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Secondary Metabolites in Medicinal and Aromatic Plants (MAPs): Potent Molecules in Nature’s Arsenal to Fight Human Diseases

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Medicinal and Aromatic Plants

Abstract

Nature, the supreme artist, and scientists have designed almost an infinite range of plant molecular bioactive molecules for drugs operative for the remedy of innumerable human disorders in the biosynthetic laboratory of plants. From 250,000 to 300,000 plant species which exist on Earth, only about 5000 were investigated for chemical compounds with pharmacological and biological activities. More than 25% of pharmaceutical molecules are plant based through sequestration of the novel bioactive compounds. The 200,000 known secondary metabolites with widespread chemical structures are manly categorized into phenolics, terpenoids or terpenes, and steroids and alkaloids. Secondary metabolites perform significant functions in plants including role as signaling molecules, chemical defense mechanism and adaptation, pollination and seed dispersal, protection from predators, herbivores, pathogens, and allelopathic agents. Medicinal and aromatic plants (MAPs) are bestowed with both the aromatic and medicinal properties and contain bioactive secondary metabolites with a broad range of pharmacological and therapeutic potentials such as antioxidant, antitumor, anticancer, antiviral, antimicrobial, anti-inflammatory, antiatherosclerotic, antidepressant, antidiabetic, hepatoprotective, antithrombotic, vasoprotective, and immunoprotective effects, cardiovascular improver, memory enhancer, anti-AIDS, anti-Alzheimer’s, anti-Parkinson’s disease, and anti-cognitive impairment.

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References

  • Aazami MH, Tahmasbi AM, Ghaffari MH, Naserian AA, Valizadeh R, Ghaffari AH (2013) Effects of saponins on rumen fermentation, nutrients digestibility, performance, and plasma metabolites in sheep and goat kids. Ann Rev Res Biol 3(4):596–607

    Google Scholar 

  • Abdullah W, Elsayed WM, Abdelshafeek KA, Nazif NM, Singab ANB (2016) Chemical constituents and biological activities and cleome genus: a brief review. Int J Pharmacogn Phytochem Res 8(5):777–787

    Google Scholar 

  • Abu-Taweel GM (2018) Cardamom (Elettaria cardamomum) perinatal exposure effects on the development, behavior and biochemical parameters in mice offspring. Saudi J Biol Sci 25(1):186–193

    Article  CAS  PubMed  Google Scholar 

  • Adnyana IK (2013) Efficacy and safety o-desmethyl quinine compare to quinine for nocturnal leg cramp. Int J Med Sci 13:819–823

    Google Scholar 

  • Adukwu EC, Bowles M, Jones VE, Bone H (2016) Antimicrobial activity, cytotoxicity and chemical analysis of lemongrass essential oil (Cymbopogon flexuosus) and pure citral. Appl Microbiol Biotechnol 100(22):9619–9627

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aerts RJ, Mordue AJ (1997) Feeding deterrence and toxicity of neem triterpenoids. J Chem Ecol 23(9):2117–2132

    Article  CAS  Google Scholar 

  • Agyapong VIO, Singh K, Savage M, Thekiso TB, Finn M, Farren CK, McLoughlin DM (2013) Use of codeine-containing medicines by Irish psychiatric inpatients before and after regulatory limitations on their supply. Ir J Psychol Med 30:7–12

    Article  CAS  PubMed  Google Scholar 

  • Ali SI, Gopalakrishnan B, Venkatesalu V (2017) Pharmacognosy, phytochemistry and pharmacological properties of Achillea millefolium L.: a review. Phytother Res 31(8):1140–1161. https://doi.org/10.1002/ptr.5840

    Article  CAS  PubMed  Google Scholar 

  • Al-Snafi AE (2015) Chemical constituents and pharmacological importance of Agropyron repens – a review. Res J Pharmacol Toxicol 1(2):37–41

    Google Scholar 

  • Amadi SW, Zhang Y, Wu G (2016) Research progress in phytochemistry and biology of Aframomum species. Pharm Biol 54(11):2761–2770. https://doi.org/10.3109/13880209.2016.1173068

    Article  CAS  PubMed  Google Scholar 

  • Andersen ØM, Markham KR (2006) Flavonoids: chemistry, biochemistry, and applications. CRC Taylor & Francis, Boca Raton, Florida

    Google Scholar 

  • Andrade JM, Faustino C, Garcia C, Ladeiras D, Reis CP, Rijo P (2018) Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity. Future Sci OA 4(4):FSO283. https://doi.org/10.4155/fsoa-2017-0124

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ashour M, Wink M, Gershenzon J (2010) Biochemistry of terpenoids: monoterpenes, sesquiterpenes and diterpenes. In: Wink M (ed) Biochemistry of plant secondary metabolism. Wiley, New York, pp 258–303

    Chapter  Google Scholar 

  • Badreldin HA, Gerald B, Musbah OT, Abderrahim N (2008) Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 46:409–420

    Article  CAS  Google Scholar 

  • Bartosz G (2003) Strategia ataku. In: Druga twarz tlenu. PWN, Warszawa, Polska, pp 15–142. [In Polish]

    Google Scholar 

  • Bairwa R, Sodha RS, Rajawat BS (2012) Trachyspermum ammi. Pharmacogn Rev 6(11):56–60

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baloglu E, Kingston GI (1999) The taxane diterpenoids. J Nat Prod 62:1448–1472

    Article  CAS  PubMed  Google Scholar 

  • Barata AM, Rocha F, Lopes V, Bettencourt E, Figueiredo AC (2011) Medicinal and aromatic plants – Portugal. In: Ozturk M, Ameenah G-FB (eds) Medicinal and aromatic plants of the world, encyclopedia of life support systems (EOLSS). Developed under the auspices of the UNESCO. Eolss Publishers, Oxford, http://www.eolss.net

    Google Scholar 

  • Baser KHC (2005) New trends in the utilization of medicinal and aromatic plants. In: III WOCMAP congress on medicinal and aromatic plants-volume 2: conservation, cultivation and sustainable use of medicinal and aromatic plants, vol 676. The Hague, International Society for Horticultural Science, pp 11–23

    Google Scholar 

  • Bejeuhr G (1994) In: Hänsel R, Keller K, Rimpler H, Schneider G (eds) Hagers Handbuch der Pharmazeutischen Praxis, vol 4–6, 5th edn. Springer Verlag, Heidelberg, pp 1992–1994

    Google Scholar 

  • Bejeuhr G (1998) In: Blaschek W, Hänsel R, Keller K, Reichling J, Rimpler G, Schneider G (eds) Hagers Handbuch der Pharmazeutischen Praxis, vol 2, 5th edn. Springer Verlag, Heidelberg, p 3

    Google Scholar 

  • Bellamy D, Pfister A (1992) World medicine—plants, patients and people. Blackwell Publishers, Oxford

    Google Scholar 

  • Bennets HW, Underwood EJ, Shier FL (1946) A specific breeding problem of sheep in subterranean clover pastures in Western Australia. Aust Vet J 22(1):2–12

    Article  Google Scholar 

  • Bennett RN, Wallsgrove RM (1994) Secondary metabolites in plant defence mechanisms. New Phytol 127(4):617–633

    Article  CAS  PubMed  Google Scholar 

  • Bharti VK, Malik JK, Gupta RC (2016) Ashwagandha: multiple health benefits. In: Gupta R (ed) Nutraceuticals: efficacy, safety and toxicity. Academic Press/Elsevier, Amsterdam, pp 717–733

    Chapter  Google Scholar 

  • Bino RJ, Hall RD, Fiehn O, Kopka J, Saito K, Draper J et al (2004) Potential of metabolomics as a functional genomics tool. Trends Plant Sci 9(9):418–425. https://doi.org/10.1016/j.tplants.2004.07.004

    Article  CAS  PubMed  Google Scholar 

  • Bombardelli E, Morazzoni P, Griffini A (1996) Aesculus hippocastanum L. Fitoterapia 67:483–511

    CAS  Google Scholar 

  • Bores GM, Huger FP, Petko W, Mutlib AE, Camacho F, Rush DK, Selk DE, Wolf V, Kosley RW, Davis L Jr, Vargas HM (1996) Pharmacological evaluation of novel Alzheimer’s disease therapeutics: acetylcholinesterase inhibitors related to galantamine. J Pharmacol Exp Ther 277:728–738

    CAS  PubMed  Google Scholar 

  • Boukhatem MN, Ferhat MA, Kameli A, Saidi F, Kebir HT (2014) Lemon grass (Cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan J Med 9(1):25431

    Article  PubMed  Google Scholar 

  • Bourgaud F, Gravot A, Milesi S, Gontier E (2001) Production of plant secondary metabolites: a historical perspective. Plant Sci 161:839–851

    Article  CAS  Google Scholar 

  • Bown D (1995) The RHS encyclopedia of herbs and their uses. Dorling Kindersley, London

    Google Scholar 

  • Brant SMG (2016) Nutraceuticals in hepatic diseases. In: Gupta R (ed) Nutraceuticals: efficacy, safety and toxicity. Academic Press/Elsevier, Amsterdam, pp 87–99

    Chapter  Google Scholar 

  • Breitmaier E (2006) Terpenes: flavors, fragrances, pharmaca, pheromones. Wiley-VCH Verlag GmbH & Co. KGAA, Weinheim

    Book  Google Scholar 

  • Brendler T, Brinckmann JA, Schippmann U (2018) Sustainable supply, a foundation for natural product development: the case of Indian frankincense (Boswellia serrata Roxb. ex Colebr.). J Ethnopharmacol 225:279–286

    Article  CAS  PubMed  Google Scholar 

  • Brower V (2008) Back to nature: extinction of medicinal plants threatens drug discovery. J Natl Cancer Inst 100(12):838–839

    Article  PubMed  Google Scholar 

  • Bruneton J (1999) Pharmacognosy phytochemistry medicinal plants, 2nd edn. Lavoisier Publishing, Londres/Paris/New York, p 1136

    Google Scholar 

  • Bruneton (2002) J. Phytothérapie—Les Données de L‘évaluation. Lavoisier; Paris, France.

