED WOUND HEALING IN THE 

DERMIS OF DIABETIC MICE JULIANA DA COSTA FLORIM, ANA FLÁVIA MARÇAL 

PESSOA, KAIO FERNANDO VITZEL, HOSANA GOMES RODRIGUES, RUI CURI, 

MARCELO LAZZARON LAMERS, MARINILCE FAGUNDES DOS SANTOS 

I - 11 ROLE OF LAMININ IN ALLOREACTIVE T-CELL MIGRATION DURING 

ACUTE REJECTION ARIANY OLIVEIRA SANTOS, WILSON SAVINO, INGO RIEDERER 

I - 12 IMMATURE THYMOCYTES ARE RELEASED INTO THE PERIPHERY OF 

TRYPANOSOMA CRUZI ACUTELY INFECTED MICE BY A S1P-DEPENDENT 

MECHANISM AILIN LEPLETIER, LILIANE SILVA DE ALMEIDA, NAIARA MARAN, 

MARCELO EINICKER LAMA, ANA ROSA PÉREZ, ALIRIO MELENDES, WILSON SAVINO, 

ALEXANDRE MORROT LIMA 

I - 13 IMMUNOENDOCRINE INTERACTIONS DURING LYMPHOCYTE 

MIGRATION IN HUMAN CHAGAS DISEASE LUIZ RICARDO BERBERT, ANA ROSA 

PÉREZ, OSCAR BOTTASSO, WILSON SAVINO 

J – Cell Signaling 

J1-J48 

J - 1 OUTSIDE-IN SIGNALING BY VE-CADHERIN PROMOTES LOCAL RAC 

ACTIVATION AND ENHANCEMENT OF LUNG ENDOTHELIAL BARRIER BY ILOPROST 

XINYONG TIAN, OLEKSII DUBROVSKYI, YUFENG TIAN, NOUREDDINE ZEBDA, 

NICOLENE SARICH, ANNA BIRUKOVA 

J - 2 ASSOCIATION BETWEEN ADHERENS JUNCTIONS AND TIGHT 

JUNCTIONS VIA RAP1-AFADIN IS REQUIRED FOR PROTECTIVE EFFECTS OF 

OXIDIZED PHOSPHOLIPIDS NOUREDDINE ZEBDA, PANFENG FU, VALERY POROYKO, 

IVAN COKIC, KONSTANTIN BIRUKOV 

J - 3 PROTEOMIC ANALYSIS OF SNAKE VENOM GLAND ACTIVATION 

AND VENOM PRODUCTION MILENE SCHMIDT LUNA, RICHARD HEMMI VALENTE, 

JONAS PERALES, MONICA LARUCCI VIEIRA, NORMA YAMANOUYE 

J - 4 KNOCKDOWN OF ARHGAP21 MODULATES THE EXPRESSION OF 

GENES RELATED TO HYPOXIA AND GLYCOLYSIS IN ADENOCARCINOMA PROSTATE 

CELL LINES MARIANA LAZARINI, MARCOS MARANGONI, JOÃO AGOSTINHO 

MACHADO NETO, PATRICIA SEVEVERINO, CARLOS ALBERTO MOREIRA-FILHO, 

FABÍOLA TRAINA, SARA TERESINHA OLALLA SAAD 

J - 5 SUB-CELLULAR LOCALIZATION OF NEK7 AND ITS INTERACTION 

PROTEINS EDMÁRCIA ELISA DE SOUZA, GABRIELA VAZ MEIRELLES, BÁRBARA 

BIATRIZ GODOY, EDUARDO CRUZ MORAES, JULIANA HELENA COSTA SMETANA, 

JÖRG KOBARG 

J - 6 FLOTILLINS STABILIZE CADHERIN COMPLEXES AT CELL-CELL 

CONTACTS THROUGH INTERACTION WITH THE F-ACTIN CYTOSKELETON EMILIE 

GUILLAUME, FRANCK COMUNALE, STÉPHANE BODIN, CÉCILE GAUTHIER-ROUVIÈRE 

108

J - 7 SYMPATHETIC OUTFLOW ON PROTEIN EXPRESSION IN THE MOUSE 

PAROTID GLAND CÍNTIA SCUCUGLIA HELUANY, MILENE SCHIMIDT LUNA, NORMA 

YAMANOUYE 

J - 8 FUNCTIONAL CHARACTERIZATION CELL CYCLE REGULATING 

KINASE NEK7 AND ITS INTERACTION PROTEINS BÁRBARA BIATRIZ DE GODOY, 

EDMÁRCIA ELISA SOUZA, SMETANA, J.H.C., JÖRG KOBARG 

J - 9 INTEGRATION OF MULTIPLE SIGNALING ROUTES IN T CELLS CAN 

CONTROL GENERATION AND SURVIVAL OF LONG-LIVED ANTIBODY-SECRETING 

CELLS LIDIANE ZITO GRUND, MÔNICA LOPES FERREIRA, CARLA LIMA 

J - 10 PKC AND CALCIUM BUT NOT PLC ARE INTRACELLULAR 

MESSENGERS OF VASOCONSTRICTOR RESPONSE INDUCED BY ANGIOTENSIN II IN 

THE SNAKE CROTALUS DURISSUS TERRIFICUS MÉLANIE MRQ LE DIAGON, MARIA 

CRISTINA BRENO 

J - 11 CELLULAR DISTRIBUTION OF ADHESION MOLECULES (CAMS) IN 

PANCREATIC ISLETS OF OBESE AND PRE-DIABETIC MICE. VIVIANE TANNURI 

FERREIRA LIMA FALCAO, DANIELA APARECIDA MASCHIO, LUÍZA MARTINEZ 

PERDIGUEIRO, JUNIA CAROLINA REBELO DOS SANTOS SILVA, MARIANNE R 

SANTOS, CAROLINA P.F. CARVALHO, MARIA TEREZA CARTAXO, CARLA BEATRIZ 

COLLARES BUZATO 

J - 12 SPATIAL REGULATION OF RAS SIGNALLING NETWORKS VERONICA 

ARAN, IAN PRIOR 

J - 13 FLUOXETINE ATTENUATED TREK-2-MEDIATED APOPTOTIC CELL 

DEATH IN HEK293A CELLS KEE RYEON KANG, CHEOL SOON LEE 

J - 14 BRAIN CAMP/CA2+ SIGNALING GENES IN FAT TISSUE IMPLANTED 

POLYCYSTIC OVARIAN SYNDROME MOUSE JORGE KEDE, EDUARDO HENRIQUE DA 

SILVA FREITAS, CARLOS FERNANDES BATISTA, MARIA DE NAZARETH GAMBOA 

RITTO, ISIDORO BINDA NETO, SAMUEL MARCOS RIBEIRO DE NORONHA, SILVANA 

APARECIDA ALVES CORRÊA DE NORONHA, ISMAEL DALE COTRIM GUEREIRO DA 

SILVA 

J - 15 TYROSINE PHOSPHORYLATION PLAYS A ROLE IN INCREASING 

MASPIN PROTEIN LEVELS AND ITS CYTOPLASMIC ACCUMULATION MARIANA 

TAMAZATO LONGHI, NATHALIE CELLA 

J - 16 NADPH OXIDASE ACTIVATION MEDIATED BY PROTEIN DISULFIDE 

ISOMERASE OVEREXPRESSION IN VSMC: ROLE OF ANGIOTENSIN II RECEPTOR 

(AT1R) RENATA DE CASTRO GONÇALVES, FRANCISCO RAFAEL MARTINS 

LAURINDO, DENISE DE CASTRO FERNANDES 

J - 17 TXNIP IS RESPONSIBLE FOR IMPAIRED GLUCOSE TOLERANCE IN 

THE DIABETIC MICE JO SEONG-HO, PARK JOO-MAN, KIM MI-YOUNG, KIM TAE- 

HYUN, AHN YONG-HO 

J - 18 PALMITATE INDUCES INTRACELLULAR CALCIUM (CA2+) 

MOBILIZATION IN MONONUCLEAR CELLS FROM TYPE 2 DIABETIC PATIENTS 

CAROLINE MARIA DE OLIVEIRA VOLPE, FERNANDA SARMENTO FAGUNDES-NETTO, 

RAQUEL MIRANDA GONZAGA, POLLYANNA STEPHANIE GOMES, JOSÉ AUGUSTO 

NOGUEIRA-MACHADO 

J - 19 TIMP1/ Β1-INTEGRIN/CD63 COMPLEX: RESISTANCE TO ANOIKIS 

ALONG MELANOCYTE MALIGNANT TRANSFORMATION BY PI3-K/AKT SIGNALING 

PATHWAY MARIANA TORICELLI PINTO, FABIANA HENRIQUES MACHADO DE 

MELO, MIRIAM GALVONAS JASIULIONIS 

J - 20 ACTIVATION OF RAC1 THROUGH A FAK-INDEPENDENT PATHWAY 

IN INHIBITION OF MIGRATION MEDIATED BY RECK GENE IN HUMAN GLIOMA 

RAQUEL BRANDÃO HAGA, FERNANDA LEVE, JOSÉ ANDRÉ MORGADO-DIAZ, SILVYA 

STUCHI MARIA-ENGLER 

J - 21 SUMOYLATION OF THE HUMAN REGULATORY PROTEIN KI-1/57 

AND ITS FUNCTION IN THE CELL ÂNGELA SAITO, KALIANDRA DE ALMEIDA 

GONÇALVES, MARCOS TADEU DOS SANTOS, JÖRG KOBARG 

J - 22 REGULATION OF WILSON DISEASE ATPASE (ATP7B) ACTIVITY LUIZA 

HELENA DALTRO CARDOSO, ELAINE HILARIO DE SOUZA, ADALBERTO VIEYRA, 

JENNIFER LOWE 

J - 23 MODULATION OF TRL2 AND TLR4 ACTIVATION BY MAPK 

INHIBITOR :EVALUATION OF ROS PRODUCTION BY PBMNC FORM TYP2 DIABETIC 

PATIENTS. FERNANDA SARMENTO FAGUNDES NETTO, CAROLINE MARIA OLIVEIRA 

VOLPE, RAQUEL MIRANDA GONZAGA, POLLYANNA STEPHANIE GOMES, JOSÉ 

AUGUSTO NOGUEIRA-MACHADO 

J - 24 TRANSITION TO WIDESPREAD VASCULAR CELL LOSS DUE TO 

SUSTAINED ENDOPLASMIC RETICULUM STRESS IS MARKED BY INCREASED 

OXIDANT GENERATION, BUT OXIDANTS DO NOT INDUCE CELL DEATH JOÃO 

WOSNIAK JÚNIOR, PHELIPE MONTEIRO FELÍCIO, NATHÁLIA ARAÚJO, FRANCISCO 

RAFAEL MARTINS LAURINDO 

J - 25 FGFS/FGFRS SIGNALING IN HUMAN KERATINOCYTES EDUARDO 

LOPES DA SILVA, JULIANA DIAS ZEIDLER, ANDRE ZELANI, SOLANGE M T SERRANO, 

HUGO AGUIRRE ARMELIN 

J - 26 MODULATION OF P2X7 RECEPTORS BY GLYCOSAMINOGLYCANS 

(GAG) GIOCONDA EMANUELLA DINIZ DE DANTAS MOURA, RAFAEL LIMA CASAES 

RODRIGUES, FABIO DUPART NASCIMENTO, EDGAR JEAN PAREDES GAMERO, 

IVARNE LUIS DOS SANTOS TERSARIOL, HELENA BONCIANI NADER 

J - 27 CHARACTERIZATION OF MASPIN SUMOYLATION CRISTIANE LUMI 

HIRATA, NATHALIE CELLA 

J - 28 PROTEIN KINASE B (PKB, AKT) IS INVOLVED IN RHIPICEPLAHUS 

(BOOPHILUS) MICROPLUS EMBRYO CELL LINE BME26 SURVIVAL LEONARDO 

ARAUJO DE ABREU, CHRISTIANO CALIXTO DA CONCEIÇÃO, SATORU KONNAI, 

KASUHIRO OHASHI, ITABAJARA DA SILVA VAZ JR, CARLOS JORGE LOGULLO DE 

OLIVEIRA 

J - 29 A POSSIBLE INTERPLAY BETWEEN RELAXIN AND FSH TO REGULATE 

SERTOLI CELL FUNCTION. ALINE ROSA DO NASCIMENTO, THAÍS FABIANA 

GAMEIRO LUCAS, CATARINA SEGRETI PORTO, MARIA FÁTIMA MAGALHÃES LAZARI 

J - 30 PS-1/GAMMA-SECRETASE-DEPENDENT CADHERIN CLEAVAGE 

REGULATES OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW 

MESENCHYMAL STROMAL CELLS BY CONTROLLING THE TRANSLOCATION OF THE 

ACTIVE SIGNALING FORM OF BETA-CATENIN TO NUCLEUS DANIELLE CABRAL 

BONFIM, RHAYRA BRAGA DIAS, CLAUDIA DOS SANTOS MERMELSTEIN, MARIA 

ISABEL DORIA ROSSI 

J - 31 NITRIC OXIDE AMELIORATES THE OXIDATIVE STRESS INDUCED BY 

ARSENIC IN WATER HYACINTH HELOÍSA MONTEIRO DE ANDRADE, JURACI ALVES 

DE OLIVEIRA, JOSÉ LINO NETO, JOSÉ CAMBRAIA, FERNANDA DOS SANTOS 

FARNESE, CRISTIANE JOVELINA DA SILVA 

J - 32 DOES NITRIC OXIDE ACTIVATE ANTIOXIDATIVE ENZYMES IN 

PLANTS EXPOSED TO ARSENIC? JURACI ALVES DE OLIVEIRA, HELOÍSA MONTEIRO 

DE ANDRADE, JOSÉ LINO NETO, JOSÉ CAMBRAIA, FERNANDA DOS SANTOS 

FARNESE 

J - 33 MODULATION OF NADPH OXIDASE BY PROTEOGLYCANS IN CHO- 

K1 AND CHO-745 CELLS. SHEYLA VARELA LUCENA, GISELLE ZENKER JUSTO, ZAIANE 

MENESES CAMILO, TIAGO RODRIGUES, DAYSE CAROLINE SEVERIANO DA CUNHA, 

HELENA BONCIANI NADER, IVARNE LUIS DOS SANTOS TERSARIOL 

J - 34 CHARACTERIZATION OF EPITHELIAL CELL SIGNALLING DURING 

CANDIDA ALBICANS AND NON-ALBICANS INVASION BY INDUCED ENDOCYTOSIS 

DIANA BAHIA, ALEXIS BONFIM-MELO, PALOMA KOREHISA MAZA, RENATO 

ARRUDA MORTARA, ARNALDO COLOMBO, ANA CAROLINA BARBOSA PADOVAN, 

ERIKA SUZUKI, RICARDO SÉRGIO COUTO DE ALMEIDA 

J - 35 SIGNALING PATHWAYS ASSOCIATED WITH NEUTROPHIL 

EXTRACELLULAR TRAPS (NETS) FORMATION BY NEUTROPHILS STIMULATED 

WITH LEISHMANIA AMAZONENSIS THIAGO SOARES DE SOUZA VIEIRA, ANDERSON 

GUIMARÃES BAPTISTA COSTA, MICHELLE TANNY CUNHA DO NASCIMENTO, 

RAFAEL MARIANTE, ELVIRA MARIA SARAIVA 

J - 36 EXPRESSION PROFILE ASSESSMENT OF NUCLEAR RECEPTORS AND 

CO-REGULATORS GENES IN BREAST CANCER CELL SK-BR3 AFTER HCG, 

ANGIOTENSIN 1-7 AND ESTRADIOL TREATMENTS ISIDORO BINDA NETO, WERICA 

BERNARDO, GABRIELA SOARES BRITO, ADRIANA CARVALHO, JORGE KEDE, 

EDUARDO HENRIQUE DA SILVA FREITAS, CARLOS FERNANDES BATISTA, MARIA DE 

NAZARETH GAMBOA RITTO, SAMUEL MARCOS RIBEIRO DE NORONHA, SILVANA 

APARECIDA ALVES CORRÊA DE NORONHA, GIL FACINA, ISMAEL DALE COTRIM 

GUERREIRO DA SILVA 

J - 37 COMPARTMENTALIZATION OF REDOX PROCESSES, NOX4 AND 

ENDOPLASMIC RETICULUM CHAPERONES WITHIN LIPID DROPLETS IN VASCULAR 

SMOOTH MUSCLE CELLS. THALITA BALSAMO ABRAHAO, ANGELICA A AMANSO, 

VICTOR DEBBAS, PATRICIA T BOZZA, EDLAINE LINARES, OHARA AUGUSTO, 

BERNARD LASSEGUE, KATHY K GRIENDLING, FRANCISCO RM LAURINDO 

J - 38 IS TRYPANOSOMA CRUZI P21 A CHEMOKINE-LIKE PROTEIN? ADELE 

AUD RODRIGUES, TATIANA MORDENTE CLEMENTE1, FABRÍCIO CASTRO 

MACHADO, PAULO CÉSAR FERREIRA DOS SANTOS, FERNANDO DE QUEIRÓZ 

CUNHA, TIAGO WILSON PATRIARCA MINEO, CLAUDIO VIEIRA DA SILVA 

J - 39 EARLY WEANING-STIMULATED PROLIFERATION AND 

DIFFERENTIATION IN THE GASTRIC MUCOSA: ARE MAPK OR SRC SIGNALING 

PATHWAYS INVOLVED? LUCIANA HARUMI OSAKI, CRUZ ALBERTO MENDOZA 

RIGONATI, PATRÍCIA GAMA 

J - 40 THIOREDOXIN-1 INTERACTS WITH ADAM17 AND MODULATES ITS 

HB-EGF SHEDDASE IN A P38 AND ERK1/2-INDEPENDENT PATHWAYS ANNELIZE Z 

B ARAGAO, DANIELA C GRANATO, MARIA LUIZA C NOGUEIRA, FERNANDO M 

SIMABUCO, ANA C M ZERI, ADRIANA F PAES LEME 

J - 41 INVOLVEMENT OF PROTEIN KINASE C AND PHOSPHOLIPASE C IN 

THE ACTIVATION OF CLOCK GENES BY BLUE LIGHT MARIA NATHÁLIA DE 

CARVALHO MAGALHÃES MORAES, BRUNO C. R. RAMOS, LEONARDO HENRIQUE R 

G LIMA, ANA MARIA DE LAURO CASTRUCCI 

J - 42 ACTIVATION OF THE ASCORBATE-GLUTATHIONE CYCLE BY NITRIC 

OXIDE: SIGNALING UNDER STRESS CONDITIONS TRIGGERED BY ARSENIC 

FERNANDA SANTOS FARNESE, JURACI ALVES DE OLIVEIRA, LUHAN ISAAC SIMAN, 

NEIDIQUELE MARIA DA SILVEIRA, GRASIELLE SOARES GUSMAN 

J - 43 RESTORATION OF LEPTIN RECEPTORS IN POMC NEURONS IN 

DB/DB MICE AND ROLE OF LIVER IN MAINTAINING THE GLUCOSE HOMEOSTASIS 

109

MARIANA SARTO FIGUEIREDO, ALAN VICENTE FERREIRA, PATRICIA CRISTINA 

LISBOA, ELAINE DE OLIVEIRA, CHRISTIAN BJORBAEK, EGBERTO GASPAR DE MOURA 

J - 44 INVESTIGATION OF THE MECHANISM OF MOLECULAR 

INTERACTION BETWEEN THE N-TYPE CALCIUM CHANNELS AND G PROTEINS 

LUCIENE BRUNO VIEIRA, LUARA AUGUSTA BATISTA, MARCUS VINÍCIUS GOMEZ, 

GERALD WERNER ZAMPONI 

J - 45 LIMITED PROTEOLYSIS BY CALPAIN A REGULATES 

CACTUS/IKAPPAB FUNCTION AND DORSAL-VENTRAL PATTERNING IN THE 

DROSOPHILA EMBRYO HELENA ARAUJO, MARCIO FONTENELE, GERTHRUD 

SCHUPBACH 

J - 46 NOVEL MODULATORS OF WNT/BETA-CATENIN PATHWAY 

THROUGH FUNCTIONAL SCREENING OF NATURAL COMPOUNDS BÁRBARA DE 

FARIA DA FONSECA, DÉBORA MALTA CERQUEIRA, NATHÁLIA DA GRAÇA AMADO, 

RICARDO KUSTER, JOSÉ GARCIA ABREU JR 

J - 47 P2X7 RECEPTOR MEDIATES APOPTOSIS IN EPITHELIAL CELLS HCT8 

VIA REACTIVE OXYGEN SPECIES VANESSA RIBEIRO FIGLIUOLO, HAYANDRA 

FERREIRA NANINI, ALESSANDRA ALVES ABALO, GIANI FRANÇA SANTORO, CLÁUDIA 

MARA LARA MELO COUTINHO, ROBSON COUTINHO SILVA 

J - 48 MESENTERIAL FAT UPR AND TLR4 ACTIVATION MARKERS WERE 

ASSOCIATED WITH OBESOGENIC GUT MICROBIOTA CARLA EVELYN COIMBRA 

NUÑEZ, VIVIANE SOARES RODRIGUES, MURILLO LINO BUTION, RAFAEL DE 

MORAES PEDRO, MÁRCIO JOSÉ DA SILVA, ÉRIKA ANNE ROBLES ROMAN, DANIELE 

CRISTINA VITORINO, WANDERLEY DIAS DA SILVEIRA, ELIANA PEREIRA DE ARAÚJO 

K – Cell Therapy 

K1-K16 

K - 1 HEPATIC CELLS: AN ALTERNATIVE SOURCE TO REPOPULATE THE 

BIO-ARTIFICIAL LIVER LANUZA ALABY PINHEIRO FACCIOLI, GRAZIELLE SUHETT 

DIAS, LUIZ FERNANDO QUINTANILHA, SANDRO TORRENTES CUNHA, BERNARDO 

JORGE DA SILVA MENDES, RACHEL RACHID, MARCIA ATTIAS, CHRISTINA MAEDA 

TAKIYA, ADRIANA BASTOS CARVALHO, REGINA COELI DOS SANTOS GOLDENBERG 

K - 2 BONE MARROW CELLS DERIVED-FIBROBLAST GROWTH FACTOR-2 

INDUCES GLIAL CELL PROLIFERATION IN THE REGENERATING PERIPHERAL 

NERVOUS SYSTEM ALVARO CARRIER RUIZ, ROBERTHA MARIANA RODRIGUES 

LEMES, RICARDO AUGUSTO DE MELO REIS, ROSALIA MENDEZ-OTERO, VICTOR 

TÚLIO RIBEIRO RESENDE 

K - 3 IDENTIFICATION OF CARDIOMYOCYTES TRANSDIFFERENTIATED 

FROM ADIPOSE DERIVED MESENCHYMAL STEM CELLS BIANCA FERRARINI 

ZANETTI, SANG WON HAN 

K - 4 MONONUCLEAR CELLS FROM HUMAN UMBILICAL CORD BLOOD 

PROMOTES FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY IN RATS 

LUCIANO PALMEIRO RODRIGUES, DAIKELLY IGLESIAS BRAGHIROLLI, FABRÍCIO DO 

COUTO NICOLA, DANIELA STEFFENS, LAUREN VALENTIM, ALESSANDRO WITCZAK, 

GEANCARLO ZANATTA, MATILDE ACHAVAL, PATRICIA PRANKE, CARLOS 

ALEXANDRE NETTO 

K - 5 RETINAL SPHERES SIMILAR STRUCUTURES-DERIVED FROM DENTAL 

PULP STEM CELLS ARE POSITIVE FOR PAX-6 MARKER BRUNA PEREIRA DE MORAIS, 

LISLEY INATA MAMBELLI, NELSON FORESTO LIZIER, BABYLA GERALDES MONTEIRO, 

JOSÉ ÁLVARO PEREIRA GOMES, IRINA KERKIS 

K - 6 INTERNALIZATION ASSAY OF POLY-Ε-CAPROLACTONE 

NANOPARTICLES USING PERITONEAL MACROPHAGES: THE ACTION OF FREE OR 

NANOENCAPSULATED ZINC (II) PHTALOCYANINE AMANDA SANTOS FRANCO DA 

SILVA, EDUARDO RICCI JUNIOR, MORGANA TEIXEIRA LIMA CASTELO BRANCO, 

LYCIA DE BRITO GITIRANA 

K - 7 INSULIN COATING IN HIDROXYAPATITE INCREASES OSTEOBLASTIC 

CELLS ATTACHMENT MOEMA A HAUSEN, ELENA MAVROPOULOS, JÉSSICA 

DORNELAS, SUZANA DOS ANJOS, ALEXANDRE ROSSI 

K - 8 RADIATION-INDUCED LIVER DAMAGE IN MICE: AN EXPERIMENTAL 

MODEL TO STUDY TISSUE REGENERATION GRAZIELLESUHETT DIAS, LANUZA 

ALABY FACCIOLI PINHEIRO, SANDRO TORRENTES CUNHA, TIAGO SOUZA VILAS- 

BÔAS, ALYNE HENRIQUES CORDEIRO, LUIZ FERNANDO QUINTANILHA, BRUNO 

DIAZ PAREDES, CRISTINA MAEDA TAKIYA, PAULO CÉSAR CANARY, ADRIANA 

BASTOS CARVALHO, REGINA COELI GOLDENBERG SANTOS 

K - 9 REPAIR OF SKIN DAMAGE WITH ADIPOSE-DERIVED STEM CELLS 

USING SODIUM CARBOXYMETHYLCELLULOSE SCAFFOLD IN RATS CRISTIANO 

RODRIGUES, ELISA VASCONCELLOS SOARES, ADRIANO MARTIMBIANCO DE ASSIS, 

MARILDA DA CRUZ FERNANDES, LÉDER LEAL XAVIER, ALEXANDRE TAVARES 

DUARTE DE OLIVEIRA, MÁRCIA ROSÂNGELA WINK 

K - 10 A GASTRIN-RELEASING PEPTIDE RECEPTOR ANTAGONIST 

ENHANCES VIABILITY AND PROLIFERATION OF NEUROBLASTOMA CELLS: 

PREVENTION BY A HISTONE DEACETYLASE INHIBITOR VIVIANE RÖSNER DE 

ALMEIDA, ANA LUCIA ABUJAMRA, ALGEMIR LUNARDI BRUNETTO, GILBERTO 

SCHWARTSMANN, RAFAEL ROESLER 

K - 11 EVALUATION OF THE WHOLE BONE MARROW INFLUENCE ON THE 

INNATE IMMUNITY IN A MODEL OF ACUTE LIVER FAILURE CAROLINA URIBE 

CRUZ, CARLOS OSCAR KIELING, MÓNICA LUJÁN LÓPEZ, LAURA SIMON, GUSTAVO 

OCH MUÑOZ, LUISE MEURER, URSULA MATTE 

K - 12 PLATELET IMPROVES SURVIVAL IN A RAT MODEL OF ACUTE LIVER 

FAILURE LAURA SIMON, MÓNICA LUJAN LÓPEZ, ALESSANDRO OSVALDT, 

CAROLINA URIBE CRUZ, CARLOS OSCAR KIELING, GUSTAVO OCHS DE MUÑOZ, 

LUISE MEURER, URSULA MATTE 

K - 13 CELL THERAPY FOR ACUTE LIVER FAILURE: EXPERIMENTAL STUDY 

WITH MICROENCAPSULATED CELLS LAURA SIMON, CARLOS OSCAR KIELING, 

CAROLINA URIBE CRUZ, MÓNICA LUJAN LÓPEZ, ALESSANDRO OSVALDT, GUSTAVO 

OCHS DE MUÑOZ, LUISE MEURER, URSULA MATTE 

K - 14 PRODUCTION OF RECOMBINANT HUMAN VASCULAR 

ENDOTHELIAL GROWTH FACTORS IN MAMMALIAN EXPRESSION SYSTEMS FOR 

ANGIOGENESIS AND WOUND HEALING ANA CLAUDIA OLIVEIRA CARREIRA, 

GUSTAVO GROSS BELCHIOR, FERNANDA CÂMARA MARQUES SODRÉ, THERI LEICA 

THEGAKI, RAQUEL SANTANA CRUZ, MARI CLEIDE SOGAYAR 

K - 15 THE PRE-CONDITIONING WITH BRADYKININ-POTENTIATING 

PEPTIDES DERIVED FROM BOTHROPS JARARACA SNAKE VENOM INCREASES THE 

THERAPEUTIC EFFECT OF ANGIOGENIC STEM CELLS IN A HINDLIMB ISCHEMIA 

MODEL ALAN SALES BARBOSA, BRÍGIDA GOMES DE ALMEIDA SCHIMER, MARIA 

CECÍLIA CAMPOS CANESSO, JOUSIE MICHEL PEREIRA, DANIELLE ALVES IANZER, 

ANTÔNIO CARLOS MARTINS DE CAMARGO, PATRÍCIA GONÇALVES TEIXEIRA, 

ANTÔNIO CARLOS VIEIRA CABRAL, MAURO MARTINS TEIXEIRA, LUCÍOLA DA SILVA 

BARCELOS 

K - 16 BONE MARROW MONONUCLEAR CELL THERAPY REDUCES 

REACTIVE MICROGLIOSIS AND HIPPOCAMPAL CA1 PYRAMIDAL CELL DEATH 

FOLLOWING GLOBAL CEREBRAL ISCHEMIA IN RATS. ALANE BERNARDO RAMOS, 

ANDRÉIA VASCONCELOS- DOS-SANTOS, WAGNER MONTEIRO CINTRA, ROSALIA 

MENDEZ-OTERO 

L – Cells as Biosensors 

L1-L7 

L - 1 ENVIRONMENTAL ASSESSMENT USING MUCOUS CELLS OF SCALE 

EPITHELIUM IN FISH REBECA MAMEDE DA SILVA ALVES, JOSÉ AUGUSTO 

SENHORINI, RITA DE CÁSSIA GIMENEZ DE ALCÂNTARA ROCHA, BRUNO FIORELINI 

PEREIRA, FLÁVIO HENRIQUE CAETANO 

L - 2 CYTOMORPHOLOGICAL CHANGES IN THE ARMORED CATFISH 

LORICARICHTHYSANUS, IN THE SINOS RIVER (RIO GRANDE DO SUL, BRAZIL), 

DURING AN EPISODE OF FISH MORTALITY AND CORRELATION WITH THE 

PRESENCE OF HERBICIDES CARLOS AUGUSTO BORBA MEYER NORMANN, KARINA 

JOB DI LACCIO, MILENE SANTANA PINTO, VALESCA VEIGA CARDOSO CASALI 

L - 3 ABCB1 AND ABCC1 PROTEINS ACTIVITY IN COELOMOCYTES OF THE 

SEA URCHIN ECHINOMETRA LUCUNTER. LEONARDO LIMA DOS SANTOS, PATRICIA 

MIRELLA DA SILVA SCARDUA, LUIS FERNANDO MARQUES DOS SANTOS 

L - 4 EFFECTS OF CHRONIC USE OF GRAPE JUICE ON HEPATOCYTES OF 

WISTAR RATS IN HIGH-FAT DIET CARLOS AUGUSTO BORBA MEYER NORMANN, 

ISELDE BUCHNER, NIARA MEDEIROS, DENISE LACERDA, PAULA RIGON, JOÃO 

ANTÔNIO HENRIQUES, ROSANE GOMEZ, CAROLINE DANI, CLAUDIA FUNCHAL 

L - 5 BIOMARKERS OF LEPROSY: NEUTROPHIL CD64 EXPRESSION AS A 

BIOMARKER OF ERYTHEMA NODOSUM LEPROSUM VERÔNICA SCHMITZ PEREIRA, 

RHANA BERTO PRATA, SHEILA SANTOS BRANDÃO, MAYARA ABUD MENDES, ALICE 

MIRANDA, JOSÉ AUGUSTO NERY, EUZENIR NUNES SARNO 

L - 6 IMMUNOFLUORESCENCE OF THE MUSHROOM BODIES OF 

STINGLESS BEES, SCAPTOTRIGONA POSTICA (LATREILLE, 1807), TREATED WITH 

IMIDACLOPRID BY INGESTION HELLEN MARIA SOARES, ROBERTA CORNÉLIO 

FERREIRA NOCELLI, CYNTHIA RENATA DE OLIVEIRA JACOB, OSMAR MALASPINA 

L - 7 EVALUATION OF THE TOXICITY ON STINGLESS BEE 

SCAPTOTRIGONA POSTICA (HYMENOPTERA, APIDAE MELIPONINI) MUSHROOM 

BODIES, TREATED WITH SUBLETHAL DOSES OF FIPRONIL CYNTHIA RENATA DE 

OLIVEIRA JACOB, HELLEN MARIA SOARES, ROBERTA CORNÉLIO FERREIRA NOCELLI, 

OSMAR MALASPINA 

110

M – Cytoskeleton 

M1-M13 

M -1 VISUALIZATION OF CYTOSKELETON OF TRITRICHOMONAS FOETUS 

BY FESEM (HIGH RESOLUTION FIELD EMISSION SCANNING ELECTRON 

MICROSCOPY) IVONE ROSA DE ANDRADE, WANDERLEY DE SOUZA, MARLENE 

BENCHIMOL 

M -2 A SMALL MOLECULE TARGETING CDC42-INTERSECTIN 

INTERACTION DISRUPTS GOLGI ORGANIZATION AND SUPPRESSES CELL MOTILITY 

AMY FRIESLAND, YAXUE ZHAO, YAN-HUA CHEN, HUCHEN ZHOU, QUN LU 

M -3 THE IMMUNOLOCALIZATION OF CYTOSKELETAL PROTEINS AND 

THE BASEMENT MEMBRANE MARKER LAMININ IN THE OVIDUCT OF THE 

DOMESTIC FOWL (GALLUS DOMESTICUS) MARY CATHRINE MADEKUROZWA 

M -4 PROBABLE INVOLVEMENT OF THE RAC1 GTPASE IN 

RADIOSENSITIVITY OF HELA CELLS JULIANA HARUMI OSAKI, GISELE ESPINHA 

TEIXEIRA DA SILVA, FÁBIO LUIS FORTI 

M -5 RHOA GTPASE MEDIATES RECOVERY OF MELANOMA CELLS 

DAMAGED BY ULTRAVIOLET RADIATION GISELE ESPINHA TEIXEIRA DA SILVA, 

FÁBIO LUÍS FORTI 

M -6 PROTEIN INTERACTION DURING ASYMMETRIC CELL DIVISION IN 

BACILLUS SUBTILIS MAXWELL DE CASTRO DURVALE, FREDERICO JOSE GUEIROS 

FILHO 

M -7 REGULATION OF MICROTUBULES DYNAMICS BY DYNAMIN-2 IN 

HELA CELLS MAKIKO MORITA, KOZUE HAMAO, KEITA TANAKA, YASUYUKI SERA, 

HIROSHI HOSOYA 

M -8 PARTICIPATION OF CORTICAL ACTIN FROM NON- AND 

PHAGOCYTIC CELLS DURING TOXOPLASMA GONDII INVASION PROCESS BRENO 

COSTA LANDIM, SARA HISSAE HIRAIWA, PRISCILA SILVA FRANCO, ELOISA VIEIRA 

AMÁLIA FERRO, JULIANA GONZAGA DE OLIVEIRA 

M -9 CYTOKERATINS CROSSTALK IN BREAST CANCER THAISE 

GONÇALVES DE ARAÚJO, KARINA MARANGONI, YARA CRISTINA DE PAIVA MAIA, 

GALBER RODRIGUES ARAÚJO, PATRÍCIA TERRA ALVES, LARISSA PRADO MAIA, 

DONIZETE WILLIAM SANTOS, LUANDA CALÁBRIA, CARLOS UEIRA-VIEIRA, LUIZ 

RICARDO GOULART FILHO 

M -10 STUDYING A PROTEIN-PROTEIN INTERACTION THAT REGULATES 

BACTERIAL CELL DIVISION VALDIR BLASIOS JUNIOR, ALEXANDRE WILSON BISSON 

FILHO, PATRÍCIA CASTELLEN, RODRIGO PORTUGAL, JEFFERSON BETTINI, 

FREDERICO GUEIROS FILHO 

M -11 EXPRESSION OF THE CYTOSKELETAL PROTEINS ACTIN AND 

TUBULIN IN OSTEOGENIC CELLS CULTURED ON BIOACTIVE GLASS-BASED 

SURFACES CAROLINA SCANAVEZ MARTINS, LUCAS NOVAES TEIXEIRA, LARISSA 

MOREIRA SPINOLA DE CASTRO, MÁRCIO MATEUS BELOTI, ADALBERTO LUIZ ROSA, 

PAULO TAMBASCO DE OLIVEIRA 

M -12 MURINE MACROPHAGE CYTOSKELETON ALTERATIONS CAUSED BY 

AQUEOUS EXTRACT OBTAINED FROM ROOTS OF PHYSALIS ANGULATA RAQUEL 

RAICK PEREIRA DA SILVA, ANA PAULA DRUMMOND RODRIGUES, AMANDA 

ANASTÁCIA PINTO HAGE, GILMARA DE NAZARETH TAVARES BASTOS, EDILENE 

OLIVEIRA DA SILVA 

M -13 MITOCHONDRIA ARE ANCHORED BY ACTIN FILAMENTS TO THE 

CORTEX AND ARE MOTILE IN SEA URCHIN EGGS ISSEI MABUCHI, TOMOKO 

TAKAGI, SHINYA INOU, MAKOTO GODA 

N – Developmental 

Biology 

N1-N51 

N - 1 INFLUENCE OF SONIC HEDGEHOG SIGNALLING PATHWAY IN THE 

EAR DEVELOPMENT ALICE HELENA DOS REIS RIBEIRO, JOSÉ GARCIA RIBEIRO 

ABREU, JOSÉ MARQUES DE BRITO NETO 

N - 2 ECTODERMAL-DERIVED ENDOTHELIN1 DRIVES DEVELOPMENT OF 

THE MOUSE MANDIBULAR ARCH INTERMEDIATE DOMAI ANDRE 

LUIZ PASQUA TAVARES, ELVIN L GARCIA, KATHERIN KUHN, CRYSTAL M WOODS, 

TREVOR WILLIAMS, DAVID E. CLOUTHIER 

N - 3 DEGENERATION AND CELL REGENERATION IN THE MIDGUT OF 

PODISUS NIGRISPINUS (HETEROPTERA: PENTATOMIDAE) DURING THE POST- 

EMBRYONIC DEVELOPMENT APARECIDA DAS DORES TEIXEIRA, MARIA DO CARMO 

QUEIROZ FIALHO, JOSÉ COLA ZANUNCIO, JOSÉ EDUARDO SERRÃO 

N - 4 DEVELOPING A MODEL FOR THE STUDY OF THE HUMAN 

MESENCHYMAL STEM CELLS’ POTENCY USING CHICK EMBRYOS INGRID 

ROSENBURG CORDEIRO, JOSÉ MARQUES DE BRITO NETO, MARIA ISABEL DORIA 

ROSSI 

N - 5 PIWI PROTEINS AND HISTONE METHYLATION IN THE RAT 

PRIMORDIAL GERM CELL DEVELOPMENT RENATO BORGES TESSER, TAIZA 

STUMPP 

N - 6 RAT GONOCYTE QUIESCENCE DEPENDS ON CASPASE 3 

EXPRESSION AND OCT4 DOWNREGULATION PRISCILA HENRIQUES DA SILVA, 

RENATO BORGES TESSER, CRISTIANE TOBARA MARUYAMA, TAIZA STUMPP 

N - 7 UVB ENVIRONMENTALLY RELEVANT DOSES INHIBIT EARLY 

EMBRYONIC DEVELOPMENT OF SEA URCHIN ECHINOMETRA LUCUNTER. 

