Silybum marianum (Milk thistle)
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Milk thistle Pharmacognosy Pharmacolgy
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Silybum marianum (Milk thistle)
- 3. Silybum marianum Introduction Chemical Constituents Uses Mechanism of Action Side effects Toxicity Dosage Contraindications Drug Interactions
- 4. INTRODUCTION Family: Asteraceace Botanical Name: Sillybum marianum English Name: Milk thistle Urdu Name: Oont Katara Part Used: Seeds, leaves, flowers and roots
- 6. USES Silibinin is used as anti-oxidant and anti-neoplastic Silychristin is used as anti-inflammatory Silydianin is also used as anti-oxidant Silibinin is used as hepato-protective agent It is used as anti-depressant It is used as demulcent It is used as laxative Tocopherols prevent from brain stroke
- 7. MECHANISM OF ACTION Silymarin • Hinder inflammatory process by inhibiting by inhibiting neutrophil migration and kuppfer cells inhibition • Also inhibit the inhibitory mediators, i.e., prostaglandins and leukotrienes, release of histamine from basophils Silymarin • Protect live from Hepato-toxins and thus increase regenerative capacity of liver • Block the Hepato toxins binding site Tocopherol • Tocopherol inhibit the platelets to from blood clot thus prevent the brain stroke
- 8. MECHANISM OF ACTION Silychristin • Inhibit the prostaglandin synthetase to treat inflammation Silymarin • Increases the hepatic content of glutathione (Both oxidized and reduced) • Glutathione is a powerful oxidant, detoxify a number of contents
- 9. TOXICITY Appears to be low Toxic
- 10. SIDE EFFECTS Increased bile flow Laxative effect Slow rate of clotting May cause mild loose stools
- 11. DOSAGE Typical dose is 240-900mg twice or thrice a day of the extract Take 2ml of the tincture thrice a day
- 12. DRUG INTERACTIONS May cause interactions with Anti Psychotics butyrophenones Phenothiazines Phenytoin Halothane Anti allergic drugs Fexofenadine Anti- hyperlipidemic drugs Lovastatin Anti-anxiety drugs Alprazolam Anti platelet or Anti-coagulant Warfarin
- 13. CONTRAINDICATIONS Should be avoided during pregnancy and breast feeding Should be avoided by people allergic to this plant Must be avoided in case of hormone related cancers Must be avoided in hemophilia