    Google Scholar 

  • Busse GD (2006) DRUGS the straight facts-morphine. Chelsea House Publishers, An imprint of Infobase Publishing, New York

    Google Scholar 

  • Byler KB, Setzer W (2018) Protein targets of frankincense: a reverse docking analysis of terpenoids from Boswellia oleo-gum resins. Medicines 5:96

    Article  CAS  PubMed Central  Google Scholar 

  • Catarino MD, Silva AMS, Cruz MT, Cardoso SM (2017) Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions. Food Funct 8(9):3355–3365. https://doi.org/10.1039/c7fo00881c

    Article  CAS  PubMed  Google Scholar 

  • Cerri M, Reale L, Zadra C (2019) Metabolite storage in Theobroma cacao L. seed: Cyto-histological and phytochemical analyses. Front Plant Sci 10:1599. https://doi.org/10.3389/fpls.2019.01599

    Article  PubMed  PubMed Central  Google Scholar 

  • Chauhan NB, Mehla J (2015) Ameliorative effects of nutraceuticals in neurological disorders. In: Watson R, Preedy V (eds) Bioactive nutraceuticals and dietary supplements in neurological and brain disease. Academic Press/Elsevier, Amsterdam, pp 245–260

    Chapter  Google Scholar 

  • Checkoway H, Powers K, Smith-Weller T, Franklin GM, Longstreth WT Jr, Swanson PD (2002) Parkinson’s disease risks associated with cigarette smoking, alcohol consumption and caffeine intake. Am J Epidemiol 155:732–738

    Article  PubMed  Google Scholar 

  • Chevallier A (2001) Encyclopedia of medicinal plants. Dorling Kindersley, London

    Google Scholar 

  • Cho YS, Yeum KJ, Chen CY, Beretta G, Tang G, Krinsky N, Yoon S, Lee-Kim YC, Blumberg JB, Russell RM (2007) Phytonutrients affecting hydrophilic and lipophilic antioxidant activities in fruits, vegetables and legumes. J Sci Food Agric 87:1096–1107

    Article  CAS  Google Scholar 

  • Combs GF, Welch RM, Duxbury JM, Uphoff NT (1996) Food–based approaches to preventing micronutrient malnutrition: an international agenda. Cornell University Press, Ithaca

    Google Scholar 

  • Corzo-Martínez M, Corzo N, Villamiel M (2007) Biological properties of onions and garlic. Trends Food Sci Technol 18:609–625

    Article  CAS  Google Scholar 

  • Crozier A (2008) Plant secondary metabolites: their role in the human diet. Planta Med 74(3):315–315

    Article  Google Scholar 

  • Crozier A, Clifford MN, Ashihara H (2006) In: Crozier A, Clifford MN, Ashihara H (eds) Plant secondary metabolites: occurrence, structure and role in the human diet… diet. Wiley-Blackwell, New York, p 384. ISBN: 978-1-405-12509-3

    Chapter  Google Scholar 

  • Damanhouri ZA, Ahmad A (2014) A review on therapeutic potential of Piper nigrum L. (Black pepper): The king of spices. Med Aromat Plants 3:161

    Article  CAS  Google Scholar 

  • Davies TGE, Field LM, Usherwood PNR, Williamson MS (2007) DDT, pyrethrins, pyrethroids and insect sodium channels. IUBMB Life 59(3):151–162

    Article  CAS  PubMed  Google Scholar 

  • de Macedo LM, dos Santos EM, Militão L, Tundisi LL, Ataide JA et al (2020) Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and its topical applications: a review. Plan Theory 9:651. https://doi.org/10.3390/plants9050651

    Article  CAS  Google Scholar 

  • Demain AL, Fang A (2000) The natural functions of secondary metabolites. In: Fiechter A (ed) History of modern biotechnology I. Advances in biochemical engineering/biotechnology, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44964-7_1

  • Dewick PM (2001) Medicinal natural products. Wiley, Chichester

    Book  Google Scholar 

  • Diplock AT (1999) Scientific concepts of functional foods in Europe—consensus document. Br J Nutr 81:1–27

    Article  Google Scholar 

  • Dobson CM (2004) Chemical space and biology. Nature 432(7019):824–828

    Article  CAS  PubMed  Google Scholar 

  • Dopham DD, Kelso GF, Yang Y, Hearn MT (2014) Studies on the oxidative N-demethylation of atropine, thebaine and oxycodone using a Fe III-TAML catalyst. Green Chem 16:1399–1409

    Article  CAS  Google Scholar 

  • Duke JA (2002) Handbook of medicinal herbs, 2nd edn. CRC Press, Boca Raton

    Book  Google Scholar 

  • Edeoga HO, Okwu DE, Mbaebie BO (2005) Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 4(7):685–688

    Article  CAS  Google Scholar 

  • Edewor TI, Olajire AA (2011) The flavones from Acanthospermum hispidum DC and their antibacterial activity. Int J Org Chem 1:132–141

    Article  CAS  Google Scholar 

  • Efferth T (2015) Artemisinin–second career as anticancer drug? World J Tradit Chin Med 1:2–25

    Article  Google Scholar 

  • Eid SY, El-Readi MZ, Wink M (2012) Carotenoids reverse multidrug resistance by interfering with ABC-transporters in cancer cells. Phytomedicine 19:977–987

    Article  CAS  PubMed  Google Scholar 

  • Eliasova A, Repcak M, Pastirova A (2004) Quantitative changes of secondary metabolites of Matricaria chamomilla by abiotic stress. Zeitschrift fur Naturforschung C 59(7–8):543–548

    Article  CAS  Google Scholar 

  • El-Tawil S, Al-Musa T, Valli H, Lunn MP, El-Tawil T, Weber M (2010) Quinine for muscle cramps. Cochrane Database Syst Rev 12:CD005044

    Google Scholar 

  • Eun MC, Jae KH (2004) Anti-inflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia 75:557–565

    Article  Google Scholar 

  • Evans WC (ed) (2009) Trease and Evans Pharmacognosy, 16th edn. W.B. Saunders, Elsevier, Edinburgh, p xiii+585; ISBN 0-7020-2617-4; 59.95 GBP

    Google Scholar 

  • Falk AJ, Smolenski SJ, Bauer L, Bell CL (1975) Isolation and identification of three new flavones from Achillea millefolium L. J Pharm Sci 64:1838–1842

    Article  CAS  PubMed  Google Scholar 

  • Farnsworth NR, Solejarto DD (1991) Global importance of medicinal plants. In: Akerele O, Heywood V, Synge H (eds) Conservation of medicinal plants. Cambridge University Press, Cambridge, UK

    Google Scholar 

  • Ferreira JFS, Luthria DL, Sasaki T, Heyerick A (2010) Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules 15:3135–3170

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fewell AM, Roddick JG (1993) Interactive antifungal activity of the glycoalkaloids α-solanine and α-chaconine. Phytochemistry 33:323–328

    Article  CAS  Google Scholar 

  • Firn R (2010) Nature’s chemicals. Oxford University Press, Oxford, pp 74–75

    Google Scholar 

  • Flegkas A, Ifantis TM, Barda C, Samara P, Tsitsilonis O, Skaltsa H (2019) Antiproliferative activity of (−)-rabdosiin isolated from Ocimum sanctum L. Medicines 6:37

    Article  CAS  PubMed Central  Google Scholar 

  • Fowsiya J, Madhumitha G (2017) Preliminary phytochemical analysis, antioxidant and cytotoxicity test of Carissa edulis Vahl dried fruits. IOP Conf Series: Mater Sci Eng 263:022018

    Article  Google Scholar 

  • Fraenkel GS (1959) The raison d’être of secondary plant substances. Science 129:1466–1470

    Google Scholar 

  • Fraire-Velázquez S, Balderas-Hernández VE (2015) Abiotic stress in plants and metabolic responses. In: Vadhati K, Leslie C (eds) Abiotic stress – plant responses and applications in agriculture. InTech, Vukovar

    Google Scholar 

  • Gakuubi MM, Wanzala W, Wagacha JM, Dossaji SF (2016) Bioactive properties of Tagetes minuta L. (Asteraceae) essential oil: a review. Am J Essent Oils Nat Prod 4(2):27–36