JOCELMO CÁSSIO DE ARAUJO LEITE, SUELENN GUEDES DA SILVA, JOSÉ PINTO DE 

SIQUEIRA JUNIOR, LUIS FERNANDO MARQUES DOS SANTOS 

N - 8 ABCB1 PROTEIN PROTECTS SEA URCHIN EMBRYONIC 

DEVELOPMENT AGAINST UVB INJURIOUS EFFECTS. SUELLEN GUEDES DA SILVA, 

JOCELMO CÁSSIO DE ARAUJO LEITE, JOSÉ PINTO DE SIQUEIRA JUNIOR, LUIS 

FERNANDO MARQUES-SANTOS 

N - 9 INVOLVEMENT OF MITOCHONDRIAL PERMEABILITY TRANSITION 

PORE (MPTP) AND CALCIUM RELEASING IN FERTILIZED EGGS OF SEA URCHIN. 

ELIS TORREZAN GONÇALVES RAMALHO NITÃO, LUIS FERNANDO MARQUES- 

SANTOS 

N - 10 PRENATAL GLUCOCORTICOID TREATMENT AFFECTS ERYTHROID 

AND MEGAKARYOCYTIC CELLS OF RAT FETUSES AND NEWBORNS FLÁVIA 

MACEDO DE OLIVEIRA NEVES, CAMILA CICCONI PACCOLA, SANDRA MIRAGLIA, 

IVONE CIPRIANO 

N - 11 HDAC ACTIVITY IS NECESSARY FOR THE MORPHOGENESIS OF 

POLARIZED TISSUES CARLA AUGUSTA BARRETO MARQUES, ERIKA NEGREIROS, 

HELENA ARAUJO, KATIA CARNEIRO, TATHYANA LAMIM 

N - 12 CHARACTERIZATION OF ABCB1 AND ABCC1 PROTEINS 

FUNCTIONAL ACTIVITY DURING EMBRYONIC DEVELOPMENT OF SEA URCHIN 

ECHINOMETRA LUCUNTER ELIS TORREZAN GONÇALVES RAMALHO NITÃO, CAIO 

CEZAR OLIVEIRA DE LUCENA, LUIS FERNANDO MARQUES-SANTOS 

N - 13 THE SUBCELLULAR DISTRIBUTION OF THE ASYMMETRIC PROTEIN 

NODAL IN GLIAL CELLS PLAYS A KEY ROLE DURING DEVELOPMENT AND 

PHYSIOPATHOLOGY OF THE CENTRAL NERVOUS SYSTEM MARIA CECÍLIA 

OLIVEIRA FERREIRA NUNES, GUILHERME MARQUES DE MATTOS, SUZANA A. 

KAHN, FLAVIA LIMA, VIVALDO MOURA-NETO, KATIA CARNEIRO 

N - 14 EFFECTS OF TAURINE SUPPLEMENTATION ON ARTERIAL PRESSURE 

AND THE NEURONAL NUMBER OF BRAIN STEM IN THE OFFSPRING OF FEMALE 

RATS SUBJECTED TO PROTEIN RESTRICTION DURING PREGNANCY JOSE EDUARDO 

SCABORA, MARCELO CARDOSO DE LIMA, PATRÍCIA ALINE BOER, JOSE ANTOMIO 

ROCHA GONTIJO 

N - 15 RGMA EXPRESSION PATTERN IN SKELETAL MUSCLE CELLS IS 

SIMILAR TO MYOSINS ALINE FAGUNDES MARTINS, GREGORY THOMAS KITTEN, 

GERLUZA APARECIDA BORGES SILVA, DÉBORA CRISTINA INDELICATO DE MIRANDA, 

AMANDA VASCONCELOS ALBUQUERQUE, LUIZ LEHMANN COUTINHO, ÉRIKA 

CRISTINA JORGE 

N - 16 CHARACTERIZATION OF THE PATTERN OF BHC4-1-LACZ 

EXPRESSION IN DROSOPHILA LINES TRANSFORMED WITH MUTANT VERSIONS OF 

THE BHC4-1 RING GLAND ENHANCER IVANA MARIA DE ARAUJO FURTADO, 

MARÍLIA HARUMI ISHIZAWA, NADIA MONESI 

N - 17 MORPHOLOGICAL ASSESSMENT OF THE HEART OF THE MOSQUITO 

AEDES AEGYPTI DURING THE POST-EMBRYONIC DEVELOPMENT ANA CAROLINA 

MACHADO LEÓDIDO, GUSTAVO FERREIRA MARTINS 

N - 18 RATART RETROTRANSPOSON INTERFERING IN THE LARVAL 

DEVELOPMENT OF RHYNCHOSCIARA AMERICANA PAULA REZENDE-TEIXEIRA, 

GLAUCIA MARIA MACHADO-SANTELLI 

N - 19 THE ROLE OF THE MATERNAL DPP/BMP PATHWAY ON THE 

REGULATION OF RNA LEVELS IN THE EARLY DROSOPHILA MELANOGASTER 

EMBRYO. NATHÁLIA PENTAGNA MACIELLO DRUMMOND PIRES, MARCIO RIBEIRO 

FONTENELE, HELENA MARIA MARCOLLA ARAÚJO 

N - 20 DNA DAMAGE SIGNALING AND REPAIR PATHWAYS IN OCULAR 

ORGANOGENESIS PAULO MATHEUS GUERRA RIBEIRO DE SOUSA RODRIGUES, 

GABRIEL RODRIGUES CAVALHEIRO, PIERRE-OLIVIER FRAPPART, RODRIGO ALVES 

PORTELA MARTINS 

N - 21 MORPHOFUNCTIONAL CHARACTERIZATION OF THE PROSTATE IN 

CALOMYS CALLOSUS (RODENTIA, CRICETIDAE) RODENT. RENATO SIMÕES 

CORDEIRO, KÁRITA ROSA DE ALMEIDA, DANIELE LISBOA RIBEIRO, TATIANA CARLA 

TOMIOSSO, MARCELO EMÍLIO BELETTI, LUIZ ROBERTO FALLEIROS JÚNIOR, REJANE 

MAIRA GÓES, SEBASTIÃO ROBERTO TABOGA 

111

N - 22 HISTOLOGICAL STUDY OF THE HEMATOPOIETIC ACTIVITY OF THE 

MURINE PLACENTA NATHÁLIA AZEVEDO PORTILHO, PRISCILA TAVARES GUEDES, 

PEDRO PAULO DE ABREU MANSO, MARCELO PELAJO-MACHADO 

N - 23 AGE-RELATED CHANGES IN DNA AMOUNTS OF NEURONAL NUCLEI 

FROM MOUSE BRAIN CORTEX. ARE NEURONS POLYPLOID OR ANEUPLOID? 

HENRIQUE FERREIRA RODRIGUES, TAFAREL ANDRADE DE SOUZA, FLÁVIA GERELLI 

GHIRALDINI, MARCELO EMÍLIO BELETTI, MARIA LUIZA SILVEIRA MELLO, ALBEROT 

DA SILVA MORAES 

N - 24 KON-TIKI INITIATES FORCE-RESISTANT ATTACHMENT OF 

DROSOPHILA FLIGHT MUSCLES TO TENDONS. WEITKUNAT MANUELA, GRILL W. 

STEPHAN, SCHNORRER FRANK 

N - 25 ANALYSIS OF FGF-8 IN DIDELPHIS ALBIVENTRIS, A PROMISING 

EXPERIMENTAL MODEL FOR THE DEVELOPMENTAL BIOLOGY AREA ÍRIA 

GABRIELA DIAS DOS SANTOS, ALINE GONÇALVES LIO COPOLA, ERIKA CRISTINA 

JORGE, ADRIANA MOREIRA, JOSÉ BENTO ALVES, ALFREDO MIRANDA DE GÓES, 

CRISTIANE APARECIDA DE SOUSA, GERLUZA APARECIDA BORGES SILVA 

N - 26 ARE CALPAINS INVOLVED IN CACTUS/IKAPPAB DEGRADATION 

DURING MUSCLE FORMATION IN DROSOPHILA MELANOGASTER AND CHICK 

EMBRYONIC MUSCLES? MÁRCIO AUGUSTO BUFFOLO, HELENA M.MARCOLLA 

ARAUJO, CLAUDIA MERMELSTEIN 

N - 27 DIFFERENTIAL EFFECTS OF MASTICATORY DEPRIVATION REGIMES 

AND REHABILITATION ON THE LOCOMOTOR AND EXPLORATORY ACTIVITIES OF 

AGED ALBINO SWISS MICE. DIEGO DE JESUS SILVA, FABÍOLA DE CARVALHO 

CHAVES DE SIQUEIRA MENDES, ANDRÉ PINHEIRO GURGEL FELÍCIO, MARINA 

NEGRÃO FROTA DE ALMEIDA, MANOELA FALSONI, MARCIA LORENA FERREIRA DE 

ANDRADE, JOÃO BENTO TORRES NETO, CRISTOVAM WANDERLEY PICANÇO-DINIZ, 

MARCIA CONSENTINO KRONKA SOSTHENES 

N - 28 EXPRESSION OF MYC TRANSCRIPTION FACTORS IN DEVELOPING 

MOUSE LENS ANIELLE LINS GOMES, GABRIEL RODRIGUES CAVALHEIRO, RODRIGO 

ALVES PORTELA MARTINS 

N - 29 THE ROLE OF MYOSIN VA IN THE NEURITOGENESIS OF DORSAL 

ROOT GANGLIA TRKA-POSITIVE NEURONS TATIANE YUMI NAKAMURA KANNO, 

CHAO YUN IRENE YAN, ENILZA MARIA ESPREAFICO 

N - 30 CELLULAR STRESS INDUCED BY UV-RADIATION ON 

MACROBRACHIUM OLFERSI EMBRYOS VALQUIRIA MACHADO CARDOSO, EVELISE 

MARIA NAZARI, DIB AMMAR, YARA MARIA RAUH MÜLLER 

N - 31 MORPHOLOGICAL AND GROWTH ANALYSIS OF SKELETAL MUSCLE 

IN COLOSSOMA MACROPOMUM (TAMBAQUI) DARUZI CEZAR FELIPPE, 

FERNANDA DE MELLO, NÍVIA LOTHHAMMER, LUIS R. J. GUERREIRO, LEANDRO C. 

GODOY, DANILO P. STREIT JR 

N - 32 104 µM IS THE LOWEST CONCENTRATION OF 20-OH ECDYSONE 

THAT STILL INDUCES THE ACTIVITY OF BHSGAMP-1, A GENE THAT ENCODES AN 

AMP, IN THE SALIVARY GLAND OF BRADYSIA HYGIDA (DIPTERA, SCIARIDAE) 

GABRIELA MORILHA ZANAROTTI, JORGE CURY DE ALMEIDA 

N - 33 THE SMAD1 EXPRESSION IN CRANIAL NEURAL CREST CONTROL 

FORE- AND MIDBRAIN PATTERNING. DIEGO PINHEIRO AGUIAR, NICOLE LE 

DOUARIN 

N - 34 EFFECTS OF HOMOCYSTEINE ON MESENCHYMAL CELLS DURING 

LIMB DEVELOPMENT OF GALLUS DOMESTICUS EMBRYOS GILIAN FERNANDO 

BOURCKHARDT, KAROLINE KOBUS, EVELISE MARIA NAZARI, MANUELA CECCHINI, 

YARA MARIA RAUH MÜLLER, DIB AMMAR 

N - 35 MYC PROTO-ONCOGENES REGULATE LENS DEVELOPMENT 

GABRIEL RODRIGUES CAVALHEIRO, ANIELLE LINS GOMES 

N - 36 SALDANA-CABOVERDE A, KOS L (2012). THE TRANSCRIPTION 

FACTORS ETS1 AND SOX10 INTERACT DURING MELANOCYTE DEVELOPMENT IN 

THE MOUSE EMBRYO. AMY SALDANA-CABOVERDE, LIDIA KOS 

N - 37 MEMBRANE METALLOPROTEINASE 1 (MT1-MMP) EXPRESSION IN 

THE DEVELOPMENT OF THE INTESTINAL EPITHELIUM OF RATS KAMILA CAROLINE 

CAMARGO, MARIA ALBERTINA DE MIRANDA SOARES, JOSÉ ROSA GOMES 

N - 38 ULTRAVIOLET B RADIATION (UVB) AFFECTS CELL PROLIFERATION 

DURING EARLY EMBRYONIC DEVELOPMENT OF FRESHWATER PRAWN 

MACROBRACHIUM OLFERSI. ELIANE CRISTINA ZENI, GUILHERME AUGUSTO MAIA, 

FRANCIELY POLLO, DIB AMMAR, YARA MARIA RAUH MÜLLER, EVELISE MARIA 

NAZARI 

N - 39 EFFECT OF METHYLMERCURY ON EMBRYONIC DEVELOPMENT OF 

GALLUS DOMESTICUS FABIANA DE FATIMA FERREIRA, EVELISE MARIA NAZARI, 

YARA MARIA RAUH MÜLLER 

N - 40 CHOLESTEROL SYNTHESIS INHIBITION IN ZEBRAFISH MYOGENESIS 

LAISE MONTEIRO CAMPOS, EDUARDO ANDRÉS RÍOS MORRÍS, NAIARA 

RODRIGUES, CLÁUDIA DOS SANTOS MERMELSTEIN, MANOEL LUIS COSTA 

N - 41 CARBOHYDRATE EXPRESSION IN AORTA-GONAD-MESONEPHROS 

REGION DURING EARLY CHICK EMBRYO DEVELOPMENT PATRICIA ALZUETA 

MORENO MARTINEZ, PRISCILA TAVARES GUEDES, BARBARA CRISTINA EUZEBIO 

PEREIRA DIAS DE OLIVEIRA, JORGE JOSÉ DE CARVALHO, MARCELO PELAJO 

MACHADO 

N - 42 WNT/BETA-CATENIN SIGNALING MODULATION BY MEMBRANE 

MICRODOMAINS IN EMBRYONIC DEVELOPMENT ANDRESSA LUY KAJISHIMA, 

ALICE HELENA REIS, JOSE GARCIA ABREU 

N - 43 REGULATION BETWEEN WNT AND SHH SIGNALING IN FOREBRAIN 

DEVELOPMENT FERNANDA PEREIRA DE OLIVEIRA, ALICE HELENA DOS REIS, 

ANDRESSA LUY KAJISHIMA, JOSE GARCIA ABREU 

N - 44 MORPHOLOGICAL AND HISTOCHEMICAL STUDY OF THE LIVER IN 

HEMISORUBIM PLATYRHYNCHOS LARVAE AND ADULT CLAUDEMIR KUHN 

FACCIOLI, RENATA ALARI CHEDID, ANTONIO CARLOS DO AMARAL, IRENE BASTOS 

FRANCESCHINI VICENTINI, CARLOS ALBERTO VICENTINI 

N - 45 GLYCOSYLATION PROCESSES MODULATE BMP PATHWAY DURING 

DROSOPHILA MELANOGASTER DEVELOPMENT AMANDA RIBEIRO CÂMARA, ERIKA 

MICHELE AVELINO NEGREIROS GONÇALVES, KATIA CARNEIRO DE PAULA, HELENA 

MARIA MARCOLLA ARAUJO, ADRIANE REGINA TODESCHINI 

N - 46 HOMOCYSTEINE CAUSES DISRUPTIONS ON SPINAL CORD 

MORPHOLOGY AND CHANGES THE EXPRESSION OF THE PAX 1/9 AND SOX 9 

GENE PRODUCTS IN THE AXIAL MESENCHYME OF THE CHICKEN KAROLINE 

KOBUS, GILIAN F. BOURCKHARDT, DIB AMMAR, EVELISE MARIA NAZARI, YARA 

MARIA RAUH MÜLLER 

N - 47 EARLY DEVELOPMENT OF THE NEOTROPICAL FISH, LEPORINUS 

OBTUSIDENS (VALENCIENES, 1836) RENATA ALARI CHEDID, CLAUDEMIR KUHN 

FACCIOLI, RICARDO HIDEO MORI, IRENE BASTOS FRANCESCHINI VICENTINI, 

CARLOS ALBERTO VICENTINI 

N - 48 FUNCTIONAL ANALYSIS OF RHODNIUS PROLIXUS DV PATTERNING 

MATEUS ANTONIO BERNI, MÁRCIO RIBEIRO FONTENELE, MARCOS HENRIQUE 

FERREIRA SORGINE, RODRIGO NUNES DA FONSECA, HELENA MARIA MARCOLLA 

ARAÚJO 

N - 49 STRUCTURE OF THE ESOPHAGEAL EPITHELIUM IN HEMISORUBIM 

PLATYRHYNCHOS LARVAE AND ADULT CLAUDEMIR KUHN FACCIOLI, RENATA 

ALARI CHEDID, ANTONIO CARLOS DO AMARAL, IRENE BASTOS FRANCESCHINI 

VICENTINI, CARLOS ALBERTO VICENTINI 

N - 50 THE INFLUENCE OF SONIC HEDGEHOG SIGNALLING PATHWAY IN 

THE EAR DEVELOPMENT LEONARDO POLON, ALICE HELENA DOS REIS, JOSE 

GARCIA RIBEIRO ABREU JUNIOR, JOSÉ MARQUES DE BRITO NETO 

N - 51 MULTIPOTENT NEURAL AND SKELETOGENIC-ADIPOGENIC 

PROGENITORS IN THE AVIAN TRUNK NEURAL CREST JULIANA DE MATTOS 

COELHO AGUIAR, NICOLE LE DOUARIN, ELISABETH DUPIN 

O – Epigenetics 

O1-O18 

O -1 GENETIC AND EPIGENETIC STUDY OF THE GENE TFF1 IN GASTRIC 

TUMORS IN PATIENTS OF THE NORTH REGION OF BRAZIL CYNTHIA FARIAS VIEIRA 

DE MELO, MARISE LOPES FERMINO, RUBISTENIA MIRANDA SOARES DE ARAÚJO, 

TALITTA DANTAS ARRUDA, CACILDA CASARTELLI, ROMMEL RODRÍGUEZ BURBANO, 

ELEONIDAS MOURA LIMA 

O -2 METHYLATION PATTERN OF GENE TP53 IN GASTRIC 

ADENOCARCINOMA CYNTHIA FARIAS VIEIRA DE MELO, RUBISTENIA MIRANDA 

SOARES DE ARAÚJO, TALITTA DANTAS ARRUDA, ELEONIDAS MOURA LIMA 

O -3 CPG ISLAND METHYLATION OF CASPASE 8 APOPTOSIS-RELATED 

GENE IN HUMAN SAMPLE EPITHELIAL OVARIAN CARCINOMA LETÍCIA DA 

CONCEIÇÃO BRAGA, ANA PAULA ÁLVARES DA SILVA RAMOS, AGNALDO LOPES DA 

SILVA FILHO, LUCIANA MARIA SILVA 

O -4 METHYLATION PROFILE MUTLΑ SUBUNIT OF DNA MISMATCH 

REPAIR RUBISTENIA MIRANDA SOARES DE ARAÚJO, CYNTHIA FARIAS VIEIRA DE 

MELO, TALITTA DANTAS ARRUDA, ELEONIDAS MOURA LIMA 

O -5 DNA METHYLATION RATE AND VITAMINS CONCENTRATIONS IN 

WOMEN WITH RECURRENT MISCARRIAGES NATHALIA SIERRA MONTEIRO, 

JESSICA CARRILHO BRITTO, KELMA CORDEIRO DA SILVA GIUSTI, MÁRIO HENRIQUE 

BURLACCHINI DE CARVALHO, ANTÔNIO AMORIM FILHO, ELVIRA MARIA GUERRA 

SHINOHARA 

O -6 STUDY OF UGT1A1 GENE POLYMORPHISMS AND ASSOCIATION 

WITH THE ADVERSE EFFECTS IRINOTECAN: A PILOT STUDY HELEN TAIS DA ROSA, 

MICHELLE FRAGA EISENHARDT, MARCELO LUIS DOTTO, CÁTIA SEVERO, JULIANA 

FONTELLA, LIA POSSUELO 

O -7 IN SITU IDENTIFICATION AND LOCALIZATION OF NUCLEAR 

GLYCOPROTEINS IN CORTICAL NEURONS FROM MICE WITH THREE DIFFERENT 

AGES TAFAREL ANDRADE DE SOUZA, INGRID CORTIZO PRIETO, HENRIQUE 

112

FERREIRA RODRIGUES, FLAVIA GERELLI GHIRALDINI, MARIA LUIZA SILVEIRA 

MELLO, ALBERTO DA SILVA MORAES 

O -8 ROLE OF SIRT1 IN THE ESTABLISHMENT OF ABERRANT EPIGENETIC 

MARKS ASSOCIATED WITH MELANOCYTE MALIGNANT TRANSFORMATION 

FABIANA MARCELINO MELISO, FERNANDA MOLOGNONI, MIRIAM GALVONAS 

JASIULIONIS 

O -9 EXPRESSION, EPIGENETIC REGULATION AND FUNCTION OF 

GAMMA-SYNUCLEIN IN MELANOMA PROGRESSION ANA CAROLINA MONTEIRO, 

CAMILA FERREIRA DE SOUZA, MIRIAM GALVONAS JASIULIONIS 

O -10 GENE EXPRESSION ASSESSMENT OF THE POLYCOMB & TRITHORAX 

COMPLEXES IN THE BRAIN OF FAT-TISSUE-IMPLANTED POLYCYSTIC OVARIAN 

SYNDROME MICE EDUARDO HENRIQUE DA SILVA FREITAS, SAMUEL MARCOS 

RIBEIRO DE NORONHA, CARLOS FERNANDES BAPTISTA, MARIA DE NAZARETH 

GAMBOA RITTO, JORGE KEDE, ISIDORO BINDA NETO, SILVANA APARECIDA ALVES 

CORREA DE NORONHA, ISMAEL DALE COTRIM GUERREIRO DA SILVA 

O -11 THE PATTERN OF WNT5A GENE METHYLATION DIFFERS FROM 

MEDULLARY THYROID CARCINOMA (MTC) CELL LINE AND WITHIN SIBLINGS 

CARRYING THE SAME RET C634R ACTIVATING MUTATION, AND CORRELATES 

WITH EARLY ONSET OF FAMILIAL MTC TUMOR MIRIAN GONÇALVES CARDOSO, 

MARINA MALTA LETRO KIZYS, MICHELLE YURI HARADA, DANIELA FILIPPINI 

IERARDI, SUSAN CHOW LINDSEY, FLÁVIA DE OLIVEIRA FACURI VALENTE, MARIA 

CLARA DE CARVALHO MELO, ROSANA DELCELO, JOÃO ROBERTO MACIEL 

MARTINS, RUI MONTEIRO DE BARROS MACIEL, MIRIAM GALVONAS JASIULIONIS, 

MAGNUS RÉGIOS DIAS DA SILVA 

O -12 EXPRESSION PROFILE AND SUBCELLULAR LOCALIZATION OF A 

NOVEL HUMAN LYSINE METHYLTRANSFERASE SETD4 IN BREAST CANCER JERUSA 

ARAÚJO QUINTÃO ARANTES FARIA, CAROLINA ANDRADE, ANA CAROLINA DE 

ANGELIS CAMPOS, HELENICE GOBBI, ALFREDO MIRANDA GOES, DAWIDSON ASSIS 

GOMES, FABIO PITTELLA SILVA 

O -13 EPIGENETIC MODIFIERS 5-AZA-2’-DEOXYCYTIDINE AND 

TRICHOSTATIN A INFLUENCE ADIPOCYTE DIFFERENTIATION OF HUMAN 

MESENCHYMAL STEM CELLS JAIESA ZYCH, CRISCIELE KULIGOVSKI, MARCO A 

STIMAMIGLIO, ALEXANDRA SENEGAGLIA, PAULO S BROFMAN, BRUNO 

DALLAGIOVANNA, SAMUEL GOLDENBERG, ALEJANDRO CORREA 

O -14 VASCULAR DYSFUNCTION IN IUGR UMBILICAL VEIN IS 

ACCOMPANIED WITH EPIGENETIC ALTERATIONS IN ENOS PROMOTER. 

BERNARDO JAVIER KRAUSE LEYTON, IVO CARRASCO WONG, PAOLA CASANELLO 

TOLEDO 

O -15 EPIGENETIC EVENTS SEEM TO BE IMPORTANT TO DYNAMIC 

PHENOTYPE SWITCHING ALONG MELANOCYTE MALIGNANT TRANSFORMATION 

ALICE SANTANA MORAIS, MIRIAM GALVONAS JASIULIONIS 

O -16 PROMOTER HYPERMETHYLATION OF E-CADHERIN IN 

ASTROCYTOMAS WALLAX AUGUSTO SILVA FERREIRA, MARIANA DINIZ ARAÚJO, 

SYMARA RODRIGUES-ANTUNES, MARICELI BAIA DOS SANTOS, NILSON PRAIA 

ANSELMO, JOSÉ REGINALDO NASCIMENTO BRITO, MARIA LÚCIA HARADA, 

ROMMEL MARIO RODRIGUEZ BURBANO, BÁRBARA DO NASCIMENTO BORGES 

O -17 METHYLATION PATTERN OF MIR-124A2 AND MIR-124A3 IN 

ASTROCYTIC TUMORS MARICELE BAIA DOS SANTOS, MARIANA DINIZ ARAÚJO, 

WALLAX AUGUSTO SILVA FERREIRA, SYMARA RODRIGUES-ANTUNES, JOSÉ 

REGINALDO NASCIMENTO BRITO, DOUGLAS VASCONCELOS, NILSON PRAIA 

ANSELMO, ROMMEL MARIO RODRIGUEZ BURBANO, MARIA LÚCIA HARADA, 

BÁRBARA DO NASCIMENTO BORGES 

O -18 REGULATION OF SUGARCANE MICRORNAS IN PATHOGENS 

RESPONSES BÁRBARA COSTA PEIXOTO, FLÁVIA THIBEAUT, CRISTIAN ANTONIO 

ROJAS, ADRIANA SILVA HEMERLY, PAULO CAVALCANTI GOMES FERREIRA 

P – Extracellular Matrix 

P1-P37 

P - 1 HISTOLOGICAL AND ULTRASTRUCTURAL ANALYSIS OF THE EFFECTS 

OF ELECTRICAL STIMULATION ON CARTILAGE HEALING IN ADULT MALE RATS 

(RATTUS NORVEGICUS). DENISE CRISTINA ZUZZI, CARLA DE CAMPOS CICCONE, 

PAULO PINTO JOAZEIRO, LAURECIR GOMES, MARCELO AUGUSTO MARRETTO 

ESQUISATTO 

P - 2 STRUCTURAL FEATURES OF THE HYALINE CARTILAGE DURING 

REPAIR PROCESS IN IMMATURE MALE RATS (RATTUS NORVEGICUS) TREATED 

WITH MICROCURRENT. CARLA DE CAMPOS CICCONE, DENISE CRISTINA ZUZZI, 

PAULO PINTO JOAZEIRO; LAURECIR GOMES; MARCELO AUGUSTO MARRETTO 

ESQUISATTO 

P - 3 PSYCHOLOGICAL STRESS AND FISH OIL SUPLEMENTATION ON 

CUTANEOUS WOUND HEALING ALICE DOS SANTOS ROSA, LUANA GABRIELA 

BANDEIRA, ANDRÉA MONTE-ALTO-COSTA, BRUNA ROMANA-SOUZA 

P - 4 OVARIAN HORMONES EFFECT ON BIGLYCAN SECRETION BY 

DECIDUAL CELLS IN VITRO AMBART ESTER COVARRUBIAS CISTERNA, MARIANA 

CASTRO ÁVILA, VANESSA MORAIS FREITA, TELMA MARIA TENORIO ZORN 

P - 5 HETEROLOGOUS EXPRESSION, PURIFICATION AND ACTIVITY OF A 

HYALURONIDASE FROM BROWN SPIDER VENOM LOXOSCELES INTERMEDIA 

VALÉRIA PEREIRA FERRER, THIAGO LOPES DE MARI, LUIZA HELENA GREMSKI, 

RAFAEL BERTONI DA SILVEIRA, OLGA MEIRI CHAIM, ANDREA SENFF RIBEIRO, 

SILVIO SANCHES VEIGA 

P - 6 STRUCTURAL AND BIOCHEMICAL MODIFICATIONS IN TENDON 

FIBROCARTILAGE METAPLASIA OF BULLFROGS (RANA CATESBEIANA) DURING 

MATURATION AND AGING. VALDENILSON JOSÉ ZORÉL, LAURECIR GOMES, 

MARCELO AUGUSTO MARRETTO ESQUISATTO 

P - 7 POSTMETAMORPHOSIS MATURATION OF ARTICULAR CARTILAGE 

FROM THREE ANATOMICAL SITES IN BULLFROG (RANA CATESBEIANA) KNEE 

JOINT: A STRUCTURAL STUDY. ANDRÉ HEBLING, MARCELO AUGUSTO MARRETTO 

ESQUISATTO, LAURECIR GOMES 

P - 8 STRUCTURAL ANALYSIS OF THE REPAIR PROCESS IN SKIN WOUNDS 

EXPERIMENTALLY INDUCED IN MALE WISTAR RATS (RATTUS NORVEGICUS). 

THAIS LARISSA PEROTTI, MARINA VIGANÓ PENTEADO, JOSÉ EDUARDO SCABORA, 

MARCELO AUGUSTO MARRETTO ESQUISATTO 

P - 9 EFFECT OF PROTEIN RESTRICTION DIET ON THE REPAIR PROCESS IN 

SKIN WOUNDS, EXPERIMENTALLY INDUCED, IN FEMALE WISTAR RATS (RATTUS 

NORVEGICUS). MARINA VIGANÓ PENTEADO, THAIS LARISSA PEROTTI, JOSE 

EDUARDO SCABORA, MARCELO AUGUSTO MARRETTO ESQUISATTO 

P - 10 EFFECTS OF MICROCURRENT AND INGAP-LASER (670NM) IN THE 

REPAIR OF EXPERIMENTAL WOUNDS IN HEALTHY AND ALLOXAN-DIABETIC RATS. 

LIA MARA GROSSO NEVES, RAFAEL LUÍS MATHEUS, MARCELO AUGUSTO 

MARRETO ESQUISATTO, MARIA ESMÉRIA COREZOLA DO AMARAL, GLAUCIA 

MARIA TECH DOS SANTOS, FERNANDA APARECIDA SAMPAIO MENDONÇA 

P - 11 DIFFERENTIAL DISTRIBUTION AND REMODELING OF ELASTIC 

SYSTEM FIBERS IN THE HEART OF SPONTANEOUSLY HYPERTENSIVE RATS MILENE 

SANCHES GALHARDO, MARIANA METERA VERAS, JULIANA MORA VERIDIANO, 

MARCELO ALVES FERREIRA, OLGA MARIA DE TOLEDO CORRÊA, MARIA CLAUDIA 

IRIGOYEN, ELIA GARCIA CALDINI 

P - 12 BETA-ADRENOCEPTOR BLOCKADE COMPROMISES THE 

CUTANEOUS WOUND HEALING OF CHRONIC LESIONS THATIANA L. ASSIS DE 

BRITO, ANDRÉA MONTE-ALTO-COSTA, BRUNA ROMANA-SOUZA 

P - 13 ULTRASTRUCTURAL AND BIOCHEMICAL ANALYSIS OF 

EXTRACELLULAR MATRIX IN SCIATIC NERVE FROM WISTAR MALE RATS DURING 

MATURATION AND AGING HALINE BALLESTERO FÊO, ANDREA APARECIDA DE 

ARO, LAURECIR GOMES, MARCELO AUGUSTO MARRETTO ESQUISATTO 

P - 14 BIOCHEMISTRY AND HISTOCHEMISTRY OF OLIGOCHAETAS: 

LOCALIZATION AND CHARACTERIZATION OF SULFATED GLYCOSAMINOGLYCANS 

IN THE BODY OF THE EARTHWORM EISENIA ANDREI LAINA CRISTINA FERREIRA, 

RITA DE CASSIA LIMA MARTINS, CELIA YELIMAR PALMERO QUINTANA, LUIZ 

EURICO NASCIUTTI, LUIZ CLAUDIO FRANCISCO DA SILVA 

P - 15 EFFECT OF THE ALOE VERA OINTMENT IN THE REORGANIZATION 

OF THE COLLAGEN FIBERS DURING TENDON HEALING ANDREA APARECIDA DE 

ARO, BENEDICTO DE CAMPOS VIDAL, UMAR NISHAN, MYLENA OLIVEIRA PEREZ, 

RODNEY A. RODRIGUES, MARY ANN FOGLIO, JOAO ERNESTO DE CARVALHO, 

LAURECIR GOMES, EDSON ROSA PIMENTEL 

P - 16 EFFECT OF THE CALENDULA OFFICINALIS CREAM DURING THE 

INFLAMMATORY PHASE OF TENDON HEALING MYLENA OLIVEIRA PEREZ, ANDREA 

APARECIDA DE ARO, CRISTIANO PEDROZO VIEIRA, RODNEY A. RODRIGUES, 

LAURECIR GOMES, EDSON ROSA PIMENTEL 

P - 17 BIOMECHANICAL PROPERTIES OF INTERPUBIC TISSUES DURING 

PREGNANCY AND AFTER DELIVERY OF MICE C57BL6 M. M. M. SILVA, V. S. ROSA, 

S. R. CONSONNI, L. C. V. ALVES, P. P. JOAZEIRO 

P - 18 THE FOLLICULAR THYROID CELL LINE PCCL3 DIFFERENTIALLY 

RESPONDS TO LAMININ AND TO POLYLAMININ, A POLYMERIC FORM OF 

LAMININ ASSEMBLED AT ACIDIC PH CELIA YELIMAR PALMERO QUINTANA, 

LEANDRO MIRANDA ALVES, MADALENA M. SANT’ANA BARROSO, ELAINE C. DE 

SOUZA, DANIEL E. MACHADO, ANTONIO PALUMBO JUNIOR, CARLOS A. DO 

NASCIMENTO, CLAUDIA S. MERLMESTEIN, CHRISTINA M. TAKIYA, DENISE P. 