    Google Scholar 

  • Gao S, Hu M (2010) Bioavailability challenges associated with development of anti-cancer phenolics. Mini Rev Med Chem 10:550–567

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gehm BD, McAndrews JM, Chien P, Jameson JL (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 94(25):14138–14143

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gershenzon J, Mary TJ (1983) Secondary metabolites and the higher classification of angiosperms. Nord J Bot 3(1):5–34

    Article  CAS  Google Scholar 

  • Goldberg G (2003) Plants: diet and health. In: Goldberg G (ed) The report of a British nutrition foundation task force. Blackwell Science, Oxford, p 347

    Google Scholar 

  • Goutam B (2011) Natural products in the drug discovery programmes in Alzheimer’s: impacts and prospects. Asia Pac Biotech News 15:14–34

    Google Scholar 

  • Grabley S, Thiericke R (1999) Drug discovery from nature. Springer, Berlin/Heidelberg, p 347

    Google Scholar 

  • Graham LE, Graham JM, Wilcox LW (2006) Plant biology. Pearson/Prentice Hall, Upper Saddle River, p 670

    Google Scholar 

  • Gu L, Li N, Gong J, Li Q, Zhu W, Li J (2011) Berberine ameliorates intestinal epithelial tight- junction damage and down-regulates Myosin light chain kinase pathways in a mouse model of Endotoxinemia. J Infect Dis 203:1602–1612

    Article  CAS  PubMed  Google Scholar 

  • Guardia T, Rotelli AE, Juarez AO, Pelzer LE (2001) Anti-inflammatory properties of plant flavonoids. Effects of Rutin, Quercetin and Hesperidin on adjuvant arthritis in rat. Farmaco 56:683–687

    Article  CAS  PubMed  Google Scholar 

  • Guclu-Ustundag O, Mazza G (2007) Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 47:231–258

    Article  CAS  PubMed  Google Scholar 

  • Hajek P, McRobbie H, Myers K (2013) Efficacy of Cytisine in helping smokers quit. Systematic review and meta-analysis. Thorax 68:1037–1042

    Article  PubMed  Google Scholar 

  • Hallock YF, Cardelinna JH, Schaffer M, Bringmann G, Lee AY, Clardy J, Francois G, Boyd MR (1998) Korundamine A, a novel HIV-inhibitory and antimalarial “hybrid” naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis. Bioorg Med Chem Lett 8(13):1729–1734

    Article  CAS  PubMed  Google Scholar 

  • Han X, Parker TL (2017) Lemongrass (Cymbopogon flexuosus) essential oil demonstrated anti-inflammatory effect in pre-inflamed human dermal fibroblasts. Biochimie Open 4:107–111

    Article  PubMed  PubMed Central  Google Scholar 

  • Hänsel R, Sticher O, Steinegger E (2007) Pharmakognosie—Phytopharmazie, 8th edn. Springer Verlag, Heidelberg

    Book  Google Scholar 

  • Harborne JR (1993) Introduction to ecological biochemistry, 4th edn. Academic Press/Elsevier, London, p 318

    Google Scholar 

  • Harborne JB (1999) Classes and functions of secondary metabolites from plants. In: Walton NJ, Brown DE (eds) Chemicals from plants: perspectives on plant secondary products. Imperial College Press, London

    Google Scholar 

  • Harborne JB, Baxter H (1993) Phytochemical dictionary—a handbook of bioactive compounds from plants. Taylor & Francis, London

    Google Scholar 

  • Harborne JB, Herbert B (1999) The handbook of natural flavonoids. Wiley, Chichester

    Google Scholar 

  • Hartmann T (2007) From waste products to ecochemicals: fifty years research of plant secondary metabolism. Phytochemistry 68:2831–2846

    Article  CAS  PubMed  Google Scholar 

  • Heal KG, Taylor Robinson AW (2010) Tomatine adjuvantation of protective immunity to a major pre-erythrocytic vaccine candidate of malaria is mediated via CD8+T cell release of IFN-gamma. J Biomed Biotechnol 2010:834326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hecht SS (2004) Chemoprevention by Isothiocyanates. In: Kelloff GJ, Hawk ET, Sigman CC (eds) Promising cancer chemopreventive agents, volume 1: cancer chemopreventive agents. Humana Press, Totowa, pp 21–35

    Chapter  Google Scholar 

  • Hegnauer R (1963) The taxonomic significance of alkaloids. In: Swain T (ed) Chemical plant taxonomy. Academic Press, London/New York, pp 389–427

    Chapter  Google Scholar 

  • Herms DA, Mattson WJ (1992) The dilemma of plants: to grow or defend. Q Rev Biol 67:283–335

    Article  Google Scholar 

  • Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F (1995) Flavonoids intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 155:381–386

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann D (2003) Medical herbalism: the science and practice of herbal medicine. Healing Arts Press, Rochester. ISBN: 978-089281749-8

    Google Scholar 

  • Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, Hall WL, Cassidy A (2008) Flavonoids, flavonoid rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 88:38–50

    Article  CAS  PubMed  Google Scholar 

  • Hornok L (1992) Cultivation and processing of medicinal plants. Publ Akademiai Kiado, Budapest, pp 42–55

    Google Scholar 

  • Hosseinzadeh S, Jafarikukhdan A, Hosseini A, Armand R (2015) The application of medicinal plants in traditional and modern medicine: a review of Thymus vulgaris. Int J Clin Med 6:635–642

    Article  Google Scholar 

  • Houghton PJ, Ren Y, Howes M (2006) Acetylcholinesterase inhibitors from plants and fungi. Nat Prod Rep 23:181–199

    Article  CAS  PubMed  Google Scholar 

  • Howes MR, Houghton P (2009) Acetylcholinesterase inhibitors of natural origin. Int J Biomed Pharm Sci 3:67–86

    Google Scholar 

  • Hsieh LE, Lin CN, Su BL et al (2010) Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus. Antivir Res 88(1):25–30. https://doi.org/10.1016/j.antiviral.2010.06.010

    Article  CAS  PubMed  Google Scholar 

  • Hu G, Bidel S, Jousilahti P, Antikainen R, Tuomilehto J (2007) Coffee and tea consumption and the risk of Parkinson’s disease. Mov Disord 22:2242–2248

    Article  PubMed  Google Scholar 

  • Idris S, Mishra A, Khushtar M (2020) Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine. J Basic Clin Physiol Pharmacol 31(5):20190115. https://doi.org/10.1515/jbcpp-2019-0115

    Article  CAS  Google Scholar 

  • Inoue M, Craker L (2014) Medicinal and aromatic plants-uses and functions. In: Dixon G, Aldous D (eds) Horticulture: plants for people and places, vol 2. Springer, Dordrecht, pp 645–669. https://doi.org/10.1007/978-94-017-8581-5

    Chapter  Google Scholar 

  • Iwashina T (2003) Flavonoid function and activity to plants and other organisms. Biol Sci Space 17:24–44

    Article  PubMed  Google Scholar 

  • Jabamalairaj A, Priatama RA, Heo J et al (2019) Medicinal metabolites with common biosynthetic pathways in Solanum nigrum. Plant Biotechnol Rep 13:315–327. https://doi.org/10.1007/s11816-019-00549-w

    Article  Google Scholar 

  • Jakhetia V, Patel R, Khatri P, Pahuja N, Garg S, Pandey A, Sharma SA (2010) Cinnamon: a pharmacological review. IJAST 1:19–23

    Google Scholar 

  • Jakubowski H (2003) On the health benefits of Allium sp. Nutrition 19:167–168

    Article  CAS  PubMed  Google Scholar 

  • James HD (2012) In: Rao V (ed) Phytochemicals: extraction methods, basic structures and mode of action as potential chemotherapeutic agents, phytochemicals – a global perspective of their role in nutrition and health. Intech

    Google Scholar 

  • Jana S, Shekhawat GS (2010) Anethum graveolens: an Indian traditional medicinal herb and spice. Pharmacogn Rev 4(8):179–184. https://doi.org/10.4103/0973-7847.70915

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jensen AA, Gharagozloo P, Birdsall NJ, Zlotos DP (2006) Pharmacological characterization of strychnine and brucine analogues at Glycine and α7 Nicotinic Acetylcoline receptors. Eur J Pharmacol 539:27–33

    Article  CAS  PubMed  Google Scholar 

  • Jeong EJ, Lee KY, Kim SH, Sung SH, Kim YC (2008) Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice. Eur J Pharmacol 588:78–84

    Article  CAS  PubMed  Google Scholar 

  • Jones ME, Kossel A (1953) A biographical sketch. Yale J Biol Med 26(1):80–97

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jones MG, Hughes J, Tregova A, Milne J, Tomsett AB, Collin HA (2004) Biosynthesis of the flavour precursors of onion and garlic. J Exp Bot 55(404):1903–1918

    Article  CAS  PubMed  Google Scholar 

  • Jonsson T, Christensen CB, Jordening H, Frølund C (1988) The bioavailability of rectally administered morphine. Pharmacol Toxicol 62(4):203–205

    Article  CAS  PubMed  Google Scholar 

  • Joo SS, Won TJ, Lee DI (2005) Reciprocal activity of ginsenosides in the production of proinflammatory repertoire, and their potential roles in neuroprotection in vitro. Planta Med 71:476–481

    Article  CAS  PubMed  Google Scholar 

  • Jordan MA, Leslie W (2004) Microtubules as a target for antic cancer drugs. Nat Rev Cancer 4(4):253–265

    Article  CAS  PubMed  Google Scholar 

  • Julian PL, Pikl J (1935) Studies in the indole series V. the complete synthesis of physostigmine (Eserine). Percy L J Am Chem Soc 57:755–757

    Article  CAS  Google Scholar 

  • Kalemba D, Synowiec A (2019) Agrobiological interactions of essential oils of two menthol mints: Mentha piperita and Mentha arvensis. Molecules 25(1):59. https://doi.org/10.3390/molecules25010059

    Article  CAS  PubMed Central  Google Scholar 

  • Kamboj VP (2000) Herbal medicine. Curr Sci 78(1):3539

    Google Scholar 

  • Kaneko H, Nakanishi K (2004) Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically, its anti-stress action for prevention of disease. J Pharmacol Sci 95:158–162

    Article  CAS  PubMed  Google Scholar 

  • Karr A (2007) Pharmacognosy and pharmacobiotechnology (revised-expanded second edition). New Age International Limted Publishers, New Delhi, pp 332–600

    Google Scholar 

  • Kaur A, Garg S, Shiekh BA, Singh N, Singh P, Bhatti R (2020) In Silico studies and in vivo MAOA inhibitory activity of Coumarins isolated from Angelica archangelica extract: an approach toward antidepressant activity. ACS Omega 5(25):15069–15076. https://doi.org/10.1021/acsomega.0c00887

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kenny OM, McCarthy CM, Brunton NP, Hossain MB, Rai DK, Collins SG (2013) Anti-inflammatory properties of potato Glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages. Life Sci 92(13):775–782

    Article  CAS  PubMed  Google Scholar 

  • Kim JB, JH Y, Ko E, Lee KW, Song AK, Park SY, Shin I, Han W, Noh DY (2010) The Alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest. Phytomedicine 17:436–440

    Article  CAS  PubMed  Google Scholar 

  • Kinghorn AD (2001) Pharmacognosy in the 21st century. J Pharm Pharmacol 53(2):135–148. https://doi.org/10.1211/0022357011775334

    Article  CAS  Google Scholar 

  • Kishimoto Y, Tani M, Kondo K (2013) Metabolic syndrome, diabetes mellitus, cardiovascular and neurodegenerative diseases. Eur J Clin Nutr 67:532–535

    Article  CAS  PubMed  Google Scholar 

  • Kishore K, Singh M (2005) Effect of bacosides, an alcoholic extract of Bacopa monnieri Linn. (Brahmi), on experimental amnesia in mice. Indian J Exp Biol 43:640–645

    PubMed  Google Scholar 

  • Koes R, Verweij W, Quattrocchio F (2005) Flavonoids: a colourful model for the regulation and evolution of biochemical pathways. Trends Plant Sci 10:236–242

    Article  CAS  PubMed  Google Scholar 

  • Kosakowska O, Baczek K, Przybył JL, Pawełczak A, Rolewska K, Weglarz Z (2020) Morphological and chemical traits as quality determinants of common thyme (Thymus vulgaris L.), on the example of ‘standard winter’ cultivar. Agronomy 10:909. https://doi.org/10.3390/agronomy10060909

    Article  CAS  Google Scholar 

  • Krings U, Berger RG (1998) Biotechnological production of flavours and fragrances. Appl Microbiol Biotechnol 49(1):1–8

    Article  CAS  PubMed  Google Scholar 

  • Krzyzanowska J, Czubacka A, Oleszek W (2009) Dietary phytochemicals and human health. In: Giardi MT, Rea G, Berra B (eds) Bio-farms for nutraceuticals: functional food and safety control by biosensors. Landes BioScience, Georgetown. Release date: January 1, 2010

    Google Scholar 

  • Kuriyama SI, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ebihara S, Awata S, Nagatomi R, Arai H, Tsuji I (2006) Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1. Am J Clin Nutr 83:355–361

    Article  CAS  PubMed  Google Scholar 

  • Le Marchand L (2002) Cancer preventive effects of flavonoids – a review. Biomed Pharmacother 56:296–301

    Article  PubMed  Google Scholar 

  • Leaman DJ (2008) The International standard for sustainable wild collection of medicinal and aromatic plants (ISSC-MAP): elements of ISSC-MAP resource assessment guidance relevant to cites NDF. International Expert Workshop on CITES Non-Detriment Findings Perennial Plant Working Group (Ornamentals, Medicinal and Aromatic Plants Cancun, Mexico)

    Google Scholar 

  • Lee S, Park Y, Han E, Choi H, Chung KH (2011) Thebaine in hair as a market for chronic use of illegal opium poppy substances. Forensic Sci Int 204:115–118

    Article  CAS  PubMed  Google Scholar 

  • Leung KW, Wong AST (2010) Pharmacology of ginsenosides: a literature review. Chin Med 5:20

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li YM, Jiang SH, Gao WY, Zhu DY (2000) Phenylpropanoid glycosides from Scrophularia ningpoensis. Phytochemistry 54:923–925

    Article  CAS  PubMed  Google Scholar 

  • Lim HS, Kim JH, Ha HK, Seo CS, Shin HK (2012) Comparative study of the anti-inflammatory effects of Menthae Herba from Korea and China. Korean J Pharmacogn 43:231–238

    CAS  Google Scholar 

  • Madhumitha G, Elango G, Roopan SM (2016) Biotechnological aspects of ZnO nanoparticles: overview on synthesis and its applications. Appl Microbiol Biotechnol 100(2):571–581

    Article  CAS  PubMed  Google Scholar 

  • Madziga HA, Sanni S, Sandabe UK (2010) Phytochemical and elemental analysis of Acalypha wilkesiana leaf. J Am Sci 6:510–514

    Google Scholar 

  • Mahomoodally MF, Fakim AG (2013) Harnessing traditional knowledge to treat existing and emerging infectious diseases in Africa. In: Rai MK, Kon KV (eds) Fighting multidrug resistance with herbal extracts, essential oils and their components. Academic Press, London, pp 223–235. https://doi.org/10.1016/B978-0-12-398539-2.00015-X

    Chapter  Google Scholar 

  • Manivel P, Roopan SM, Kumar RS, Khan NF (2009) Synthesis of 3 substituted isoquinolin-1yl-2- (Cycloalk-2-eneylidene) hydrazines and their antimicrobial properties. J Chil Chem Soc 54(2):183–185

    Article  CAS  Google Scholar 

  • Manoharachary C, Nagaraju D (2016) Medicinal plants for human health and welfare. Ann Phytomed 5(1):24–34

    Google Scholar 

  • Marambaud P, Zhao H, Davies P (2005) Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides. J Biol Chem 280:37377–37382

    Article  CAS  PubMed  Google Scholar 

  • Matsuura H (2001) Saponins in garlic as modifiers of the risk of cardiovascular disease. J Nutr 131:1000S–1005S

    Article  CAS  PubMed  Google Scholar 

  • Mattoo A, Giardi MT, Raskind A, Edelman M (1999) Dynamic metabolism of photosystem II reaction center proteins and pigments. A review. Physiol Plant 107:454–446

    Article  CAS  Google Scholar 

  • Mbaze LM, Lado JA, Wansi JD, Shiao TC, Chiozem DD, Mesaik MA, Choudhary MI, Lacaille-Dubois MA, Wandji J, Roy R, Sewald N (2009) Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae). Phytochemistry 70(11–12):1442–1447. https://doi.org/10.1016/j.phytochem.2009.08.007

    Article  CAS  PubMed  Google Scholar 

  • McBrien NA, Stell WK, Carr B (2013) How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt 33:373–378

    Article  PubMed  Google Scholar 

  • McCaleb R (1990) Nature’s medicine for memory loss. Herbal Gram 23:15

    Google Scholar 

  • McMurry JE (2015) Organic chemistry with biological applications. In: Secondary metabolites: an introduction to natural products chemistry. Cengage Learning Ltd, Stamford, pp 1016–1046

    Google Scholar 

  • Mehboob H, Iqbal M, Ejaz M, Bibi G, Sarwar U, Iftikhar S et al (2017) A review on secondary metabolites of Rosa laevigata Michaux: an important medicinal plant. Biochem Anal Biochem 6:326

    Article  CAS  Google Scholar 

  • Mehrafarin A, Qadri A, Rezazadeh S, Badi HN, Noormohammadi G, Zand E (2010) Bioengineering of important secondary metabolites and metabolic pathways in fenugreek (Trigonella foenum-graecum L). J Med Plants 3(35):1–18

    Google Scholar 

  • Mkaddem M, Bouajila J, Ennajar M, Lebrihi A, Mathieu F, Romdhane M (2009) Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils. J Food Sci 74:358–363