CARVALHO, CAMILA HOCHMAN MENDEZ, TATIANA COELHO-SAMPAIO, LUIZ 

EURICO NASCIUTTI 

P - 19 COLLAGEN GLYCATION TO GENERATE SKIN RECONSTRUCTED 

MIMICKING AGED AND DIABETIC SKIN IN VITRO PAULA COMUNE PENNACCHI, 

MAÍRA ESTANISLAU SOARES DE ALMEIDA, MARIA CLARA DE ARAÚJO CREPALDI, 

MARINILCE FAGUNDES DOS SANTOS, SILVYA STUCHI MARIA-ENGLER 

P - 20 EXTRACELLULAR MATRIX ALTERATIONS IN INTERVERTEBRAL DISC 

DEGENERATION MARIA BETHANIA ROSSI PIVA, LILIAN ZERBINATTI OLIVEIRA, 

CINTIA PEREIRA OLIVEIRA, CAMILA DE MELO ACCARDO, IVARNE LUIS DOS SANTOS 

TERSARIOL, HELENA BONCIANI NADER, LUCIANO MILLER REIS RODRIGUES, MARIA 

APARECIDA DA SILVA PINHAL 

113

P - 21 IN VITRO EFFECTS OF SILVER NANOPARTICLES ON HUMAN 

FIBROBLAST LARISSA FERNANDA DE ARAUJO VIEIRA, IANA MAYANE MENDES 

NICÁCIO VIANA, CÁSSIO ERÁCLITO ALVES DOS SANTOS, ANA RÚBIA BATISTA 

RIBEIRO, JANDIR MIGUEL HICKMANN, SALETE SMANIOTTO 

P - 22 EVALUATION OF FIBRILLIN-1'S ROLE IN ARTERIAL 

THROMBOGENESIS. PLATELETS PROTEOMIC ANALYSIS. CATHERINE NATALIA 

PEREIRA, DANIEL MARTINS-DE-SOUZA, ADRIANA PAES LEME, LYGIA V. PEREIRA, 

CRISTINA P. VICENTE, JOSÉ CAMILLO NOVELLO, CLAUDIO C. WERNECK 

P - 23 NOVEL ALPL GENETIC ALTERATION AFFECTING THE TNAP 

COLLAGEN BINDING DOMAIN IS ASSOCIATED WITH AN 

ODONTOHYPOPHOSPHATASIA PHENOTYPE LUCIANE MARTINS, THAISÂNGELA L. 

RODRIGUES, MARIANA MARTINS RIBEIRO, MIKI TAKETOMI SAITO, ANA PAULA 

OLIVEIRA GIORGETTI, ENILSON ANTONIO SALLUM, MÁRCIO ZAFFALON CASATI, 

FRANCISCO HUMBERTO NOCITI JUNIOR 

P - 24 IN VITRO EFFECTS OF INSULIN-LIKE GROWTH FACTOR-1 AND 

CHEMOKINE LIGAND-2 ON ENDOTHELIAL CELLS IANA MAYANE MENDES NICÁCIO 

VIANA, MAÍRA ESTANISLAU SOARES DE ALMEIDA, MARIA DANIELMA DOS SANTOS 

REIS, MARVIN PAULO LINS, SILVANA AYRES-MARTINS, SALETE SMANIOTTO 

P - 25 METALOPROTEINASES, MYOFIBROBLASTS AND KI-67 EVALUATION 

IN KERATOCYSTIC ODONTOGENIC TUMOR AND FOLLICLE PERICORONAL GRASIELI 

DE OLIVEIRA RAMOS, ALINE COSTA, JULIANA CRISTINA PORTO, DANIELLA SERAFIN 

COUTO VIEIRA, ELENA RIET CORREA RIVERO 

P - 26 INHIBITION OF TGF-Β PATHWAY REVERTS EXTRACELLULAR 

MATRIX REMODELING IN T. CRUZI-INFECTED CARDIAC MICROTISSUES PATRÍCIA 

MELLO FERRÃO, MARIANA CALDAS WAGHABI, LUCIANA RIBEIRO GARZONI 

P - 27 DISTRIBUTION OF PROTEOGLYCANS IN ANEURYSM AND 

DISSECTION OF THE HUMAN ASCENDING AORTA THIAGO HENRIQUE SCHULTZ, 

VINÍCIUS ORNELAS BICALHO, RICARDO RIBEIRO DIAS, NOEDIR ANTONIO GROPPO 

STOLF, PAULO SAMPAIO GUTIERREZ, LUCIANO DE FIGUEIREDO BORGES 

P - 28 MESTEROLONE AND AEROBIC EXERCISE EFFECTS ON THE ECM OF 

THE TAIL TENDON OF C57BL/6 TRANSGENIC MICE. TATIANA CARLA TOMIOSSO, 

KARINA FONTANA, MARIA ALICE DA CRUZ HÖFLING G, EDSON ROSA PIMENTEL 

P - 29 EXPRESSION AND DISTRIBUTION OF ANNEXIN II IN ANEURYSM 

AND DISSECTION OF THE HUMAN ASCENDING AORTA SÁVIO MELO RABELO, 

MILLANE VIEIRA SANTOS, RICARDO RIBEIRO DIAS, NOEDIR ANTONIO GROPPO 

STOLF, PAULO SAMPAIO GUTIERREZ, LUCIANO DE FIGUEIREDO BORGES 

P - 30 DERMAL EQUIVALENT WITH MELANOMA AS A PLATFORM TO 

SCREENING ANTITUMORAL MOLECULES MANOELA TIAGO DOS SANTOS, CARLA 

ABDO BROHEM, EDSON MENDES OLIVEIRA, RAFAEL DUARTE PAES, ANA CAMPA, 

SILVIA BERLANGA DE MORAES BARROS, SILVYA STUCHI MARIA ENGLER 

P - 31 ROLE OF LAMININ ISOFORMS IN THE PROLIFERATION, 

MIGRATION, DIFFERENTIATION AND DEATH OF HUMAN MYOBLASTS: 

APPLICATION FOR CELL THERAPY INGO RIEDERER, ELISA NEGRONI, DANIELLE 

INGRID BEZERRA DE VASCONCELOS, ELIANE CORREA DE SANTANA, DAIANE 

CRISTINA FERREIRA GOLBERT, MARCELO RIBEIRO ALVES, CAMILA SANCHES, 

SORAYA CHAOUCH, GILLIAN SANDRA BUTLER BROWNE, VINCENT MOULY, WILSON 

SAVINO 

P - 32 INFLUENCE OF OPN ON MINERALIZATION OF OSTEOGENIC CELLS 

CULTURED ON A NANOSTRUCTURED TITANIUM SURFACE ADRIEL HENRIQUE 

PEIXOTO DA SILVA GERALDO, FABÍOLA SINGARETTI DE OLIVEIRA, RICARDO DELLA 

COLETTA, ADALBERTO LUIZ ROSA, PAULO TAMBASCO DE OLIVEIRA, PATRICIA 

ADACHI 

P - 33 TRITERPENE UVAOL STIMULATES PHAGOCYTOSIS AND 

EXTRACELLULAR MATRIX PRODUCTION IN PERITONEAL MACROPHAGES IN 

VITRO. REBEKA RAÍSA SOUZA DE MELO, IANA MAYANE MENDES NICÁCIO VIANA, 

LARISSA FERNANDA DE ARAÚJO VIEIRA, ALTAIR ROGÉRIO ALVES BRANDÃO, 

EMILIANO BARRETO, SALETE SMANIOTTO 

P - 34 TISSUE ENGINEERED THREE DIMENSIONAL IN VITRO: 

DECELLULARIZATION AND RECELULARIZATION OF THE KIDNEYS. ANDREZA 

BASTOS MARTINS, BERNARDO JORGE DA SILVA MENDES, ANTONIO CARLOS 

CAMPOS DE CARVALHO, JORGE LUIZ DA CUNHA MORAES, JOSE ROBERTO SILVA, 

RODRIGO NUNES DA FONSECA, CINTIA MONTEIRO DE BARROS, JACKSON DE 

SOUZA MENEZES, REGINA COELI DOS SANTOS GOLDENBERG 

P - 35 HEPARANASE-1 SILENCING COMPROMISES SMOOTH MUSCLE CELL 

DIFFERENTIATION DURING VENTRAL PROSTATE MORPHOGENESIS IN VITRO 

GUILHERME OLIVEIRA BARBOSA, TAIZE AUGUSTO MACHADO, ALEXANDRE BRUNI 

CARDOSO, HERNANDES F. CARVALHO 

P - 36 EFFECT OF THE TREATMENT WITH STATINS ON THE DEEP DIGITAL 

FLEXOR TENDON OF RATS LETÍCIA PRADO DE OLIVEIRA, CRISTIANO PEDROZO 

VIEIRA, FLÁVIA DA RÉ GUERRA, EDSON ROSA PIMENTEL 

P - 37 CHRONIC ADMINISTRATION OF STATINS CAUSES BIOCHEMICAL 

CHANGES IN ACHILLES TENDON LETÍCIA PRADO DE OLIVEIRA, CRISTIANO 

PEDROZO VIEIRA, FLÁVIA DA RÉ GUERRA, EDSON ROSA PIMENTEL 

Q – Gene Therapy 

Q1-Q5 

Q -1 GM-CSF GENE THERAPY TO RABBIT HIND LIMB ISCHEMIA 

LEONARDO MARTINS SILVA, VIVIAN YOSHIKO SAMOTO, PRISCILA MARTINS 

ANDRADE DENAPOLI, LEONARDO PINTO CARVALHO, ALEXANDRE SOUTO, JOÃO 

CARLOS COSTA BAPTISTA SILVA, SANG WON HAN 

Q -2 MESENCHYMAL STEM CELLS LOWER PROLIFERATION AND 

INVASION OF GLIOBLASTOMA CELLS, EXPLOITING THE IMMUNE RESPONSE 

MEDIATING CHEMOKINES TAMARA T. LAH, MOTALN H, GRUDEN K, HREN M, 

PRIMON M, SCHICHOR CH 

Q -3 INHIBITORY EFFECT OF ENDOSTATIN ON TUMOR CELL DENSITY IN 

METASTATIC RENAL CELL CARCINOMA ZENÓBIO ANTONIO VIANA DE BARROS, 

MARINA DE SOUZA BRAGA, KAREN CRISTINA BARBOSA CHAVES, MARIA HELENA 

BELLINI 

Q -4 INTRAPERITONEAL INJECTION EFFECT OF MESENCHYMAL STEM 

CELLS MODIFIED WITH IDUA TO TREAT MUCOPOLYSACCHARIDOSIS TYPE I IN 

MPSI MOUSE PRISCILA KEIKO MATSUMOTO MARTIN, ROBERTA SESSA STILHANO, 

FLAVIA HELENA DA SILVA, VIVIAN YOSHIKO SAMOTO, GIOVANI BRAVIN PERES, 

SANG WON HAN 

Q -5 EXPRESSION OF A PROAPOPTOTIC MYOSIN VA FRAGMENT 

RETARDS MELANOMA TUMOR GROWTH IN ANIMAL MODEL ANTONIO CARLOS 

BORGES, PABLO MARCO PEIXOTO, ANA PAULA BARRETO DE PAIVA, DENISE 

PIMENTA DA SILVA LEITAO-MAZZI, KATHLEEN W KINNALLY, ENILZA MARIA 

ESPREAFICO 

R – Host-Parasite 

Interaction 

R1-R75 

R -1 EVALUATION OF JOANNESIA PRINCEPS AQUEOUS EXTRACT 

ANTHELMINTIC ACTIVITY IN NATURALLY INFECTED MICE BY SYPHACIA 

OBVELATA, ASPICULURIS TETRAPTERA AND VAMPIROLEPIS NANA. HELCIO 

RESENDE BORBA, JENNIFER VIEIRA GOMES, JESSICA TAMARA DOS SANTOS 

TEIXIERA, MARIANA DA SILVA DE MELLO, PATRÍCIA FAMPA, LENÍCIO GONÇALVES, 

FRANCISCO DE ASSIS DA SILVA, VIVIANE MOREIRA DE LIMA 

R -2 THE DIVERSE AND DYNAMIC NATURE OF LEISHMANIA 

PARASITOPHOROUS VACUOLES STUDIED BY MULTIDIMENSIONAL IMAGING 

FERNANDO ROBERTO OLIVEIRA REAL, RENATO ARRUDA MORTARA 

R -3 MORPHOLOGICAL CHANGES IN THE CYST WALL OF THE PARASITE 

GIARDIA LAMBLIA DURING EXCYSTATION PROCESS VICTOR DO VALLE PEREIRA 

MIDLEJ, ISADORA PEIXOTO MEINIG, MARLENE BENCHIMOL 

R -4 TRITRICHOMONAS FOETUS EXPRESSES DIFFERENT ECTO- 

PHOSPHATASE ACTIVITIES DURING THE PSEUDOCYST FORMATION ANTONIO 

PEREIRA-NEVES, JOSÉ ROBERTO MEYER-FERNADES, MARLENE BENCHIMOL 

R -5 PRIMARY CULTURES OF SEVERAL TISSUES FROM THE MOLLUSK 

BIOMPHALARIA TENAGOPHILA (ORBIGNY, 1835), VECTOR OF SCHISTOSOMIASIS 

ARISTEU SILVA NETO, AMANDA CIPRIANO ARAÚJO, MARIANA PEDROSA GARCIA, 

CONSUELO LATORRE FORTES DIAS, PAULO MARCOS ZECH COELHO, LUCIANA 

MARIA SILVA 

R -6 STRUCTURAL AND ULTRASTRUCTURAL CHARACTERIZATION OF 

PRIMARY CULTURE CELLS FROM DIFFERENT TISSUES OF BIOMPHALARIA 

TENAGOPHILA ARISTEU SILVA NETO, LUIZ CARLOS ALVES, FÁBIO ANDRÉ BRAYNER 

DOS SANTOS, CONSUELO LATORRE FORTES DIAS, PAULO MARCOS ZECH COELHO, 

LUCIANA MARIA SILVA 

R -7 INVESTIGATION ON THE BEHAVIOR OF TRICHOMONAS TENAX 

ÉRIKA BERTOZZI, IVONE DE ANDRADE ROSA, LUIZ CARLOS DOS SANTOS RIBEIRO, 

MARLENE BENCHIMOL 

R -8 IDENTIFICATION OF FLAGELLATED PROTISTS IN THE GUT OF THE 

TERMITE COPTOTERMES GESTROI LIGIA FERREIRA NASCIMENTO, SEVERINO A. 

LUCENA, REGINALDO CONSTANTINO, MARLENE BENCHIMOL 

R -9 LYSOSOME DYNAMICS: WHAT IS THE IMPORTANCE OF 

CHOLESTEROL FOR T. CRUZI ENTRY INTO CELLS? BÁRBARA HISSA DE CARVALHO 

VIEIRA COUTO, PAULA MAGDA DA SILVA ROMA, ANA PAULA ALVES, FÁBIO 

PEREIRA SANTOS, ANA MARIA DE PAULA, UBIRAJARA AGERO BATISTA, OSCAR 

NASSIF DE MESQUITA, CRISTINA GUATIMOSIM FONSECA, LUCIANA DE OLIVEIRA 

ANDRADE 

114

R -10 COMPARATIVE STUDY OF SYNTHESIZED PENTAVALENT 

ANTIMONIAL COMPOUNDS WITH GLUCANTIME IN MURINE MODEL KELLY 

CRISTINA KATO, ADRIEL ARAÚJO FERNANDES FERREIRA, ELIANE DE MORAIS 

TEIXEIRA, ANA LÚCIA TELES RABELLO, CYNTHIA PERES DEMICHELI, MARCELA 

SANTOS PROCÓPIO, FREDERIC JEAN GEORGES FREZARD, JOSÉ DIAS CORRÊA 

JUNIOR 

R -11 SALIVARY GLAND AS A SOURCE OF NEUROTROPHIC FACTOR IN 

EXPERIMENTAL TRYPANOSOMIASIS LUCIANA DE OLIVEIRA ANDRADE, RICARDO 

TOSHIO FUGIWARA, LUISA ALMEIDA FIGUEIREDO, EGLER CHIARI, PATRICIA 

MASSARA MARTINELLI, PATRICIA MASSARA MARTINELLI 

R -12 CYTOKINE POLYMORPHISMS ANALYSIS IN PATIENT WITH 

AMERICAN CUTANEOUS LEISHMANIASIS FÁBIO RIBEIRO QUEIROZ, FLÁVIA 

PERRIM DE MELO, LETICIA DA CONCEIÇÃO BRAGA, ANA CRISTINA DE CARVALHO 

BOTELHO, LINTON WALLIS FIGUEIREDO SOUZA, LUCIANA MARIA SILVA 

R -13 IMMUNE RESPONSE IN RAT NEURON-GLIA CO-CULTURES 

INFECTED WITH NEOSPORA CANINUM: ROLE OF OXIDE NITRIC SYNTHETASE 

INDUCIBLE ALEX BARBOSA DOS SANTOS, ERICA ETELVINA VIANA DE JESUS, 

GREGORY FERRAZ, ALEXANDRE MORAES PINHEIRO, CÁTIA SUSE RIBEIRO, MAIARA 

REIS ARRUDA, ISABELA COSTA BARRETO DE ALMEIDA, SILVIA COSTA, MARIA DE 

FÁTIMA DIAS COSTA 

R -14 DECREASE OF CCL2 IN MOUSE INFECTED WITH LEISHMANIA 

BRAZILIENSIS IN THE PRESENCE OF ADENOSINE SAMARA FREIRE VALENTE, THAIS 

VIANA FIALHO, LEANDRO LICURSI DE OLIVEIRA, SÉRGIO OLIVEIRA DE PAULA, LUÍS 

CARLOS CROCCO AFONSO, EDUARDO DE ALMEIDA MARQUES DA SILVA 

R -15 REORGANIZATION OF THE MYOCARDIAL MORPHOLOGY AND 

CARDIOMYOCYTES MECHANICAL PROPERTIES IN EXPERIMENTAL 

TRYPANOSOMA CRUZI INFECTION RÔMULO DIAS NOVAES, ARLETE RITA 

PENITENTE, MARTA ROCHA ARAÚJO, REGGIANI VILELA GONÇALVES, ANDRÉ 

TALVANI, CLÓVIS ANDRADE NEVES, ANTÔNIO JOSÉ NATALI, IZABEL REGINA DOS 

SANTOS COSTA MALDONADO 

R -16 EFFECT OF PREINFECTION TREADMILL TRAINING ON THE 

MORPHOLOGY AND FUNCTION OF CARDIOMYOCYTES IN A MURINE MODEL OF 

CHAGAS’ CARDIOMYOPATHY RÔMULO DIAS NOVAES, ARLETE RITA PENITENTE, 

MARTA ROCHA ARAÚJO, REGGIANI VILELA GONÇALVES, ANDRÉ TALVANI, CLÓVIS 

ANDRADE NEVES, ANTÔNIO JOSÉ NATALI, IZABEL REGINA DOS SANTOS COSTA 

MALDONADO 

R -17 APOE4/4 TARGETED REPLACEMENT AND APOE KNOCKOUT 

WEANLING MICE HAVE DISTINCT ADAPTATIONS FOLLOWING 

CRYPTOSPORIDIUM PARVUM INFECTION AND MALNUTRITION ORLEÂNCIO 

GOMES RIPARDO DE AZEVEDO, DAVID BOLICK, ALDO A. M. LIMA, MICHEL P. VITEK, 

REINALDO B. ORIA, JAMES K. ROCHE, RICHARD L. GUERRANT 

R -18 ISOLATION AND PURIFICATION OF LEISHMANIA 

INFANTUM/CHAGASI LECTINS. THAÍS VIANA FIALHO MARTINS, SAMARA FREIRE 

VALENTE, SÍLVIA ALMEIDA CARDOSO, SÉRGIO OLIVEIRA DE PAULA, LEANDRO 

LICURSI DE OLIVEIRA, EDUARDO DE ALMEIDA MARQUES DA SILVA 

R -19 HEMOLYMPH CELLS OF LYMNAEA COLUMELLA, SAY, 1817, A 

VECTOR FOR FASCIOLOSIS IN BRAZIL VINICIUS MARQUES ANTUNES RIBEIRO, 

ARISTEU SILVA NETO, LUCIANA MARIA SILVA, WALTER DOS SANTOS LIMA 

R -20 COMPARISON OF THE ADHESION TAX OF WILD AND MUTANTS 

STRAINS HAEMOPHILUS INFLUENZAE IN HEC1B AND A549 CELL LINES JULIA 

NOGUEIRA VARELA, MÁRIO SÉRVULO IZIDORO, JR., DANILO ANTONINI ALVES, 

GISELE CRISTIANE GENTILLE CURY, LUCIANA MARIA DE HOLLANDA, RAFAELLA 

FABIANA CARNEIRO PEREIRA, MARCELO LANCELLOTTI 

R -21 WHY COINFECT CELLS WITH NON-VIRAL PATHOGENS? MICHEL 

RABINOVITCH 

R -22 IMMUNOHISTOCHEMICAL DETECTION OF GP43 IN THE LIVER OF 

SWISS MICE WITH PARACOCCIDIOIDOMYCOSIS ELAINE SCIUNITI BENITES 

MANSANO, TEREZINHA INEZ ESTIVALET SVIDZINSKI, EDILAINE MARTINS 

MORATTO , MARIANA CRISTINA VICENTE UMADA ZAPATER, MARIA DOS ANJOS 

FORTUNATO, LUZMARINA HERNANDES 

R -23 HISTOPATHOLOGICAL EVALUATION AND PHYSICOCHEMICAL BY 

RAMAN SPECTROSCOPY IN LIVER OF SWISS MICE WITH 

PARACOCCIDIOIDOMYCOSIS ELAINE SCIUNITI BENITES MANSANO, TEREZINHA 

INEZ ESTIVALET SVIDZINSKI, EDILAINE MARTINS MORATTO, MAURO LUCIANO 

BAESSO, GUTIERREZ RODRIGUÊS DE MORAIS, LUZMARINA HERNANDES 

R -24 THE TREATMENT TACHYZOITES OF TOXOPLASMA GONDII ON THE 

HOST CELL INTERACTION INDUCED CONVERSION FOR BRADYZOITES FORMS 

LOYZE PAOLA OLIVEIRA DE LIMA, THAYANE RITA BORGES DE FARIA, JULIANA DE 

ARAÚJO PORTES, PEDRO SOUTO RODRIGUES, RENATO AUGUSTO DAMATTA, 

WANDERLEY DE SOUZA, SERGIO HENRIQUE SEABRA 

R -25 GPI PBPGA1P OF P. BRASILIENSIS IS A SURFACE ANTIGEN THAT 

ACTIVATES MAST CELLS THROUGH THE TRANSCRIPTION FACTOR NF-KAPPA B 

INDEPENDENT OF THE HIGH AFFINITY IGE RECEPTOR CLARISSA XAVIER RESENDE 

VALIM, LUISA KARLA ARRUDA, CONSTANCE OLIVER, PAULO SERGIO RODRIGUES 

COELHO, MARIA CELIA JAMUR 

R -26 MAY THE ADIPOSE TISSUE BE A TRYPANOSOMA CRUZI RESERVOIR 

IN PATIENTS WITH CHRONIC CHAGAS DISEASE? ADALIENE VERSIANI MATOS 

FERREIRA, MARCELA SEGATTO DO CARMO, ZÉLIA MENEZES, ÍTALO FARIA DO 

VALLE, ANDRÉA MARA MACEDO, CLÁUDIO GELAPE, LUCIANA DE OLIVEIRA 

ANDRADE, FNU NAGAJYOTHI, PHILIPP E. SCHERER, MAURO MARTINS TEIXEIRA, 

HERBERT B. TANOWITZ 

R -27 NEUTROPHIL EXTRACELLULAR TRAPS (NETS) DECREASE THE 

VIABILITY OF TOXOPLASMA GONDII GABRIELA VERAS DE MORAES, TATIANA 

PAREDES SANTOS, ANDERSON GUIMARÃES COSTA, ELVIRA SARAIVA, MARCIA 

ATTIAS 

R -28 BINDING OF THE WHEAT GERM LECTIN TO CRYPTOCOCCUS 

NEOFORMANS CHITOOLIGOMERS IMPAIRS EXTRACELLULAR POLYSACCHARIDE 

RELEASE, TLR2-MEDIATED INTERACTION WITH PHAGOCYTES, AND BRAIN 

COLONIZATION IN MICE. FERNANDA L. FONSECA, ALLAN J. GUIMARÃES, 

FABIANNO F. DUTRA, FERNANDA D. SILVA, JULIAN E. MUÑOZ, CARLOS P. 

TABORDA, MARCELO T. BOZZA, LEONARDO NIMRICHTER, ARTURO CASADEVALL, 

MARCIO L. RODRIGUES 

R -29 ULTRASTRUCTURAL ANALYSIS OF HOST CELL CYTOSKELETON 

DURING TOXOPLASMA GONDII INVASION THAYANA ARAUJO DA CRUZ, TATIANA 

C. PAREDES SANTOS, WANDERLEY DE SOUZA, MARCIA ATTIAS 

R -30 CRYPTOCOCCUS NEOFORMANS-MACROPHAGE INTERACTION: 

CYTOSKELETON INVOLVEMENT UPON HOST CELL ENTRY CAROLINE REZENDE 

GUERRA, SERGIO HENRIQUE SEABRA, SONIA ROZENTAL 

R -31 IFN-GAMMA PLAYS A UNIQUE ROLE IN PROTECTION AGAINST 

LOW VIRULENT TRYPANOSOMA CRUZI STRAIN ADELE AUD RODRIGUES, FABIANA 

SILVA, FLÁVIA ALVES MARTINS, ANA FLÁVIA OLIVEIRA NOTÁRIO, ALINE ALVES DA 

SILVA, CECÍLIO PURCINO DA SILVA SOUZA NETO, JASSON SEBASTIAN SANABRIA 

SAOSA, GRACE KELLY DA SILVA, CATARINA V. HORTA, DARIO S. ZAMBONI, JOÃO 

SANTANA DA SILVA, ELOISA A. V. FERRO, CLAUDIO VIEIRA DA SILVA 

R -32 THE ROLE OF CYTOSKELETON, COMPONENTS OF IP3/DAG 

SIGNALING PATHWAY AND IRON IN EHRLICHIA CANIS PROLIFERATION KARINE 

CANUTO LOUREIRO DE ARAUJO, MARCELO ARANTES LEVENHAGEN, ROSIANE 

NASCIMENTO ALVES, SUSANA ELISA RIECK, MARCELO BAHIA LABRUNA, MARCELO 

EMÍLIO BELETTI 

R -33 PURIFICATION PROTOCOLS OF A 21 KDA RECOMBINANT PROTEIN 

BASED ON THE NATIVE TRYPANOSOMA CRUZI P21: A TOOL TO STUDY ITS 

BIOLOGICAL FUNCTIONS DURING PARASITE-HOST INTERACTION MARLUS ALVES 

DOS SANTOS, CLAUDIO VIEIRA DA SILVA, PAULA CRISTINA BRIGIDO, KARINE 

CANUTO LOUREIRO DE ARAÚJO, PRISCILA CASTRO CORDEIRO FERNANDES 

R -34 ATYPICAL ENTEROPATHOGENIC ESCHERICHIA COLI (AEPEC) 