    Article  CAS  Google Scholar 

  • Moghaddam M, Farhadi N (2015) Influence of environmental and genetic factors on resin yield, essential oil content and chemical composition of Ferula assa-foetida L. populations. J Appl Res Med Aromat Plants 2(3):69–76

    Google Scholar 

  • Mohsenikia M, Alizadeh AM, Kodayari S, Kodayari KA, Zamani M (2013) The protective and therapeutic effects of Alpha-solanine on mice breast cancer. Eur J Pharmacol 718:1–9

    Article  CAS  PubMed  Google Scholar 

  • Montanher AB, Zucolotto SM, Schenkel EP, Fröde TS (2007) Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model. J Ethnopharmacol 109(2):281–288

    Article  PubMed  Google Scholar 

  • Monteiro Â, Colomban S, Azinheira HG, Guerra-Guimarães L, Céu Silva MD, Navarini L, Resmini M (2020) Dietary antioxidants in coffee leaves: impact of botanical origin and maturity on Chlorogenic acids and Xanthones. Antioxidants 9:6. https://doi.org/10.3390/antiox9010006

    Article  CAS  Google Scholar 

  • Morillo M, Rojas J, Lequart V, Lamarti A, Martin P (2020) Natural and synthetic derivatives of the steroidal glycoalkaloids of solanum genus and biological activity. Nat Prod Chem Res 8:371. https://doi.org/10.35248/2329-6836.20.8.371

    Article  Google Scholar 

  • Morrow WJ, Yang YW, Sheikh NA (2004) Immunobiology of the Tomatine adjuvant. Vaccine 22:2380–2384

    Article  CAS  PubMed  Google Scholar 

  • Moudi M, Go R, Yong Seok Yien C, Nazre M (2013) Vinca alkaloids. Int J Prev Med 4(11):1231–1235

    PubMed  PubMed Central  Google Scholar 

  • Moussaieff A, Mechoulam R (2009) Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials. J Pharm Pharmacol 61:1281–1293

    Article  CAS  PubMed  Google Scholar 

  • Musayeib NMA, Mohamed GA, Ibrahim SRM, Ross SA (2014) New thiophene and flavonoid from Tagetes minuta leaves growing in Saudi Arabia. Molecules 19(3):28192828

    Google Scholar 

  • Mutschler E, Geisslinger G, Kroemer HK, Schäfer-Korting M (2008) Arzneimittelwirkungen—Lehrbuch der Pharmakologie und Toxikologie, 9th edn. Wissenschaftliche Verlagsgesellschaft, Stuttgart

    Google Scholar 

  • Mwita C, Mwai L, Newton C (2012) Antiepileptic properties of quinine: a systematic review. Ann Neurosci 19:14–20

    Article  CAS  Google Scholar 

  • Nassar MI, Aboutabl ESA, Makled YA, El-Khrisy EDA, Osman AF (2010) Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. Piperitum. Rev Latinoamer Quim 38:2

    Google Scholar 

  • Neukirch H, D’Ambrosio M, Dalla VJ, Guerriero A (2004) Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester. Phytochem Anal 15(1):30–35

    Article  CAS  PubMed  Google Scholar 

  • Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH (2006) Curry consumption and cognitive function in the elderly. Am J Epidemiol 164:898–906

    Article  PubMed  Google Scholar 

  • Ngo LT, Okogun JI, Folk WR (2013) 21st century natural product research and drug development and traditional medicines. Nat Prod Rep 30:584–592

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nichenametla SN, Taruscio TG, Barney DL, Exon JH (2006) A review of the effects and mechanism of polyphenolics in cancer. Crit Rev Food Sci Nutr 46:161–183

    Article  CAS  PubMed  Google Scholar 

  • Nicolaou KC, Chen JS, Corey EJ (2011) Classics in total synthesis. Further targets, strategies, methods III. Wiley-VCH, Weineim

    Google Scholar 

  • Oberlies NH, Kroll DJ (2004) Camptothecin and taxol: historic achievements in natural products research. J Nat Prod 67:129–135

    Article  CAS  PubMed  Google Scholar 

  • Okigbo RN, Eme UE, Ogbogu S (2008) Biodiversity and conservation of medicinal and aromatic plants in Africa. Biotechnol Mol Biol 3(6):127134

    Google Scholar 

  • Okunade AL (2002) Ageratum conyzoides L. (Asteraceae). Fitoterapia 73:1–16

    Article  CAS  PubMed  Google Scholar 

  • Okunade A, Hufford C, Clark A, Lentz D (1997) Antimicrobial properties of the constituents of Piper aduncum. Phytother Res 11:142–144

    Article  Google Scholar 

  • Padhan B, Panda D (2020) Potential of neglected and underutilized yams (Dioscorea spp.) for improving nutritional security and health benefits. Front Pharmacol 11:496. https://doi.org/10.3389/fphar.2020.00496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Padilla A, Hogan R, Kaiser RB (2007) The toxic triangle: destructive leaders, susceptible followers, and conducive environments. Leadersh Q 18:176–194

    Article  Google Scholar 

  • Pandita D (2020) Saffron (Crocus sativus L.): phytochemistry, therapeutic significance and omics-based biology. In: Aftab T, Hakeem K (eds) Medicinal and aromatic plants: expanding their horizons through Omics. Academic Press/Elsevier, Amsterdam, pp 325–396. https://doi.org/10.1016/B978-0-12-819590-1.00014-8

    Chapter  Google Scholar 

  • Pandita D, Pandita A, Pandita S (2013a) The Revitalizing & Recuperative Higher Tracheophytes of Jammu Province, Jammu and Kashmir (India). Int J Indigenous Med Plants 47(1):1603–1620

    Google Scholar 

  • Pandita D, Pandita A, Pandita S (2013b) Herbaceous Medicinal & Therapeutic Plants of District Samba of Jammu Province, Jammu & Kashmir (India). Int J Indigenous Med Plants 46(2):1224–1238

    Google Scholar 

  • Pandita D, Pandita A, Pandita S (2015a) Pharmacological and phytochemical portrayal of monocotyledonous medicinal plants of Jammu and Kashmir abound with antidiabetic potential. J Microbiol Biotech Res 5(6):28–33

    CAS  Google Scholar 

  • Pandita D, Pandita A, Pandita S (2015b) Pharmacological and phytochemical portrayal of dicotyledonous medicinal plants of Jammu and Kashmir abound with antidiabetic potential. J Microbiol Biotech Res 5(6):16–27

    CAS  Google Scholar 

  • Pandita D, Pandita A, Pandita S (2016) Is “the doctrine of signatures” signature sequences designed by god? Int J Sci Res Publ 6(11):568–572

    Google Scholar 

  • Panter KE, Welch KD, Gardner DR, Green BT (2013) Poisonous plants: effects on embryo and fetal development. Birth Defects Res C Embryo Today 99:223–234

    Article  CAS  PubMed  Google Scholar 

  • Pareek A, Kumar A (2014) Bioprospecting and genetic transformation of Bacopa monnieri L. the source of traditional Indian ayurvedic medicine: a review. J Pharm Sci Innov 3(6):504–506

    Article  Google Scholar 

  • Park EK, Choo MK, Kim EJ, Han MJ, Kim DH (2003) Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull 26:1581–1584

    Article  CAS  PubMed  Google Scholar 

  • Pavarini DP, Pavarini SP, Niehues M, Lopes NP (2012) Exogenous influences on plant secondary metabolite levels. Anim Feed Sci Technol 176:5–16

    Article  CAS  Google Scholar 

  • Payne GF, Bringi V, Prince C, Shuler M (1991) The quest for commercial production of chemicals from plant cell culture. In: Payne GF, Bringi V, Prince C, Shuler ML (eds) Plant cell and tissue culture in liquid systems. Hanser, Munich, pp 1–10

    Google Scholar 

  • Pengelly A (2004) The constituents of medicinal plants: an introduction to the chemistry and therapeutics of herbal medicine. 2nd ed. CABI, Wallingford, p 184. ISBN-10: 0851998070

    Google Scholar 

  • Perez DP, Lim W, Seiler JP, Yi G, Peiris M, Shortridge KF, Webster RG (2003) Role of quail in the interspecies transmission of h9 influenza A viruses: molecular changes on HA that correspond to adaptation from ducks to chickens. J Virol 77(5):3148–3156

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Poiroux-Gonord F, Bidel L, Fanciullino AL, Gautier H, Lauri-López F, Urban L (2010) Health benefits of vitamins and secondary metabolites of fruits and vegetables and prospects to increase their concentrations by agronomic approaches. J Agric Food Chem 58:12065–12082

    Article  CAS  PubMed  Google Scholar 

  • Porreca F, Cowan A, Raffa RB, Tallarida RJ (1983) Ketazocines and morphine: effects on gastrointestinal transit after central and peripheral administration. Life Sci 32:1785–1790

    Article  CAS  PubMed  Google Scholar 

  • Prakash P, Gupta N (2005) Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian J Physiol Pharmacol 49(2):125–131

    CAS  PubMed  Google Scholar 

  • Prasad A, Muthamilarasan M, Prasad M (2020) Synergistic antiviral effects against SARS-CoV-2 by plant-based molecules. Plant Cell Rep 39(9):1109–1114. https://doi.org/10.1007/s00299-020-02560-w