SECRETES A SOLUBLE ANTI-PHAGOCYTIC FACTOR KEYDE CRISTINA MARTINS DE 

MELO, RAFAEL MARQUES PORTO, DANIEL CARVALHO PIMENTA, RITA DE CASSIA 

RUIZ 

R -35 3D VIEW OF INTERCONNECTIONS BETWEEN ENDOPLASMIC 

RETICULUM PROFILES AND INNER MEMBRANE COMPLEX OF TOXOPLASMA 

GONDII TATIANA CHRISTINA PAREDES SANTOS, WANDERLEY DE SOUZA, MARCIA 

ATTIAS 

R -36 TRYPANOSOMA CRUZI EXTRACELLULAR AMASTIGOTES (EAS) AND 

HOST CELL SIGNALING: MORE PIECES TO THE PUZZLE DIANA BAHIA, ALEXIS 

BONFIM-MELO, ÉDEN RAMALHO FERREIRA, RENATO ARRUDA MORTARA 

R -37 ROLE OF REACTIVE OXYGEN SPECIES (ROS) ON NEUTROPHIL 

EXTRACELLULAR TRAPS (NETS) INDUCED BY LEISHMANIA AMAZONENESIS 

NATALIA CADAXO ROCHAEL, MICHELLE TANNY CUNHA DO NASCIMENTO, 

ANDERSON BAPTISTA GUIMARÃES-COSTA, MATHEUS PINTO DE OLIVEIRA, 

MARCUS FERNANDES DE OLIVEIRA, ELVIRA MARIA SARAIVA 

R -38 INVESTIGATION OF YELLOW FEVER VIRUS-INDUCED ENDOPLASMIC 

RETICULUM STRESS DANIEL SANCHES, CLAUDIA MONTEIRO DA ROCHA, SAMIR 

PEREIRA DACOSTA CAMPOS, LUCIANE PINTO GASPAR, MARCOS DA SILVA FREIRE, 

BRUNO SOUZA GONÇALVES, LUCIANA BARRETO CHIARINI, JERSON LIMA DA SILVA, 

ANDRE MARCO DE OLIVEIRA GOMES, ANDRÉA CHEBLE DE OLIVEIRA 

R -39 MEDICINAL PLANT EXTRACTS: AN ALTERNATIVE APPROACH TO 

CONTROL INTRACELLULAR MULTIPLICATION OF LEISHMANIA AMAZONENSIS 

SAMUEL COTA TEIXEIRA, THAISE LARA TEIXEIRA, MARIA APARECIDA DE SOUZA, 

CLAUDIO VIEIRA DA SILVA 

R -40 NADPH OXIDASE ACTIVATION IS ASSOCIATED WITH INVASION OF 

HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY GROUP B STREPTOCOCCUS 

JESSICA SILVA SANTOS DE OLIVEIRA, RAFAELA SILVA DOS SANTOS, PRESCILLA EMY 

NAGAO, GABRIELA DOS SANTOS JONATHAN 

R -41 PROTECTIVE MECANISMS IN THE SMALL INTESTINE INDUCED BY 

PREVIOUS TREATMENT WITH THE SOLUBLE ANTIGEN OF TACHYZOITES (STAG) IN 

MICE INFECTED ORALLY WITH TOXOPLASMA GONDII ALEXSANDRA ALVES 

BEZERRA MARTINS, LUCIANA ALVES DE SOUSA, LETÍCIA BRUNO, TÚLIO HENRIQUE 

DE FREITAS, PAULO VICTOR CZARNEWSKI BARENCO, ESTER CRISTINA BORGES 

ARAÚJO, NEIDE MARIA SILVA 

R -42 EFFECTS OF SALMONELLA ENTERITIDIS SEROVAR TYPHIMURIUM 

INFECTION IN ADENOCARCINOMIC HUMAN ALVEOLAR BASAL EPITHELIAL CELLS 

A549: PATHOGEN INDUCES APOPTOSIS JULIA NOGUEIRA VARELA, MÁRIO 

SÉRVULO IZIDORO JR., DANILO ANTONINI ALVES, RAFAELLA FABIANA CARNEIRO 

115

PEREIRA, LUCIANA MARIA DE HOLLANDA, MARCELO BROCCHI, MARCELO 

LANCELLOTTI 

R -43 IN VITRO INTERACTION OF AEROMONAS SPP. STRAINS WITH HEP- 

2 AND CACO-2 CELL LINES ANDRÉA FONSECA FERREIRA, PAULA AZEVEDO DOS 

SANTOS, ANGELA CORRÊA DE FREITAS ALMEIDA 

R -44 SCREENING OF NEW COMPOUNDS THAT INHIBIT THE REPLICATION 

OF HIV-1 SANDRO COSTA POEYS, LÍDIA MOREIRA LIMA, LUCIANA JESUS DA COSTA 

R -45 CYTOTOXIC ACTIVITY OF AEROMONAS STRAINS ISOLATED FROM 

CLINICAL SAMPLES FOR A HUMAN INTESTINAL CELL LINE (HRT-18) ANA CAROLINE 

WIPPICH, STELA COSTA, SUELEN WOLF, CYNTIA MARIA TELLES FADEL-PICHET, 

KATIA SABRINA PALUDO 

R -46 IN VITRO ANALYSIS OF NEISSERIA MENINGITIDIS’ INFECTION IN 

HUMAN IMMORTALIZED CELLS RAFAELLA FABIANA CARNEIRO PEREIRA, MÁRIO 

SÉRVULO IZIDORO JÚNIOR, RENAN KOSSEKI JACINTO, MARCELO LANCELLOTTI 

R -47 THE ROLE OF THE LAS GENE IN THE VIRULENCE OF HAEMOPHILUS 

INFLUENZAE BIOGROUP AEGYPTIUS ASSOCIATED WITH BRAZILIAN PURPURIC 

FEVER GISELE CRISTIANE GENTILE CURY, RAFAELLA FABIANA CARNEIRO PEREIRA, 

LUCIANA MARIA DE HOLANDA, MARCELO LANCELLOTTI 

R -48 TRANSLATIONAL REGULATION OF IMMUNODEFICIENCY TYPE 1 

VIRUS (HIV-1) BY POLIOVIRUS 2A PROTEASE RAQUEL AMORIM, SARA MESQUITA 

COSTA, EDSON ELIAS DA SILVA, LUCIANA JESUS DA COSTA 

R -49 TOXOPLASMA GONDII PERSISTENCE IN ACTIVATED 

MACROPHAGES: INOS DEGRADATION MECHANISMS JULIANA DA CRUZ PADRÃO, 

GABRIEL RABELLO DE ABREU CABRAL, SERGIO HENRIQUE SEABRA, MARIA DE 

FÁTIMA SARRO DA SILVA, RENATO AUGUSTO DAMATTA 

R -50 ABSENCE OF LENTIVIRAL ACCESSORY PROTEIN NEF INCREASES 

HIV-1 PR CATALYTIC ACTIVITY REDUCING MATURE VIRAL PARTICLES 

PRODUCTION AND ENZYME INCORPORATION LUIZA MONTENEGRO MENDONÇA, 

SANDRO COSTA POEYS, LUCIANA JESUS DA COSTA 

R -51 GALECTIN-3 PARTICIPATION IN TRYPANOSOMA CRUZI CELL 

INVASION, INTRACELLULAR TRAFFIC AND MULTIPLICATION ALINE ALVES DA 

SILVA, FABRÍCIO CASTRO MACHADO, REBECCA TAVARES E SILVA, CLAUDIO VIEIRA 

DA SILVA 

R -52 EFFECT OF THIOPHENACETAMIDE AGAINST MYCOBACTERIUM 

BOVIS (BCG) INFECTION. FATIMA MARIA FIGUEROA VERGARA, ANDRÉ LUIS 

PEIXOTO CANDÉA, PATRÍCIA PACHECO DA SILVA, MARCUS VINÍCIUS NORA, MARIA 

DAS GRAÇAS MULLER DE OLIVEIRA HENRIQUES 

R -53 EVALUATION OF TH1 CYTOKINE EXPRESSION DURING CEREBRAL 

MALARIA INFECTION IN MSG-OBESE MICE. RENAN VILLANOVA HOMEM DE 

CARVALHO, CHRISTIANE LIMA MACHADO, ANA GUALBERTO, SARA MALAGUTI 

SOARES, GABRIELA COELI MENEZES EVANGELISTA, POLLYANA SALVADOR, GILSON 

COSTA MACEDO, JACY GAMEIRO 

R -54 ULTRASTRUCTURAL STUDY OF CANDIDA ALBICANS ADHESION TO 

GERBIL (MERIONES UNGUICULATUS) VAGINAL AND UTERINE EPITHELIUM 

THALITTA HETAMARO AYALA LIMA, CAROLINA MARTINS TREMÉA, LUIZ HENRIQUE 

ATHAIDES RAMOS, SEBASTIÃO ROBERTO TABOGA, LÚCIA KIOKO HASIMOTO E 

SOUZA, FERNANDA CRISTINA ALCANTARA DOS SANTOS, JOSIANE FAGANELLO 

R -55 INVESTIGATION OF LIPID BODIES IN TRYPANOSOMA CRUZI AND 

THEIR CORRELATION WITH CHAGAS’ DISEASE DANIEL AFONSO DE MENDONÇA 

TOLEDO, HELOISA D’AVILA BIZARRO, LÍVIA TEIXEIRA, CÉLIO FREIRE DE LIMA, 

PATRÍCIA TORRES BOZZA, ROSSANA C. N. MELO 

R -56 ISOLATION AND CHARACTERIZATION OF GENES CODING FOR 

PHYTOCYSTATINS FROM BLACK PEPPER- FUSARIUM SOLANI F. SP. PIPERIS 

INTERACTION ALINE MEDEIROS LIMA, SÁVIO PINHO DOS REIS, WENDELL UPTON 

DE BRITO, LILIANE SOUZA CONCEIÇÃO TAVARES, ELAINE CRISTINA PESSOA DOS 

SANTOS, CLAUDIA REGINA BATISTA DE SOUZA 

R -57 NAPHTHOQUINONE DERIVATIVE CHEMOTHERAPY ACTION IN THE 

IN VITRO DEVELOPMENTAL OF TOXOPLASMA GONDII. LUCIANA LEMOS RANGEL 

DA SILVA, JULIANA DE ARAÚJO PORTES, SÉRGIO HENRIQUE SEABRA, RENATO 


R -58 THE ROLE OF UBIQUITIN-PROTEASOME SYSTEM IN VIRAL 

PRODUCTION AND INFECTIVITY OF SIVCPZ MARCELA SABINO CUNHA, LUCIANA 

JESUS DA COSTA 

R -59 PI3K AND AKT SIGNAL PATHWAY ARE INVOLVED DURING 

INVASION OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY GROUP B 

STREPTOCOCCUS RAFAELA SILVA DOS SANTOS, JESSICA SILVA SANTOS DE 

OLIVEIRA, GABRIELA DA SILVA SANTOS, PRESCILLA EMY NAGAO 

R -60 CELLULAR STUDIES OF A HISTONE DESACETYLASES INHIBITOR ON 

LEISHMANIA AMAZONENSIS BRUNNO RENATO FARIAS VERÇOZA, JULIANY COLA 

FERNANDES RODRIGUES, WANDERLEY DE SOUZA, FRANZ BRACHER 

R -61 MECHANISM OF INTERACTION BETWEEN PHAGOSOMES AND RAB 

7-ENRICHED LIPID BODIES DURING MYCOBACTERIAL INFECTION NATALIA R 

ROQUE, SILVIA L. LAGE, ROSSANA MELO, HUGO C. CASTRO-FARIA-NETO, HELOISA 

D'AVILA, PATRICIA TORRES BOZZA 

R -62 MACROPHAGE MIGRATION INHIBITORY FACTOR ACTS AS A KEY 

REGULATOR OF LIPID METABOLISM DURING DENGUE VIRUS INFECTION GISELLE 

BARBOSA DE LIMA, LÍGIA DE ALMEIDA PAIVA, IRANAIA ASSUNÇÃO MIRANDA, 

MARCELO TORRES BOZZA, ANDREA THOMPSON DA POIAN, PATRÍCIA TORRES 

BOZZA 

R -63 USING PROTEOMIC ANALYSIS TO IDENTIFY CHEMOTHERAPEUTIC 

AGENTS IN MACROPHAGES INFECTED WITH LEISHMANIA CARLOS EDUARDO 

SAMPAIO GUEDES, BEATRIZ ROCHA SIMÕES DIAS, ANTONIO LUIS DE OLIVEIRA 

ALMEIDA PETERSEN, KERCIA PINHEIRO CRUZ, NIARA DE JESUS ALMEIDA, JULIANA 

PERRONE BEZERRA DE MENEZES, LUIZ ANTÔNIO RODRIGUES DE FREITAS, 

PATRICIA SAMPAIO TAVARES VERAS 

R -64 DENGUE AND YELLOW FEVER VIRUS-MEGAKARYOBLASTS 

INTERACTION: ROLE IN HEMOSTATIC ALTERATIONS SAMIR PEREIRA DA COSTA 

CAMPOS, MARIANA GARRIDO DE CASTRO, DANIEL SANCHES, CLAUDIA MONTEIRO 

DA ROCHA, MARIANA FIGUEIREDO RODRIGUES, JERSON LIMA DA SILVA, ANDRE 

MARCO DE OLIVEIRA GOMES, ANDRÉA CHEBLE DE OLIVEIRA 

R -65 COMPARISON IN SILICO OF ZIP TRANSPORTERS EXTRACELLULAR 

DOMAINS DISTRIBUTION OF LEISHMANIA SP AND MAMMAL HOSTS. JULIA 

ZERLOTINI DE LUCAS, RENATA ANDRADE AVILA, IARA FREITAS LOPES, LUCIANO 

RIVAROLI 

R -66 MICROBICIDAL RESPONSE IN MACROPHAGES INFECTED WITH L. 

(L.) AMAZONENSIS AFTER TREATMENT WITH AQUEOUS EXTRACT FROM ROOT 

OF PHYSALIS ANGULATA BRUNO JOSÉ MARTINS DA SILVA, RAQUEL RAICK 

PEREIRA DA SILVA, ANA PAULA DRUMMOND RODRIGUES, LUIS HENRIQUE SEABRA 

DE FARIAS, CAROLINE MARTINS ALMEIDA, PAULA CRISTINA RODRIGUES FRADE, 

GILMARA DE NAZARETH TAVARES BASTOS, EDILENE OLIVEIRA DA SILVA 

R -67 STUDY OF THE ROLE OF DIPEPTIDYL-PEPTIDASE 8-LIKE AND 

OTUBAIN GENES IN TRYPANOSOMA CRUZI INFECTION DEBORA TORRES ALVES 

FIGUEIREDO, FLAVIA NADDER MOTTA ARENAS, GRAZIELLA SANTANA FEITOSA 

FIGUEIREDO, JAIME MARTINS DE SANTANA, IZABELA MARQUES DOURADO 

BASTOS 

R -68 INFLAMMASOME ACTIVATION NEGATIVELY REGULATES LIPID 

BODY BIOGENESIS DURING MYCOBACTERIUM BOVIS BCG INFECTION CARLA 

FREITAS, DARIO ZAMBONI, VALÉRIE QUESNIAUX, BERNHARD RYFFEL, PATRICIA 

BOZZA 

R -69 THE ROLE OF SCAVENGER RECEPTOR MARCO IN INFECTION OF 

MURINE MACROPHAGES WITH LEISHMANIA MAJOR NIARA DE JESUS ALMEIDA, 

CARLOS EDUARDO SAMPAIO GUEDES, BEATRIZ ROCHA SIMÕES DIAS, PATRÍCIA 

SAMPAIO TAVARES VERAS 

R -70 HOST CELL SIGNALING PATHWAYS INVOLVED IN INVASION OF 

ENTEROINVASIVE ESCHERICHIA COLI (EIEC) AND SHIGELLA FLEXNERI PATRÍCIA 

FARIA PRADO, FLÁVIA ALVES MARTINS, LUCAS GONÇALVES FERREIRA, MARINA 

BAQUERIZO MARTINEZ, MARIA APARECIDA DE SOUZA, CLAUDIO VIEIRA DA SILVA 

R -71 EVALUATION OF TRANSLOCATOR PROTEIN EXPRESSION IN CBA 

MACROPHAGES INFECTED WITH LEISHMANIA BEATRIZ ROCHA SIMÕES DIAS, 

CARLOS EDUARDO SAMPAIO GUEDES, KERCIA PINHEIRO CRUZ, NIARA DE JESUS 

ALMEIDA, PATRICIA SAMPAIO TAVARES VERAS 

R -72 DETECTION AND IMMUNOLOCALIZATION OF THE ENZYME 

CONSTITUTIVE NITRIC OXIDE SYNTHASIS (CNOS) IN PROMASTIGOTES FORMS OF 

THE LEISHMANIA (VIANNIA) BRAZILIENSIS AND LEISHMANIA (LEISHMANIA) 

AMAZONENSIS RODRIGO RIBEIRO FURTADO, ANA PAULA DRUMMOND 

RODRIGUES, LUIS HENRIQUE SEABRA DE FARIAS, AMANDA ANASTÁCIA PINTO 

HAGE, CAROLINE MARTINS ALMEIDA, BRUNO JOSÉ MARTINS SILVA, EDILENE 

OLIVEIRA DA SILVA 

R -73 ULTRASTRUCTURAL DIFFERENCES IN THE ENGULFMENT PROCESS 

OF THREE LEISHMANIA SPECIES BY MACROPHAGE AND MICROGLIA JOSÉ 

ANTONIO PICANÇO DINIZ JUNIOR, PATRÍCIA KARLA SANTOS RAMOS, MAYSA DE 

VASCONCELOS BRITO 

R -74 COULD SEROTONIN LEVELS IN THE INTESTINE MANAGE THE 

CHAGASIC MEGACOLON DEVELOPMENT? FERNANDA CHAVES OLIVEIRA, ENIO 

CHAVES OLIVEIRA, SALUSTIANO GABRIEL NETO, ALEJANDRO OSTEMAIER 

LUQUETTI, AXEL BREHMER, ALEXANDRE BARCELOS MORAIS DA SILVEIRA, 

MICHELLE APARECIDA RIBEIRO DE FREITAS 

R -75 IN SILICO STRUCTURAL ANALYSIS OF EXTRACELLULAR DOMAIN OF 

TRYPANOSOMA BRUCEI TRANSFERRIN RECEPTOR RENATA ANDRADE AVILA, 

JULIA ZERLOTINI DE LUCAS, IARA FREITAS LOPES, LUCIANO RIVAROLI 

116

S – Methods in Cell 

Biology 

S1-S30 

S - 1 COMPARATIVE HISTOCHEMICAL ANALYSIS OF THE VENOM 

GLANDS OF THE BEE, AFRICANIZED APIS MELLIFERA AND THE WASP, POLISTES 

VERSICOLOR. ALINE FERNANDA CATAE, THAISA CRISTINA ROAT, MARIO SÉRGIO 

PALMA, ROBERTA CORNÉLIO FERREIRA NOCELLI, OSMAR MALASPINA 

S - 2 NUCLEAR MORPHOMETRIC ANALYSIS (NMA): A NEW METHOD 

FOR SCREENING OF APOPTOSIS, MITOSIS, SENESCENCE AND MITOTIC 

CATASTROPHE EDUARDO CREMONESE FILIPPI CHIELA, MANUEL MENEZES DE 

OLIVEIRA NETO, BRUNO JURKOVSKI, SÍDIA MARIA JACQUES-CALLEGARI, VINÍCIUS 

DUVAL DA SILVA, GUIDO LENZ 

S - 3 SECRETION SYNTHESIS BY VENOM RESERVOIR OF WASP 

TRYPOXYLON LACTITARSE SAUSSURE (HYMENOPTERA: CRABRONIDAE) JÔNATAS 

CHAGAS DE OLIVEIRA, RUSLEYD MARIA MAGALHÃES DE ABREU 

S - 4 STANDARDIZATION OF TOTAL DNA QUANTIFICATION AND 

DETERMINATION OF AT/CG BASE PAIRS COMPOSITION METHODOLOGIES FOR 

STINGLESS BEES, BY MEANS OF FLOW CYTOMETRY FERNANDA APARECIDA 

FERRARI SOARES, CARLOS ROBERTO CARVALHO, MARA GARCIA TAVARES 

S - 5 DIFFERENTIAL HSP 70 AND HYPOXIA-INDUCIBLE FACTOR 1A (HIF- 

1A) EXPRESSION IN LIVER OF PROCHILODUS ARGENTEUS CAUGHT IN DIFFERENT 

SITES OF SÃO FRANCISCO RIVER HEDER JOSÉ RIBEIRO, MARCELA SANTOS 

PROCÓPIO, FABIANA ALVES, DEBORAH RIBEIRO NASCIMENTO, ALMIR DE SOUSA 

MARTINS, JOSÉ DIAS CORRÊA JUNIOR 

S - 6 CDTE/CDS QUANTUM DOTS BIOCONJUGATED TO CONCANAVALIN 

A LECTIN TO STUDY CARBOHYDRATES EXPRESSION IN CANDIDA ALBICANS 

DENISE PATRÍCIA LINS AZEVEDO TENÓRIO, CAMILA GALVÃO DE ANDRADE, PAULO 

EUZÉBIO CABRAL FILHO, CAMILA CAMPOS SANTOS, ILKA TIEMY KATO, MARTHA 

SIMÕES RIBEIRO, SEVERINO ALVES JUNIOR, EDUARDO ISIDORO CARNEIRO 

BELTRÃO, LUIZ BEZERRA DE CARVALHO JUNIOR, ADRIANA FONTES, BEATE 

SAEGESSER SANTOS 

S - 7 IDENTIFICATION OF PARAPOXVIRUS ISOLATED FROM AN 

OUTBREAK IN GOATS IN CEARÁ STATE, BRAZIL, BY TRANSMISSION ELECTRON 

MICROSCOPY TECHNIQUES. MARCIA HELENA BRAGA CATROXO, ANA MARIA 

CRISTINA RABELO PINTO DA FONSECA MARTINS, SELMA PETRELLA, FABÍOLA DE 

SOUZA, BEATRIZ DI BOARETO NASTARI, RODRIGO BARBOSA DE SOUZA 

S - 8 MEMBRANE NANOTUBES: MECHANISMS OF FORMATION AND 

FUNCTIONS IN CELLS BRUNO PONTES, NATHAN BESSA VIANA, YARENI AYALA, 

ANNA CAROLINA CARVALHO DA FONSECA, LUCIANA FERREIRA ROMÃO, RACKELE 

FERREIRA AMARAL, LEONARDO TAVARES SALGADO, FLÁVIA REGINA DE SOUZA 

LIMA, LORAINE CAMPANATI, MARCOS FARINA, VIVALDO MOURA NETO, H. 

MOYSES NUSSENZVEIG 

S - 9 MORPHOLOGICAL AND ULTRASTRUCTURAL STUDY OF SALIVARY 

GLAND OF TRIATOMA INFESTANS (HEMIPTERA, TRIATOMINAE) NADJA BIONDINE 

MARRIEL, PAULO FILEMON PAOLUCCI PIMENTA, ANA CAROLINA BORELLA ANHÊ 

S - 10 EVALUATION OF THE TOXICITY OF THALIDOMIDE INCORPORATED 

IN BIODEGRADABLE IMPLANTS PEDRO ALCANTARA FONSECA DE SOUZA, SÍLVIA 

LIGÓRIO FIALHO, ARMANDO SILVA-CUNHA, LUCIANA MARIA SILVA 

S - 11 IDENTIFICATION AND EVALUATION OF BIOLOGICAL 

CONSERVATION OF DIFFERENT TOXINS FROM BROWN SPIDER VENOM 

(LOXOSCELES GENUS) IN THREE SPECIES OF GREATER IMPACT ON PARANÁ: L. 

INTERMEDIA, L. LAETA AND L. GAUCHO FERNANDA NUNES SOUZA, DANIELA 

REGINA BUCH, GABRIEL OTTO MEISSNER, DILZA TREVISAN SILVA, MÁRCIA HELENA 

APPEL, RAFAEL BERTONI DA SILVEIRA, DANIELE CHAVES MOREIRA, LUIZA HELENA 

GREMSKI, ANDREA SENFF-RIBEIRO, OLGA MEIRI CHAIM, SILVIO SANCHES VEIGA 

S - 12 CONSTRUCTION OF A CDNA LIBRARY FOR ANTIMICROBIAL 

PEPTIDES FROM HYPSIBOAS SEMILINEATUS LORENA NACIF MARÇAL, MONISE 

VIANA ABRANCHES, GRACIELLE RODRIGUES PEREIRA, NATÁLIA CRISTINA SANTOS 

COSTA, HELIOMAR CAZELLI DE OLIVEIRA FILHO, RENATO NEVES FEIO, EDUARDO 

RESENDE HONDA, SÉRGIO OLIVEIRA DE PAULA, LEANDRO LICURSI DE OLIVEIRA 

S - 13 DEVELOPMENT OF A BIOENGINEERED HUMAN-SKIN CHICK 

EMBRYO MODEL FOR TESTING DRUGS FOR SKIN INFLAMMATORY DISORDERS 

KAREN JACKSON, ROTEM BEN SHUSHAN, HILA YEHUDA, LEONID KOGAN, SNAIT 

TAMIR 

S - 14 ATOMIC FORCE MICROSCOPY AS A TOOL TO STUDY THE 

MITOCHONDRIAL DNA OF TRYPANOSOMATIDS MARCELO ZOGOVICH, DANIELA 

LEÃO GONÇALVES, LILIAN TEREZINHA COSTA, WANDERLEY DE SOUZA, DANIELLE 

PEREIRA CAVALCANTI 

S - 15 UNRAVELING OPTIMIZED CONDITIONS FOR CARTILAGE TISSUE 

ENGINEERING USING THREE-DIMENSIONAL HIGH-DENSITY HUMAN STEM CELL 

CULTURES. LEANDRA SANTOS BAPTISTA, KARINA RIBEIRO SILVA, CAROLINA DA 

SILVA GOUVEIA PEDROSA, RONALDO JOSÉ FARIA CORREIA DO AMARAL, JOÃO 

VITOR BELIZÁRIO DOS SANTOS, RADOVAN BOROJEVIC, JOSÉ MAURO GRANJEIRO 

S - 16 OPTICAL TWEEZERS TO EVALUATE THE LEISHMANIA 

AMAZONENSIS AND TRYPANOSOMA CRUZI MOTILITY BEFORE AND AFTER 

TREATMENT WITH LIPPIA SIDOIDES ESSENTIAL OIL ALINE DULCE PITT DA ROCHA 

OLIVEIRA, DIEGO CÉSAR NUNES DA SILVA, ANA CAROLINA SANTOS ROSA NUNES, 

ALINE CAROLINE DA SILVA, AMANDA SILVA DOS SANTOS ALIANÇA, DIVAR 

FERNANDES PIRES NETO, ANDREZA RAPOSO BORGES, BEATE SAEGESSER DOS 

SANTOS, REGINA CÉLIA BRESSAN QUEIROZ DE FIGUEIREDO, ADRIANA FONTES 

S - 17 HISTOLOGICAL EVALUATION OF BIOMATERIAL CHITOSAN- 

GELATIN-BASED EFFECTS IN INTRAORAL BONE REPAIR IN RATS IGOR DANIEL 

GARCIA REIS, MATHEUS HENRIQUE SANTOS ASSIS, LUIZ BERTOLDO DA COSTA 

FILHO, FERNANDO ANTÔNIO MAUAD ABREU, PETERSON DE OLIVEIRA DUTRA, 

ALFREDO MIRANDA GÓES, GERLUZA APARECIDA BORGES SILVA 

S - 18 PREDICTION OF AUTOPHAGY IN VITRO BY A COLORIMETRIC 

APPROACH WALESKA KERLLEN MARTINS GARDESANI, DIVINOMAR SEVERINO, 

CLEIDIANE SOUZA, BEATRIZ SIMONSEN STOLF, MAURÍCIO SILVA BAPTISTA 

S - 19 FLUORESCENCE PLATE READER TO EVALUATE CDTE/CDS-MPA AND 

CDTE/CDS-MSA BIOCONJUGATION TO ANTI-A ANTIBODIES – APPLICATIONS IN 

IMMUNOHEMATOLOGY PAULO EUZEBIO CABRAL FILHO, KILMARA HIGIA GOMES 

CARVALHO, ALUIZIO GONÇALVES BRASIL JUNIOR, ELISA SOARES LEITE, BEATE 

SAEGESSER SANTOS, ADRIANA FONTES 

S - 20 EVALUATION OF DIFFERENT METHODOLOGIES TO ACHIEVE 

EFFICIENT EXPRESSION OF THE DENGUE VIRUS NS1 PROTEIN IN HEPG2 CELLS 

KÍSSILA RABELO, EDSON ROBERTO ALVES DE OLIVEIRA, ADA MARIA DE BARCELOS 

ALVES, SIMONE MORAIS DA COSTA 

S - 21 MEASUREMENT OF PROTEIN DISULFIDE ISOMERASE REDUCTASE 

ACTIVITY IN BIOLOGICAL SAMPLES BY INSULIN ASSAY DENISE DE CASTRO 

FERNANDES, MONICA MASSAKO WATANABE, FRANCISCO RAFAEL MARTINS 

LAURINDO 

S - 22 OBTENTION OF 3D SPHEROIDAL CULTURE FROM MC3T3-E1 

MURINE PRE-OSTEOBLASTIC CELLS FOR BIOCOMPATIBILITY STUDIES EMANUELLE 

STELLET LOURENÇO, ROBER FREITAS BACHINSKI, ADRIANA BRANDÃO RIBEIRO 

LINHARES, JOSÉ MAURO GRANJEIRO, GUTEMBERG GOMES ALVES 

S - 23 PREDICTION OF ACUTE TOXICITY OF A MEDICINAL PLANT 

CASEARIA SYLVESTRIS FLUID EXTRACT BY IN VITRO MODEL ALINE ZANCHETI 

AMENI, ANDREA CECILIA DORION RODAS, SILVANA LIMA GÓRNIAK 

S - 24 CRYO-SCANNING ELECTRON MICROSCOPY FOR THE ADVANCED 

STUDY OF CRYO-FIXED AND HYDRATED SAMPLES. RENATA TRAVASSOS, 

EDUARDO JOSÉ LOPES TORRES, KILDARE MIRANDA, MÁRCIA ATTIAS 

S - 25 BACTERIAL CELL CULTURE IMPROVEMENT AIMING THE 

PRODUCTION OF CISTINE KNOT FAMILY PEPTIDE FROM BROWN SPIDER 

(LOXOSCELES INTERMEDIA) VENOM GABRIEL OTTO MEISSNER, FENADO H. 

MATSUBARA, ALINE VIANA BEDNASKI, EDUARDO MENDONÇA, LUCAS PEDROSA, 

LUIZA HELENA GREMSKI, SILVIO SANCHES VEIGA, OLGA MEIRI CHAIM 

S - 26 IMMUNE CELL CULTURE IN TROPICAL SEA URCHIN LYTECHINUS 

VARIEGATUS PAOLA CRISTINA BRANCO, DOUGLAS AMARAL DOS SANTOS, 

DÉBORA ALVARES LEITE FIGUEIREDO, JOSÉ ROBERTO MACHADO CUNHA DA SILVA 

S - 27 STANDARDIZATION OF COMET ASSAY WITH DAPHNIA MAGNA 

STRAUS (1820) FERNANDA FLEIG ZENKNER, CAMILA GONÇALVES ATHANÁSIO, 

JOEL HENRIQUE ELLWANGER, DANIEL PRÁ, EDUARDO ALEXIS LOBO, ALEXANDRE 

RIEGER 

S - 28 EVALUATION OF THE IN VIVO CROSS LINKING METHOD FOR 

LEISHMANIA BRAZILIENSIS TO OBTAIN COMPLEXES WITH OTUBAIN, A 

DEUBIQUITYLATING ENZYME CLENIA DOS SANTOS AZEVEDO, JULIANA ARAUJO 

CARNEIRO, JHONATA LIMA PEREIRA, FLAVIA NADER MOTTA ARENAS, JAIME 

MARTINS DE SANTANA, IZABELA MARQUES DOURADO BASTOS 

S - 29 CORRELATIVE MICROSCOPY WITH ‘SHUTTLE & FIND’ – COMBINING 

THE POWER OF IMAGING DEVICES. JENS MARKUS RIETDORF 

S - 30 ULTRASTRUCTURAL ANALYSIS OF THE MYCELIUM OF 

DEMATIACEOUS MOLD CURVULARIA SP UNDER THE ACTION OF THE 

ANTIFUNGAL AGENT AMPHOTERICIN B ADRIANO BIANCALANA, FERNANDA 

SIMAS CORRÊA BIANCALANA, LUZIA LYRA, ANGÉLICA ZANINELLI SCREIBER 

T – Neurobiology 

T1-T85 

T - 1 EFFECTS OF VENOUS ANESTHETIC ETOMIDATE ON SYNAPTIC 

VESICLE EXOCYTOSIS AT THE MICE NEUROMUSCULAR JUNCTION PRISCILA 

APARECIDA COSTA VALADÃO, CRISTINA GUATIMOSIM FONSECA, JANICE 

HENRIQUES DA SILVA, RENATO SANTIAGO GOMEZ 

117

T - 2 OPTICAL AND ULTRASTRUCTURAL ANALYSIS OF NEUROMUSCULAR 

JUNCTIONS FROM DIAPHRAGMS OF MICE WITH CHOLINERGIC DYSFUNCTION 

HERMANN ALECSANDRO RODRIGUES, MATHEUS DE CASTRO FONSECA, PATRÍCIA 

MASSARA MARTINELLI, PATRÍCIA MARIA D'ALMEIDA LIMA, VÂNIA FERREIRA 

PRADO, MARCO ANTÔNIO MÁXIMO PRADO, CRISTINA GUATIMOSIM FONSECA 

T - 3 EFFECTS OF INHALATORY ANESTHETIC SEVOFLURANE ON 

SYNAPTIC VESICLE EXOCYTOSIS AT THE MOUSE NEUROMUSCULAR JUNCTION 

MATHEUS DE CASTRO FONSECA, JANICE HENRIQUES DA SILVA, RENATO SANTIAGO 

GOMEZ, CRISTINA GUATIMOSIM 

T - 4 EFFECT OF UVA AND UVB ON THE EXPRESSION OF SEROTONIN IN 

THE CENTRAL OLFACTORY SYSTEM OF THE CRAB UCIDES CORDATUS. GABRIELLE 

DE JESUS FERREIRA, GABRIELA HOLLMANN, ÁLVARO LEITÃO, SILVANA ALLODI 

T - 5 INCREASE IN PROPORTION OF SUBSTANCE P NERVE FIBERS IN 

INDIVIDUALS WITH CHAGASIC MEGAESOPHAGUS RODOLFO DUARTE 

NASCIMENTO, PATRÍCIA ROCHA MARTINS, JACQUELINE GARCIA DUARTE, DÉBORA 

D’ÀVILA REIS 

T - 6 RELATION BETWEEN THE AREA OF GFAP ENTERIC GLIAL CELLS AND 

THE NUMBER OF NEURONS IN ESOPHAGUS OF CHAGASIC INDIVIDUALS 

RODOLFO DUARTE NASCIMENTO, PATRÍCIA ROCHA MARTINS, JACQUELINE 

GARCIA DUARTE, DÉBORA D’ÀVILA REIS 

T - 7 LOSS OF INTERSTITIIAL CELLS OF CAJAL MIGHT PRECEED 

DENERVATION PROCESS IN CHRONIC TRYPANOSOMA CRUZI INFECTION PATRÍCIA 

ROCHA MARTINS, RODOLFO DUARTE NASCIMENTO, JACQUELINE GARCIA DUARTE, 

SHEILA ADAD, DÉBORA D’ÀVILA REIS 

T - 8 DENDRITIC SPINES IN THE MEPD OF RATS: MORPHOLOGY AND 

CONNECTIVITY DALPIAN, F., BRUSCO, J., MOREIRA J.E., RASIA-FILHO, A. 

T - 9 ATP CONTROLS PROLIFERATION IN VIVO OF RAT RETINAL 

PROGENITORS LUANA DE ALMEIDA PEREIRA, ALFRED FRANCO SHOLL, ANA LUCIA 

MARQUES VENTURA, LUCIANNE FRAGEL MADEIRA 

T - 10 MOLECULAR TOOLS TO ANALISYS OF HUNTINGTON’S DISEASE 

HAPLOTYPES (CAG/CCG TRINUCLEOTIDE REPEATS) ON HTT GENE IN BRAZILIAN 

PATIENTS LUCIANA DE ANDRADE AGOSTINHO, CATIELLY FERREIRA ROCHA, 

ENRIQUE MEDINA-ACOSTA, HAZEL NUNES BARBOZA, ANTONIO FRANCISCO ALVES 

DA SILVA, SIMÃO PEDRO FERNANDES PEREIRA, EDUARDO RIBEIRO PARADELA, 

ANDRÉ LUIS DOS SANTOS FIGUEIREDO, EDUARDO DE MATOS NOGUEIRA, REGINA 

MARIA PAPAIS ALVARENGA, SUELY RODRIGUES DOS SANTOS, CARMEN LUCIA 

ANTÃO PAIVA 

T - 11 VIRAL ENCEPHALITIS INDUCED BY DENGUE VIRUS IN ALBINO 

SWISS MICE: THE INFLAMMATORY RESPONSE IN NEONATE’S NERVOUS SYSTEM 

GIOVANNI FREITAS GOMES, MAIRA CATHERINE PEREIRA TURIEL, CÉSAR AUGUSTO 

RAIOL FORO, BRUNNO GOMES PINHO, CARLA MAISA DAMASCENO REGO, MARINA 

CUTRIM MAGALHAES, PEDRO FERNANDO DA COSTA VASCONCELOS, CRISTOVAM 

WANDERLEY PICANÇO DINIZ 

T - 12 PARKINSON`S DISEASE AND CEREBELLUM: NEW WAY OF 

ANALYZING THE BRAIN LESIONS BY A PARAQUAT-INDUCED CLASSICAL 

EXPERIMENTAL MODEL JOEL HENRIQUE ELLWANGER, FERNANDA FLEIG ZENKNER, 

JULIANO ASSMANN, DANIEL PRÁ, MICHELE GASSEN KELLERMANN, ALEXANDRE 

RIEGER, JOÃO ANTONIO PÊGAS HENRIQUES, DEIVIS DE CAMPOS 

T - 13 EXPRESSION OF ALPHA SYNUCLEIN AND HIPERPHOSPHORYLATION 

OF TAU IN THE BRAIN OF AGED RATS EXPOSED TO LOW CONCENTRATIONS OF 

ROTENONE CAROLLINY MOURA DA SILVA, MICHAEL FERNANDES DE ALMEIDA, 

MERARI DE FÁTIMA RAMIRES FERRARI 

T - 14 EFFECT OF PROPOFOL ON ACETYLCHOLINE RELEASE IN RAT 

HIPPOCAMPUS SYNAPTOSOMES FLÁVIA LAGE PESSOA DA COSTA, NANCY 

SCARDUA BINDA, LUANNA DA SILVA MONTEIRO, RENATO SANTIAGO GOMEZ, 

MARCUS VINÍCIUS GOMEZ 

T - 15 SYNAPTIC CHANGES IN THE CORTEX OF INDIVIDUALS WITH 

MESIAL TEMPORAL LOBE EPILEPSY ALONG AGING: LIPOFUSCIN GRANULES AS 

MARKERS OF AGE SUÉLEN MERLO, ANA BEATRIZ NAKAYAMA, JANAINA BRUSCO, 

MARCOS ANTÔNIO ROSSI, CARLOS GILBERTO CARLOTTI JÚNIOR, JORGE EDUARDO 

MOREIRA 

T - 16 NEUROGENESIS AND SYNAPTIC PLASTICITY IN RATS SUBMITTED 

TO MATERNAL SEPARATION AND ENRICHED ENVIRONMENT SUÉLEN MERLO, 

JOSÉ INÁCIO LEMOS, LENALDO BRANCO ROCHA, MARCOS ANTÔNIO ROSSI, JORGE 

EDUARDO MOREIRA 

T - 17 CONSTANT EXPRESSION OF ALFA-SINUCLEIN AND UBIQUITIN 

ALONG AGING IN THE CORTEX OF INDIVIDUALS WITH MESIAL TEMPORAL LOBE 

EPILEPSY ANA BEATRIZ SOUZA NAKAYAMA, SUÉLEN MERLO, JANAÍNA BRUSCO, 

MARCOS ANTÔNIO ROSSI, CARLOS GILBERTO CARLOTTI JR, JORGE EDUARDO 

MOREIRA 

T - 18 MORPHOMETRIC ANALYSIS OF SOLEUS AND TRICEPS BRACHII 

SKELETAL MUSCLES OF MICE WITH CHOLINERGIC DYSFUNCTION MATHEUS 

PROENÇA SIMÃO MAGALHÃES GOMES, HERMANN ALECSANDRO RODRIGUES, 

PATRÍCIA MASSARA MARTINELLI, VANIA FERREIRA PRADO, MARCO ANTÔNIO 

MÁXIMO PRADO, CRISTINA GUATIMOSIM FONSECA 

T - 19 EFFECT OF CONDITIONED MEDIUM FROM CULTURES OF 

OLFACTORY ENSHEATHING GLIA ON HIPPOCAMPAL NEURAL CELLS IN VITRO. 

LITIA ALVES DE CARVALHO, ROBERTA PEREIRA DE MELO GUIMARÃES, RICARDO 

AUGUSTO DE MELO REIS, LENY ALVES CAVALCANTE 

T - 20 FOOD RESTRICTION DOES NOT INTERFERE IN AGE-RELATED LOSS 

OF GLIA AND CHOLINERGIC MYENTERIC NEURONS JOÃO PAULO FERREIRA 

SCHOFFEN, JONATAS DE PAULA OLIVEIRA, ANA PAULA DE SANTI RAMPAZZO, 

CARLA POSSANI CIRILO, MARIANA CRISTINA VICENTE UMADA ZAPATER, 

FERNANDO AUGUSTO VICENTINI, ANACHARIS BABETO DE SÁ-NAKANISHI, 

JURANDIR FERNANDO COMAR, MARIA RAQUEL MARÇAL NATALI 

T - 21 IMPOVERISHED ENVIRONMENT AND REDUCED MASTICATORY 

ACTIVITY AGGRAVATE AGING SPATIAL MEMORY DECLINE IN ALBINO SWISS MICE 

ALBERT LUIZ COSTA DA COSTA, FABÍOLA DE CARVALHO CHAVES DE SIQUEIRA 

MENDES, MARINA NEGRÃO FROTA DE ALMEIDA, ANDRÉ PINHEIRO GURGEL 

FELÍCIO, MANOELA FALSONI, MARCIA LORENA FERREIRA DE ANDRADE;, JOÃO 

BENTO TORRES NETO;, CRISTOVAM WANDERLEY PICANÇO-DINIZ;, MARCIA 

CONSENTINO KRONKA SOSTHENES. 