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Prats E, Galindo JC, Bazzalo ME, León A, Macías FA, Rubiales D, Jorrín JV (2007) Antifungal activity of a new phenolic compound from Capitulum of a head rot-resistant sunflower genotype. J Chem Ecol 33:2245–2253

    Article  CAS  PubMed  Google Scholar 

  • Puneet G, Aditi S, Vinayak K, Anant GN, Samir D, Nikhil M (2013) Camellia sinensis (tea): Implications and role in preventing dental decay. Pharmacogn Rev 7(14):152–156. https://doi.org/10.4103/0973-7847.120515

    Article  CAS  Google Scholar 

  • Purmova J, Opletal L (1995) Phytotherapeutic aspects of diseases of the cardiovascular system. 5. Saponins and possibilities of their use in prevention and therapy. Ceska Slov Farm 44:246–251

    CAS  PubMed  Google Scholar 

  • Qian JZ, Wang BC (2010) New research progress in pharmacological activities of hesperidin. Nat Prod Res Dev 22:176–180

    CAS  Google Scholar 

  • Qiu X, Reed DW, Hong H, MacKenzie SL, Covello PS (2001) Identification and analysis of a gene from calendula officinalis encoding a fatty acid conjugase. Plant Physiol 125(2):847–855

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Radad K, Gille G, Moldzio R, Saito H, Ishige K, Rausch WD (2004) Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPPþ -affected mesencephalic dopaminergic cells. J Neural Transm 111:37–45

    Article  CAS  PubMed  Google Scholar 

  • Rauha JP, Remes S, Heinonen M, Hopia A, Kkahkonen M, Kuyala T, Pihlaya K, Vuorela H, Vuorela P (2000) Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Int J Food Microbiol 56:3–12

    Article  CAS  PubMed  Google Scholar 

  • Reyburn H, Mtove G, Hendriksen I, von Seidlein L (2009) Oral qui-nine for the treatment of uncomplicated malaria. Br Med J 339:b2066. https://doi.org/10.1136/bmj.b2066

    Article  Google Scholar 

  • Rhodes MJC (1996) Physiologically-active compounds in plant–foods: an overview. Proc Nutr Soc 55:371–384

    Article  CAS  PubMed  Google Scholar 

  • Rice-Evans C, Miller N, Paganga G (1997) Antioxidant properties of phenolic compounds. Trends Plant Sci 2:152–159

    Article  Google Scholar 

  • Robards K, Antolovich M (1997) Analytical chemistry of fruit bioflavonoids – a review. Analyst 122:11R–34R

    Article  CAS  Google Scholar 

  • Roberts MF, Strack D, Wink M (2010) Biosynthesis of alkaloids and betalains. In: Annual plant reviews, vol 40: biochemistry of plant secondary metabolism, 2nd edn. Wiley/Blackwell, Oxford, pp 20–91

    Chapter  Google Scholar 

  • Rocha KKR, Souza GA, Ebaid GX, Seiva FRF, Cataneo AC, Novelli ELB (2009) Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. Food Chem Toxicol 47(6):1362–1367

    Article  CAS  PubMed  Google Scholar 

  • Rodney C, Toni M, Kutchan N, Lewis G (2000) Biochemistry and molecular biology of plants. In: Buchanan B, Gruissem W, Jones R (eds) Natural products. Wiley, Rockville, pp 1253–1348

    Google Scholar 

  • Roopan SM, Khan FN (2010) ZnO nanoparticles in the synthesis of AB ring core of camptothecin. Chem Papers 64(6):812–817

    Article  CAS  Google Scholar 

  • Rowe DJ (2004) Chemistry and technology of flavors and fragrances. Blackwell, Oxford. https://doi.org/10.1002/9781444305517.fmatter

    Book  Google Scholar 

  • Rozov-Ung I, Mreyound A, Moore J, Wilding GE, Khawam E, Lackner JM, Sitrin MD (2014) Detection of drug effects on gastric emptying and contractility using a wireless motility capsule. BMC Gastroenterol 14:2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ruberto G, Baratta MT, Deans SG, Dorman HJD (2000) Antioxidant and antimicrobial activity of Foeniculum activity and Crithmum maritimum essential oils. Planta Med 66:687–693

    Article  CAS  PubMed  Google Scholar 

  • Rudakewich M, Ba F, Benishin CG (2001) Neurotrophic and neuroprotective actions of ginsenosides Rb1 and Rg1. Planta Med 67:533–537

    Article  CAS  PubMed  Google Scholar 

  • Russo A, Borrelli F (2005) Bacopa monnieri, a reputed nootropic plant: an overview. Phytomedicine 12:305–317. https://doi.org/10.1016/j.phymed.2003.12.008

    Article  CAS  PubMed  Google Scholar 

  • Saeidnia S, Gohari AR, Mokhber-Dezfuli N, Kiuchi F (2011) A review on phytochemistry and medicinal properties of the genus Achillea. Daru 19(3):173–186

    CAS  PubMed  PubMed Central  Google Scholar 

  • Saller R, Reichling J, Hellenbrecht D (1995) Phytotherapie—Klinische, Pharmakologische und Pharmazeutische Grundlagen. Karl F. Haug Verlag, Heidelberg

    Google Scholar 

  • Salminen JP, Karonen M (2011) Chemical ecology of tannins and other phenolics: we need a change in approach: chemical ecology of tannins. Funct Ecol 25:325–338. https://doi.org/10.1111/j.1365-2435.2010.01826.x

    Article  Google Scholar 

  • Samuelsson G (2004) Drugs of natural origin: a textbook of pharmacognosy, 5th edn. Swedish Pharmaceutical Press, Stockholm

    Google Scholar 

  • Santos ARS, De Campos ROP, Miguel OG, Filho VC, Siani AC, Yunes RA, Calixto JB (2000) Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae). J Ethnopharmacol 72:229–238

    Article  CAS  PubMed  Google Scholar 

  • Sarikurkcu C, Locatelli M, Tartaglia A et al (2020) Enzyme and biological activities of the water extracts from the plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum that are used as Folk remedies in Turkey. Molecules 25(5):1202. https://doi.org/10.3390/molecules25051202

    Article  CAS  PubMed Central  Google Scholar 

  • Sasidharan I, Venugopal VV, Menon AN (2012) Essential oil composition of two unique ginger (Zingiber officinale Roscoe) cultivars from Sikkim. Nat Prod Res 26(19):1759–1764

    Article  CAS  PubMed  Google Scholar 

  • Sato T, Miyata G (2000) The nutraceutical benefit, part IV: garlic. Nutrition 16:787–788

    Article  CAS  PubMed  Google Scholar 

  • Scalbert A, Johnson IT, Saltmarsh M (2005) Polyphenols: antioxidants and beyond. Am J Clin Nutr 81:215S–217S

    Article  CAS  PubMed  Google Scholar 

  • Schmeller T, Wink M (2008) Utilization of alkaloids in modern medicine. In: Roberts MF, Wink M (eds) Alkaloids: biochemistry, ecology and medicinal applications. Plenum, New York, pp 435–459

    Google Scholar 

  • Schmeller T, El-Shazly A, Wink M (1997) Allelochemical activities of pyrrolizidine alkaloids: interactions with neuroreceptors and acetylcholine related enzymes. J Chem Ecol 23:399–416

    Article  CAS  Google Scholar 

  • Seigler DS (1998) Plant secondary metabolism. Springer Science: Business Media. ISBN: 978-1-4613-7228-8; ISBN: 978-1-4615-4913-0 (eBook)., New York. https://doi.org/10.1007/978-1-4615-4913-0

    Book  Google Scholar 

  • Sepulveda G, Porta H, Rocha M (2003) La participación de los metabolitos secundarios en la defensa de las plantas. Rev Mex Fitopatol 21:355–363

    Google Scholar 

  • Serafini M, Peluso I, Raguzzini A (2010) Flavonoids as anti-inflammatory agents. Proc Nutr Soc 69(3):273–278. https://doi.org/10.1017/S002966511000162X

    Article  CAS  PubMed  Google Scholar 

  • Shailajan S, Wadke P, Joshi H, Tiwari B (2013) Evaluation of quality and efficacy of an ethnomedicinal plant Ageratum conyzoides L. in the management of pediculosis. J Young Pharm 5(4):139–143. https://doi.org/10.1016/j.jyp.2013.10.005

    Article  PubMed  PubMed Central  Google Scholar 

  • Sharma PR, Shanmugavel M, Saxena AK, Qazi GN (2008) Induction of apoptosis by a synergistic lignan composition from Cedrus deodara in human cancer cells. Phytother Res 22(12):1587–1594. https://doi.org/10.1002/ptr.2511

    Article  CAS  PubMed  Google Scholar 

  • Sharma M, Ahuja A, Gupta R, Mallubhotla S (2015) Enhanced bacoside production in shoot cultures of Bacopa monnieri under the influence of abiotic elicitors. Nat Prod Res 29(8):745–749

    Article  CAS  PubMed  Google Scholar 

  • Sharma S, Rasal VP, Patil PA, Joshi RK (2017) Mentha arvensis essential oil suppressed airway changes induced by histamine and ovalbumin in experimental animals. Nat Prod Res 32(4):468–472

    Article  CAS  PubMed  Google Scholar 

  • Sharoni Y, Stahl W, Danilenko M, Levy J (2004) Anticancer activity of carotenoids: from human studies to cellular processes and gene regulation. In: Carotenoids in health and disease. CRC Press, Boca Raton, pp 165–196

    Google Scholar 

  • Simera M, Poliacek J, Jakus J (2010) Central antitussive effect of codeine in the anesthetized rabbit. Eur J Med Res 15:184–188

    Article  PubMed  PubMed Central  Google Scholar 

  • Simpson BB, Conner-Ogorzaly M (1986) Economic botany. McGraw-Hill, New York

    Google Scholar 

  • Singh G (2004) Plant systematics. An integrated approach. Science Publishers, Enfield-Plymouth

    Google Scholar 

  • Singh D, Chaudhuri PK (2018) A review on phytochemical and pharmacological properties of holy basil (Ocimum sanctum L.). Ind Crop Prod 118:367–382

    Article  CAS  Google Scholar 

  • Singh B, Sharma RA (2020) Secondary metabolites of medicinal plants: ethnopharmacological properties, biological activity and production strategies, vol 3. Wiley-VCH, Weinheim

    Book  Google Scholar 

  • Singh V, Dayal R, Bartley J (1999) Volatile constituents of Vitex negundo leaves. Planta Med 65:580

    Article  CAS  PubMed  Google Scholar 

  • Sitaram N, Weingartner H, Gilin JC (1978) Physostigmine: improvement of long-term memory process in normal humans. Science 201:272–276

    Article  Google Scholar 

  • Skolnick AA (1997) Old herbal chinese medicine used for fever yields possible new Alzheimer’s disease therapy. JAMA 277:776

    Article  CAS  PubMed  Google Scholar 

  • Somasegaran P, Hoben HJ (1994) Handbook for rhizobia: methods in legume-rhizobium technology. Springer-Verlag, New York

    Book  Google Scholar 

  • Soni P, Siddiqui AA, Dwivedi J, Soni V (2012) Pharmacological properties of Datura stramonium L. as a potential medicinal tree: an overview. Asian Pac J Trop Biomed 2(12):1002–1008. https://doi.org/10.1016/S2221-1691(13)60014-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stamp N (2003) Out of the quagmire of plant defense hypotheses. Q Rev Biol 78(1):23–55

    Article  PubMed  Google Scholar 

  • Suh KS, Chon S, Oh S, Kim SW, Kim JW, Kim YS, Woo JT (2009) Prooxidative effects of green tea polyphenol (−)-epigallocatechin-3-gallate on the HIT-T15 pancreatic beta cell line. Cell Biol Toxicol 26(3):189–199

    Article  CAS  PubMed  Google Scholar 

  • Surveswaran S, Cai Y, Corke H, Sun M (2007) Systematic evaluation of natural phenolic antioxidants from 133 Indian medicinal plants. Food Chem 102:938953

    Article  CAS  Google Scholar 

  • Tadeusz A (2015) Alkaloids: chemistry, biology, ecology, and applications, 2nd edn. Elsevier, Amsterdam. ISBN: 13: 978-0444594334

    Google Scholar 

  • Taiz L, Zeiger E (2002) Plant physiology. Sinauer Associates, Incorporated, Publishers, New York

    Google Scholar 

  • Tajidin NE, Shaari K, Maulidiani M et al (2019) Metabolite profiling of Andrographis paniculata (Burm. f.) Nees young and mature leaves at different harvest ages using 1H NMR-based metabolomics approach. Sci Rep 9:16766. https://doi.org/10.1038/s41598-019-52905-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tasdemir D, Brun R, Franzblau SG, Sezgin Y, Clls I (2008) Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila. Phytomedicine 15:209–215

    Article  CAS  PubMed  Google Scholar 

  • Teiten MH, Gaascht F, Dicato M, Diedrich M (2013) Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions. Biochem Pharmacol 86:1239–1247

    Article  CAS  PubMed  Google Scholar 

  • Teshika JD, Zakariyyah AM, Zaynab T, Zengin G, Rengasamy KRR, Pandian SK et al (2018) Traditional and modern uses of onion bulb (Allium cepa L.): a systematic review. Crit Rev Food Sci Nutr 59(sup1):S39–S70. https://doi.org/10.1080/10408398.2018.1499074

    Article  CAS  PubMed  Google Scholar 

  • Teuscher E, Lindequist U (2010) Biogene Gifte—Biologie, Chemie, Pharmakologie, Toxikologie, 3rd edn. Stuttgart, Germany, Wissenschaftliche Verlagsgesellschaft

    Google Scholar 

  • Teuscher E, Melzig MF, Lindequist U (2012) Biogene Arzneimittel. Ein Lehrbuch der Pharmazeutischen Biologie, 7th edn. Wissenschaftliche Verlagsgesellschaft, Stuttgart

    Google Scholar 

  • Thakur M, Melzig MF, Fuchs H, Weng A (2011) Chemistry and pharmacology of saponins: special focus on cytotoxic properties. Botanics: Targets Therapy 1:19–29

    Google Scholar 

  • Thirumurugan D, Cholarajan A, Raja SSS, Vijayakumar R (2018) An introductory chapter: secondary metabolites. In: Vijayakumar R, SSS R (eds) Secondary metabolites-sources and applications. IntechOpen, London. https://doi.org/10.5772/intechopen.79766

    Chapter  Google Scholar 

  • Thomas SG, Rien I, Steber CM (2005) Gibberellin metabolism and signaling. Vitam Horm 72:289–338

    Article  CAS  PubMed  Google Scholar 

  • Thomson M, Ali M (2003) Garlic (Allium sativum): a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets 3(1):67–81

    Article  CAS  PubMed  Google Scholar 

  • Tomsik P, Micuda S, Sucha L, Cermakova E, Suba P, Zivny P, Rezacova M (2013) The anticancer activity of alpha-tomatine against mammary adenocarcinoma in mice. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 157:153–161

    Article  CAS  PubMed  Google Scholar 

  • Trease GE, Evans WC (2002) Pharmacognosy, 15th edn. Saunders Publishers, London; pp. 214-39342–44. 221–229, 246–249, 304–306, 331–332, 391–393

    Google Scholar 

  • Tsuda H, Ishitani Y, Takemura Y, Suzuki Y, Kato T (1997) 6-acetyl-8-hydroxy-2, 2-dimethylchromene, an antioxidant in sunflower seeds; its isolation and synthesis and antioxidant activity of its derivatives. Heterocycles 44:139–142

    Article  CAS  Google Scholar 

  • Tulp M, Bohlin L (2004) Unconventional natural sources for future drug discovery. Drug Discov Today 9:450–458

    Article  CAS  PubMed  Google Scholar 

  • Tyler VE (1993) The honest herbal, 3rd edn. Pharmaceutical Products Press, New York

    Google Scholar 

  • Tyler VE (1994) Herb of choice—the therapeutic use of phytomedicinals. Pharmaceutical Products Press, New York

    Google Scholar 

  • Umukoro S, Adrian Omogbiya I, TaghoghoEduviere A (2013) Evaluation of the effect of Jobelyn on Chemoconvulsants-induced seizure in mice. BCN 4:19–23

    Google Scholar 

  • Vágujfalvi D (1992) Active substances in medicinal plants. In: Hornok L (ed) Cultivation and processing of medicinal plants. Akadémiai Kiad o, Budapest, pp 19–41

    Google Scholar 

  • Van Wyk BE, Wink M (2004) Medicinal plants of the world. Timber Press, Portland

    Google Scholar 

  • Van Wyk BE, Wink M (2015) Phytomedicines, herbal drugs and poisons. Briza, Kew Publishing, Cambridge University Press, Cambridge

    Google Scholar 

  • Van Wyk BE, Wink C, Wink M (2015) Handbuch der Arzneipflanzen, 3rd edn. Wissenschaftliche Verlagsgesellschaft, Stuttgart

    Google Scholar 

  • Verma SK, Gantait S, Jeong BR et al (2018) Enhanced growth and cardenolides production in Digitalis purpurea under the influence of different LED exposures in the plant factory. Sci Rep 8:18009. https://doi.org/10.1038/s41598-018-36113-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Verpoorte R, van der Heijden R, Memelink J (2000) Engineering the plant cell factory for secondary metabolite production. Transgenic Res 9:323–343

    Article  CAS  PubMed  Google Scholar 

  • Verpoorte R, Kim H, Choi Y (2006) Plants as source of medicines. New perspectives. In: Bogers RJ, Craker LE, Lange D (eds) Medicinal and aromatic plants. Springer, Dordrecht, pp 261–273

    Chapter  Google Scholar 

  • Vines G (2004) Herbal harvests with a future: towards sustainable sources for medicinal plants. Plant life International, Salisbury, www.plantlife.org.uk

    Google Scholar 

  • Vishwanathan AS, Basavaraju R (2010) A review on Vitex negundo L a medicinally important plant. EJBS 3(1):30–42