T - 22 WALLERIAN DEGENERATION IN GALECTIN-3 KNOCKOUT MICE 

BRUNO DE SIQUEIRA MIETTO, SOFIA JURGENSEN HARTKE, LUCINÉIA ALVES, 

MARCELO SAMPAIO NARCISO, IRANAIA ASSUNÇÃO MIRANDA, DEA MARIA SERRA 

VILLA-VERDE, FLÁVIA REGINA SOUZA LIMA, MARCELO TORRES BOZZA, ANA MARIA 

BLANCO MARTINEZ 

T - 23 ACTIVATION OF AKT1 PROTEIN BY ALLOSTERIC MODULATORS OF 

GLUTAMATE METABOTROPIC RECEPTOR 5 IN PRIMARY CULTURE OF STRIATAL 

NEURONS FLAVIA RODRIGUES SILVA, FABIOLA MARA RIBEIRO, JULIANA 

GUIMARÃES DÓRIA, JÉSSICA MABELLE DE SOUZA, HELTON JOSÉ DOS REIS, TOMAS 

DOBRANSKY 

T - 24 HYPOTHALAMIC AND CORTICAL ASTROCYTES RESPOND 

DIFFERENTLY TO THE ADDITION OF FATTY ACID IN VITRO ÉRICA VIEIRA DOS 

SANTOS, PEDRO AUGUSTO SILVA NOGUEIRA, RENATA GRACIELE ZANON 

T - 25 OPTICAL ANALYSIS OF NEUROMUSCULAR JUNCTIONS OF 

DIAPHRAGM MUSCLE FROM A TRANSGENIC MICE MODEL FOR HUNTINGTON’S 

DISEASE BÁRBARA CAMPOS DE ARAGÃO, HERMANN ALECSANDRO RODRIGUES, 

FABÍOLA MARA RIBEIRO, CRISTINA GUATIMOSIM FONSECA 

T - 26 MASTICATORY REHABILITATION IMPROVES MICE EPISODIC-LIKE 

MEMORY ANA CARLA FADEL, ANDRÉ PINHEIRO GURGEL FELÍCIO, FABÍOLA DE 

CARVALHO CHAVES DE SIQUEIRA MENDES, RAÍSSA AIRES RIBEIRO BRINGEL, 

RODRIGO PEREZ DA SILVA, KÁTIA DE AVIZ FONSECA, JOSÉ FERNANDO CARNEIRO 

JUNIOR, ANTÔNIO LUIZ BREIA DA SILVA JUNIOR, CRISTOVAM WANDERLEY 

PICANÇO DINIZ, MARCIA CONSENTINO KRONKA SOSTHENES 

T - 27 ASPECTS OF DEGENERATION AND REGENERATION OF THE STYELA 

PLICATA NEURAL COMPLEX INDUCED BY 3-ACETYLPYRIDINE BIANCA NICOLE 

SANTOS PAEZ MEDINA, ISADORA SANTOS DE ABREU, SILVANA ALLODI, RODRIGO 

NUNES DA FONSECA, CÍNTIA MONTEIRO DE BARROS 

T - 28 ASSESSMENT CELLULAR AFTER SPINAL CORD INJURY IN RAT: 

CORRELATION WITH FUNCTIONAL RECOVERY ANDRÉA MARINS DAMASCENO 

BOMFIM, JASON ROBBERT POTAS, NEWTON GONÇALVES DE CASTRO, ROSÁLIA 

MENDEZ-OTERO 

T - 29 DECREASE OF AUTOPHAGY AFTER ROTENONE EXPOSURE IN 

CULTURED CELLS. LUANA DE SANTANA BOTTAS, MERARI DE FÁTIMA RAMIRES 

FERRARI 

T - 30 EFFECT OF CHRONIC ADMINISTRATION OF CAFFEINE ON MAP2 

AND SYNAPTOPHYSIN IN HIPPOCAMPUS OF MALE AND FEMALE RATS LETICIA 

FERREIRA PETTENUZZO, CARINA DE SOUZA MOTA, CARLA DALMAZ 

T - 31 SICKNESS BEHAVIOR AND MICROGLIAL CHANGES IN THE DENTATE 

GYRUS OF ADULT MICE (MUS MUSCULUS) AFTER INJECTION OF 

LIPOPOLYSACCHARIDE (LPS) OF SALMONELLA ENTERIC THAIS BARROSO NAVES, 

ANA CARLA FADEL, DANIEL GUERREIRO DINIZ, GIOVANNI FREITAS GOMES, 

GRAZIELLA DE ASSIS MALERBA, ANA MARIA MATOS DE OLIVEIRA ROSSY, BRUNA 

DO SOCORRO AMORIM DE LIMA, CARMEN DOS SANTOS FERNANDES, EDIANE 

BARROS DA SILVA, EDUARDO AUGUSTO CRUZ DA SILVA, LUCIANO DE SENA 

ARAUJO, MARIA DAS GRAÇAS REIS, ROSIGLEIDE GOMES DOS SANTOS, SUZANE 

SANTOS CORREA, ZAIRA MONIK NUNES BARROS, CRISTOVAM WANDERLEY 

PICANÇO DINIZ, CRISTOVAM WANDERLEY PICANÇO DINIZ 

T - 32 INVESTIGATION OF THE METABOTROPIC RECEPTOR 5 ROLE IN 

HYPERKINESIS USING A MICE MODEL OF HUNTINGTON’S DISEASE ISABELLA 

MONTEIRO GUIMARÃES, FABIOLA MARA RIBEIRO, RITA G. W. PIRES, TOMAS 

DOBRANSKY 

T - 33 PRION PROTEIN MUTATIONS ASSOCIATED WITH PRION DISEASES 

IMPAIR DIFFERENTIATION INDUCED BY LAMININ CLEITON FAGUNDES MACHADO, 

FLAVIO H. BERALDO, TIAGO G. SANTOS, DOMINIQUE BOURGEON, MICHELE C. 

LANDEMBERGER, VILMA R. MARTINS 

T - 34 FLAVONOIDS PROMOTES NEURONAL SURVIVAL AND 

SYNAPTOGENESIS IN CEREBRAL CORTEX IN VITRO ISADORA CRISTINA PEREIRA 

MATIAS, JOICE STIPURSKY, FLÁVIA CARVALHO ALCÂNTARA GOMES 

118

T - 35 STUDY OF PROTEIN CARBONYLS IN AGED RATS EXPOSED TO LOW 

DOSE OF ROTENONE MICHAEL FERNANDES DE ALMEIDA, CAROLLINY MOURA DA 

SILVA, MERARI DE FÁTIMA RAMIRES FERRARI 

T - 36 SECRETION OF STRESS INSDUCIBLE PROTEIN 1 IN MICROVESICLES 

BY ASTROCYTES GLAUCIA HAJJ, CAMILA ARANTES, MARCOS S. DIAS, ISABEL 

PORTO-CARREIRO, MARTÍN ROFFÉ, MARCO M. A. PRADO, RAFAEL LINDEN, VILMA 

R. MARTINS 

T - 37 IGF-I-INDUCED MODULATION OF THE (NA/K)-ATPASE ACTIVITY 

DURING THE POSTNATAL DEVELOPMENT OF RAT RETINA SHEILA MATURANA 

TEIXEIRA, ELIZABETH GIESTAL DE ARAUJO, LUIZ ROBERTO LEÃO FERREIRA 

T - 38 MORPHOLOGICAL CHARACTERIZATION OF CARDIAC TISSUE FROM 

A MOUSE MODEL OF CHOLINERGIC DYSFUNCTION MARINA VIVEIROS TRAJANO 

CRUZ, HERMANN ALECSANDRO RODRIGUES, PATRÍCIA MASSARA MARTINELLI, 

MARCO ANTÔNIO PRADO, VÂNIA FERREIRA PRADO, SILVIA GUATIMOSIM, 

CRISTINA GUATIMOSIM 

T - 39 LAMININ-Γ1 CHAIN AND STRESS INDUCIBLE PROTEIN 1 

SYNERGISTICALLY MEDIATE PRPC-DEPENDENT AXONAL GROWTH VIA CA2+ 

MOBILIZATION IN DORSAL ROOT GANGLIA NEURONS TIAGO GOSS DOS SANTOS, 

FLAVIO H BERALDO, GLAUCIA NM HAJJ, MARILENE H LOPES, FERNANDA CS 

LUPINACCI, MARCO AM PRADO, VILMA R MARTINS 

T - 40 SHIITAKE MUSHROOM (LENTINULA EDODES) DOES NOT CAUSE 

COGNITIVE IMPAIRMENTS, BUT INDUCES DNA DAMAGE IN HIPPOCAMPAL CELLS 

IN RATS PATRÍCIA MOLZ, JOEL HENRIQUE ELLWANGER, FERNANDA FLEIG 

ZENKNER, MORGANA TONET MENDONÇA, DEIVIS DE CAMPOS, MARISA 

TEREZINHA LOPES PUTZKE, DANIEL PRÁ, SILVIA ISABEL RECH FRANKE 

T - 41 THE BRIGHT SIDE OF PRION PROTEIN IN ALZHEIMER’ DISEASE: THE 

ROLE OF STRESS INDUCIBLE PROTEIN 1 AS A NEUROPROTECTIVE FACTOR. 

BIANCA LUISE TEIXEIRA, PEDRO HIRATA, ANA PAULA SAMPAIO, JORDANO BRITO- 

MOREIRA, SERGIO FERREIRA, MARCO PRADO, GLAUCIA HAJJ, VILMA R. MARTINS 

T - 42 HIPPOCAMPAL CELL CULTURE EXPOSED TO LOW DOSES OF 

ROTENONE EXHIBITED PROTEASOMAL ACTIVITY INHIBITION AND TAU 

HYPERPHOSPHORYLATION IN ABSENCE OF PROTEIN CARBONYLATION. RODRIGO 

DOS SANTOS CHAVES, MARILENE DEMASI, MERARI DE FATIMA RAMIRES FERRARI 

T - 43 HIGH-FAT DIET CAUSES ENTERIC NEURONAL LOSS IN THE DISTAL 

COLON OF MICE. EVANDRO JOSÉ BERALDI, LIA MARA TEOBALDO TIRONI, 

ANGÉLICA SOARES, ROBERTO BARBOSA BAZOTTE, NILZA CRISTINA BUTTOW 

T - 44 INCREASED HIPPOCAMPAL GFAP IN YOUNG RATS FROM ANIMAL 

MODEL OF AUTISM INDUCED BY PRENATAL EXPOSURE TO VALPROIC ACID 

ROBERTA BRISTOT SILVESTRIN, GIOVANA BROLESE, CRISTIANE BATASSINI, MÁRCIO 

FERREIRA DUTRA, NÚBIA BROETTO CUNHA, CARLOS ALBERTO GONÇALVES, 

CARMEM GOTTFRIED 

T - 45 IL-4 REGULATES THE LEVELS OF M3 MUSCARININC RECEPTORS IN 

RETINAL CELLS: THE ROLE OF IL-4 TYPE I RECEPTORS MARCELO GOMES GRANJA, 

LUIS EDUARDO GOMES BRAGA, ALINE ARAUJOS DOS SANTOS RABELO, ELIZABETH 

GIESTAL DE ARAUJO 

T - 46 PROLONGED MATERNAL SEPARATION AFFECTS HIPPOCAMPAL 

MORPHOLOGY AND NEUROTRANSMISSION ACCOMPANIED BY CHANGES IN 

NUTRITION-RELATED HORMONAL LEVELS PRISCILA BRISENO FROTA, DAVI DA 

CUNHA GONÇALVES, ANITA MAYARA FEITOSA SANTOS, CAMILA DE 

ALBUQUERQUE ALMEIDA, CELINA VIANA DE ARAÚJO, EMMANUEL GONÇALVES DE 

CASTRO ANDRADE, GEANNE M. DE ANDRADE, NUNO DE SOUSA, REINALDO 

BARRETO ORIÁ 

T - 47 THE PROTEIN CINASE C MODULATES THE CHOLINERGIC 

PHENOTYPE: POSSIBLE INVOLVEMENT OF INTERLEUKINS LUIS EDUARDO GOMES 

BRAGA, MARCELO GOMES GRANJA, ELIZABETH GIESTAL DE ARAUJO, ALINE 

ARAUJO DOS SANTOS 

T - 48 ENVIRONMENTAL ENRICHMENT REDUCES ANXIETY-LIKE 

BEHAVIOR ASSOCIATED WITH MASTICATORY DEPRIVATION IN ALBINO SWISS 

MICE RAISSA AIRES RIBEIRO BRINGEL, ANDRÉ PINHEIRO GURGEL FELÍCIO, FABÍOLA 

DE CARVALHO CHAVES DE SIQUEIRA MENDES, ALBERT LUIZ COSTA DA COSTA, 

ANA CARLA FADEL, RODRIGO PEREZ DA SILVA, DIEGO DE JESUS SILVA, MARCIA 

NUZANE AMORIM DE SOUZA, YANA MONTEZUMA SANTOS, CRISTOVAM 

WANDERLEY PICANÇO DINIZ, MARCIA CONSETINO KRONKA SOSTHENES 

T - 49 EVALUATION OF SOLVENTS AND CONTROLS FOR IN VITRO HUMAN 

CELL-BASED NEUROTOXICOLOGICAL STUDIES LETÍCIA APARECIDA BARBOSA 

HUMMEL, RÓBER BACHINSKI, ADRIANA BRANDÃO RIBEIRO LINHARES, JOSÉ 

MAURO GRANJEIRO, GUTEMBERG GOMES ALVES 

T - 50 INTERLEUKIN-2 (IL-2) AND RETINAL GANGLION CELL SURVIVAL: 

SIGNALING PATHWAYS INVOLVED LUCIENNE DE OLIVEIRA JESUS SOUZA, REGINA 

CÉLIA CUSSA KUBRUSLY, ELIZABETH GIESTAL DE ARAUJO 

T - 51 THE MECHANISMS OF STI1 (STRESS INDUCIBLE PROTEIN 1 ) 

SECRETION BY ASTROCYTES. MARCOS VINICIOS SALLES DIAS, GLAUCIA N. M. HAJJ, 

VILMA R. MARTINS 

T - 52 TURNOVER OF BETA-AMYLOID PRECURSOR PROTEIN IS 

REGULATED BY TWO MECHANISMS AT THE PLASMA MEMBRANE: THE 

UBIQUITIN-PROTEASOME PATHWAY AND INCORPORATION INTO 

MULTIVESICULAR BODIES HIANARA BUSTAMANTE, ANDRES RIVERA-DICTTER, 

VIVIANA CAVIERES, ALEXIS GONZALEZ, VANESSA MUÑOZ, JUAN S. BONIFACINO, 

GONZALO A. MARDONES, PATRICIA V. BURGOS 

T - 53 BLOOD-BRAIN BARRIER BREAKDOWN AND REPAIR FOLLOWING 

GLIOTOXIC DRUG INJECTION IN THE BRAINSTEM OF STREPTOZOTOCIN-DIABETIC 

RATS MARIA DE FÁTIMA MONTEIRO MARTINS, EDUARDO FERNANDES BONDAN 

T - 54 DIABETES DECREASES ASTROCYTIC GFAP EXPRESSION AFTER 

GLIOTOXIC LESION IN THE RAT BRAINSTEM EDUARDO FERNANDES BONDAN, 

MARIA DE FÁTIMA MONTEIRO MARTINS, FLÁVIO CESAR VIANI 

T - 55 DETERMINATION OF L-DOPA ADMINISTRATION EFFECTS IN A 

PARKINSON ANIMAL MODEL INDUCED BY 6-OHDA IGOR CARVALHO MARQUES, 

JÚNIA VIEIRA DOS SANTOS, MARCOS ROMÁRIO MATOS DE SOUZA, RAFAELA 

CARNEIRO CORDEIRO, LUCIANA DIAS BELCHIOR, ANDRÉ FÉRRER CARVALHO, 

DANIELLE SILVEIRA MACEDO 

T - 56 IN VITRO EFFECT OF AMPHETAMINE AND MINOCYCLINE IN THE 

MITOCHONDRIAL ACTIVITY OF RAT’S CEREBRAL CORTEX RAFAELA CARNEIRO 

CORDEIRO, IGOR CARVALHO MARQUES, CAMILA DANTAS MEDEIROS, JÚNIA 

VIEIRA DOS SANTOS, DANIELLE SILVEIRA MACEDO, ANDRÉ FÉRRER CARVALHO 

T - 57 MORPHOMETRIC EVALUATION AND IMMUNOFLUORESCENCE OF 

NEURONS OF THE PERIPHERAL NOCICEPTIVE SYSTEM IN OFFSPRING OF DIABETIC 

RATS TAÍS DE CAMPOS LIMA, CELINA MONTEIRO DA CRUZ LOTUFO 

T - 58 EFFECTS OF DEPRESSION ASSOCIATED OR NOT WITH 

ANTIDEPRESSANT TREATMENT ON THE RAT SALIVARY GLANDS PATRÍCIA HELENA 

ZANIER-GOMES, CARINA CARRARO PESSOA, TOMAZ EUGÊNIO DE ABREU SILVA, 

NANCI MENDES PINHEIRO, SIMONE DE SALES COSTA MOREIRA CARBONI, ADILHA 

MISSON RUA MICHELETTI, VIRGÍNIA OLIVEIRA CREMA 

T - 59 ASTROCYTES REGULATE GABAERGIC SYNAPSE FORMATION 

THROUGH THE TGF-BETA SIGNALING. LUAN PEREIRA DINIZ, VANESSA TORTELLI, 

LUCIANA FERREIRA ROMÃO, FLÁVIA CARVALHO ALCANTARA GOMES 

T - 60 IN VIVO EXPOSURE TO CAFFEINE CHANGES THE EXPRESSION OF A1 

AND A2A ADENOSINE RECEPTORS IN THE CHICK EMBRYO RETINA: POSSIBLE 

EFFECTS ON THE GABAERGIC SYSTEM. RAFAEL BRITO DA SILVA, ROBERTO PAES DE 

CARVALHO, KARIN DA COSTA CALAZA 

T - 61 BEHAVIOR AND NEUROCHEMICAL ALTERATIONS RELATED TO 

CHRONIC ADMINISTRATION OF ETHANOL AND STRESS EXPOSURE DANIEL 

MOREIRA SILVA, GESSYNGER MORAIS SILVA, JULIANA FERNANDES SANTOS, 

MARCELO TADEU MARIN 

T - 62 NEUROGENIC NICHE OF ADULT BRAIN: ULTRASTRUCTURAL 

ASPECTS OF CELL ELEMENTS IN SUBVENTRICULAR ZONE, IN LONG-EVANS RATS 

CARLOS ALEXANDRE DOS SANTOS HAEMMERLE, SILVIA HONDA TAKADA, LEILA 

GUISSONI CAMPOS, MARIA INÊS NOGUEIRA, II-SEI WATANABE 

T - 63 INVESTIGATION OF SYNAPTIC DEFICITS IN SEPSIS: ROLE OF GLIAL 

CELLS CAROLINA ARAUJO MORAES, TÂNIA SPOHR, GABRIEL SANTOS, JOANA 

D’AVILLA, FERNANDO AUGUSTO BOZZA, FLÁVIA REGINA SOUZA LIMA, CLAUDIA 

BENJAMIM, FLÁVIA CARVALHO ALCANTARA GOMES 

T - 64 THE TROPHIC EFFECT OF IL-4 ON RETINAL GANGLION CELLS 

INVOLVES AN INCREASE IN BDNF EXPRESSION ALINE ARAUJO DOS SANTOS, 

ELIZABETH GIESTAL DE ARAUJO, ELIZABETH GIESTAL DE ARAUJO 

T - 65 STRESS IN PRE-PUBERTAL PERIOD AND CHRONIC EXPOSURE TO 

PALATABLE DIETS – EVALUATION OF PARAMETERS OF OXIDATIVE STRESS IN THE 

HIPPOCAMPUS OF ADULT MALE RATS. DANUSA MAR ARCEGO, CARINE LAMPERT, 

RACHEL KROLOW, CRISTIE NOSCHANG, TAMIRES BEN, ANA PAULA TONIAZZO, 

CARLA DALMAZ 

T - 66 EFFECT OF CHRONIC ADMINISTRATION OF TAMOXIFEN AND/OR 

ESTRADIOL ON OXIDATIVE PARAMETERS IN BRAIN OF OVARIECTOMIZED RATS 

CARINE LAMPERT, DANUSA MAR ARCEGO, RACHEL KROLOW, CRISTIE NOSCHANG, 

DANIELA PEREIRA LAUREANO, ISADORA FERREIRA LIMA, LUISA AMÁLIA DIEHL, 

CARLA DALMAZ, LETÍCIA FERREIRA PETTENUZZO, DEUSA VENDITE 

T - 67 NEUROPROTECTIVE EFFECT OF THE METABOTROPIC GLUTAMATE 

RECEPTOR 5 POSITIVE ALLOSTERIC MODULATORS IN HUNTINGTON´S DISEASE 

JULIANA GUIMARÃES DÓRIA, VANESSA COSTA DE MIRANDA DRUMMOND, FLAVIA 

RODRIGUES SILVA, TOMAS DOBRANSKY, FABIOLA MARA RIBEIRO 

T - 68 PHARMACOLOGICAL EFFECT OF BRAZILIAN SPIDER OMEGA- 

TOXINS IN CALCIUM SIGNALING OF TRIGEMINAL NOCICEPTIVE PATHWAY 

ELIZETE MARIA RITA PEREIRA, CÉLIO JOSÉ DE CASTRO JÚNIOR, ALESSANDRA 

HUBNER DE SOUZA, NANCY SCARDUA BINDA, LUCIENE BRUNO VIEIRA, RICARDO 

SANTIAGO GOMEZ, MARCUS VINICIUS GOMEZ 

T - 69 NEURONAL DIFFERENTIATION OF HUMAN NEUROBLASTOMA CELL 

LINE SH-SY5Y AND ITS USE FOR NEUROSCIENCE RESEARCH FERNANDA MARTINS 

LOPES, GIOVANA FERREIRA LONDERO, LIANDA MARENGO DE MEDEIROS, 

ROSALVA THEREZA MEURER, GADRIELA DELEVATI COLPO, MARILDA DA CRUZ 

FERNANDES, FLAVIO KAPCZINSKI, FÁBIO KLAMT 

T - 70 SYNAPTIC CONTACTS ON DENDRITIC SPINES OF THE 

POSTERODORSAL MEDIAL AMYGDALA OF RATS JORGE E. MOREIRA, ALBERTO A. 

RASIA-FILHO, RONALD PETRALIA, BECHARA KACHAR, JORGE E. MOREIRA 

119

T - 71 LATERALIZATION OF INHIBITORY SYNAPTIC CONTACTS IN THE 

POSTERODORSAL MEDIAL AMYGDALA OF RATS JORGE E. MOREIRA, JANAINA 

BRUSCO, SUÉLEN MERLO, ALBERTO A. RASIA-FILHO, JORGE E. MOREIRA 

T - 72 THYROID HORMONES MEDIATE NEURON-ASTROCYTE 

INTERACTIONS: ROLE OF HEPARAN SULPHATE PROTEOGLYCANS ROMULO 

SPERDUTO DEZONNE, JOICE STIPURSKY, ANA PAULA BERGAMO ARAUJO, JADER 

NONES, MAURO SÉRGIO GONÇALVES PAVÃO, MARIMÉLIA PORCIONATTO, FLÁVIA 

CARVALHO ALCANTARA GOMES 

T - 73 EFFECTS OF MATERNAL NICOTINE EXPOSURE DURING LACTATION 

ON HYPOTHALAMIC NEUROPEPTIDES EXPRESSION IN THE ADULT RAT CINTIA 

RODRIGUES PINHEIRO, VIVIANE YOUNES-RAPOZO, EGBERTO G. MOURA, ALEX C. 

MANHÃES, ANA PAULA SANTOS-SILVA, ELAINE DE OLIVEIRA, PATRICIA C. LISBOA 

T - 74 EVIDENCE OF PRION PROTEIN-STRESS INDUCIBLE PROTEIN 1 

INTERACTION IN THE NEUROBIOLOGY OF TUMOR STEM CELLS REBECA 

PIATNICZKA IGLESIA, VILMA REGINA MARTINS, TIAGO GÓSS DOS SANTOS, 

MARILENE HOHMUTH LOPES 

T - 75 ENDOTHELIAL AND RADIAL GLIA CELLS INTERATION DURING 

CEREBRAL CORTEX DEVELOPMENT DANIEL FRANCIS FRANCO, JOICE STIPURSKY, 

FLÁVIA CARVALHO ALCANTARA GOMES 

T - 76 ENRICHED ENVIRONMENT INDUCES HIPPOCAMPUS CELLULAR 

PLASTICITY IN TYPE 1 DIABETIC RATS FRANCELE VALENTE PIAZZA, ETHIANE 

SEGABINAZI, LÍGIA ALINE CENTENARO, PATRÍCIA SEVERO DO NASCIMENTO, 

MATILDE ACHAVAL, SIMONE MARCUZZO 

T - 77 EFFECTS OF ENVIRONMENTAL ENRICHMENT ON MOTOR 

FUNCTIONS AND MUSCLE MORPHOLOGY ALTERATIONS IN A CEREBRAL PALSY 

RODENT MODEL MARÍLIA ROSSATO MARQUES, FELIPE DE SOUZA STIGGER, 

BRUNO SANTOS CAMPOS GOMES, ETHIANE SEGABINAZI, FRANCELE VALENTE 

PIAZZA, SÍLVIA BARBOSA, MATILDE ACHAVAL, SIMONE MARCUZZO 

T - 78 ENRICHED ENVIRONMENT PREVENTS MEMORY DEFICITS BUT NOT 

REVERT HIPPOCAMPUS CELLULAR SURVIVAL IN TYPE 1 DIABETIC RATS FRANCELE 

VALENTE PIAZZA, ETHIANE SEGABINAZI, LÍGIA ALINE CENTENARO, PATRÍCIA 

SEVERO DO NASCIMENTO, MATILDE ACHAVAL, SIMONE MARCUZZO 

T - 79 MATERNAL PROLACTIN INHIBITION DURING LATE-LACTATION IS 

ASSOCIATED WITH HIGHER NEUROPEPTIDE Y (NPY) IN ARCUATE NUCLEUS AND 

IN PARAVENTRICULAR NUCLEUS IN PROGENY AT ADULTHOOD VIVIANE RAPOZO- 

YOUNES, NAYARA PEIXOTO-SILVA, LIGIA DE ALBUQUERQUE MAIA, ALEX C. 

MANHÃES, EGBERTO GASPAR DE MOURA, ELAINE DE OLIVEIRA, PATRICIA 

CRISTINA LISBOA 

T - 80 PI3K/AKT PATHWAY REGULATES MITOSIS OF NEURAL 

PROGENITORS DURING RETINAL DEVELOPMENT ISIS MORAES ORNELAS, 

THAYANE MARTINS SILVA, LUCIANNE FRAGEL MADEIRA, ANA LÚCIA MARQUES 

VENTURA 

T - 81 ACTIVATION OF P2X7 RECEPTORS INHIBITS THE PROLIFERATION 

OF LATE DEVELOPING RETINAL PROGENITORS IN CULTURE. THAYANE MARTINS 

SILVA, ISIS MORAES ORNELAS, ROXANA MAMANI ANCCASI, ANA LÚCIA MARQUES 

VENTURA 

T - 82 ANALYSIS OF THE LIPID COMPOSITION OF THE ADULT MURINE 

BRAIN CEREBROSPINAL FLUID MARÍLIA KIMIE SHIMABUKURO, THAIS DE BARROS 

FERNANDES, GEÓRGIA CORREA ATELLA, CLAUDIA M.C. BATISTA, VALÉRIA DE 

MELLO-COELHO 

T - 83 PRELIMINARY STUDIES OF CELL VIABILITY AND OXIDATIVE STRESS 

AFTER TREATMENT WITH NICOTINE OR VARENICLINE ON NEURONAL 

HIPPOCAMPAL PRIMARY CULTURES RAPHAEL TRINDADE DOS SANTOS, VIVIANE 

YOUNES RAPOZO, CLÁUDIO CARNEIRO FILGUEIRAS, YAEL ABREU VILLAÇA, ALEX 

CHRISTIAN MANHÃES 

T - 84 ROLE OF TGF-Β1 ON RADIAL GLIA CELLS DIFFERENTIATION: 

REGULATION OF FOXG1 AND ERBB2 EXPRESSION. LAYS SOUZA DA SILVA, JOICE 

STIPURSKY SILVA, FLÁVIA CARVALHO ALCANTARA GOMES 

T85 HEPATOTOXIC (hCCP – MICROCYSTIN) AS WELL AS NON-HEPATOTOXIC 

CYANOPEPTIDES (n-hCCP) INFLUENCE NESTIN AND GFAP INTERMEDIATE 

FILAMENT ORGANIZATION IN ASTROCYTE 

ANJA BUBIK1,2, ROBERT FRANGEŽ3, TAMARA T LAH1 AND BOJAN SEDMAK1,2 

U – Plant Cell Biology 

U1-U41 

U - 1 MORPHOLOGICAL CHARACTERIZATION OF MIMOSA 

CAESALPINIIFOLIA BENTH. SEED BY CYTOCHEMICAL METHODS RÔMULO 

MESQUITA FRANCO, LUCIANA DE VASCONCELOS REBOUÇAS, RENAN DA SILVA 

SANTOS, MARIA IZABEL GALLÃO 

U - 2 MORPHOLOGICAL ANALYSIS OF MIMOSA HOSTILIS BENTH SEEDS 

BY CYTOCHEMICAL METHODS. RENAN DA SILVA SANTOS, DEBORAH ALANI DE 

OLIVEIRA, MARIA IZABEL GALLÃO 

U - 3 MORPHOLOGICAL ANALYSIS OF BAUHINIA FOFICATA, LIN SEEDS 

ARYELLI MAGALHÃES MACIEL, GABRIELA RODRIGUES FARIAS, GLEICYANNE VIEIRA 

DA COSTA, MARIA IZABEL GALLÃO 

U - 4 OBSERVATION OF SEED LIPIDS FROM NORTHEASTERN SEMI ARID 

NATIVE SPECIES THROUGH THE NILE RED JOSÉ DE BRITO VIEIRA NETO, MARIA 

IZABEL GALLÃO, ASSUERO SILVA MEIRA, BRUNO MARQUES SOARES 

U - 5 MORPHOLOGICA ANALYSIS OF CAESALPINIA PYRAMIDALIS TUL 

SEEDS PAMELA CLEMENTE DE MENESES SILVA, STELAMARIS DE OLIVEIRA PAULA, 

MARIA IZABEL GALLÃO 

U - 6 LIGHT MICROSCOPY AS A TOOL TO INVESTIGATE PRETREATMENT 

EFFECT ON SUGARCANE RICARDO CHAVES VILELA, YURI ABUD, LILIAN T. COSTA, 

WANDERLEY DE SOUZA, CELSO SANT’ANNA 

U - 7 EFFECTS OF ULTRAVIOLET RADIATION-B ON THE LEAF BLADE 

ORYZA SATIVA L. (POACEAE) CV EPAGRI 108 (1): CHANGES IN ULTRASTRUCTURAL 

ORGANIZATION. SÉRGIO LUIZ DE ALMEIDA, ÉDER CARLOS SCHMIDT, ANA 

CLAUDIA RODRIGUES, ZENILDA LAURITA BOUZON 

U - 8 DETERMINATION OF THE MUTAGENESIS AND CYTOTOXIC 

ETHANOLIC EXTRACT OF PLANTAGO MAJOR (TANSAGEM) HELEN TAIS DA ROSA, 

TATIANE DA AQUINO, DINARA JAQUELINE MOURA 

U - 9 MORPHOLOGICAL ANALYSIS OF ARTOCARPUS HETEROPHYLLUS 

LAM SEEDS GABRIELA ARAÚJO DE ABREU, ALINE PESSOA NEGREIROS, MARIA 

IZABEL GALLÃO 

U - 10 MORPHOLOGICAL CHANGES OF IN NATURA MANGOES 

SUBMITTED TO AN ELECTROLYZED WATER TREATMENT MARIA IZABEL GALLÃO, 

MARIA EDILEUZA LEITE, EBENEZER DE OLIVEIRA SILVA 

U - 11 MULTIPLICATION OF SOMATIC EMBRYOS OF BACTIS GASIPAES IN 

TEMPORARY IMMERSION SYSTEM (TIS) ANGELO SCHUABB HERINGER, DOUGLAS 

ANDRÉ STEINMACHER, MIGUEL PEDRO GUERRA 

U - 12 MATURATION AND CONVERSION OF SOMATIC EMBRYOS OF 

BACTRIS GASIPAES ANGELO SCHUABB HERINGER, DOUGLAS ANDRÉ 

STEINMACHER, MIGUEL PEDRO GUERRA 

U - 13 MORPHOLOGICAL AND HISTOCHEMICAL STUDY OF GREEN ALGAE 

(CLADOPHORA SP AND ULVA LACTUCA) TREATED WITH DIFFERENT SALINITIES 

LUZ KARIME POLO OSORIO, ÉDER C. SCHMIDT, CLAUDIANE GOUVEIA, 

MARTHIELLEN R. L. FELIX, FUNGYI CHOW, CRISTINA NASSAR, ZENILDA L. BOUZON 

U - 14 CHANGES IN THE MORPHOLOGY AND ULTRASTRUCTURE INDUCED 

BY ULTRAVIOLET RADIATION-B IN THE CARRAGENOPHYTE HYPNEA 

MUSCIFORMIS (RHODOPHYTA, GIGARTINALES) EDER CARLOS SCHMIDT, BEATRIZ 

PEREIRA, RODRIGO W. DOS SANTOS, CLAUDIANE GOUVEIA, FERNANDA RAMLOV, 

MARCELO MARASCHIN, ZENILDA L. BOUZON 

U - 15 MORPHOLOGICAL AND CELLULAR CHARACTERIZATION OF 

ZYGOTIC POLYEMBRYOS IN ARAUCARIA ANGUSTIFOLIA (BERT.) O. KUNTZE 

GLADYS DANIELA ROGGE RENNER, NEUSA STEINER, ÉDER CARLOS SCHMIDT, 

ZENILDA LAURITA BOUZON, FRANCINE LUNARDI FARIAS, MARIA LUIZA TOMAZI 

PEREIRA, MIGUEL PEDRO GUERRA 

U - 16 CELLULAR ALTERATIONS IN THE AGAROPHYTE GRACILARIA 

DOMINGENSIS TREATED WITH THE HEAVY METAL LEAD CLAUDIANE GOUVEIA, 

MARIANNE KREUSCH, EDER C. SCHMIDT, RODRIGO W. DOS SANTOS, ZENILDA L. 

BOUZON 

U - 17 EFFECTS OF CADMIUM ON THE MORPHOLOGY AND 

CYTOCHEMISTRY OF THE RED MACROALGAE PTEROCLADIELLA CAPILLACEA 

MARTHIELLEN ROOSEVELT DE LIMA FELIX, ÉDER C. SCHMIDT, LUZ K. P. OSORIO, 

CLAUDIANE GOUVEIA, MARIANNE KREUSCH, RODRIGO DOS SANTOS, ZENILDA L. 

BOUZON 

U - 18 GLOBAL DNA METHYLATION LEVELS DURING ACCA SELLOWIANA 

(O. BERG) BURRET SOMATIC EMBRYOGENESIS BY HIGH PERFORMANCE LIQUID 

CHROMATOGRAPHY-MASS SPECTROMETRY HUGO PACHECO DE FREITAS FRAGA, 

LEILA DO NASCIMENTO VIEIRA, CLARISSA ALVES CAPRESTANO, DOUGLAS ANDRÉ 

STEINMACHER, GUSTAVO AMADEU MICKE, ROSETE PESCADOR, MIGUEL PEDRO 

GUERRA 

U - 19 ENDOGENOUS FREE POLYAMINES LEVELS OF ANANAS COMOSUS 

VAR. COMOSUS NODULE CLUSTER CULTURES USING TEMPORARY IMMERSION 

BIOREACTORS HUGO PACHECO DE FREITAS FRAGA, RAMON FELIPE SCHERER, 

ANTONIO CORRÊA GARCIA, LÍRIO LUIZ DAL VESCO, DOUGLAS ANDRÉ 

STEINMACHER, MIGUEL PEDRO GUERRA 

U - 20 HISTOCHEMICAL ANALYSIS OF CALLUSES OF CEDRELA FISSILIS 

VELOSO (MELIACEAE) FERNANDA KOKOWICZ PILATTI, EDER CARLOS SCHMIDT, 

ZENILDA LAURITA BOUZON, ANA MARIA VIANA 

U - 21 HISTOMORPHOLOGY DURING SOMATIC EMBRYOGENESIS 

INDUCTION OF ACCA SELLOWIANA (O. BERG). BURRET IN RESPONSE TO THE DNA 

120

METHYLATION INHIBITOR 5-AZACITIDINE LEILA DO NASCIMENTO VIEIRA, HUGO 

PACHECO DE FREITAS FRAGA, ROSETE PESCADOR, MIGUEL PEDRO GUERRA 

U - 22 EFFECTS OF DNA METHYLATION INHIBITOR 5-AZACITIDINE ON THE 

CONVERSION OF ACCA SELLOWIANA SOMATIC EMBRYOS (O. BERG). BURRET 

LEILA DO NASCIMENTO VIEIRA, HUGO PACHECO DE FREITAS FRAGA, CLARISSA 

ALVES CAPRESTANO, ROSETE PESCADOR, MIGUEL PEDRO GUERRA 

U - 23 EFFECTS OF ULTRAVIOLET RADIATION-B IN THE RED ALGAE 

LAURENCIA CATARINENSIS (CERAMIALES, RHODOPHYTA DÉBORA TOMAZI 

PEREIRA, ÉDER CARLOS SCHMIDT, LUCIANE CRISTINA OURIQUES 

U - 24 COMPARATIVE ANALYSIS OF THE CELL ORGANIZATION OF 

PORPHYRA ACANTHOPHORA VAR. BRASILIENSIS UNDER THE EFFECTS OF 

ENVIRONMENTAL RADIATION, PAR, AND ARTIFICIAL ULTRAVIOLET RADIATION-B 

ZENILDA LAURITA BOUNZON, CARMEN S. ZITTA, RODRIGO W. DOS SANTOS, 

LUCIANE C. OURIQUES, CAROLINE DE FAVERI, CLAUDIANE GOUVEIA, EDER C. 

SCHMIDT 

U - 25 TISSUE-SPECIFIC EXPRESSION PATTERN ANALYSES OF OSASR5 

(ABA, STRESS AND RIPENING) PROMOTER IN RICE (ORYZA SATIVA L.) MARIANA 

SCHUNEMANN, RAFAEL AUGUSTO ARENHART, ADRIANO SILVÉRIO, JORGE 

ERNESTO DE ARAUJO MARIATH, MÁRCIA MARIA AUXILIADORA NASCHENVENG 

PINHEIRO MARGIS 

U - 26 INCREASED SUPEROXIDE DISMUTASE ACTIVITY IN SOYBEAN 

TREATED WITH MANGANESE-DESFERRIOXAMINE B JÉSSICA BORDOTTI NOBRE 

ESPOSITO, BRENO PANNIA ESPOSITO, RICARDO ANTUNES AZEVEDO, SILVIA 

RIBEIRO DE SOUZA 

U - 27 EFFECTS OF COPPER ON THE ARCHITECTURE AND 

ULTRASTRUCTURE OF THE RED ALGAE GRACILARIA DOMINGENSIS 

(GRACILARIALES, RHODOPHYTA) MARIANNE G. KREUSCH, CLAUDIANE GOUVEIA, 

ÉDER C. SCHMIDT, RODRIGO W. DOS SANTOS, ZENILDA L. BOUZON 

U - 28 CYTOCHEMICAL AND ULTRASTRUCTURAL CHANGES INDUCED BY 

UVB RADIATION ON SEEDLING TETRASPOROPHYTIC OF PALISADA FLAGELIFERA 

(CERAMIALES, RHODOPHYTA). LUCIANE CRISTINA OURIQUES, DÉBORA TOMAZI 

PEREIRA, ÉDER CARLOS SCHMIDT 

U - 29 IMMUNOMODULATORY ACTIVITY OF AQUEOUS EXTRACT 

OBTAINED FROM THE STEM BARK OF BOWDICHIA VIRGILIOIDES KUNTH IN MICE 

LARISSA FERNANDA DE ARAUJO VIEIRA, MARIA DANIELMA DOS SANTOS REIS, 

ALTAIR ROGÉRIO ALVES BRANDÃO, THEREZINHA DE JESUS CALADO, EMILIANO 

BARRETO, SALETE SMANIOTTO 

U - 30 A PP2C PROTEIN IN RESPONSE TO COLD TEMPERATURE OF 

ARAUCARIA ANGUSTIFOLIA ROBERTA ALVARES CAMPOS, LEONARDO JO, 

FERNANDA PICCOLO PIERUZZI, JÉSSICA FERNANDES PEREIRA, IGOR LUCOVES 

SICCHI, NATALIA PISCIRILLO, SÂMILA BIANCHE LOPES, CAROLINE ARCANJO BUENO, 

AMANDA F MACEDO, ANDRÉ LUIS WENDT DOS SANTOS, ENY IOCHEVET SEGAL 

FLOH 

U - 31 ANATOMICAL CHANGES INDUCED BY ARSENIC IN WATER 

HYACINTH (EICHHORNIA CRASSIPES (MART.) SOLMS) IULLA NAIFF RABELO DE 

SOUZA REIS, JURACI ALVES DE OLIVEIRA, MARÍLIA CONTIN VENTRELLA, JOSÉ 

CAMBRAIA, REGIANE APARECIDA CANATTO 

U - 32 PROTEOMIC ANALYSIS OF TWO VARIETIES OF ZEA MAYS 

INOCULATED WITH AZOSPIRILLUM BRASILENSE FP2 ALEXANDRO CÉZAR FALEIRO, 

ELIANDRO ESPINDULA, TOMAS PELLIZZARO PEREIRA, ANA CAROLINA 

MAISONNAVE ARISI 

U - 33 MORPHO-HYSTOLOGICAL FEATURES IN IN VITRO PROTOCORM- 

LIKE BODIES OF CATTLEYA TIGRINA RAFAELA DUARTE DE LIZ, MARISA SANTOS, 

YOHAN FRITSCHE, ROSETE PESCADOR, MIGUEL PEDRO GUERRA 

U - 34 NITRIC OXIDE ATTENUATE THE OXIDATIVE STRESS AS-INDUCED IN 

LETTUCE LEAVES NEIDIQUELE MARIA SILVEIRA, JURACI ALVES DE OLIVEIRA, LUHAN 

ISAAC SIMAN, FERNANDA SANTOS FARNESE, CLÉBERSON RIBEIRO, REGIANE 

APARECIDA CANATTO 

U - 35 EFFECTS OF DIFFERENT CYTOKININS ON CELL PROLIFERATION OF 

ROLLINIA MUCOSA (JACQ.) BAILL. FOR SECONDARY METABOLITES PRODUCTION 

THIAGO JOSÉ DE SOUZA BARBOZA, CECÍLIA DE AZEVEDO SOUZA, DÉBORA DE 

AGUIAR LAGE, NORMA ALBARELLO 

U - 36 CYTOTOXICITY STUDY OF NORANTEA BRASILIENSIS METHANOL 

EXTRACTS USING BRINE SHRIMP LETHALITY TEST ANNA FLÁVIA RODRIGUES 

MORTANI VILARDO, GRAZIELA DA SILVA MELLO, ANALU FONSECA DE SÁ, NORMA 

ALBARELLO 

U - 37 EFFECTS OF ULTRAVIOLET-B RADIATION IN CELL ORGANIZATION 

DURING THE INITIAL DEVELOPMENT OF NEMALION HELMINHOIDES (VELLEY IN 

WITH.) BATTERS (NEMALIALES, RHODOPHYTA) ELIANA DE MEDEIROS OLIVEIRA, 

LUCIANE CRISTINA OURIQUES 

U - 38 ROLE OF THE GOLGI APPARATUS IN STORAGE OF SECONDARY 

METABOLITES IN RED ALGA LAURENCIA DENDROIDEA. LILIAN JORGE HILL, 

LEONARDO TAVARES SALGADO 

U - 39 HYSTOCHEMICAL CHARACTERIZATION OF SOMATIC PRO- 

EMBRYOS OF ARAUCARIA ANGUSTIFOLIA FRANCINE LUNARDI FARIAS SOARES, 

MARIA LUIZA TOMAZI PEREIRA, BRUNA SCHEID, NEUSA STEINER, GLADYS DANIELA 

ROGGE RENNER, ÉDER CARLOS SCHMIDT, ZENILDA BOUZON, MIGUEL PEDRO 

GUERRA 

U - 40 MORPHOLOGICAL CHARACTERIZATION BY SCANNING ELECTRON 

MICROSCOPY OF SOMATIC PRO-EMBRYOS OF ARAUCARIA ANGUSTIFOLIA 

FRANCINE LUNARDI FARIAS SOARES, MARIA LUIZA TOMAZI PEREIRA, BRUNA 

SCHEID, NEUSA STEINER, GLADYS DANIELA ROGGE RENNER, ÉDER CARLOS 

SCHMIDT, ZENILDA BOUZON, MIGUEL PEDRO GUERRA 

U - 41 ROLE OF NITRIC OXIDE MOLECULE IN TOLERANCE TO ARSENIC IN 

PISTIA STRATIOTES: SIGNAL OR ANTIOXIDANT? FERNANDA DOS SANTOS 

FARNESE, JURACI ALVES DE OLIVEIRA, LUHAN ISAAC SIMAN, REGIANE APARECIDA 

CANATTO, CRISTIANE JOVELINA DA SILVA 

V – Plasma Membrane 

and Organelles 

V1-V10 

V - 1 AQUAPORIN LOCALIZATION IN ANT EXCRETORY SYSTEM MARIA 

DO CARMO QUEIROZ FIALHO, DIHEGO DE OLIVEIRA AZEVEDO, LUIZA CARLA 

BARBOSA MARTINS, JOSÉ EDUARDO SERRÃO 

V - 2 WATER-FLUXES AND THE FUNCTION OF CANALICULI IN THE 

MIDGUT OF PHIBALOSOMA PHYLLINUM (PHASMIDA, PHASMATIDAE) EMILIANO 

CARNEIRO MONTEIRO, WALTER RIBEIRO TERRA, ALBERTO AUGUSTO GONÇALVES 

DE FREITAS CASTRO RIBEIRO 

V - 3 THE DIGESTIVE SYSTEM OF BUCEPHALOGONIA XANTHOPHIS 

(HEMIPTERA, CICADELLIDAE): THE ORGANIZATION OF THE LUMINAL SYSTEM OF 

MEMBRANES ALEXANDRE HIROSHI UTIYAMA, WALTER RIBEIRO TERRA, ALBERTO 

FREITAS RIBEIRO 

V - 4 INFLUENCE OF ALKALINE PH ON MAGNETOSOME FORMATION BY 

“CANDIDATUS MAGNETOVIBRIO BLAKEMOREI” PEDRO ERNESTO LOPES LEÃO, 

FERNANDA ABREU, DENNIS A. BAZYLINSKI, ULYSSES LINS 

V - 5 PATHWAYS REGULATING SECRETORY LYSOSOME BIOGENESIS AND 

SECRETION ABBIE L NEILSON, ERICA B WILSON, JOSEPHINE L MEADE, JACQUELYN 

BOND, GRAHAM P COOK 

V - 6 EXPOSURE OF LUMINAL MEMBRANES OF LLC-PK1 CELLS TO ANG II 

INDUCES DIMERIZATION OF AT1/AT2 RECEPTORS TO ACTIVATE SERCA AND TO 

PROMOTE CA2+ MOBILIZATION FERNANDA MAGALHÃES FERRÃO, LUCIENNE 

SILVA LARA, FLÁVIA AXELBAND, JULIANA DIAS, ADRIANA K CARMONA, ROSANA I 

REIS, CLÁUDIO M COSTA-NETO, ADALBERTO VIEYRA, JENNIFER LOWE 

V - 7 STRUCTURAL CHARACTERIZATION OF CARGO-BINDING SITES OF 

THE MU4-SUBUNIT OF ADAPTOR PROTEIN COMPLEX 4 BREYAN H. ROSS, YIMO 

LIN, PATRICIA V. BURGOS, JUAN S. BONIFACINO, GONZALO A. MARDONES 

V - 8 ORGANIZATION OF THE DIGESTIVE SYSTEM OF THE FRUIT FLY 

ANASTREPHA SERPENTINA (DIPTERA: TEPHRITIDAE) CAMILA SILVA LEAL, 

ALEXANDRE HIROSHI UTIYAMA, ALBERTO FREITAS RIBEIRO 

V - 9 RAPID ASSEMBLY AND INTERNALIZATION OF CAVEOLAE PROMOTE 

RESEALING IN INJURED CELLS AND MUSCLE FIBERS PATRICIA ELAINE DE ALMEIDA, 

MATTHIAS CORROTTE, CHRISTINA TAM, MARIA CECILIA FERNANDES, MAURO 

CORTEZ, TIMOTHY K. MAUGEL, NORMA W. ANDREWS 

V - 10 THE LISOSOMAL TARGETING OF CD4 BY HIV-1 NEF REQUIRES Γ2, A 

NOVEL ISOFORM OF GAMMA ADAPTIN EULÁLIA MARIA LIMA DA SILVA, RODRIGO 

ORLANDINI DE CASTRO, LUIS LAMBERTI PINTO DA SILVA 

X – Proteolysis 

X1-X10 

X - 1 AGH IS A NEW HEMOGLOBIN ALPHA-CHAIN FRAGMENT WITH 

ANTINOCICEPTIVE BIOLOGICAL ACTIVITY NATALIA MAZINI RIBEIRO, LILIAN C. 

RUSSO, LEANDRO M. CASTRO, CAMILA S. DALE, ALANA R. FIGUEIREDO, FABIO C. 

GOZZO, VANESSA RIOLI, EMER S. FERRO 

X -2 PURIFICATION AND PARTIAL BIOCHEMICAL CHARACTERIZATION 

OF A METALLOPROTEASE FROM BOTHROPS MOOJENI VENOM THALITA 

KRISTHINA ALVES SILVA, CARLA CRISTINE NEVES MAMEDE, MAYARA RIBEIRO DE 

QUEIROZ, BRUNA BARBOSA DE SOUSA, ANA LUIZA ZACOUR MARINHO, NADIA 

CRISTINA GOMES DE MORAIS, KELLY CORTES FONSECA, DÉBORAH FERNANDA DA 

CUNHA PEREIRA, THAÍS MIRANDA MIGLIORINI, MARIANA SANTOS MATIAS, FÁBIO 

DE OLIVEIRA 

121

X -3 INTRACELLULAR PEPTIDE ANALYSES IN CELLS EXPRESSING THE 

IMMUNE PROTEASOME: POSSIBLE CORRELATIONS TO CELL SIGNALING 

ELISABETE RODRIGUES DO MONTE SILVA, EMER SUAVINHO FERRO, VANESSA 

RIOLI, LILIAN C RUSSO, LEANDRO M. DE CASTRO, FÁBIO C. GOZZO 

X -4 IDENTIFICATION OF E3 UBIQUITIN- LIGASE SCF1(FBXO25) 

SUBSTRATES THROUGH THE UBIQUITINATION IN VITRO ASSAY USING PROTEIN 

MICROARRAY FELIPE ROBERTI TEIXEIRA, ADRIANA OLIVEIRA MANFIOLLI, CLÁUDIA 

SOSSAI SOARES, ANA CAROLIAN HUMANES, MARCELO DAMARIO GOMES 

X -5 FUNCTIONAL CHARACTERIZATION OF THE FBXO25 NUCLEAR 

BODIES (FANDS) ADRIANA OLIVEIRA MANFIOLLI, FELIPE ROBERTI TEIXEIRA, 

MUNIRA MUHAMMAD ABDEL BAQUI, CLÁUDIA SOSSAI SOARES, ANA CAROLINA 

HUMANES, CACILDA DIAS PEREIRA, MARCELO DAMÁRIO GOMES 

X -6 PURIFICATION AND CHARACTERIZATION BIOCHEMISTRY OF P3G2: 

AN ENZYME COAGULANT AND Α- FIBRINOGENOLYTIC SNAKE VENOM OF 

BOTHROPS MOOJENI MARIANA SANTOS MATIAS, ANA LUIZA ZACOUR MARINHO, 

MAYARA RIBEIRO DE QUEIROZ, CARLA CRISTINE NEVES MAMEDE, DÉBORAH 

FERNANDA DA CUNHA PEREIRA, THALITA KRISTHINA ALVES SILVA, KELLY CORTES 

FONSECA, THAÍS MIRANDA MIGLIORINI, BRUNA BARBOSA DE SOUSA, NADIA 

CRISTINA GOMES DE MORAIS, IGOR DE AZAMBUJA QUEIROZ RIBEIRO, FÁBIO DE 

OLIVEIRA 

X -7 CLONING AND EXPRESSION OF A RECOMBINANT SERINE 

PROTEASE INHIBITOR FROM LOXOSCELES INTERMEDIA VENOM: A MEMBER OF 

SERPIN FAMILY LUIZA HELENA GREMSKI, JENIFER NOWATZKI, DILZA TREVISAN 

SILVA, RAFAEL BERTONI DA SILVEIRA, WALDEMIRO GREMSKI, ANDREA SENFF 

RIBEIRO, OLGA MEIRI CHAIM, SILVIO SANCHES VEIGA 

X -8 ANALYSIS OF SUBSTRATES AND PRODUCTS OF NEUROLYSIN (EC 

3.4.24.16) IN MOUSE BRAIN USING QUANTITATIVE PEPTIDOMICS LEANDRO 

MANTOVANI DE CASTRO, VITOR OLIVEIRA, FÁBIO CÉZAR GOZZO, EMER SUAVINHO 

FERRO 

X -9 EVALUATION OF BIOLOGICAL ACTIVITY OF MATRIX 

METALLOPROTEINASES FROM THE VENOM OF BOTHROPS ATROX AFTER 

AUTOPROTEOLYSIS REBECCA TAVARES E SILVA, MARIA DAS DORES NOGUEIRA 

NORONHA, ANDRÉ MIASATO HIGA, ANDRÉ LUIZ FERREIRA DA SILVA, KARLA 

NUNES DA SILVA, PAULA CRISTINA BRÍGIDO CARVALHO NEVES, JORGE LUIS LÓPEZ- 

LOZANO 

X -10 EDEMATOGENIC ACTIVITY INDUCED BY TOXINS FROM THE 

BOTHROPS ATROX VENOM AFTER AUTOPROTEOLYSIS REBECCA TAVARES E SILVA, 

MARIA DAS DORES NOGUEIRA NORONHA, ANDRÉ MIASATO HIGA, ANDRÉ LUIZ 

FERREIRA DA SILVA, KARLA NUNES DA SILVA, PAULA CRISTINA BRÍGIDO CARVALHO 

NEVES, JORGE LUIS LÓPEZ-LOZANO 

Z – Stem Cells 

Z1-Z42 

Z - 1 EFFECTS OF THE PLATELET–ACTIVATING FACTOR ON THE 

PLURIPOTENCY OF MURINE EMBRYONIC STEM CELLS PAULA VIEGAS PEREIRA 

SIGNORETTI, LUCIANNE FRAGEL MADEIRA 

Z - 2 ULTRASTRUCTURE OF THE REGENERATIVE CELLS OF THE MIDGUT 

OF CERAEOCHRYSA CLAVERI (NAVÁS, 1911) (NEUROPTERA: CHRYSOPIDAE) 

ELTON LUIZ SCUDELER, DANIELA CARVALHO DOS SANTOS, MONIQUE CAMPOS 

PEREIRA, ANA SILVIA GIMENES GARCIA, PATRÍCIA FERNANDA FELIPE PINHEIRO 

Z - 3 ISOLATION AND CHARACTERIZATION OF STEM/PROGENITOR 

CELLS PROPERTIES OBTAINED OF HUMAN BREAST CANCER CELL LINE MILENE 

PEREIRA MOREIRA, GEOVANNI DANTAS CASSALI, LUCIANA MARIA SILVA 

Z - 4 LEPTIN FRAGMENTS MODULATE THE MURINE HEMATOPIESIS 

CAROLINA CARVALHO DIAS, AMANDA NOGUEIRA-PEDRO, CHRISTIANO M. VAZ 

BARBOSA, VANI XAVIER DE OLIVEIRA JUNIOR, ANTONIO MIRANDA, EDGAR J. 

PAREDES-GAMERO 

Z - 5 GLUTATHIONE DEPENDENT OSTEOGENIC DIFFERENTIATION OF 

SKIN MESENCHYMAL PROGENITORS OCCURS THROUGH MAPK SIGNALING 

MARIA FERNANDA FORNI, LAURA POLIZEL, ADRIANO SARTORI, ERIK HALCSIK, 

ETELVINO BECHARA, MARI CLEIDE SOGAYAR 

Z - 6 VIABILITY, PROLIFERATION AND GENOTOXIC EFFECTS OF 

ELECTROSPRAYING ON MESENCHYMAL STEM CELLS DAIKELLY IGLESIAS 

BRAGHIROLLI, FERNANDA ZAMBONNI, PEDRO CHAGASTELLES, DINARA MOURA, 

JENIFER SAFFI, JOÃO ANTÔNIO PEGAS HENRIQUES, DIOGO ANDRÉ PILGER, 

PATRICIA PRANKE 

Z - 7 TISSUE REGENERATION, BIOENGINEERING AND STEM CELLS: 

BIBLIOMETRIC ANALYSIS OF PUBLICATIONS BETWEEN 2000 AND 2010 CRISTIANE 

REGINA SCHER, PEDRO CHAGASTELLES, ALEXANDRE MENEGHELLO FUENTEFRIA, 

PATRICIA PRANKE 

Z - 8 ISOLATION AND NEUROGENIC DIFFERENTIATION OF 

MESENCHYMAL STEM CELLS FROM HUMAN DECIDUOS TEETH PULP VIRGINIA 

ETGES HELFER, THAYANE CRESTANI, KERLIN QUINTILIANO, DIOGO ANDRÉ PILGER, 

PATRÍCIA PRANKE 

Z - 9 INFLUENCE OF THE TIME OF INCUBATION ON MESENCHYMAL 

STEM CELL ADHESION ON NANOFIBER MATRICES DAVI SILVEIRA DOS SANTOSS, 

KERLIN QUINTILIANO, THAYANE CRESTANI, VIRGINIA ETGES HELFER, DAIKELLY 

IGLESIAS BRAGHIROLLI, DIOGO ANDRÉ PILGER, PATRICIA PRANKE 

Z - 10 INCORPORATION OF VEGF ON PLGA SCAFFOLDS PRODUCED BY 

ELECTROSPINNING ANNELISE RIBEIRO DA ROSA, KERLIN QUINTILIANO, DANIELA 

STEFFENS, NÍVEO STEFFEN, DIOGO ANDRÉ PILGER, PATRICIA PRANKE 

Z - 11 DEVELOPMENT OF NGF LOADED SCAFFOLDS AND ASSOCIATION 

WITH MESENCHYMAL STEM CELLS FOR NERVE TISSUE ENGINEERING KERLIN 

QUINTILIANO, THAYANE ANTONIOLLI CRESTANI, DAVI SILVEIRA DOS SANTOS, 

VIRGINIA ETGES HELFER, ANNELISE RIBEIRO DA ROSA, GERALDO PEREIRA JOTZ, 

DIOGO ANDRÉ PILGER, PATRICIA PRANKE 

Z - 12 A NEW BIOMATERIAL OF NANOFIBERS WITH THE MICROALGA 

SPIRULINA AS SCAFFOLDS FOR USE IN TISSUE ENGINEERING DANIELA STEFFENS, 

MICHELLE LERSCH, ANNELISE ROSA, CRISTIANE SCHER, THAYANE CRESTANI, 

MICHELE GREQUE MORAIS, JORGE ALBERTO VIEIRA DA COSTA, PATRICIA PRANKE 

Z - 13 EVALUATION OF BONE REGENERATION PROMOTED BY THE 

ASSOCIATION OF SCAFFOLDS SEEDED WITH STEM CELLS FROM THE PULP OF 

HUMAN DECIDUOUS TEETH GERSON ARISOLY XAVIER ACASIGUA, LISIANE 

BERNARDI, DAIKELLY IGLESIAS BRAGHIROLLI, MANOEL SANT”ANA FILHO, PATRICIA 

PRANKE, ANNA CHRISTINA MEDEIROS FOSSATI 

Z - 14 MESENCHYMAL STEM CELL ADHESION AND PROLIFERATION RATES 

ON SCAFFOLDS OF POLY(LACTIC-CO-GLYCOLIC ACID) (PLGA) WITH DIFFERENT 

NANOFIBER DIAMETERS FERNANDA ZAMBONI, MARIANA DE CONTO FIN, 

DAIKELLY IGLESIAS BRAGHIROLLI, DIOGO ANDRÉ PILGER, PATRICIA PRANKE 

Z - 15 CHARACTERIZATION OF CULTURE EXPANDED MULTIPOTENT 

MESENCHYMAL STROMAL CELLS FROM EQUINE ADIPOSE TISSUE ARMANDO DE 

MATTOS CARVALHO, ANA LUCIA MILUZZI YAMADA, MARJORIE ASSIS GOLIM, LUIS 

EMILIANO C ÁLVAREZ, LUCIANA LEAL JORGE, MARIANA LOPES, ELENICE DEFFUNE, 

CARLOS ALBERTO HUSSNI, ANA LIZ GARCIA ALVES 

Z - 16 ISOLATION OF MESENCHYMAL STEM CELLS FROM THE CARDIAC 

MUSCLE OF GALLUS GALLUS RAQUEL CALLONI, PATRICK TURCK, GABRIHEL 

STUMPF VIEGAS, ELVIRA ALÍCIA APARÍCIO CORDERO, DIEGO BONATTO 

Z - 17 THE ROLE OF CASRS DURING ADULT RAT MESENCHYMAL STEM 

CELLS PROLIFERATION AND APOPTOSIS FERNANDA MARIA POLICARPO TONELLI, 

RODRIGO RIBEIRO RESENDE, LUIZ ORLANDO LADEIRA 

Z - 18 BIOMODULATION OF HUMAN EMBRYONIC STEM CELLS AFTER 

LOW POWER LASER IRRADIATION JULIANA F. MANGOLIN, ANDREZA C. DE 

SIQUEIRA SILVA, ERIANE ELLER DE SIQUEIRA, SUEMI SOARES BATISTA, CRISTINA 

PACHECO SOARES, NEWTON SOARES DA SILVA 

Z - 19 MESENCHYMAL STEM CELLS THERAPY IN ANIMAL MODEL OF 

DILATED CARDIOMYOPATHY INDUCED BY DOXORUBICIN: TROPONIN I LEVELS 

AND HISTOLOGICAL EVALUATION. HELENA FLORES MELLO, PRISCILLA 

DOMINGUES MÖRSCHBÄCHER, TUANE NERISSA ALVES GARCEZ, ANA HELENA DA 

ROSA PAZ, ALESSANDRA BILESKI MAGRISSO, VIVIAM NUNES PIGNONE, LANUCHA 

FIDELIS DA LUZ MOURA, ANELISE BONILLA TRINDADE, ELIZABETH OBINO CIRNE- 

LIMA, EMERSON ANTÔNIO CONTESINI 

Z - 20 EVALUATION OF FREQUENCY AND FUNCTIONALITY OF 

MESENCHYMAL CELL POPULATIONS IN OBESE AND EX-OBESE HUMAN 

SUBCUTANEOUS ADIPOSE TISSUE KARINA RIBEIRO DA SILVA, JOAO REGIS IVAR 

CARNEIRO, CESAR CLAUDIO-DA-SILVA, ANTÔNIO AUGUSTO PEIXOTO DE SOUZA, 

RADOVAN BOROJEVIC, LEANDRA SANTOS BAPTISTA 

Z - 21 HUMAN MENSTRUAL BLOOD DERIVED MESENCHYMAL CELLS AS 

NEW HUMAN FEEDER-LAYER SYSTEM FOR HUMAN EMBRYONIC STEM CELLS 

DANÚBIA SILVA DOS SANTOS, VANESSA CARVALHO COELHO DE OLIVEIRA, KARINA 

DUTRA ASENSI, LEANDRO VAIRO, ADRIANA BASTOS CARVALHO, ANTONIO CARLOS 

CAMPOS DE CARVALHO, REGINA COELI DOS SANTOS GOLDENBERG 

Z - 22 MAGNETIC RESONANCE IMAGING DETECTS EMBRYONIC STEM 

CELLS LABELED WITH SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES IN 

THE MURINE HEART GUILHERME VISCONDE BRASIL, DANÚBIA SILVA DOS SANTOS, 

ANDRÉIA DE VASCONCELOS DOS SANTOS, CLERIO FRANCISCO DE AZEVEDO FILHO, 

FERNANDA FREIRE TOVAR MOLL, ROSÁLIA MENDEZ OTERO, REGINA COELI DOS 

SANTOS GOLDENBERG, ANTONIO CARLOS CAMPOS DE CARVALHO 

Z - 23 DEVELOPMENT OF A NEW METHODOLOGY OF HUMAN DERMIS 

STEM CELL ENCAPSULATION IN CARRAGEENAN HYDROGEL ADDELI BEZ BATTI 

ANGULSKI, MICHELE RODE, TALITA JEREMIAS, LEILA HAYASHI, ANDREA 

GONÇALVES TRENTIN, GIORDANO WOSGRAU CALLONI 

Z - 24 17-BETA-ESTRADIOL EFFECTS IN MESENCHYMAL STEM CELLS 

UNDER OSTEOGENIC DIFFERENTIATION IN VITRO. PATRICK TURCK, RAQUEL 

CALLONI, GABRIHEL STUMPF VIEGAS, ELVIRA ALÍCIA APARÍCIO CORDERO, DIEGO 

BONATTO 

Z - 25 EFFECTS OF DEXAMETHASONE ON MESENCHYMAL STEM CELLS 

MORPHOLOGY, FUNCTIONALITY AND VIABILITY NATÁLIA SCHNEIDER, FABIANY 

DA COSTA GONÇALVES, HELENA FLORES MELLO, CRISTINA FLORES, ELIZABETH 

122

OBINO CIRNE LIMA, EDUARDO PANDOLFI PASSOS, LUÍSE MEURER, ANA HELENA 

DA ROSA PAZ 

Z - 26 MESENCHYMAL STEM CELLS FROM MENSTRUAL BLOOD ARE 

MORE RESISTANT TO OXIDATIVE STRESS THAN PLURIPOTENT STEM CELLS 

KARINA DUTRA ASENSI, RODRIGO SOARES FORTUNATO, DANIELLE FERREIRA DE 

REZENDE, THAÍSA SILVA PACHECO, DANÚBIA SILVA DOS SANTOS, DEIVID DE 

CARVALHO RODRIGUES, TAIS HANAE KASAI-BRUNSWICK, ELAINE CRISTINA LIMA 

DE SOUZA, ANTONIO CARLOS CAMPOS DE CARVALHO, DENISE PIRES CARVALHO, 

ADRIANA BASTOS CARVALHO, REGINA COELI DOS SANTOS GOLDENBERG 

Z - 27 COMPARISON BETWEEN FIBROBLASTS AND MESENCHYMAL STEM 

CELLS DERIVED FROM DERMAL AND ADIPOSE TISSUE CARLA ABDO BROHEM, 

CAROLINE LEAL RADOSKI, CAMILA MIRANDA DE CARVALHO, MARCELA CONTADOR 

BAPTISTA, BRUNA BASTOS SWINKA, FLÁVIA CRYSTINA SANTI, CÍCERO DE ANDRADE 

URBAN, RUTH MARIA GRAF, ISRAEL HENRIQUE STOKFISZ FEFERMAN, MÁRCIO 

LORENCINI 

Z - 28 IN VITRO AND IN VIVO OSTEOINDUCTIVE POTENTIAL OF POLY-3- 

HYDROXYBUTYRATE/POLYBUTYLENE SUCCINATE SCAFFOLDS COLONIZED BY 

ADIPOSE TISSUE DERIVED STEM CELLS THAIS MARIA DA MATA MARTINS, ANA 

CLÁUDIA CHAGAS DE PAULA, ALESSANDRA ZONARI, ALEXANDRA RODRIGUES 

PEREIRA DA SILVA, SILVIENE NOVIKOFF, ALFREDO MIRANDA DE GOES 

Z - 29 CHARACTERIZATION OF MULTIPOTENT MESENCHYMAL STROMAL 

CELLS OBTAINED FROM WHOLE BONE MARROW PLATED WITHOUT FICOLL 

GRADIENT NAYARA DE FREITAS MARTINS, FERNANDA BARRA FRANCO, FERNANDA 

DE SOUZA MARTINS, PATRÍCIA FIDELIS DE OLIVEIRA 

Z - 30 HAIR FOLLICLE DERIVED MESENCHYMAL CELLS SUPPORT 

UNDIFFERENTIATED GROWTH OF HUMAN EMBRYONIC STEM CELLS VANESSA 

CARVALHO COELHO DE OLIVEIRA, DANÚBIA SILVA DOS SANTOS, LEANDRO VAIRO, 

ADRIANA BASTOS CARVALHO, ANTÔNIO CARLOS CAMPOS DE CARVALHO, REGINA 

COELI DOS SANTOS GOLDENBERG 

Z - 31 CELL THERAPY AND PHYSICAL ACTIVITY: A THERAPEUTIC 

APPROACH IN A MICE SPINAL CORD INJURY TAMIRES BRAGA MASSOTO, MARINA 

BAIRROS HEBERLE, FERNANDA MARTINS DE ALMEIDA, ADRIANO BIANCALANA, 

ANA MARIA BLANCO MARTINEZ, SUELEN ADRIANI MARQUES 

Z - 32 EFFECTS OF AGING ON THE SUBVENTRICULAR ZONE OF THE 

MURINE BRAIN ARE REGULATED BY GROWTH HORMONE TREATMENT IN VIVO 

AND IN VITRO. MARILIA KIMIE SHIMABUKURO, LARISSA GUTMAN PARANHOS 

LANGHI, CHIN JIA LIN, ROGER CHAMMAS, CLAUDIA MARIA DE CASTRO BATISTA, 

VALÉRIA DE MELLO-COELHO 

Z - 33 EXTRACELLULAR ADENINE NUCLEOTIDES METABOLISM IN 

MESENCHYMAL STEM CELLS FROM DIFFERENT MURINE TISSUES ISABELE 

CRISTIANA ISER, PAULA ANDREGHETTO BRACCO, RAFAEL FERNANDES ZANIN, 

NANCE BEYER NARDI, ANA MARIA OLIVEIRA BATTASTINI, MÁRCIA ROSÂNGELA 

WINK 

Z - 34 ROLE OF CARDIAC MICROENVIRONMENT ON CARDIOMYOGENIC 

DIFFERENTIATION OF STEM CELLS ANNY WALOSKI ROBERT, ANA PAULA RESSETTI 

ABUD, ANDRESSA VAZ SCHITTINI, ALEJANDRO CORREA, MARISE B. A. COSTA, 

FRANCISCO D. A. COSTA, ALEXANDRA SENEGAGLIA, PAULO S. BROFMAN, MARCO 

AUGUSTO STIMAMIGLIO 

Z - 35 FUNCIONAL AND PHENOTYPICAL CHARACTERIZATION OF ACUTE 

CHAGASIC CARDIOMYOPATHY IN CHIMERIC MICE CAMILA IANSEN IRION, BRUNO 

DIAS PAREDES, GUILHERME VISCONDE BRASIL, SANDRO TORRENTES DA CUNHA, 

DÉBORA BASTOS MELLO, ISALIRA PEROBA REZENDE RAMOS, ANTONIO CARLOS 

CAMPOS DE CARVALHO, ADRIANA BASTOS CARVALHO, REGINA COELI DOS 

SANTOS GOLDENBERG 

Z - 36 ALTERED OXYGEN METABOLISM ASSOCIATED TO NEUROGENESIS 

OF INDUCED PLURIPOTENT STEM CELLS DERIVED FROM A SCHIZOPHRENIC 

PATIENT BRUNA DA SILVEIRA PAULSEN, RENATA DE MORAES MACIEL, ANTONIO 

GALINA, MARIANA SOUZA SILVEIRA, CLEIDE DOS SANTOS SOUZA, HANNAH 

DRUMMOND, ERNESTO NASCIMENTO POZZATTO, HAMILTON SILVA JUNIOR, 

LEONARDO CHICAYBAM, RAFFAEL MASSUDA, PEDRO SETTI PERDIGÃO, MARTIN 

BONAMINO, PAULO SILVA BELMONTE DE ABREU, NEWTON GOLÇALVES CASTRO, 

HELENA BRENTANI, STEVENS KASTRUP REHEN 

Z - 37 NEW APPROACH TO CULTURE HUMAN ADIPOSE STEM CELL 

SEEDED ON PHB-HV SCAFFOLDS FOR BONE TISSUE ENGINEERING APPLICATION 

ANA CLAUDIA CHAGAS DE PAULA, ALEXANDRA RODRIGUES PEREIRA DA SILVA, 

ALESSANDRA ZONARI, THAÍS MARIA DA MATA MARTINS, SILVIENE NOVIKOFF, 

ALFREDO MIRANDA GOES 

Z - 38 CHARACTERIZATION OF ISOLATED AND CULTURE EXPANDED 

SYNOVIAL MESENCHYMAL STEM CELLS FROM HORSES SYNOVIUM. ANA LIZ 

GARCIA ALVES, JAYESH DUDHIA, ROBERTA FERRO DE GODOY, ROGER K W SMITH 

Z - 39 EPIDERMAL GROWTH FACTOR-SCAFFOLDS AND MESENCHYMAL 

STEM CELLS: A NEW APPROACH FOR NERVE TISSUE ENGINEERING THAYANE 

CRESTANI, KERLIN QUINTILIANO, VIRGINIA ETGES HELFER, DAVI SILVEIRA DOS 

SANTOS, GERALDO JOTZ, DIOGO ANDRÉ PILGER, PATRICIA PRANKE 

Z - 40 ANALYSIS OF THE UNFOLDED PROTEIN RESPONSE (UPR) IN 

EMBRYONIC STEM CELLS DAIANNE NEVES MANDARINO TORRES, MARIANA 

PARANHOS STELLING, STEVENS KASTRUP REHEN, LUCIANA BARRETO CHIARINI 

Z - 41 THREE-DIMENSIONAL SUGARCANE-BASED SCAFFOLD FOR HUMAN 

MESENCHYMAL STEM CELLS CULTURE MARYANA ROBERTA PEDROSA DIAS, 

BELYSSA SANTOS DE MORAES, ANDRIU DOS SANTOS CATENA, LUANA 

ALBUQUERQUE BARROS, SILVÂNIA TAVARES PAZ, ELIETE CAVALCANTI DA SILVA, 

JOSÉ LAMARTINE DE ANDRADE AGUIAR, PALOMA LYS DE MEDEIROS 

Z - 42 A FLORAL REPRESSOR BROTHER OF FT AND TFL1 (BFT) 