    Google Scholar 

  • Waghorn G (2008) Beneficial and detrimental effects of dietary condensed tannins for sustainable sheep and goat production—Progress and challenges. Anim Feed Sci Technol 147:116–139. https://doi.org/10.1016/j.anifeedsci.2007.09.013

    Article  CAS  Google Scholar 

  • Waghorn GC, Shelton ID, McNabb WC, McCutcheon SN (1994) Effects of condensed tannins in Lotus pedunculatus on its nutritive value for sheep. 2. Nitrogenous aspects. J Agric Sci 123:109–119. https://doi.org/10.1017/S0021859600067836

    Article  CAS  Google Scholar 

  • Wagner H, Vollmar A, Bechthold A (2007) Pharmazeutische Biologie 2. Biogene Arzneistoffe und Grundlagen von Gentechnik und Immunologie, 7th edn. Wissenschaftliche Verlagsgesellschaft, Stuttgart

    Google Scholar 

  • Wahle KWJ, Brown I, Rotondo D, Heys SD (2009) Plant phenolics in the prevention and treatment of cancer. In: Giardi MT, Rea G, Berra B (eds) Bio-farms for Nutraceuticals: functional food and safety control by biosensors. Springer, Boston, pp 36–51

    Google Scholar 

  • Wallace RJ (2007) Antimicrobial properties of plant secondary metabolites. Proc Nut Soc 63:621–629

    Article  CAS  Google Scholar 

  • Wang DH, Du F, Liu HY, Liang ZS (2010) Drought stress increases iridoid glycosides biosynthesis in the roots of Scrophularia ningpoensis seedlings. J Med Plants Res 4(24):2691–2699

    Article  CAS  Google Scholar 

  • Wang JG, Xu CC, Wong YK, Li YJ, Liao FL, Jiang TL, Tu YY (2019) Artemisinin, the magic drug discovered from traditional Chinese medicine. Engineering 5:32–39

    Article  CAS  Google Scholar 

  • Weathers PJ, Towler MJ (2012) The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. Planta Med 78(10):1024–1026

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weiß RF, Fintelmann V (2002) Lehrbuch der Phytotherapie, 10th edn. Stuttgart, Hippokrates Verlag

    Google Scholar 

  • Weinberg ED (1971) Secondary metabolism: Raison d’etre. Perspect Biol Med 14(4):565–577

    Google Scholar 

  • West R, Zatonski W, Cedzynska M, Lewandowska D, Pazik J, Ayeyard P, Stapleton J (2011) Placebo-controlled trial of Cytisine for smoking cessation. N Engl J Med 365:1193–1200

    Article  CAS  PubMed  Google Scholar 

  • WHO (1993) Research guidelines for evaluating the safety and efficacy of herbal medicines. World Health Organization, Geneva

    Google Scholar 

  • WHO (1998) General guidelines for methodologies on research and evaluation of traditional medicine. World Health Organization, Geneva

    Google Scholar 

  • WHO (2002) Traditional medicine strategy 2014–2023. World Health Organization, Geneva. http://apps.who.int/iris/bitstream/10665/92455/1/9789241506090_eng.pdf?ua=1

    Google Scholar 

  • WHO (2013) The WHO traditional medicine strategy 2014–2023. WHO, Geneva. ISBN 978 92 4 150609 0WHO/EDM/TRM/2000.1, Geneva, p 128.

    Google Scholar 

  • Wichtl M, Bisset NG (2000) Herbal drugs and phytopharmaceuticals. CRC Press, Boca Raton

    Google Scholar 

  • Wiesenauer M (2012) Phyto Praxis, 5th edn. Springer, Heidelberg

    Google Scholar 

  • Wilkinson JA, Brown AMG (1999) Horse chestnut – Aesculus hippocastanum: potential applications in cosmetic skin-care products. Int J Cosmetic Sci 21:437–447

    Article  CAS  Google Scholar 

  • Wink M (1988) Plant breeding: importance of plant secondary metabolites for protection against pathogens and herbivores. Theor Appl Gen 75:225–233

    Article  CAS  Google Scholar 

  • Wink M (1993) Allelochemical properties and the raison d’être of alkaloids. In: The alkaloids: chemistry and pharmacology, vol 43, pp 1–118. https://doi.org/10.1016/S0099-9598(08)60134-0

    Chapter  Google Scholar 

  • Wink M (2000) Interference of alkaloids with neuroreceptors and ion channels. In: Atta-Ur-Rahman (ed) Bioactive natural products, vol 11. Elsevier, Amsterdam, pp 3–129

    Google Scholar 

  • Wink M (2003) Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. Phytochemistry 64:3–19

    Article  CAS  PubMed  Google Scholar 

  • Wink M (2008) Plant secondary metabolism: diversity, function and its evolution. Nat Prod Commun 3:1205–1216

    CAS  Google Scholar 

  • Wink M (2010) Functions of plant secondary metabolites and their exploitation in biotechnology. Annual plant reviews, vol 39. Wiley-Blackwell, London

    Book  Google Scholar 

  • Wink M (2015) Modes of action of herbal medicines and plant secondary metabolites. Medicines 2:251–286. https://doi.org/10.3390/medicines2030251

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wink M, van Wyk BE (2010) Mind-altering and poisonous plants of the world. Timber Press, Portland

    Google Scholar 

  • Wink M, Schmeller T, Latz-Brüning B (1998) Modes of action of allelochemical alkaloids: interaction with neuroreceptors, DNA and other molecular targets. J Chem Ecol 24:1881–1937

    Article  CAS  Google Scholar 

  • Woldemichael GM, Wink M (2001) Identification of biological activities of triterpenoid saponins from Chenopodium quinoa. J Agric Food Chem 49:2327–2332

    Article  CAS  PubMed  Google Scholar 

  • Xu R, Zhao W, Xu J, Shao B, Qin G (1996) Studies on bioactive saponins from Chinese medicinal plants. Adv Exp Med Biol 404:371–382

    Article  CAS  PubMed  Google Scholar 

  • Xu L, Wu Y, Zhao X, Zhang W (2015) The study on biological and pharmacological activity of coumarins. In: Asia-pacific energy equipment engineering research conference; AP3ER pp 135–138

    Google Scholar 

  • Yang X, Zhao J, Cui Y, Liu X, Ma C, Hattori M, Zhaung L (1999) Anti HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis. J Nat Prod 62:1510–1513

    Article  CAS  PubMed  Google Scholar 

  • Yeoman MM, Yeoman CL (1996) Tansley review no. 90, manipulating secondary metabolism in cultured plant cells. New Phytol 134:553–569

    Article  CAS  PubMed  Google Scholar 

  • Yi Z, Wang Z, Li H, Liu M (2004) Inhibitory effect of tellimagrandin I on chemically induced differentiation of human leukemia K562 cells. Toxicol Lett 147(2):109–119

    Article  CAS  PubMed  Google Scholar 

  • Yonekura-Sakakibara K, Tohge T, Matsuda F, Nakabayashi R et al (2008) Comprehensive flavonol profiling and transcriptome coexpression analysis leading to decoding gene-metabolite correlations in Arabidopsis. Plant Cell 20:2160–2176

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yue PYK, Wong DYL, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TPD (2006) The angiosuppressive effects of 20(R)-ginsenoside Rg3. Biochem Pharmacol 72:437–445

    Article  CAS  PubMed  Google Scholar 

  • Zha W, Liang G, Xiao J, Studer EJ, Hylemon PB Jr, Pandak WM, Wang G, Li X, Zhou H (2010) Berberine inhibits IV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. PLoS One 5:e9069

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang Q, Cai L, Zong G, Luo W (2010) Simultaneous determination of Jatrorrhizine, Palmatine, Berberine and Obacunone in Phellodendri Amurensis Cortx by RP-HPLC. Zhongguo Zhong Yao Za Zhi 35:2061–2164

    CAS  PubMed  Google Scholar 

  • Zhao BT, Kim TI, Kim YH, Kang JS, Min BS, Son JK et al (2018) A comparative study of Mentha arvensis L. and Mentha haplocalyx Briq by HPLC. Nat Prod Res 32(2):239–242

    Article  CAS  PubMed  Google Scholar 

  • Zhou JX, Braun MS, Wetterauer P, Wetterauer B, Wink M (2019) Antioxidant, cytotoxic, and antimicrobial activities of Glycyrrhiza glabra L., Paeonia lactiflora Pall., and Eriobotrya japonica (Thunb.) Lindl. extracts. Medicines 6:43

    Article  CAS  PubMed Central  Google Scholar 

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  1. Government Department of School Education, Jammu, Jammu and Kashmir, India

    Deepu Pandita

  2. Vatsalya Clinic, New Delhi, India

    Anu Pandita

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  1. Department of Botany, Aligarh Muslim University, Aligarh, India

    Tariq Aftab

  2. Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

    Khalid Rehman Hakeem

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Pandita, D., Pandita, A. (2021). Secondary Metabolites in Medicinal and Aromatic Plants (MAPs): Potent Molecules in Nature’s Arsenal to Fight Human Diseases. In: Aftab, T., Hakeem, K.R. (eds) Medicinal and Aromatic Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-58975-2_2

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