MODULATES FLOWERING INITIATION UNDER HIGH SALINITY IN ARABIDOPSIS JE 

CHANG WOO, JAE YONG RYU, PIL JOON SEO, CHUNG-MO PARK 

123

Author Index 

ABDELHAY ESFW B - 117 

ABRAHAO TB J - 37 

ABRANCHES MV B -48 

ABREU GA U - 9 

ABREU IS H - 16 

ABREU JG B – 221, J – 46, 

N – 42, N - 43 

ABREU LA J - 28 

ABREU RMM S - 3 

ABRUNHOSA VM A - 81 

ACASIGUA GAX Z - 13 

ADACHI P P - 32 

AFONSO RCH B - 194 

AGOSTINHO LA T - 10 

AGOSTINI LP B - 93 

AGUIAR DP N - 33 

AGUIAR JMC N - 51 

AGUIAR JUNIOR O D - 94 

AGUIAR RB B - 250 

AGUIAR TT A - 83 

AIRES MB D – 40, D - 42 

ALBARELLO N U – 35, U - 36 

ALBUQUERQUE AV D - 11 

ALEVI KCC D – 18, D – 113, 

D – 117, D – 

118, D – 124 

ALLODI A T - 4 

ALLODI S F – 3, I - 1 

ALMEIDA ACF R -43 

ALMEIDA CEV B - 3 

ALMEIDA CJG C - 108 

ALMEIDA GS C - 14 

ALMEIDA JC N - 32 

ALMEIDA MES I - 9 

ALMEIDA MF T - 35 

ALMEIDA NK R -69 

ALMEIDA PE V - 9 

ALMEIDA RSC J - 34 

ALMEIDA SL U - 7 

ALMEIDA TF C - 5 

ALMEIDA VR K - 10 

ALONSO GC H - 19 

ALPONTI RF A - 119 

ALVES ALG Z – 15, Z - 38 

ALVES GG E -6, E -9, S – 

22, T - 49 

ALVES HHO A - 84 

ALVES LL C - 70 

ALVES LP I - 7 

ALVES MGCF A - 8 

ALVES NR D - 115 

ALVES RMS L - 1 

AMARAL MGC A - 76 

AMARAL RF B - 97 

AMARAL SS G - 5 

AMBRÓSIO F C – 76, C – 78 

AMMAR D N - 34 

AMORIM R R -48 

ANDRADE HM J - 31 

ANDRADE IR M -1 

ANDRADE JKF B - 180 

ANDRADE LM B - 1 

ANDRADE LO R -9, R -11 

ANGULSKI ABB Z - 23 

ANHÊ ACB S - 9 

ANSELMO TC C - 43 

ANTONIOLI E A - 4 

APOLINARIO LM C - 55 

AQUINO T E -4 

ARAGAO AB J - 40 

ARAGÃO BC T - 25 

ARAN V J - 12 

ARAÚJO AF C - 92 

ARAUJO CB G - 12 

ARAÚJO DAM B – 60, B – 206, 

B – 208, 

ARAUJO EG F – 10, T – 45, T 

-50, T - 64 

ARAÚJO EP C – 115, J - 48 

ARAÚJO FA C – 68, C - 110 

ARAUJO H J - 45 

ARAÚJO HMM N – 19, N - 48 

ARAÚJO HSS B – 98, B – 99, B 

- 157 

ARAUJO JUNIOR ALC B -207 

ARAÚJO JÚNIOR RF B – 94, B - 111 

ARAUJO KCL R -32 

ARAÚJO LCC C - 111 

ARAÚJO MDD B - 195 

ARAÚJO RMS O -4 

ARAÚJO TG B -209, M -9 

ARAÚJO WM B - 76 

ARAÚJO-MARTINS L T - 64 

ARCEGO DM T - 65 

ARCHANGELO LF A - 26 

ARISI ACM U - 32 

ARMELIN HA B – 82, B – 112, 

F – 1, J - 25 

ARMILIATO N D - 61 

ARO AA P - 15 

ARRUDA LB G - 18 

ARRUDA RF B - 158 

ASENSI KD Z - 26 

ASSIS LHC D - 68 

ASSUNÇÃO CLS B - 189 

ASSUNÇÃO FS B - 106 

ATHAYDE RM C - 23 

ATTIAS M R -27, R -29, R - 

35 

ATTIAS M S - 24 

AUGUSTO LMM H - 17 

AUGUSTO LS A - 102 

AUGUSTO TM B - 137 

AVELAR GF D - 140 

AVILA RA R -75 

AYRES R F - 15 

AYUB LC B - 186 

AZEREDO-OLIVEIRA MTV D – 16, D – 18, D 

– 19, D – 20, D – 

21, D – 22, D - 

86 

AZEVEDO CS S - 28 

AZEVEDO EPC C - 75 

AZEVEDO OGR C – 49, R -17 

BACK SH C - 22 

BAHIA D J – 34, R -36 

BALARINI MK D - 31 

BANZATO TP D - 50 

BÁO SN B – 12, B – 15, B 

- 22 

BAPTISTA LS S – 15, Z - 20 

BAPTISTA MS G – 21, S - 18 

BARBOSA AS K - 15 

BARBOSA CRR B - 7 

BARBOSA FAR A - 16 

BARBOSA GO P - 35 

BARBOSA JLP C - 41 

BARBOSA LA B - 44 

BARBOZA TJS U - 35 

BARCELOS LS K - 15 

BARJA-FIDALGO C B – 171, C – 112, 

C - 117 

BARRETO EO C - 92 

BARROS CM A – 12, A – 74, A 

– 78, H – 16, T - 

27 

BARROS LG C - 21 

BARROS LRC C - 83 

BARROS NMT B - 235 

BARROS SBM G - 30 

BARROS TAA I - 3 

BARROS ZAV Q -3 

BASTIANI MA C - 16 

BASTOS IMF R -67, S - 28 

BASTOS NF B - 239 

BATISTA AA A – 64, B - 226 

BATISTA JR M C - 67 

BATISTA JÚNIOR ML F - 26 

BATISTA NV C - 35 

BATISTA TH F - 20 

BATTATASTINI AMO B - 181 

BECKENKAMP A B – 108, B - 153 

BEGNINI KR B - 225 

BEGUELINI MR D - 90 

BEHLING CS D - 57 

BELETTI ME D – 92, D – 121, 

D – 122, D – 

123, D – 125, D 

– 126, R -32 

BELIZÁRIO J B - 184 

BELLINI MH Q -3 

BELTRAN JSO G - 17 

BELUSSO JV C – 84, C - 87 

BENCHIMOL M G – 6, M -1, R -3, 

R -4, R -7, R - 8 

BENFATO MS C – 31 

BENJAMIM CF C – 69, C – 70, C 

– 85, I - 8 

BERALDI EJ T - 43 

BERBERT LR I - 13 

BERNARDES PTT C – 24, C - 25 

BERNARDO PS B - 236 

BERNHARD T E -4 

BERNI MA N - 48 

BERTAGLIA RS A - 31 

BERTOZZI E R -7 

BETTEGA M G - 37 

BEVILACQUA E D – 63, D – 120, 

D - 139 

BIANCALANA A S - 30 

BIANCARDI MF D - 133 

BIASOLI D B - 52 

BIGUETTI CC C - 8 

BINDA NETO I J - 36 

BIRUKOV K J - 2 

BIRUKOVA A J - 1 

BISPO-DA-SILVA LB A - 33 

BITTENCOURT JÚNIOR PIH C - 27 

BIZARRO HDAS C - 107 

BLASIOS JUNIOR V M -10 

BLOISE FFB H - 4 

BOMFIM AMD T - 28 

BOMFIM CCB B - 60 

BOMFIM RS A - 85 

BONATTO D Z – 16, Z - 24 

BONDAN EF T – 53, T - 54 

BONFIM DC J - 30 

BORBA HR B – 2, R -1 

BORDIN DL B - 156 

BORELLA MI A - 98 

BORELLI P G - 17 

BORGES AC Q -5 

BORGES BN B – 195, B – 200, 

O -16, O -17 

BORGES HL B – 52, B – 143, 

C - 93 

BORGES LF P – 27, P - 29 

BOTTAS LS T - 29 

BOURCKHARDT GF N - 34 

BOUZON ZL U – 7, U – 13, U 

– 14, U – 16, U – 

17, U – 24, U - 

27 

BOZZA FA G - 38 

BOZZA P R -68 

BOZZA PT C – 95, C – 97, C 

– 107, C – 108, R 

-61, R -62 

BRACCO PA B - 244 

BRACHER F R -60 

BRAGA CA D - 114 

BRAGA LC O -3 

BRAGA LEG T - 47 

BRAGHIROLLI DI Z - 6 

BRANCO PC I – 5, S - 26 

BRANDT JZ D - 17 

BRASIL GV Z - 22 

BRENO MC J - 10 

BRIE I-C B - 58 

BRINGEL RAR T - 48 

BRITO IRR B - 227 

BRITO MV R -73 

BRITO NETO JM N – 1, N - 50 

BRITO NM B - 171 

BRITO TLA P - 12 

BROHEM CA Z - 27 

BRUNO AN B - 147 

BRUSCO J T - 70 

BUBIK A T-85 

BUENO GCL B - 65 

BUFFOLO MA N - 26 

BUFFON A B – 87, B – 95, B 

– 108, B – 153, B 

- 170 

BURGOS PV T - 52 

BUSATTO FF B - 152 

BUSTAMANTE H T - 52 

BUTTOW NC T - 43 

BUZATO CBC J - 11 

CABRAL FILHO PE S - 19 

CAETANO FH G – 3, L - 1 

CAGNON VHA D – 91, D – 96, D 

– 98, D – 105, D 

- 129 

CAIXEIRO APA A - 18 

CAIXETA DC A - 65 

CALAZA KC T - 60 

CALDEIRA EJ C - 1 

CALDINI EG P - 11 

CALLONI GW A – 16, Z - 23 

CALLONI R Z - 16 

CÂMARA AR N - 45 

CAMARGO KC N - 37 

CAMARGOS DS B - 42 

CAMPOS D T - 12 

CAMPOS JUNIOR PHA D - 72 

CAMPOS LM N - 40 

CAMPOS MRC A - 49 

CAMPOS MS D - 137 

CAMPOS RA U - 30 

CAMPOS SGP D - 51 

CAMPOS SPC R -64 

CAMPOS TA A - 66 

CAMPOS VMA B – 3, B - 14 

CANATTO RA U – 31, U - 34 

CANDIDO NM B - 36 

CANIUGUIR A A - 46 

124

CANO MIN A – 3, A – 35, F – 

18, F - 21 

CANUTO KS B - 20 

CAPITANIO JS B – 71, B - 212 

CAPPELLARI AR B - 181 

CAPUCHO C D - 14 

CARA DC C – 19, C – 34, C 

– 35, C - 39 

CARBALLO CB A – 85, C - 91 

CARDEAL LBS B - 61 

CARDIN LT C - 30 

CARDOSO C B - 249 

CARDOSO LHD J - 22 

CARDOSO MG O -11 

CARDOSO SV B - 11 

CARDOSO VM N - 30 

CARMO ER B - 252 

CARMO LAS A - 89 

CARNEIRO K N - 13 

CARREIRA ACO K - 14 

CARVALHO ACC Z - 22 

CARVALHO ADZ C - 57 

CARVALHO AF T - 56 

CARVALHO AL B - 217 

CARVALHO ALH B - 150 

CARVALHO AM Z - 15 

CARVALHO CR C – 40, C – 43, C 

- 44 

CARVALHO DFF T - 75 

CARVALHO HF A – 36, A – 105, 

B – 137, B – 138, 

E -11, H – 12, I – 

6, P - 35 

CARVALHO JG B - 6 

CARVALHO LA T - 19 

CARVALHO MGC B - 154 

CARVALHO ND G - 36 

CARVALHO RVH R -53 

CARVALHO SC C - 60 

CASALI VVC L - 2 

CASANELLO P A - 46 

CASTELUCCI BG D – 15, D - 131 

CASTRO LM X -8 

CASTRO NFC D - 107 

CASTRUCCI AML A – 120, J - 41 

CATAE AF S - 1 

CATISTI R D - 1 

CATROXO MHB S - 7 

CAVALCANTE LA T - 19 

CAVALCANTI DP S - 14 

CAVALHEIRO GRC N - 35 

CAVALHEIRO RP B - 86 

CECON E C - 105 

CELLA N J – 15, J - 27 

CERRI PS G - 32 

CHAIM OM S - 25 

CHAMMAS R B - 166 

CHAVES CR F - 4 

CHAVES NL B -15 

CHAVES RS T - 42 

CHEDID RA N - 47 

CHEN Y-H B - 5 

CHIARINI LB B – 237, F – 19, 

Z - 40 

CHIELA ECF S - 2 

CHIN-YUAN H G – 1, G - 2 

CHUANG Y-L G - 1 

CHUNG HT C - 22 

CICCONE CC P – 2 

CIPRIANO I N - 10 

CISTERNA AEC P - 4 

CLOUTHIER DE N - 2 

COELHO VM C - 77 

COGO AJD H - 18 

COLANERI GN B - 78 

COLLARES T B - 213 

COLLARES-BUZATO CB F - 8 

COLQUHOUN A B – 177, B - 178 

CONTESINI EA Z - 19 

COOK GP V - 5 

CORDEIRO E C - 17 

CORDEIRO IR N - 4 

CORDEIRO RC T - 56 

CORDEIRO RS N - 21 

CORREA A O -13 

CORREA CL I - 1 

CORRÊA DEC H - 10 

CORRÊA JR B - 172 

CORREA OMT D - 13 

CORRÊA-FEITOSA VL A – 21, A - 22 

CORRÊA-JUNIOR JD A – 107, F – 6, R 

-10, S - 5 

CORREA-NORONHA SAA B - 77 

CORTE ALVA F - 11 

CÔRTE-REAL S A – 97, A - 100 

CORTEZ BA B - 130 

COSSOLIN JFS G - 8 

COSTA AFAF B - 211 

COSTA AGB C - 66 

COSTA ALC 

COSTA BRC I - 2 

COSTA CFP D - 24 

COSTA CGCM B - 182 

COSTA EBO H - 6 

COSTA FLP T - 14 

COSTA GA B - 131 

COSTA GMJ D - 74 

COSTA JP A - 114 

COSTA LJ R -44, R -48, R - 

50, R -58 

COSTA MFD R -13 

COSTA ML H – 5, N - 40 

COSTA MSA A - 112 

COSTA NCS B - 129 

COSTA RA C - 40 

COSTA RMB B - 201 

COSTA SM B – 183, S - 20 

COUTO BHCV R -9 

CRECZYNSKI-PASA TB A – 72, B - 189 

CREMA VO H – 7, T - 58 

CRESTANI T Z - 39 

CRUZ CKF D - 116 

CRUZ CU A – 38, K - 11 

CRUZ MVT T - 38 

CRUZ TA R -29 

CUNHA MS R -58 

CURY GCG R -47 

CUSTÓDIO MR A - 96 D – 107, D 

– 108, D – 113, 

D – 117, D – 

118, D - 124D – 

127, D - 130 

DALMAZ C T – 30, T - 65 

DAL-PAI-SILVA M A – 31, A - 37 

DALPIAN F T - 8 

DAMASCENO EM A – 56, A - 57 

DAMATTA RA A – 83, C – 99, E 

-7, E -8, R -49, R 

-57 

DAMIANI RM B - 204 

DANTAS VWM B - 146 

DAVID LRS B - 12 

DEALMEIDA CE B – 14, B - 17 

DELELLA FK D - 3 

DEZONNE RS T - 72 

DIAMANTE MAS A – 91, B - 197 

DIAS BRS R -71 

DIAS CC Z - 4 

DIAS FCR D - 54 

DIAS G D – 43, D – 64 

DIAS GS K - 8 

DIAS MA B - 132 

DIAS MHS B - 112 

DIAS MRP Z - 41 

DIAS MVS T - 51 

DIAS OFG B - 25 

DIAS RB H - 14 

DIAS RS C - 29 

DIAS SMG B - 57 

DIAS WB B - 45 

DIAZ BL B - 215 

DÍAZ JAM B - 68 

DINIZ CWP T – 11, T - 31 

DINIZ JR JAP R -73 

DINIZ LP T - 59 

DOBRANSKY T T – 23, T - 32 

DOLDER H D – 95, G - 31 

DOLDER MAH A – 60, A – 91, B 

– 197, D – 28, D 

– 29, D - 30 

DOMENICONI RF D - 67 

DONADIO JL B - 45 

DONATTI L A – 67, A - 92 

DORE CMPG B - 67 

DÓRIA JG T - 67 

DREWES CC B - 165 

DUARTE MEL H - 17 

DUARTE ML A - 25 

DUBOC LF A - 56 

DUMAS ML B - 55 

DUPIN E N - 51 

DURANTE AC B - 98 

DURVALE MC M -6 

EL-CHEIKH MC F - 9 

ELLWANGER JH T - 12 

EMRICH LC A - 74 

ESPINDOLA FS A – 58, A – 62, A 

- 65 

ESPOSITO JBN U - 26 

ESPREAFICO EM B – 228, B – 241, 

B -243, B – 247, 

B – 248, B – 249, 

N – 29, Q -5 

ESQUISATTO MAM P – 1, P – 2, P – 

6, P – 8, P – 9, P 

– 13 

ESTRELA MS B - 240 

EVANGELISTA RC C - 51 

FAÇANHA ALO H - 18 

FAÇANHA AR B – 63, B – 131, 

B - 158 

FACCIOLI CK N – 44, N - 49 

FACCIOLI LAP K - 1 

FACINA CH D – 53, D – 86 

FADEL AC T - 26 

FAGANELLO J R -54 

FALCAO VTFL J - 11 

FALEIRO AC U - 32 

FARIA AMC C - 118 

FARIA JAQA O -12 

FARIA NETO HCC C - 74 

FARIA PA G - 16 

FARIA PR B – 18, B - 107 

FARIA TF C - 42 

FARIAS ND B - 62 

FARIAS PS D - 42 

FARNESE FS J – 32, J – 42, U - 

42 

FARO TAS B - 200 

FARSKY SHP B - 165 

FAVARO PMB B - 122 

FÉ AR C - 86 

FEIO DCA B - 238 

FEITOZA F B - 178 

FELBER YT D - 81 

FELICIONI F D – 87, D – 101 

FELIPPE DC N - 31 

FELISBINO SL B – 26, B – 216, 

D - 3 

FELIX RL U - 17 

FÊO HB P - 13 

FERNANDES DC J – 16, S - 21 

FERNANDES KPS C – 21, C – 58, C 

- 62 

FERNANDES LR B - 185 

FERNANDES PCC R -33 

FERRÃO FM V - 6 

FERRÃO PM P - 26 

FERRARI MFR A – 29, T – 13, T 

– 29, T – 35, T – 

42 

FERREIRA AF R -43 

FERREIRA AMR B – 163, B - 164 

FERREIRA AT H - 15 

FERREIRA AVM R -26 

FERREIRA FF N - 39 

FERREIRA FRL B -127 

FERREIRA GJ T - 4 

FERREIRA KBO C - 96 

FERREIRA LC P - 14 

FERREIRA LRL T - 37 

FERREIRA PCG O -18, U - 37 

FERREIRA WAS O -16 

FERREIRA-MACHADO SC B -17 

FERRER VP P - 5 

FERRO ES G – 12, X -1, X -8 

FIALHO MCQ V - 1 

FIERRO IM C - 86 

FIGLIUOLO VR J - 47 

FIGUEIRA SF B - 219 

FIGUEIREDO CC B -127 

FIGUEIREDO DTA R -67 

FIGUEIREDO JB C - 85 

FIGUEIREDO MS J - 43 

FILIPPIN FB B - 214 

FIORE APZP F - 14 

FISCHER-FODOR E B - 58 

FLÁVIO KAPCZINSKI F G - 34 

FLOH EIS U - 30 

FLORIM JC I - 10 

FOCHI RA D - 100 

FOCK RA C - 11 

FOGAÇA E D - 78 

FOGUEL D C – 66, C - 75 

FONSECA AS B -16, B – 20, B – 

31, F - 5 

FONSECA BF J - 46 

FONSECA CG B – 88,T – 18, T 

– 2, T - 25 

FONSECA FL R -28 

FONSECA HLS H - 11 

FONSECA MC T - 3 

FONSECA RC C - 39 

FONSECA WF D - 106 

FONTANETTI CS A - 64 

FONTES A S – 16, S - 19 

FONTES AM H - 6 

FORNI MF Z – 5 

FORTES GB B - 162 

FORTI FL M -4, M -5 

FOSSATI ACM Z - 13 

FRADE PCR A - 111 

FRAGA HPF U – 18, U - 19 

FRANÇA FS B - 29 

FRANÇA LR D – 36, D – 68, D 

– 70, D – 72, D – 

73, D – 74, D 

125

– 80, D – 82, D – 

140 

FRANÇA MM B - 104 

FRANCELIN C A - 5 

FRANCISCO G B - 166 

FRANCISCO JS A - 108 

FRANCO DG C - 100 

FRANCO FO F - 26 

FRANCO RM U - 1 

FRANCO-BELUSSI L C - 2 

FRANK S N - 24 

FRANKE SIR A – 17, A – 32, T 

- 40 

FREIRE NETO CA B - 72 

FREITAS C R -68 

FREITAS EHS O -10 

FREITAS JR B – 151, C - 10 

FREITAS KM A – 60, G - 31 

FREITAS LJA D – 44, D - 46 

FREITAS MAR R -74 

FREITAS SM B - 75 

FREITAS VM B – 73, B – 115, 

B – 168, B - 199 

FRIESLAND A M -2 

FROTA PB T - 46 

FRUET AC G - 30 

FUNCHAL C L - 4 

FUNGARO TP C - 32 

FURLAN AS A - 45 

FURTADO IMA N - 16 

FURTADO RR R -72 

GALHARDO MS P - 11 

GALINDO LT I - 4 

GALLÃO MI U – 1, U – 10, U 

– 2, U – 5, U - 9 

GAMA P A – 1, F – 14, F – 

17, H – 1, J - 39 

GAMEIRO J R -53 

GANDOLPHI LC D - 108 

GARCIA ASG D - 77 

GARCIA E COSTA F D - 93 

GARCIA HC D - 11 

GARCIA MCD H - 8 

GARCIA PMA D - 82 

GARDESANI WKM S - 18 

GARNIQUE ADMB B -192 

GARZONI LR A – 39, P - 26 

GASTARDELO TS B - 41 

GATTASS CR B – 37, B - 38 

GAUTHIER-ROUVIÈRE C J - 6 

GEISSLER K C - 36 

GELALETI GB B - 103 

GENTI-RAIMONDI S A - 55 

GERALDO AHPS P - 32 

GHIZONI H A - 1 

GIANNOTTI KC C - 59 

GICQUEL T A - 79 

GIL CD C - 72 

GIORDANO RJ B – 61, B - 80 

GIROL AP C - 3 

GITIRANA LB A – 108, K - 6 

GOBBO MG A - 63 

GODA M M -13 

GODOY BB J - 8 

GOES AM Z – 28, Z - 37 

GÓES RM A – 63, D – 24, D 

– 41, D – 69 

GOLDENBER RCS K – 1, K – 8, P – 

34, Z – 21, Z – 

26, Z – 30, Z - 35 

GOMES A T - 75 

GOMES AL N – 28, N - 35 

GOMES FCA T – 34, T – 59, T 

– 63, T – 72, T - 

84 

GOMES FILHO SA C - 110 

GOMES FS C - 115 

GOMES GF T - 11 

GOMES JMM F - 6 

GOMES JR B – 151, B – 186, 

B – 252, C - 10, 

N - 37 

GOMES L P - 7 

GOMES LF D - 66 

GOMES MD X -4, X - 5 

GOMES MPSM T - 18 

GOMES PF A - 15 

GOMEZ MV T – 14, T - 68 

GOMEZ RS T - 1 

GONÇALVES BF D - 23 

GONÇALVES CA C - 73 

GONÇALVES GJM B - 107 

GONÇALVES IB A - 26 

GONÇALVES RC J - 16 

GONÇALVES WA C - 79 

GONTIJO JAR N - 14 

GONZAGA ACR D - 32 

GONZÁLEZ A B - 109 

GONZÁLEZ MJ A - 117 

GORJÃO R A - 84 

GÓRNIAK SL S - 23 

GORTZ LW G - 35 

GOSMANN G B -160 

GOTTFRIED C T - 44 

GOULART FILHO LR B – 174, M -9 

GOULART LR B -209 

GOUVEIA C U - 16 

GOZZO EC X -3 

GRANATO AEC A - 59 

GRANJA MG T - 45 

GRANJEIRO JM G – 11, G – 15, S 

- 15 

GREGORIO LS D - 4 

GREMSKI LH X -7 

GRUND LZ J - 9 

GUATIMOSIM C T – 3, T - 38 

GUEDES CES R -63 

GUEDES HG B - 94 

GUEIROS FILHO FJ M -6, M -10 

GUERRA CR R -30 

GUERRA MP U – 11, U – 12, U 

– 15, U – 18, U – 

19, U – 21, U – 

22, U – 33, U – 

40, U - 41 

GUERRA MT D - 55 

GUERRANT RL R -17 

GUIDO BC B - 172 

GUILHERME RF C - 69 

GUILLAUME E J - 6 

GUIMARÃES IM T - 32 

GUIMARÃES LPTPG B - 38 

GUSMAN GS J - 42 

HA KS B - 53 

HACKENHAAR FS C - 31 

HADDAD NF B -66 

HAEMMERLE CAS T - 62 

HAGA RB J - 20 

HAGE AAP A - 116 

HAIFIG I A - 19 

HAJJ G T - 36 

HAMAO K A - 73 

HAN SW K – 3, Q -1, Q -4 

HANSEN HP B - 119 

HATANAKA E A – 44, C - 47 

HAUSEN MA K - 7 

HAYASHI JPM C - 58 

HAYASHI MAF B – 224, B - 251 

HEBLING A P - 7 

HELFER VE Z - 8 

HELUANY CS J - 7 

HENRIQUE BVM B - 242 

HENRIQUES F C - 67 

HENRIQUES JAP B – 156, B – 173, 

C – 4, F - 11 

HENRIQUES MG C - 109 

HENRIQUES MGMO R -52 

HERINGER AS U – 11, U - 12 

HERLINGER AL B – 85, B - 232 

HERNANDES L R -22, R -23 

HETZL AC D - 91 

HILL LJ U - 39 

HIRAIWA SH D - 104 

HIRAKI KRN B - 175 

HIRATA CL J - 27 

HOFMANN JUNIOR AE A – 68, D - 103 

HOLLMANN G F - 3 

HOSCH NG F - 22 

HOSOYA H A – 73, A – 75, 

M -7 

HOTTZ ED G - 38 

HROMAS R B - 56 

HUMMEL LAB T - 49 

IAMONTE M A - 48 

IERARDI DF B - 49 

IGLESIA RP T - 74 

IKEDA ET T - 71 

INTROÍNI GO D - 52 

IONTA M F - 20 

IONTA M F – 22, F – 27, H 

- 10 

IRION CI Z - 35 

ISER IC Z - 33 

JACKSON K S - 13 

JACOB CRO L - 7 

JAEGER MC B - 196 

JAEGER RG B – 74, B – 125, 

B – 167, B - 220 

JAMUR MC A – 28, A – 49, R 

-25 

JASIULIONIS MG B – 30, B – 49, B 

- 78 

JASIULIONIS MG J – 19, O -8, O - 

9, O -15 

JESUS LWO A - 98 

JIMÉNEZ-GARCÍA LF A - 118 

JOANITTI GA B - 75 

JOAZEIRO PP D – 12, D – 15, D 

– 131, P - 17 

JONATHAN GS R -40 

JORGE EC N - 15 

JUSTO GZ B – 148, B - 190 

KAJISHIMA AL N - 42 

KALDIS P F - 16 

KANG KR J - 13 

KANNO TYN N - 29 

KATO KC R -10 

KATZ SG D - 88 

KAWAHARA R B - 176 

KAWALL HG A - 13 

KEDE J J - 14 

KEMPINAS WG D – 49, D – 50, D 

- 55 

KERKIS I B – 251, K - 5 

KIDO LA D - 98 

KIM S-M A - 20 

KIOKA N B - 96 

KIPPER FC A - 69 

KISAKI MK G - 27 

KLAMT F B – 29, B – 149, 

H – 13, T - 69 

KOBARG J A – 45, J – 5, J – 

8, J - 21 

KOBUS K N - 46 

KONDO T A - 75 

KOS L N - 36 

KRAUSE LMF B - 179 

KREBSBACH P A - 67 

KREUSCH MG U - 27 

KRUEGER B C - 36 

KUHNE F A - 105 

LABRIOLA L G - 7 

LACERDA JZ B - 83 

LACERDA SMSN D - 73 

LACERDA TCS B - 222 

LACOUTH P A - 96 

LADEIRA LO Z - 17 

LADISLAU T B - 198 

LAGENTE V A – 79, A - 80 

LAH TT Q -2 

LAMERS ML B – 25, B – 110, 

E -10 

LAMIM T N - 11 

LAMPERT C T - 66 

LANCELLOTTI M R -20, R -42, R - 

46, R -47 

LANDIM BC M -8 

LANGHI LGP C - 77 

LARA NLM D - 70 

LARANJO LT A - 50 

LAUAND C B - 113 

LAURA SIMON L K – 12, K - 13 

LAURINDO FRM A – 71, I – 7, J – 

24, J – 37, S - 21 

LAUS AC B - 217 

LAZARI MFM D – 109, J - 29 

LAZARINI M J - 4 

LAZAROTTI MP B - 33 

LE DIAGON MMRQ J - 10 

LE DOUARIN N N - 33 

LEAL CS V - 8 

LEAL L B - 245 

LEÃO PEL V - 4 

LEDUR PF B - 40 

LEE CS J - 13 

LEIGUEZ E C - 104 

LEIMGRUBER C C - 6 

LEITÃO A B - 56 

LEITÃO RFC B - 133 

LEITE EL A – 8, B - 67 

LEITE GB D - 2 

LEITE JCA N - 7 

LEITE MF B – 1, F - 4 

LEITE RP D – 28, D - 30 

LEME AFP B – 176, J - 40 

LEMOS MS D - 92 

LENZ G B – 23, B – 40, B 

– 89, B – 218, S - 

2 

LEÓDIDO ACM N - 17 

LEONARDO AMC A – 19, A - 50 

LEPLETIER A I - 12 

LEYTON BJK O -14 

LIMA ABA E -8 

LIMA ACC D - 21 

LIMA AM I – 12, R -56 

LIMA C J - 9 

LIMA EM O -1 O -2 O -4 

LIMA FRS B – 88, B – 90, B 

- 97 

LIMA GB R -62 

LIMA GDA D - 34 

LIMA LPO R -24 

LIMA MA B - 115 

LIMA MS B - 173 

LIMA NS A - 52 

126

LIMA PDL B - 238 

LIMA PHS B - 191 

LIMA TC B – 121, T - 57 

LIMA TDFA F - 23 

LIMA THA R -54 

LIMA VM B – 2, R -1 

LIMA WS R -19 

LIMA-SALGADO TM C - 32 

LINHARES ABR H - 9 

LINO-NETO J A – 18, D – 39, D 

– 43, D – 64, D – 

66 

LINS MP A - 30 

LINS U V - 4 

LISBOA PC A – 52, T – 73, T 

- 79 

LISONI FCR C - 30 

LIZ RD U - 33 

LOBATO S B - 54 

LOBBA ARM B - 70 

LOGULLO C A - 99 

LOMBELLO CB E -3 

LONGHI MT J - 15 

LOPES AA C - 101 

LOPES AG B - 132 

LOPES DV C - 54 

LOPES FM T - 69 

LOPES JR B - 100 

LOPES KAR A - 7 

LOPES MH B – 43, T - 74 

LOPES TS G - 15 

LÓPEZ-LOZANO JL X -10, X - 9 

LORENCINI M Z - 27 

LORENCINI RM D - 129 

LORENZI VCB A - 23 

LORENZON AR D - 120 

LOTFI CFP B - 104 

LOTUFO CMC T - 57 

LOURENÇO ES S - 22 

LOURO ID B – 92, B - 93 

LOWE J J – 22, V - 6 

LU Q M -2 

LU Z B - 5 

LUCAS JZ R -65 

LUCENA SV J - 33 

LUNA MS B – 81, J - 3 

MABUCHI I M -13 

MACCHI BM C - 99 

MACEDO DS T - 55 

MACHADO ACL A - 90 

MACHADO CF T - 33 

MACHADO CM D - 67 

MACHADO DE C - 61 

MACHADO JR J B - 219 

MACHADO SM G - 10 

MACHADO-SANTELLI GM A – 10, B – 113, 

B – 130, N - 18 

MADEIRA LF T – 9, Z - 1 

MADEKUROZWA M MC -3 

MADI-RAVAZZI L A - 95 

MAGRINI TD A - 2 

MAI C A - 17 

MAIA RC B – 140, B - 236 

MALASPINA O L – 6, L – 7, S - 1 

MALDONADO CA B – 21, C - 6 

MALDONADO IRSC R -15, R -16 

MALPARTIDA HMG B - 245 

MALTA JCO A - 121 

MANCINI K A - 51 

MANCINI KC A - 57 

MANFIOLLI AO X -5 

MANGOLIN JF Z - 18 

MANHÃES AC T - 83 

MANSANO ESB R -22, R -23 

MANSANO RAW G - 7 

MARANGON CG B - 135 

MARÇAL LN B – 51, S - 12 

MARCELINO RC D - 106 

MARCIANO RS B - 31 

MARCONDES PG B - 50 

MARCUZZO S T – 76, T – 77, T 

- 78 

MARDONES GA V - 7 

MARGIS MMANP U - 25 

MARIA-ENGLER SS P – 30, J – 20, P 

- 19 

MARIA-ENGLER SS B - 214 

MARIANO LIF D - 126 

MARIN MT T - 61 

MARKUS RP C – 100, C – 105, 

C - 113 

MARQUES CAB N - 11 

MARQUES IC T - 55 

MARQUES MB B - 123 

MARQUES MF A - 94 

MARQUES MJ A – 47, C – 55, C 

- 60 

MARQUES MR T - 77 

MARQUES PE C - 15 

MARQUES SA Z - 31 

MARQUES-SANTOS LF D - 10 

MARQUES-SANTOS LFM L - 3 N - 7 N - 12 

N - 8 N - 9 

MARRIEL NB S - 9 

MARTIN PKM Q -4 

MARTINATTI CK G - 14 

MARTINELLI PM R -11 

MARTINEZ AMB T - 22 

MARTINEZ PAM N - 41 

MARTINHO OCL B – 9, B – 10, B - 

19 

MARTINS AAB R -41 

MARTINS AB P - 34 

MARTINS ACA A - 88 

MARTINS AF N - 15 

MARTINS AMC G – 22, G - 26 

MARTINS CM A - 62 

MARTINS CS M -11 

MARTINS DFC A - 12 

MARTINS FA A - 53 

MARTINS FF D - 9 

MARTINS GF N - 17 

MARTINS GVF B – 206, B - 208 

MARTINS L P - 23 

MARTINS MFM T - 53 

MARTINS MR C - 114 

MARTINS NF Z - 29 

MARTINS PR C - 9 

MARTINS PR T - 7 

MARTINS RAP N – 20, N - 28 

MARTINS TMM Z - 28 

MARTINS TVF R -18 

MARTINS VR B – 43, B – 116, 

B – 222 

MARTINS VR T – 33, T – 36, T 

– 39, T – 41, T - 

51 

MARTINS WK G - 19 

MASCHIO DA F - 7 

MASSOTO TB Z - 31 

MATIAS ICP T - 34 

MATIAS MS X -6 

MATOS AV C - 25 

MATOS DG B - 143 

MATOS NS B - 187 

MATSUBARA FH A - 103 

MATSUMOTO MA C - 8 

MATSUMURA CY A - 47 

MATTA SLP D – 25, D – 26, D 

– 31, D – 85, D – 

89, D – 134, D 

- 135 

MATTE U A – 38, K – 11, K 

– 12, K – 13 

MATTOS RM A - 6 

MAYA-MONTEIRO CM B – 239, C - 14 

MAYORAL EE C - 1 

MAZUCATOC VM A - 24 

MAZZI DPSL B - 228 

MEDEIROS J-VR C – 37, C - 38 

MEDEIROS PL Z - 41 

MEDINA BNSP T - 27 

MEISSNER GO A – 61, S - 25 

MELISO FM O -8 

MELLO AA A - 78 

MELLO CLO B - 237 

MELLO CP G - 13 

MELLO HF Z - 19 

MELLO JC G - 24 

MELLO PA B - 87 

MELLO-COELHO V H – 4, H – 11, T – 

82, Z - 32 

MELO AC C - 88 

MELO CFV O -1, O -2 

MELO CM A - 34 

MELO EN D – 54, D – 119, 

D – 132 

MELO FP C - 7 

MELO KCM R -34 

MELO RAM B - 161 

MELO RCN A – 89, C – 96, G 

- 33 R -55 

MELO RRS P - 33 

MELO TQ A - 29 

MENDES SP D - 65 

MENDES-DA-CRUZ FS B - 134 

MENDEZ-OTERO R K – 16, T - 28 

MENDONÇA FAS P - 10 

MENDONÇA LM R -50 

MENDONÇA PP D - 20 

MENDONÇA RZ G - 36 

MENESES GCM G - 22 

MENEZES GB C – 15, C – 28, C 

– 102, G - 5 

MENI AZ S - 23 

MERLO S T – 15, T - 16 

MERMELSTEIN CS A – 81, H – 2, H 

– 3, N - 26 

MESQUITA LV E -5 

MESQUITA-FERRARI RA C – 41, C - 56 

METZ C B - 109 

MIDLEJ VVP R -3 

MIETTO BS T - 22 

MIMURA KK C - 89 

MIRAGLIA SM D – 6, D - 8 

MIRANDA A G - 4 

MIRANDA DC D – 85, D – 89, D 

– 134, D - 135 

MIRANDA F B - 221 

MIRANDA MASP B - 133 

MIRANDA NF B - 68 

MIRANDA-ALVES L B -66 

MISSASSI G D - 49 

MOLINA RAS B -243 

MOLOGNONI F B - 30 

MOLZ P A – 32, T - 40 

MONESI N N - 16 

MONTE SM C - 91 

MONTE-ALTO COSTA A C – 5, C - 12 

MONTEIRO AC O -9 

MONTEIRO EC V - 2 

MONTEIRO JC A - 51 

MONTEIRO NS O -5 

MONTEIRO VA B - 188 

MONTENEGRO RC B - 234 

MONTICO F D - 96 

MORAES AS A – 54, N – 23, O 

-7 

MORAES CA T - 63 

MORAES GV R -27 

MORAES IB A - 58 

MORAES JA C - 112 

MORAES JZ B – 250, C - 63 

MORAES MNCM J - 41 

MORAES VWR G - 23 

MORAIS AS O -15 

MORAIS BP K - 5 

MORAIS DB D – 25, D – 26, D 

- 27 

MORANDI FILHO R D – 123, D - 127 

MORANDI V B - 146 

MOREIRA CPS B - 7 

MOREIRA JE T – 70, T – 71, T 

– 15, T – 16, T - 

17 

MOREIRA MP Z - 3 

MOREIRA RJP B - 79 

MORGADO-DÍAZ JA B – 50, B – 72, B 

– 76, B – 79, B - 

191 

MORITA M M -7 

MOROZ A B - 26 

MORRIS EAR H - 5 

MORTARA RA R -2, R -36 

MOSCARDINI F B - 105 

MOTOYAMA AB B - 187 

MOTTA CM A - 90 

MOTTA LL H - 13 

MOTTA MCM A – 88, F – 25, F 

- 13 

MOURA DJ U - 8 

MOURA EG B -207, J - 43 

MOURA GEDD J - 26 

MOURA NETO V A – 106, B – 69, 

B – 106, B - 194 

MOURA RS B -24 

MOYSÉS GR B - 148 

MÜLLER CB C - 16 

MÜLLER YMR D – 61, N – 30, N 

– 39, N – 46 

MURATA GM C - 47 

NADER HB B – 86, J - 26 

NAGAI MA B - 193 

NAGAO PE R -59 

NAKAMA KK C - 103 

NAKAYAMA ABS T - 17 

NASCIMENTO AR J - 29 

NASCIMENTO J B - 95 

NASCIMENTO LF R -8 

NASCIMENTO LPS D - 94 

NASCIMENTO NG C - 80 

NASCIMENTO RD T – 5, T - 6 

NASCIMENTO SC B - 223 

NASCIUTTI LE A – 6, A – 77, B – 

8, B – 105, C – 

65, P - 18 

NATALI MRM T - 20 

NAVA A D - 138 

NAVES TB T - 31 

NAZARENO A E -1 

NAZARI EM N - 38 

NDREWS NW V - 9 

NEGRI E C - 73 

NEILSON AL V - 5 

NEIVA M B - 224 

NETTO CA G – 29, K - 4 

NETTO FSF J - 23 

127

NEVES FMO N - 10 

NEVES LMG P - 10 

NEVES MM D – 33, D - 34 

NEVES RL B - 235 

NICOLAU LAD C – 37, C - 38 

NIERO ELO B -192 

NISHAN U A - 42 

NISIMURA LM A - 39 

NITÃO ETGR N – 9, N - 12 

NOBRE LTDB B - 139 

NOCE BPD A - 99 

NOCITI JUNIOR FH P - 23 

NOGUEIRA-MACHADO JA J – 18, J - 23 

NORMANN CABM L – 2, L - 4 

NOVAES RD R -15, R -16 

NUNES MCOF N - 13 

NUNES PR C – 27, F - 16 

NUNES VS A - 3 

NUÑEZ CEC J - 48 

NUSSENZVEIG HM S - 8 

OGIAS D F - 17 

OKADA FK D - 8 

OLALLA-SAAD S B – 122, B – 126, 

J - 4 

OLIANI SM B – 41, B – 83, C 

– 3, C – 52, C – 

71, C - 89 

OLIVA MLV B – 91, B - 136 

OLIVA SU D - 6 

OLIVEIRA AC R -38, R -64 

OLIVEIRA ACBF A - 106 

OLIVEIRA ADPR S - 16 

OLIVEIRA APS A - 22 

OLIVEIRA C C – 2, D – 2, D - 

4 

OLIVEIRA CA D – 32, D – 47, D 

– 48, D – 75, D – 

7 6 

OLIVEIRA CB B -160 

OLIVEIRA CFA D - 36 

OLIVEIRA CJL J - 28 

OLIVEIRA DC C - 11 

OLIVEIRA EG B - 8 

OLIVEIRA EM U - 38 

OLIVEIRA F X -2, X - 6 

OLIVEIRA FC R -74 

OLIVEIRA FP N - 43 

OLIVEIRA JA J - 32 

OLIVEIRA JC S - 3 

OLIVEIRA JG D – 104, M -8 

OLIVEIRA JS D - 132 

OLIVEIRA JSS R -40 

OLIVEIRA LL B -48, B – 129, S 

- 12 

OLIVEIRA LP P – 36, P - 37 

OLIVEIRA ML E -11 

OLIVEIRA MP B - 220 

OLIVEIRA PF Z - 29 

OLIVEIRA PT H – 19, M -11 

OLIVEIRA RB F - 8 

OLIVEIRA RJS B - 19 

OLIVEIRA RL D - 76 

OLIVEIRA RR C - 65 

OLIVEIRA SBP H - 12 

OLIVEIRA SKM C - 106 

OLIVEIRA VA B - 149 

OLIVEIRA VCC Z - 30 

OLIVER C A – 23, A - 24 

ORIÁ RB C – 49, C – 50, C 

– 51, T - 46 

ORNELAS IM T - 80 

ORTOLANI-MACHADO CF D - 78 

OSAKI JH M -4 

OSAKI LH G – 14, J - 39 

OSORIO LKP U - 13 

OTA CCC G – 35, G - 37 

OURIQUES LC U – 23, U – 28, U 

- 38 

PAÇÓ-LARSON ML A – 11, A – 14, A 

– 15, A - 27 

PADRÃO JC R -49 

PÁDUA TA C - 64 

PAFFARO AMA D – 84, D – 87, D 

– 101, D – 102, 

D – 111, D - 114 

PAFFARO JUNIOR VA D – 35, D – 56, D 

– 62, D - 81 

PAIVA CAL T - 10 

PAIVA PMG C - 111 

PALLADINO MV B - 190 

PALUDO KS R -45 

PANZETTA-DUTARI GM A - 55 

PAOLI F B -16 

PAPA MP G - 18 

PAREDES BD A - 94 

PAREDES-GAMERO EJ G – 4, Z - 4 

PARISE CB C - 63 

PARK C-M Z - 42 

PARK H-S A - 20 

PARREIRA GG A - 43 

PASSOS JL D - 84 

PASSOS LAC D - 105 

PATRICIA PRANKE P Z – 6, Z – 7, Z – 

8, Z – 10, Z – 9, Z 

– 11, Z – 12, Z – 

14, Z – 39 

PAUL AL F - 12 

PAULA ACC Z - 37 

PAULA CAA B - 136 

PAULA JUNIOR R C - 72 

PAULA SO C - 29 

PAULSEN BS Z - 36 

PAZ AHR Z - 25 

PECLI E SILVA C I - 8 

PEDREIRO MRD A - 92 

PEDRO AN B – 13, H - 15 

PEDROSA CSG G - 11 

PEIXOTO AR D - 99 

PEIXOTO BC O -18 

PELAJO-MACHADO M N – 41, N - 22 

PENNACCHI PC P - 19 

PENTEADO MV P - 9 

PERDE-SCHREPLER M B - 59 

PEREIRA BF G - 3 

PEREIRA CG B - 247 

PEREIRA CN P - 22 

PEREIRA DA B - 144 

PEREIRA DT U - 23 

PEREIRA EMR T - 68 

PEREIRA GB A - 11 

PEREIRA JAL A - 113 

PEREIRA JRCS B - 34 

PEREIRA LA T - 9 

PEREIRA LX A - 43 

PEREIRA MC D - 5 

PEREIRA MJB G - 8 

PEREIRA MLG D - 93 

PEREIRA NP D - 22 

PEREIRA RFC R -46 

PEREIRA RVS C - 34 

PEREIRA VS L - 5 

PEREIRA-NEVES A R -4 

PERERIA NP D – 16, D - 19 

PEREZ AM F - 21 

PEREZ APS D - 128 

PEREZ DA C - 19 

PEREZ MO P - 16 

PERINI VR D - 71 

PEROTTI TL P - 8 

PERUQUETTI RL D - 83 

PESSOA AFM C - 90 

PETTENUZZO LF T - 30 

PFAFFENSELLER B G - 34 

PIAZZA FV T – 76, T - 78 

PIECHNIK CA A - 13 

PIEDADE WP A - 37 

PILATTI FK U - 20 

PIMENTA MT D - 109 

PIMENTEL ER P – 15, P – 16, P 

– 28, P – 36, P – 

37 

PINHAL MAS A – 34, P - 20 

PINHATTI AV B - 64 

PINHEIRO APB D – 60, D - 79 

PINHEIRO CR T - 73 

PINHEIRO NM H - 7 

PINHEIRO PFF Z - 2 

PINHO CF D - 37 

PINHO V C – 13, C – 18, C 

– 79, C – 81 

PINTO JS B - 169 

PINTO ME D - 69 

PINTO MT J - 19 

PINTO NCS A - 87 

PIRES BRB B - 117 

PIRES DA C - 28 

PIRES NPMD N - 19 

PIZZATTI L B - 65 

PIZZOL JÚNIOR JP G - 32 

PLIEGO CM B - 163 

POEYS SC R -44 

POITOU C C - 114 

POLON L N - 50 

POLTRONIERI AB C - 52 

PONTES B S - 8 

PONTES CLS B - 157 

PORCIONATTO MA A – 59, I – 3, I - 4 

PORTILHO NA N - 22 

PÔRTO LCMS C - 101 

PORTUGAL CC C - 78 

POSER GV B - 64 

POSSIDONIO ACB H - 2 

POSSUELO L O -6 

POZZI R F - 2 

PRADO JL A - 93 

PRADO KM D - 63 

PRADO LCS A - 33 

PRADO PF R -70 

PRADO PS D – 58, D - 59 

PRECUP C B - 59 

PREDES FS D - 95 

PRETA CMCC F - 25 

PRIOR I J - 12 

PROCÓPIO MS A - 107 

PRUSCH DS B - 155 

PRZEPIURA TCS G - 9 

PUGA CCI D - 7 

PULEGIO M D - 41 

PUTTI JS D - 57 

QUEIROZ AC B - 145 

QUEIROZ FR R -12 

QUEIROZ MS A - 27 

QUINTANA CYP P - 18 

QUINTÃO JLD C - 102 

QUINTAR AA B - 21 

QUINTILIANO K Z - 11 

QUONDAMATTEO F B - 119 

RABELO K S - 20 

RABELO SM P - 29 

RABINOVITCH M R -21 

RACHID CVM B - 134 

RAHAL P B – 35, B - 36 

RAMÃO A B - 248 

RAMOS AB K - 16 

RAMOS BCR A - 120 

RAMOS CA A - 122 

RAMOS GOR P - 25 

RAMOS MSC C – 45, C – 46, C 

– 103 

RAMOS RGP A - 112 

RAMOS TCP A - 101 

RANGEL LBA B – 85, B – 198, 

B – 232 

RAPOZO-YOUNES V T - 79 

RASIA-FILHO A T - 8 

RAULINO JCN A – 121, A – 122 

REAL FRO R -2 

REBELATO HJ D - 1 

RECCO-PIMENTEL SM D - 52 

REGO EM B - 179 

REGO LNAA A - 95 

REHEN SK Z - 36 

REIS AC C - 18 

REIS CF B - 102 

REIS DD T – 5, T – 6, T - 7 

REIS DDA C - 9 

REIS IDG S - 17 

REIS INRS U - 31 

REIS MC C - 42 

REIS PA C - 74 

REIS RM B – 9, B - 10 

RENNER GDR U - 15 

RESENDE VTR K - 2 

REZENDE BM C - 81 

REZENDE KF A - 115 

REZENDE-TEIXEIRA P N - 18 

RIBAS VT F - 19 

RIBEIRO AAGFC V - 2 

RIBEIRO AF V – 3, V - 8 

RIBEIRO AHR N - 1 

RIBEIRO DA B – 6, F - 2 

RIBEIRO DL D - 38 

RIBEIRO FILHO AC B - 13 

RIBEIRO FILHO J C - 95 

RIBEIRO FM T - 67 

RIBEIRO HJ S - 5 

RIBEIRO JA A - 35 

RIBEIRO JU B - 226 

RIBEIRO LHG D - 29 

RIBEIRO LM C - 116 

RIBEIRO NM X -1 

RIBEIRO PC G - 25 

RIBEIRO RR A - 36 

RIBEIRO VMA R -19 

RICARDI LR A - 10 

RIEDERER I I – 11, P - 31 

RIEGER A S - 27 

RIETDORF JM S - 29 

RINALDI JC B - 216 

RIVAROLI L R -65 

RIVAROLI L R -75 

RIVERO ERC P - 25 

RIZZO E D – 44, D – 46, D 

– 58, D – 59, D – 

60, D – 71, D – 

79, D - 116 

ROBBS BK G – 39 

ROBERT AW Z - 34 

ROCHA CB E -5 

ROCHA GG B - 37 

ROCHA HAO B - 139 

ROCHA LO D - 125 

ROCHA SC B - 44 

ROCHAEL NC R -37 

RODARTE RS B – 205, B – 227 

RODRIGUES AA J – 38, R -31 

RODRIGUES APD A - 109 

128

RODRIGUES BR B - 116 

RODRIGUES C K - 9 

RODRIGUES FV A - 66 

RODRIGUES HA T - 2 

RODRIGUES HF N - 23 

RODRIGUES HF A - 54 

RODRIGUES JCF A - 93 

RODRIGUES LP K - 4 

RODRIGUES MD B - 223 

RODRIGUES ML R -28 

RODRIGUES PC B - 28 

RODRIGUES PMGRS N - 20 

RODRIGUES T G – 16, G – 20, G 

– 23, G – 24, G – 

25, G - 27 

ROESLER R B – 4, B – 155, B 

– 196, B – 230, B 

– 231, K - 10 

ROMAN SS A – 68, C – 84, C 

– 87, D – 103, D 

– 138 

ROMANA-SOUZA B P – 3, P - 12 

ROMÃO LF B - 128 

RONDON AMR B - 159 

ROQUE NR R -61 

ROSA AR Z - 10 

ROSA AS P - 3 

ROSA HT C – 4, O -6, U - 8 

ROSA VS D - 12 

ROSAS EC C - 64 

ROSI MID H – 14, J – 30, N 

- 4 

ROSS BH V - 7 

ROSSI A K - 7 

ROSSI MID B – 159, B – 211, 

C – 54 

ROSSI PIVA MB P - 20 

ROZENTAL S A – 82, R -30 

RUANO RM D - 62 

RUIZ AC K - 2 

RUIZ RC R -34 

RUIZ TRG B - 212 

RUMJANEK VMBD B – 47, B – 55 

SABA GT D - 13 

SABATINO ME F - 12 

SABINO PM B - 215 

SADDI TM D - 110 

SAEZ RC B - 57 

SAFFI J B – 152, B – 202, 

B – 203, B – 204, 

B – 233 

SAITO A J - 21 

SALDANA-CABOVERDE A N - 36 

SALES CF D - 112 

SALGADO LT U - 39 

SALLES ESL D - 56 

SALLES GN B - 84 

SAMPAIO MC C - 53 

SANCHES BDA A - 104 

SANCHES D R -38 

SANGIULIANO B B - 184 

SANT’ANA FILHO M B - 150 

SANT’ANNA C U - 6 

SANTANA DB B - 170 

SANTANA MAN B - 229 

SANTANA PT C - 94 

SANTOS AA T - 47 

SANTOS AB R -13 

SANTOS ABG C - 33 

SANTOS ACV A - 9 

SANTOS AMF C - 50 

SANTOS AO I - 11 

SANTOS BS S - 6 

SANTOS CA B - 246 

SANTOS CLP A - 100 

SANTOS DC D - 77 

SANTOS DO B - 175 

SANTOS DS C – 98, Z - 21 

SANTOS E SILVA SV D - 122 

SANTOS EM D - 48 

SANTOS ESJ B - 47 

SANTOS EV T - 24 

SANTOS FCA D - 110 

SANTOS HB A – 41, A – 76, D 

– 112, D - 115 

SANTOS HCP D - 39 

SANTOS IGD N - 25 

SANTOS JMCO B - 63 

SANTOS JMP C - 61 

SANTOS JN F - 5 

SANTOS JR AR A – 2, E -3 

SANTOS JS C - 12 

SANTOS LL C – 118, L - 3 

SANTOS LM B - 99 

SANTOS LPB A - 82 

SANTOS MA R -33 

SANTOS MB O -17 

SANTOS MF C - 90 

SANTOS MF I – 9, I - 10 

SANTOS MM D - 47 

SANTOS MO D - 27 

SANTOS MR F - 7 

SANTOS MRV A - 9 

SANTOS MT P - 30 

SANTOS NF G - 21 

SANTOS PCF A - 40 

SANTOS RS D – 111, R -59, U 

- 2 

SANTOS RT T - 83 

SANTOS TCP R -35 

SANTOS TG T - 39 

SANTOS TM A – 71, D - 97 

SANTOS VM G - 20 

SANTOS VT A - 87 

SANTOSS DS Z - 9 

SARAIVA EM J – 35, R -37 

SARAN PS B - 39 

SARNO EN L - 5 

SASSI FA B - 4 

SASSONE-CORSI P D - 83 

SAVINO W C – 83, I – 13, P - 

31 

SCABORA JE N - 14 

SCARANO WR D – 17, D – 37, D 

– 45, D – 97, D – 

99 

SCARDUA PMS B - 62 

SCHECHTMAN D A - 25 

SCHENKMAN S A – 101, A – 102 

SCHER CR Z - 7 

SCHERHOLZ PLA D - 88 

SCHICHOR CH Q -2 

SCHMIDT EC U – 24, U – 14, U 

- 28 

SCHNEIDER N Z - 25 

SCHOFFEN JPF E -1, E -2, T - 20 

SCHULTZ TH P - 27 

SCHULTZE E B - 213 

SCHUNEMANN M U - 25 

SCHUPBACH G J - 45 

SCREIBER AZ S - 30 

SCUDELER EL Z - 2 

SEABRA SH R -24 

SEDMAK B T- 85 

SEGURA-VALDEZ ML A - 118 

SEIXAS FK B - 225 

SEONG-HO J J - 17 

SERACHI FO B - 177 

SERRÃO JE N – 3, V - 1 

SERVATO JPS B - 11 

SEVERI-AGUIAR GDC D - 14 

SHIMABUKURO MK T – 82, Z - 32 

SHINOHARA EMG O -5 

SIGNORETTI PVP Z - 1 

SILVA AA R -51 

SILVA AAN D - 119 

SILVA ACS B - 142 

SILVA AH A - 72 

SILVA AN C - 13 

SILVA AO B – 114, B – 218 

SILVA AP B - 120 

SILVA AR D - 136 

SILVA ASF K - 6 

SILVA BH B - 205 

SILVA BJM R -66 

SILVA CG A - 97 

SILVA CJ J – 31, U - 42 

SILVA CL B - 101 

SILVA CM T - 13 

SILVA CV A – 40, A – 53, J 

– 38, R -31, R - 

39, R -51, R -70 

SILVA DC E -9 

SILVA DD B - 140 

SILVA DF B -24 

SILVA DJ N - 27 

SILVA DM T - 61 

SILVA DRA G - 6 

SILVA EAM R -14, R -18 

SILVA EL J - 25 

SILVA EML V - 10 

SILVA EO A – 109, A - 111, 

A - 113, A - 114, 

A – 116, M -12, 

R -66, R – 72, U - 

10 

SILVA ERM X -3 

SILVA FBF B - 164 

SILVA FG C - 45 

SILVA FILHO ACC B - 27 

SILVA FP B – 240, B – 242, 

O -12 

SILVA FR T - 23 

SILVA GAB N – 25, S - 17 

SILVA GET M -5 

SILVA GF F - 9 

SILVA GHC D - 75 

SILVA GM F - 10 

SILVA IDCG B – 77, B – 246, J 

– 14, J – 36, O - 

10 

SILVA JAF I - 6 

SILVA JG B - 82 

SILVA JH A - 77 

SILVA JPV C - 26 

SILVA JR FP B - 28 

SILVA JRMC A – 115, B – 120, 

B – 121, I – 5, S - 

26 

SILVA JÚNIOR RMP B - 161 

SILVA KA B - 32 

SILVA KEF A – 110, E -12 

SILVA KR Z - 20 

SILVA LCF P - 14 

SILVA LLP V - 10 

SILVA LLR R -57 

SILVA LM B – 27, B – 33, C 

- 7 

SILVA LM O -3, R -12, R -5, 

Q -1, R -6, S – 

10, Z - 3 

SILVA LS T - 84 

SILVA MA D - 136 

SILVA MBB A - 44 

SILVA MCC B - 91 

SILVA MMM P - 17 

SILVA MRD O -11 

SILVA MS F - 18 

SILVA MT C - 56 

SILVA NETA HL D - 10 

SILVA NM R -41 

SILVA NS G – 10, Z - 18 

SILVA PCM U - 5 

SILVA PF N - 6 

SILVA RB T - 60 

SILVA RC C – 94, C – 116, J 

- 47 

SILVA RF A - 41 

SILVA RJ D - 5 

SILVA RR B - 241 

SILVA RRP M -12 

SILVA SA D - 38 

SILVA SG N - 8 

SILVA SV B – 73, C – 117 

SILVA TA B - 168 

SILVA TG B – 180, C – 106 

SILVA TKA X -2 

SILVA TM T - 81 

SILVA TP G - 33 

SILVA VMM B – 114, B – 118, 

B – 185, B – 201 

SILVA WLB H - 9 

SILVA-NETO A R -5, R -6 

SILVEIRA BS B - 110 

SILVEIRA GF B - 147 

SILVEIRA LTR D - 45 

SILVEIRA MS F - 23 

SILVEIRA NM U - 34 

SILVEIRA PF A - 119 

SILVEIRA-LACERDA EP B - 210 

SILVESTRIN RB T - 44 

SIQUEIRA AS B – 125, B – 167 

SIQUEIRA EE B - 141 

SMAILI SS G - 13 

SMANIOTTO S 

SMANIOTTO S A – 30, P – 21, P 

– 24, P – 33 U - 

29 

SMITH RKW Z - 38 

SMUCZEK B B - 74 

SOARES BM B – 234, U - 4 

SOARES CP 

SOARES CP A – 7, B – 84, B – 

141, B – 142, B – 

182, B – 183, H - 

3 

SOARES FA B - 39 

SOARES FAF S - 4 

SOARES FLF U – 40, U - 41 

SOARES HM L - 6 

SOARES JM B - 128 

SOARES MAM G - 9 

SOBRINHO MF B - 90 

SOBRINHO PHG A - 70 

SOCODATO R C - 76 

SOGAYAR MC B - 70 

SOGAYAR MC K – 14, Z - 5 

SOLETTI RC C - 93 

SOMASUNDARAM K B - 46 

SONEHARA NM C - 71 

SONODA MT C - 46 

SOSTHENES MCK N – 27, T – 26, T 

- 48 

SOUSA AL D - 80 

SOUSA CEC C - 113 

SOUSA CM A - 48 

SOUSA LP C – 26, I - 2 

129

SOUZA AC E -10 

SOUZA ACF D - 33 

SOUZA BC C - 48 

SOUZA BK B – 230, B – 231 

SOUZA BL E -6 

SOUZA CRB R -56 

SOUZA EE J - 5 

SOUZA FN S - 11 

SOUZA FS E -7 

SOUZA IC A - 21 

SOUZA JM B - 80 

SOUZA JR PF D - 102 

SOUZA KS C – 44, D - 40 

SOUZA LEL E -2 

SOUZA LM B - 233 

SOUZA LOJ T - 50 

SOUZA MC C - 109 

SOUZA MVR B - 18 

SOUZA NETO CPS B - 145 

SOUZA NHC C - 62 

SOUZA PAF S - 10 

SOUZA RB S - 7 

SOUZA SR U - 26 

SOUZA TA O -7 

SPOHR TCLS B - 69 

STEFFENS D Z - 12 

STERNBERG C B – 162, B – 188 

STIMAMIGLIO MA Z - 34 

STREIT JR DP N - 31 

STUMPP T N – 5, N – 6 

STUR E B - 92 

SUZUKI IL F - 27 

TABOGA SR A – 70, A – 104, 

D – 7, D – 9, D – 

23, D – 51, D – 

53, D – 100, D – 

128, D – 133, D 

– 137, N - 21 

TAMIR S S - 13 

TANIWAKI NN C - 33 

TANOWITZ HB R -26 

TARQUINIO SBC B - 169 

TAVARES ALP N - 2 

TAVARES E SILVA R X -9, X -10 

TAVARES MG S - 4 

TEIXEIRA AD N - 3 

TEIXEIRA BC C - 48 

TEIXEIRA BL T - 41 

TEIXEIRA C C – 53, C – 57, C 

– 59, C – 80, C - 

104 

TEIXEIRA CFP C - 82 

TEIXEIRA FR X -4 

TEIXEIRA L C - 97 

TEIXEIRA LCM F - 24 

TEIXEIRA MM C – 23, C – 24 

TEIXEIRA S T - 37 

TEIXEIRA SC R -39 

TENÓRIO DPLA S - 6 

TERSARIOL ILS J - 33 

TESSER RB N - 5 

THOMÉ R C - 20 

TIAN X J - 1 

TODESCHINI AR N - 45 

TOLEDO DAM R -55 

TOLEDO PC O -14 

TOMIOSSO TC P - 28 

TOMIYAMA L B - 96 

TONELLI FMP Z - 17 

TONI KLG D - 65 

TONIAZZO AP G - 28 

TORRES AFC G - 26 

TORRES AMH B - 138 

TORRES DNM Z - 40 

TOSO VD A - 28 

TRAVA-AIROLDI VJ A - 4 

TRAVASSOS R S - 24 

TRINDADE GS B – 124, H - 8 

TURCK P Z - 24 

TURRI JAO B - 199 

UEIRA-VIEIRA C D - 121 

URIAS U B - 193 

UTIYAMA AH V - 3 

VAGO AR B – 32, B – 42, B 

- 54 

VALADÃO PAC T - 1 

VALENCA SS C - 88 

VALENTE SF R -14 

VALIM CXR R -25 

VALSECHI MC B - 35 

VARELA JN R -20, R -42 

VAROTTI FP B - 34 

VASCONCELOS RO B - 124 

VECCHI L B - 174 

VEIGA SS A – 61, A – 86, A 

– 103, P – 5, S – 

11, X -7 

VENDITE D T - 66 

VENTURA ALM T – 80, T - 81 

VERAS PST R -63, R -69, R - 

71 

VERÇOZA BRF R -60 

VERGARA FMF R -52 

VERINAUD L A – 5, C - 20 

VERSUTE EM D - 90 

VIANA AM U - 20 

VIANA IMMN P - 24 

VIANA MN C - 82 

VIANI FC T - 54 

VIANNA MCB A - 14 

VIAU CM B – 202, B - 203 

VICENTINI CA N – 44, N – 47, N 

- 49 

VICTONI T A - 80 

VIDAL RS B - 154 

VIEGAS GS C - 17 

VIEIRA AM B - 118 

VIEIRA JRC A – 110, B – 229, 

E – 12 

VIEIRA LB J - 44 

VIEIRA LFA P – 21, U - 29 

VIEIRA LN U – 21, U - 22 

VIEIRA NETO JP U - 4 

VIEIRA PC C - 68 

VIEIRA TSS J - 35 

VILAÇA JA B - 111 

VILANOVA-COSTA CAST B - 210 

VILARDO AFRM U - 36 

VILELA ALM B - 22 

VILELA RC U - 6 

VILLA-VERDE DMS C - 98 

VILLODRE ES B - 89 

VIOLA JPB G – 39 

VIOTTO AC G - 19 

VOLPE CMO J - 18 

VOTTO APS B - 123 

WARD LS B - 102 

WATANABE I-S T - 62 

WEINGRILL RB D - 139 

WEIS SN G – 28, G - 29 

WEITKUNAT M N - 24 

WERNECK CC P - 22 

WILLE ACM A - 86 

WINK MR A – 69, B – 135, 

B – 244, K – 9, Z 

- 33 

WIPPICH AC R -45 

WOO JC Z - 42 

WOSNIAK JÚNIOR J J - 24 

WOZNIAK RW B – 71 

XAVIER GF F - 24 

XAVIER JM B - 126 

YAMANOUYE N B – 81, J – 3, J - 7 

YONG-HO A J - 17 

YOO J-O B - 53 

YU-PEI C G - 2 

ZACARO AA B - 51 

ZAMBONI F Z - 14 

ZAMIN LL B - 23 

ZAMPONI GW J - 44 

ZANAROTTI GM N - 32 

ZANETTI BF K - 3 

ZANIER-GOMES PH T - 58 

ZANON RG T - 24 

ZAVAN B D - 35 

ZEBDA N J - 2 

ZEIDLER JD F - 1 

ZENI EC N - 38 

ZENKNER FF S - 27 

ZINGALI RB B - 144 

ZOGOVICH M S - 14 

ZORÉL VJ P - 6 

ZORN TNT P - 4 

ZUCCARI DAPC B – 100, B – 101, 

B - 103 

ZULIAN JG H - 1 

ZUMA AA F - 13 

ZÚÑIGA HAU A - 117 

ZUZA AL D - 130 

ZUZZI DC P - 1 

ZYCH J O -13 

130

Highlights: 

� Keynote Symposium by Steven Chu, U.S. Secretary of Energy, and Arthur D. Levinson, Chair, 

Genentech, Inc., and Apple, Inc. 

� Threads (meetings-within-a-meeting):1) Cell Biology and Medicine and 2) Cell Biology and the 

Physical Sciences. Daily programs will allow attendees to follow new fields while benefitting 

from a large meeting with the best research in cell biology. 

� World-class Symposia and Minisymposia speakers 

� Frontier Symposia will synthesize current, exciting progress in the field 

� Science Discussion Tables—interact with senior scientists in an intimate setting 

� Posters, mentorship, networking, career development, and education programs 

� Fun in the wonderful city of San Francisco! 

Important deadlines 

July 23, 2012 (Application Deadline) 

� Special Interest Subgroup 

July 30, 2012 (Application Deadline) 

� Abstract submission (for Minisymposium or poster consideration) 

September 4, 2012 (Application Deadline) 

� Regular abstract submission (poster only) 

October 10, 2012 

� Early registration deadline 

www.ascb.org 

131

Keynote Conference - Interevent

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